1999

Synthesis and anti-virus activity of some nucleosides analogues.: Z Naturforsch [C]. 1999 Jan-Feb;54(1-2):75-83. Unique Identifier : AIDSLINE MED/99197481; Stankova IG; Simeonov MF; Maximova V; Galabov AS; Golovinsky EV; Department of Chemistry, South-West University Neofit Rilski,; Blagoevgrad, Bulgaria. ivankast@aix.swu.bg; New 3 -, 5 -, 5-bromo-2 -deoxyuridine (3a-g) and 3 -, 5 -thymidine (4a-i) analogues with amino acid and peptide residues were synthesized and evaluated for antiviral activity. The influence of long peptide chains, essential amino acids and the effect of this structural modification on the antiviral activity has been a
Follow-up essential for positive home HIV test results [news]: Oncology (Huntingt). 1999 Jan;13(1):81. Unique Identifier : AIDSLINE MED/99151262
Fludarabine, cyclophosphamide, and dexamethasone (FluCyD) combination is effective in pretreated low-grade non-Hodgkin's lymphoma.: Ann Oncol. 1999 Jan;10(1):59-64. Unique Identifier : AIDSLINE MED/99176019; Lazzarino M; Orlandi E; Montillo M; Tedeschi A; Pagnucco G; Astori C; Corso A; Brusamolino E; Simoncini L; Morra E; Bernasconi C; Institute of Hematology, University of Pavia, Italy.; mlazzarino@smatteo.pv.it; PURPOSE: Fludarabine phosphate is effective as a single agent in low-grade non-Hodgkin s lymphoma (NHL). Combined with other antineoplastic agents it enhances the antitumor effect. Our aim was to define the therapeutic efficacy and toxicity of a combination of fludarabine, cyclopho
Cystoid macular oedema and cytomegalovirus retinitis in patients with HIV disease treated with highly active antiretroviral therapy.: Br J Ophthalmol. 1999 Jan;83(1):47-9. Unique Identifier : AIDSLINE MED/99225909; Cassoux N; Lumbroso L; Bodaghi B; Zazoun L; Katlama C; LeHoang P; Department of Ophthalmology, Pitie-Salpetriere Hospital,; Paris, France.; BACKGROUND: Although cystoid macular oedema (CMO) is a rare cause of visual loss in AIDS related cytomegalovirus ( CMV ) retinitis, nine cases are reported of CMO occurring in HIV infected patients with a prior diagnosis of CMV
High-efficiency intracellular magnetic labeling with novel superparamagnetic-Tat peptide conjugates.: Bioconjug Chem. 1999 Mar-Apr;10(2):186-91. Unique Identifier : AIDSLINE MED/99177071; Josephson L; Tung CH; Moore A; Weissleder R; Center for Molecular Imaging Research, Massachusetts General; Hospital, Boston, Massachusetts 02129, USA.; A biocompatible, dextran coated superparamagnetic iron oxide particle was derivatized with a peptide sequence from the HIV-tat protein to improve intracellular magnetic labeling of different target cells. The conjugate had a mean particle size of 41 nm and contained an average of 6.7 tat peptides. Derivatized particle
[Human immunodeficiency virus (HIV) infection. The effectiveness of different diagnostic sequences in suspected pulmonary infection]: An Med Interna. 1999 Jan;16(1):15-20. Unique Identifier : AIDSLINE MED/99189515; Cortes Blanco A; Saez Lavilla C; Martinez Lazaro R; Arazo Garces P; Borraz Lopez MV; Ascaso Bandres A; Servicio de Medicina Nuclear, Hospital Miguel Servet, Zaragoza.; BACKGROUND: Assessment of different diagnostic sequences, in patients VIH(+) with a suspected pulmonary infection. METHODS: A cross-sectional descriptive study of 76 HIV(+) patients with suspected respiratory infection. It has been determined the validity and the pretest and post-test probability of the radiology (Rx)
[A pulmonary cellular immunity study in HIV patients]: An Med Interna. 1999 Jan;16(1):21-4. Unique Identifier : AIDSLINE MED/99189516; Fernandez Fabrellas E; Gonzalez Constan E; Marin Gonzalez M; Leon P; Blanquer Olivas R; Servicio de Neumologia, Hospital Dr. Peset Aleixandre, Valencia.; BACKGROUND: Cellular immunity disorder, showed by a decreased blood level of lymphocytes T CD4, is the main indicator of progression in HIV infection. The diminished level of these lymphocytes and CD4/CD8 ratio in pulmonary samples obtained by bronchoalveolar lavage (BAL) is known, so as the enhanced level of lymphocy
[Acute pancreatitis due to amphotericin B in an HIV-positive patient (letter)]: An Med Interna. 1999 Jan;16(1):47-8. Unique Identifier : AIDSLINE MED/99189523; Catalan I; Supervia A; Saballs P; Blanco ML
[An oral ulcer due to cytomegalovirus in a patient with the acquired immunodeficiency syndrome (letter)]: An Med Interna. 1999 Jan;16(1):53. Unique Identifier : AIDSLINE MED/99189530; Mendiburu Belzunegui L; Pena Garcia A; Sanchez Sanchez C; Font Cervero A
[The effect of human immunodeficiency virus infection on the consumption of hospital resources. A correlation with the degree of immunodeficiency]: An Med Interna. 1999 Jan;16(1):8-14. Unique Identifier : AIDSLINE MED/99189514; Rovira Daudi E; Gonzalez Monte C; Belda Mira A; Pascual Izuel JM; Gonzalvo Bellver F; Hospital de Sagunto, Servicio Valenciano de Salud, Valencia.; BACKGROUND: To calculate the real cost of the Human Immunodeficiency Virus (HIV) infection in the use of hospital resources. PATIENTS AND METHODS: All the episodes of hospitalization of the years 1993, 1994 and 1995 of a general hospital have been analyzed. The patients have been classified according to the Patients M
Sharing the dance toward the next century [editorial]: J Assoc Nurses AIDS Care. 1999 Mar-Apr;10(2):20-1. Unique Identifier : AIDSLINE MED/99164800; Highsmith C
Lipid abnormalities associated with protease inhibitors.: J Assoc Nurses AIDS Care. 1999 Mar-Apr;10(2):22-30. Unique Identifier : AIDSLINE MED/99164801; Melroe NH; Kopaczewski J; Henry K; Huebsch J; HIV Programs at Regions Hospital in St. Paul, Minnesota, USA.; Treatment for HIV infection in the past 3 years has significantly improved the prognosis of people infected with HIV. Protease inhibitors have played a critical role in this improved prognosis. Recent findings indicate, however, that protease inhibitors may cause si
Hepatitis A and HIV: a clinical review of disease and strategies for prevention.: J Assoc Nurses AIDS Care. 1999 Mar-Apr;10(2):31-6. Unique Identifier : AIDSLINE MED/99164802; Kwong JJ; Fenway Community Health Center, Boston, USA.; Hepatitis A, also known as infectious hepatitis, remains one of the more commonly transmitted types of viral hepatitis in the United States . Given the high prevalence of this illness, clinicians need to be aware not only about the clinical manifestations of this disease, but also about
Quality of life and self-care management strategies of PLWAs with chronic diarrhea.: J Assoc Nurses AIDS Care. 1999 Mar-Apr;10(2):46-54. Unique Identifier : AIDSLINE MED/99164803; Henry SB; Holzemer WL; Weaver K; Stotts N; Department of Community Health Systems, University of California,; San Francisco, USA.; A case control design was used to examine quality of life and self-care management strategies in persons living with AIDS (PLWAs) with chronic diarrhea. PLWAs without chronic diarrhea (n = 20) as compared to those with chronic diarrhea (n = 20) reported significantly higher general health perceptions (p = .028). In co
Nurses decrease barriers to health care by "hyperlinking" multiple-diagnosed women living with HIV/AIDS into care.: J Assoc Nurses AIDS Care. 1999 Mar-Apr;10(2):55-65. Unique Identifier : AIDSLINE MED/99164804; Andersen MD; Smereck GA; Hockman EM; Ross DJ; Ground KJ; Well-Being Institute, USA.; The Well-Being Institute (WBI), a community-based nursing organization in Detroit, Michigan, has developed and put into practice innovative intervention and service delivery models to assist HIV-positive women who have a history of substance abuse and mental illness. These multiple-diagnosed women are known to have sp
The expressed needs of a group of HIV-infected gay men subsequent to hospital care.: J Assoc Nurses AIDS Care. 1999 Mar-Apr;10(2):66-74. Unique Identifier : AIDSLINE MED/99164805; Cederfjall C; Wredling R; Department of Internal Medicine, Karolinska Hospital.; A qualitative study was conducted to explore how a group of HIV-infected gay men experienced their encounters with the health care community and to develop a theoretical understanding of the care given from the patient s perspective. Ten HIV-infected gay men were recruited from an outpatient clinic in a city in the so
Special population: HIV/AIDS among the deaf and hard of hearing.: J Assoc Nurses AIDS Care. 1999 Mar-Apr;10(2):75-8. Unique Identifier : AIDSLINE MED/99164806; Gaskins S; Capstone College of Nursing, University of Alabama, USA.
Searching for HIV/AIDS information on the World Wide Web.: J Assoc Nurses AIDS Care. 1999 Mar-Apr;10(2):79-81. Unique Identifier : AIDSLINE MED/99164807; Mann CE; WW Clark Memorial Library, University of Portland, USA.; Providing patients and their families with information on HIV/AIDS can be a challenge given the entire range of tissues that come packaged with the disease itself. Information on treatment and resources changes rapidly due to the nature of the disease, and it can be difficult to have printed sources on hand that are u
Thalidomide: the past, present, and future.: J Assoc Nurses AIDS Care. 1999 Mar-Apr;10(2):82-4. Unique Identifier : AIDSLINE MED/99164808; Porche D; Nicholls State University, USA.; Treatment Review is intended to inform and update nurses about treatments relevant to HIV/AIDS. Product information presented in this column does not imply endorsement by the Association of Nurses in AIDS Care.
New CDC guidelines call for TB screening and treatment for all HIV-infected individuals [news]: J Assoc Nurses AIDS Care. 1999 Mar-Apr;10(2):85-6. Unique Identifier : AIDSLINE MED/99164809
Results of simplified screening for Chlamydia in female military recruits suggest testing for all sexually active young women [news]: J Assoc Nurses AIDS Care. 1999 Mar-Apr;10(2):86-7. Unique Identifier : AIDSLINE MED/99164810
New study showed average costs of care for HIV in managed care were lower for patients with undetectable viral loads [news]: J Assoc Nurses AIDS Care. 1999 Mar-Apr;10(2):87-8. Unique Identifier : AIDSLINE MED/99164811
Idiopathic CD4+ T lymphocytopenia disclosed by the onset of empyema thoracis.: Intern Med. 1999 Jan;38(1):40-4. Unique Identifier : AIDSLINE MED/99160106; Hamanishi T; Nakao T; Nishino M; Yanagawa T; Kobayashi M; Sasaki H; Matsumoto G; Sanke T; Nanjyo K; First Department of Medicine, Wakayama University of Medical; Science.; A 56-year-old man was admitted to our hospital in December 1996 due to empyema thoracis. A laboratory examination revealed lymphocytopenia and CD4+ T lymphocytopenia (
Idiopathic CD4+ T-lymphocytopenia in chronic obstructive pulmonary disease [letter]: Intern Med. 1999 Jan;38(1):71-2. Unique Identifier : AIDSLINE MED/99160113; Matsuyama W; Mizoguchi A; Hamasaki T; Wakimoto J; Iwami F; Kawabata M; Osame M
[The effect of chaihu qingxin yin on left cardiac function and T-cell subgroup in peripheral blood in children with viral myocarditis]: Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. 1997 Feb;17(2):73-5. Unique Identifier : AIDSLINE MED/99029202; Wang XF; Yan WC; Guo ZW; Liaoning College of Traditional Chinese Medicine, Shenyang.; OBJECTIVE: To observe the effect of Caihu Qingxin Yin (CHQXY) in treating viral myocarditis. METHODS: CHQXY was used to treat 52 cases of acute viral myocarditis in children, compared with the routine method using energy mixture in 32 patients. RESULTS: (1) The total effective rate of 52 patients using CHQXY was 71.2%
Paralytic poliomyelitis associated with live oral poliomyelitis vaccine in child with HIV infection in Zimbabwe: case report.: BMJ. 1999 Mar 27;318(7187):841-3. Unique Identifier : AIDSLINE MED/99192485; Chitsike I; van Furth R; Departments of Paediatrics and Immunology, Medical School of the; University of Zimbabwe, PO Box A 178, Harare, Zimbabwe.; OBJECTIVE: To describe a complication of oral vaccination with live, attenuated poliomyelitis virus in a child infected with HIV. DESIGN: Case report. SETTING: Teaching hospital in Harare, Zimbabwe . SUBJECTS: A boy of 41/2 years and his mother. MAIN OUTCOME MEASURES: Results of c
The SCID/Beige mouse as a model to investigate protection against Yersinia pestis.: FEMS Immunol Med Microbiol. 1999 Feb;23(2):107-13. Unique Identifier : AIDSLINE MED/99174525; Green M; Rogers D; Russell P; Stagg AJ; Bell DL; Eley SM; Titball RW; Williamson ED; DERA, Chemical and Biological Defense Sector, Salisbury,; Wiltshire, UK.; In this study, we have shown that severe combined immunodeficient/beige mice reconstituted with hyperimmune Balb/c lymphocytes can be used as a model to demonstrate adoptive and passive protection against plague infection. Reconstitution of severe combined immunodeficient/beige mice was successful in nine out of ten m
Live antigen carriers as tools for improved anti-tuberculosis vaccines.: FEMS Immunol Med Microbiol. 1999 Feb;23(2):165-73. Unique Identifier : AIDSLINE MED/99174532; Hess J; Kaufmann SH; Max-Planck-Institute for Infection Biology, Department of; Immunology, Berlin, Germany. Hess@mpiib-berlin.mpg.de; Recombinant (r) Mycobacterium bovis BCG strains have been constructed which secrete biologically active listeriolysin (Hly) fusion protein of Listeria monocytogenes. In human and murine macrophage-like cell lines, intracellular persistence of these r-BCG strains was reduced as compared to the parental BCG strain. By i
Genetic and non-genetic determination of repeatability of blood and milk indices in black-and-white cows.: Arch Vet Pol. 1993;33(3-4):165-76. Unique Identifier : AIDSLINE MED/99203797; Walawski K; Kaczmarczyk E; Sowinski G; Czarnik U; Zabolewicz T; Biallowicz E; Department of Animal Genetics, University of Agriculture and; Technology, Olsztyn, Poland.; A herd of cows of the same age, kept in a stable system under controlled environmental conditions, was used to estimate the repeatability of diagnostic blood and milk indices in several stages of the I, II and III lactation. Attention was paid to genetic and non-genetic sources of phenotypic variation. Statistically s
[Pediatric AIDS: epidemiological, clinical and prognostic aspects in Abidjan, Ivory Coast (letter)]: Arch Pediatr. 1999 Mar;6(3):342-3. Unique Identifier : AIDSLINE MED/99207638; Niangue-Beugre NM; Oulai MS; Gonty L; Orega M; Plo KJ; Andoh J
[Specific immunotherapy]: Arch Pediatr. 1999;6 Suppl 1:108S-113S. Unique Identifier : AIDSLINE MED/99207659; Just J; Houzel-Charavel A; Grimfeld A; Polyclinique de pneumologie pediatrique, hopital d'Enfants; Armand-Trousseau, Paris, France.; Increase of the prevalence of allergy these last 20 years is in part secondary to the modification of the allergenic charge of our environment. The specific immunotherapy (SIT) is the only etiologic treatment of the allergic disease and numbers of authors believe that, for the future, this treatment could change the n
Proxy, health, and personal care preferences: implications for end-of-life care.: Camb Q Healthc Ethics. 1999 Spring;8(2):200-10. Unique Identifier : AIDSLINE MED/99166163; Aikman PJ; Thiel EC; Martin DK; Singer PA; Dalhousie University.
Placental antibody transfer: influence of maternal HIV infection and placental malaria.: Arch Dis Child Fetal Neonatal Ed. 1998 Nov;79(3):F202-5. Unique Identifier : AIDSLINE MED/99210896; de Moraes-Pinto MI; Verhoeff F; Chimsuku L; Milligan PJ; Wesumperuma L; Broadhead RL; Brabin BJ; Johnson PM; Hart CA; Department of Medical Microbiology, University of Liverpool.; AIM: To determine the influence of placental malaria, maternal HIV infection, and maternal hypergammaglobulinaemia on transplacental IgG antibody transfer. METHODS: One hundred and eighty materno-neonatal pairs from a Malawian population were assessed. Cord and maternal serum samples were tested for total serum IgG an
A cis proline turn linking two beta-hairpin strands in the solution structure of an antibody-bound HIV-1IIIB V3 peptide.: Nat Struct Biol. 1999 Apr;6(4):331-5. Unique Identifier : AIDSLINE PDB/1B03; Tugarinov V; Zvi A; Levy R; Anglister J; Department of Structural Biology, The Weizmann Institute of; Science, Rehovot, Israel.; The refined solution structure of an 18-residue HIV-1IIIB V3 peptide in complex with the Fv fragment of an anti-gp120 antibody reveals an unexpected type VI beta-turn comprising residues RGPG at the center of a beta-hairpin. The central glycine and proline of this turn are linked by a cis peptide bond. The residues of
A novel role for the major histocompatibility complex class II transactivator CIITA in the repression of IL-4 production.: Immunity. 1999 Mar;10(3):377-86. Unique Identifier : AIDSLINE MED/99219187; Gourley T; Roys S; Lukacs NW; Kunkel SL; Flavell RA; Chang CH; Department of Microbiology and Immunology, University of Michigan; Medical School, Ann Arbor 48109, USA.; Class II transactivator (CIITA) is known as a coactivator for MHC class II gene expression in antigen-presenting cells. Surprisingly, when CIITA-/- CD4 T cells were stimulated in the presence of IL-12, they produced not only IFNgamma but also high levels of IL-4. The IL-4 production is due to the accumulation of IL-4
The role of IgE in asthma.: Clin Exp Allergy. 1998 Nov;28 Suppl 5:104-9; discussion 117-8. Unique Identifier : AIDSLINE MED/99140984; Yssel H; Abbal C; Pene J; Bousquet J; Clinique des Maladies Respiratoires and INSERM U454, Hopital; Arnaud de Villeneuve, Montpellier, France.; Asthma is a multifactorial and complex disease in which allergic factors and non-allergic triggers interact and result in bronchial obstruction and inflammation. Allergenic sensitization is important in the development of asthma and, although links between inhalant allergy and asthma have been known for many years, th
Reciprocal age-related patterns of allergen-specific T-cell immunity in normal vs. atopic infants.: Clin Exp Allergy. 1998 Nov;28 Suppl 5:39-44; discussion 50-1. Unique Identifier : AIDSLINE MED/99140975; Prescott SL; Macaubas C; Smallacombe T; Holt BJ; Sly PD; Loh R; Holt PG; TVW Telethon Institute for Child Health Research, West Perth,; Western Australia, Australia.; By adulthood there is almost universal immunological memory to aeroallergens, and the presence of allergic disease appears to be related to the nature of the underlying T-helper (Th) cell cytokine responses. The hypothesis of this study is that adult patterns of allergen specific Th-cell memory (Th-2 polarized in atop
Immunoregulatory networks in asthma.: Clin Exp Allergy. 1998 Nov;28 Suppl 5:92-6; discussion 117-8. Unique Identifier : AIDSLINE MED/99140982; Le Gros G; Erb K; Harris N; Holloway J; McCoy K; Ronchese F; Malaghan Institute of Medical Research, Wellington, New Zealand.; It is now well established that a subset of T-cell-derived cytokines (termed Th2 cytokines) programme the timing and characteristics of atopic airway disease including mast-cell sensitization, eosinophil and lymphocyte infiltration and recently mucus secretion. To date, attempts to devise ways to selectively limit the
Is allergy increasing?--early life influences.: Clin Exp Allergy. 1998 Dec;28 Suppl 6:2-7. Unique Identifier : AIDSLINE MED/99140956; Howarth PH; University Medicine, Southampton General Hospital, UK.; Data from epidemiological studies conducted in several countries worldwide have revealed that the prevalences of allergic conditions, including allergic rhinitis, asthma and eczema, have increased from the 1940s/50s to the 1990s. These allergic conditions involve specific IgE-mediated responses, and a few studies have
Epicutaneous administration of hapten through patch application augments TH2 responses which can downregulate the elicitation of murine contact hypersensitivity.: Clin Exp Allergy. 1999 Feb;29(2):271-9. Unique Identifier : AIDSLINE MED/99170084; Wang LF; Sun CC; Wu JT; Lin RH; Graduate Institute of Microbiology, Department of Dermatology,; College of Medicine, National Taiwan University, Taipei, Republic; of China.; BACKGROUND AND OBJECTIVE: Allergic contact dermatitis and its animal model, contact hypersensitivity (CHS), have long been documented as type 1 T-cell-predominant immune responses. Although type 1/type 2 T-cell deviation has been repeatedly demonstrated to play an important role in many human diseases and their animal
Norm values for eosinophil cationic protein in nasal secretions: influence of specimen collection.: Clin Exp Allergy. 1999 Mar;29(3):367-74. Unique Identifier : AIDSLINE MED/99221991; Klimek L; Rasp G; Department of Otorhinolaryngology, Johannes Gutenberg University,; Mainz, Germany.; BACKGROUND: Eosinophil granulocytes play an important role in allergic inflammation of the nasal mucosa. Eosinophil cationic protein (ECP) is a specific eosinophil granule protein released upon activation of these cells. ECP concentration in nasal secretions has been demonstrated to be a good marker for the activity o
Attenuation of house dust mite Dermatophagoides farinae-induced airway allergic responses in mice by dehydroepiandrosterone is correlated with down-regulation of TH2 response.: Unique Identifier : AIDSLINE MED/99221998; Yu CK; Yang BC; Lei HY; Chen YC; Liu YH; Chen CC; Liu CW; BACKGROUND: Dehydroepiandrosterone (DHEA), an abundant androgen in circulation, has important immunomodulating effects on T-cell differentiation; however, it is not known whether this hormone influences allergic responses. OBJECTIVE: We have established a murine model of airway inflammation induced by house dust mite
Increased prevalence of malaria in HIV-infected pregnant women and its implications for malaria control.: Trop Med Int Health. 1999 Jan;4(1):5-12. Unique Identifier : AIDSLINE MED/99217817; Verhoeff FH; Brabin BJ; Hart CA; Chimsuku L; Kazembe P; Broadhead RL; Liverpool School of Tropical Medicine, UK.; OBJECTIVES: To examine in pregnant women the relationship between HIV infection and malaria prevalence and to determine, in relation to HIV infection, the effectiveness of sulphadoxine-pyrimethamine in clearing P. falciparum infection. METHOD: Descriptive cross-sectional analysis of P. falciparum prevalence in pregnan
Evaluation of a quantitative determination of CD4 and CD8 molecules as an alternative to CD4+ and CD8+ T lymphocyte counts in Africans.: Trop Med Int Health. 1999 Feb;4(2):79-84. Unique Identifier : AIDSLINE MED/99221101; Diagbouga S; Durand G; Sanou PT; Dahourou H; Ledru E; Centre MURAZ, Organization de Coordination et de Cooperation; pour la lutte contre les Grandes Endemies, Bobo-Dioulasso,; Burkina Faso. griv.muraz@fasonet.bf; In the developed word, monitoring HIV-infected patients is routinely determined by CD4+ T lymphocyte absolute counts. The reference procedure, flow cytometry, is expensive, requires sophisticated instrumentation and operators with specific training. Due to these limitations, CD4 counting is often unavailable in develo
Oral hairy leukoplakia in a patient with acute lymphocytic leukemia.: Unique Identifier : AIDSLINE MED/99234668; Nicolatou O; Nikolatos G; Fisfis M; Belegrati M; Papadaki T; Oikonomaki E; Kalmantis T; Department of Oral Pathology and Surgery, School of Dentistry,; University of Athens, Greece.; The first case of oral hairy leukoplakia (OHL) in an HIV-negative 56-year-old patient with acute lymphocytic leukemia (ALL) is reported. A white plaque was observed while the patient was in complete remission which followed the chemotherapeutic scheme. The clinical and histopathologic findings were typical for OHL and
NIH appoints a director for its AIDS vaccine center [news]: Nat Med. 1999 Apr;5(4):362. Unique Identifier : AIDSLINE MED/99217559; Birmingham K
Finding funding for China's HIV research [news]: Nat Med. 1999 Apr;5(4):364-5. Unique Identifier : AIDSLINE MED/99217562; Watanabe ME
Fetal immunization of baboons induces a fetal-specific antibody response.: Unique Identifier : AIDSLINE MED/99217583; Watts AM; Stanley JR; Shearer MH; Hefty PS; Kennedy RC; Neonates face a high risk of infection because of the immaturity of their immune systems. Although the transplacental transfer of maternal antibodies to the fetus may convey improved postnatal immunity, this transfer occurs late in gestation and may fail to prevent in utero infection. Both fetal immunization and in ut
Syphilis: review with emphasis on clinical, epidemiologic, and some biologic features.: Clin Microbiol Rev. 1999 Apr;12(2):187-209. Unique Identifier : AIDSLINE MED/99212045; Singh AE; Romanowski B; Alberta Health STD Services, University of Alberta, Edmonton,; Alberta, Canada.; Syphilis is a chronic disease with a waxing and waning course, the manifestations of which have been described for centuries. It occurs worldwide, and the incidence varies significantly with geographic location. Transmission is mainly by sexual contact. The causative organism, Treponema pallidum, was first described i
Molecular techniques for detection, species differentiation, and phylogenetic analysis of microsporidia.: Clin Microbiol Rev. 1999 Apr;12(2):243-85. Unique Identifier : AIDSLINE MED/99212048; Franzen C; Muller A; Department of Internal Medicine I, University of Cologne, 50924; Cologne, Germany.Caspar.Franzen@Uni-Koeln.de; Microsporidia are obligate intracellular protozoan parasites that infect a broad range of vertebrates and invertebrates. These parasites are now recognized as one of the most common pathogens in human immunodeficiency virus-infected patients. For most patients with infectious diseases, microbiological isolation and id
Resistance of human cytomegalovirus to antiviral drugs.: Unique Identifier : AIDSLINE MED/99212049; Erice A; Resistance of cytomegalovirus ( CMV ) to antiviral agents is a well-recognized phenomenon that has been observed in the laboratory and in the clinical setting. Infections caused by antiviral-resistant CMV have been found exclus
[T-lymphocyte subgroup and the nature killer cell activity in cardiovascular diseases]: Hunan I Ko Ta Hsueh Hsueh Pao. 1997;22(6):535-6. Unique Identifier : AIDSLINE MED/99172655; Xie X; Dai T
Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes.: Cell. 1999 Apr 2;97(1):63-73. Unique Identifier : AIDSLINE MED/99213495; Piguet V; Gu F; Foti M; Demaurex N; Gruenberg J; Carpentier JL; Trono D; Department of Genetics, Faculty of Medicine, University of; Geneva, Switzerland.; The Nef protein of primate lentiviruses downregulates the cell surface expression of CD4 through a two-step process. First, Nef connects the cytoplasmic tail of CD4 with adaptor protein complexes (AP), thereby inducing the formation of CD4-specific clathrin-coated pits that rapidly endocytose the viral receptor. Secon
Single cell analysis of antigen-specific T cell responses in HIV-infected individuals.: Cell Immunol. 1999 Mar 15;192(2):107-12. Unique Identifier : AIDSLINE MED/99189157; Byl B; Gerard M; Libin M; Clumeck N; Goldman M; Mascart F; Hopital Erasme, Universite Libre de Bruxelles, Brussels,; B-1070, Belgium.; Antigen-specific and polyclonally induced T cell responses were analyzed in 10 HIV-infected individuals and in 14 controls by enumerating the numbers of tetanus toxoid (TT)-specific and phytohemagglutinin (PHA)-induced IFN-gamma-secreting cells (SC) and IL-4-SC using an enzyme-linked immunospot assay. Whereas the numb
Both CD4(+) T cells and CD8(+) T cells are required for iodine accelerated thyroiditis in NOD mice.: Cell Immunol. 1999 Mar 15;192(2):113-21. Unique Identifier : AIDSLINE MED/99189158; Hutchings PR; Verma S; Phillips JM; Harach SZ; Howlett S; Cooke A; Department of Pathology, University of Cambridge, Cambridge, CB2; 1QP, United Kingdom.; The nonobese diabetic (NOD) mouse, a spontaneous animal model for insulin-dependent diabetes mellitus, displays a tendency in common with human diabetic populations to develop autoimmune thyroiditis although incidence and severity of thyroid lesions vary widely among different colonies around the world. A congenic str
DOTS and drug resistance: a silver lining to a darkening cloud [editorial; comment]: Int J Tuberc Lung Dis. 1999 Jan;3(1):1-3. Unique Identifier : AIDSLINE MED/99191950; Chaisson RE; Coberly JS; De Cock KM
Risk factors for tuberculosis in patients with AIDS in London: a case-control study.: Int J Tuberc Lung Dis. 1999 Jan;3(1):12-7. Unique Identifier : AIDSLINE MED/99191952; Del Amo J; Petruckevitch A; Phillips AN; De Cock KM; Stephenson J; Desmond N; Hanscheid T; Low N; Newell A; Obasi A; Paine K; Pym A; Theodore C; Johnson AM; MRC UK Centre for Co-ordinating Epidemiological Studies of HIV; and AIDS, Department of STD, Mortimer Market Centre, London, UK.; jdelamo@isciii.es; OBJECTIVE: To identify risk factors for the acquired immune-deficiency syndrome (AIDS) associated with tuberculosis, in patients with AIDS attending 11 of the largest human immunodeficiency virus (HIV)/AIDS Units in London. DESIGN: Case-control study nested in a retrospective cohort of 2048 HIV-1 positive patients. Ca
Incidence of tuberculosis in a community of Senegalese immigrants in Northern Italy.: Int J Tuberc Lung Dis. 1999 Jan;3(1):18-22. Unique Identifier : AIDSLINE MED/99191953; Scolari C; El-Hamad I; Matteelli A; Signorini L; Bombana E; Moioli R; De Leonardis C; Nava AM; Carosi G; Clinic of Infectious and Tropical Diseases-University of Brescia,; Italy.; SETTING: Tuberculosis is the world s foremost cause of death from a single infectious agent among adults. Although morbidity and mortality rates are highest in low income countries, industrialized countries have also faced a recent resurgence of the tuberculosis epidemic. In Europe and the
Low levels of drug resistance amidst rapidly increasing tuberculosis and human immunodeficiency virus co-epidemics in Botswana [see comments]: Int J Tuberc Lung Dis. 1999 Jan;3(1):4-11. Unique Identifier : AIDSLINE MED/99191951; Kenyon TA; Mwasekaga MJ; Huebner R; Rumisha D; Binkin N; Maganu E; BOTUSA TB Project, Gaborone, Botswana, and Division of TB; Elimination, Centers for Disease Control and Prevention, Atlanta,; Georgia, USA. tak8@cdc.gov; SETTING: Botswana , southern Africa, where the tuberculosis (TB) case rate increased by 120% from 1989 to 1996 in spite of a decade of implementation of the directly observed therapy, short-course (DOTS) strategy. OBJECTIVE: To determine prevalence of and risk factors for drug-res
Prednisolone: a beneficial and safe adjunct to antituberculosis treatment? A randomized controlled trial.: Int J Tuberc Lung Dis. 1999 Jan;3(1):47-54. Unique Identifier : AIDSLINE MED/99191957; Bilaceroglu S; Perim K; Buyuksirin M; Celikten E; Department of Thoracic Medicine, Izmir Chest Diseases and Surgery; Training Hospital, Turkey. bsemra@turk.net; SETTING: A referral centre for thoracic diseases in Izmir, Turkey , 1992-1995. OBJECTIVE: To appraise the adjunctive role of prednisolone (PN) in pulmonary tuberculosis (PTB) with toxic reactions. DESIGN: After excluding other febrile causes, and 2 weeks of four/five-drug antituberc
Mycobacterium kansasii infection in a Paris suburb: comparison of disease presentation and outcome according to human immunodeficiency virus status. Groupe dEtude Des Mycobacteries de la Seine-Saint-Denis.: Int J Tuberc Lung Dis. 1999 Jan;3(1):68-73. Unique Identifier : AIDSLINE MED/99191960; Lortholary O; Deniel F; Boudon P; Le Pennec MP; Mathieu M; Soilleux M; Le Pendeven C; Loiseau P; Vincent V; Valeyre D; Service de Medecine Interne et Centre de Recherche en Pathologie; Infectieuse et Tropicale, Bobigny, France.; SETTING: Department of Seine-Saint-Denis, France . OBJECTIVE: To compare the presentation and outcome of Mycobacterium kansasii infections according to human immunodeficiency virus (HIV) status. DESIGN: Retrospective analysis of all the medical charts of adults meeting the diagnosti
High compliance in an ambulatory tuberculosis treatment programme in a rural community of Uganda.: Int J Tuberc Lung Dis. 1999 Jan;3(1):79-81. Unique Identifier : AIDSLINE MED/99191962; Nuwaha F; Department of Community Health, Mbarara University, Uganda.; The increasing numbers of clinical tuberculosis in Uganda , mainly due to the human immunodeficiency virus (HIV) epidemic, means that it is no longer possible to hospitalise all TB patients, and the feasibility of ambulatory treatment needs to be assessed. A successful ambulatory TB
Drug susceptibility of Mycobacterium tuberculosis in a rural area of Bangladesh and its relevance to the national treatment regimens.: Int J Tuberc Lung Dis. 1999 Feb;3(2):143-8. Unique Identifier : AIDSLINE MED/99190301; Van Deun A; Aung KJ; Chowdhury S; Saha S; Pankaj A; Ashraf A; Rigouts L; Fissette K; Portaels F; Damien Foundation Bangladesh, Dhaka.; SETTING: Greater Mymensingh District, a rural area of Bangladesh , at the start of the National Tuberculosis Programme (NTP). OBJECTIVES: To determine the prevalence of initial and acquired drug resistance of Mycobacterium tuberculosis, and to assess the appropriateness of the N
Use of incentives to increase compliance for TB screening in a population of intravenous drug users. Vancouver Injection Drug Use Study Group.: Int J Tuberc Lung Dis. 1999 Feb;3(2):153-5. Unique Identifier : AIDSLINE MED/99190303; FitzGerald JM; Patrick DM; Strathdee S; Rekart M; Elwood RK; Schecter MT; Montaner J; O'Shaughnessy M; British Columbia Centre for Disease Control Society, BC Centre; for Excellence in HIV/AIDS and the University of British; Columbia, Vancouver, Canada. mfitzgerald@mater.ie; SETTING: Intravenous drug users (IDUs) represent a high risk group for dual human immunodeficiency virus (HIV) and tuberculosis (TB) infection. Screening with TB skin testing has therefore been suggested in this group. Subjects compliance for returning to have TB skin test results read is a major problem. In the sett
Lymph node tuberculosis in the suburbs of Paris: 59 cases in adults not infected by the human immunodeficiency virus.: Int J Tuberc Lung Dis. 1999 Feb;3(2):162-5. Unique Identifier : AIDSLINE MED/99190305; Fain O; Lortholary O; Djouab M; Amoura I; Babinet P; Beaudreuil J; Boudon P; Desrues J; Glowinski J; Lhote F; Malbec D; Mathieu E; White C; Guillevin L; Thomas M; Department of Internal Medicine, Jean Verdier Hospital, Bondy,; France.; We report 59 cases of lymph node tuberculosis in adults not infected by the human immunodeficiency virus (HIV), observed over a period of 5 years in the North Eastern suburbs of Paris. There were 31 women and 28 men; 84.7% were aged under 44 years; 69.5% were not French, and 78% had exclusive lymph node tuberculosis.
Identification of Mycobacterium shimoidei by molecular techniques: case report and summary of the literature.: Unique Identifier : AIDSLINE MED/99190307; Mayall B; Gurtler V; Irving L; Marzec A
Gastrointestinal manifestations of HIV infection.: Hosp Med. 1999 Jan;60(1):24-8. Unique Identifier : AIDSLINE MED/99212843; Blanshard C; Academic Unit of Medical and Surgical Gastroenterology, Homerton; Hospital, London.; As patients with human immunodeficiency virus (HIV) infection become more immunocompromised, gastrointestinal symptoms become more common. Most symptoms result from opportunistic infections and can be diagnosed and treated by gastroenterologists, although medical microbiology and histopathology input is essential.
Kaposi's sarcoma in women: A clinicopathologic study.: J Cutan Med Surg. 1999 Jan;3(3):132-9. Unique Identifier : AIDSLINE MED/99182556; Smith KJ; Nelson A; Angritt P; Morz A; Skelton HG; National Naval Medical Center, Bethesda, Maryland 20089-5600,; USA.; BACKGROUND: Although all epidemiologic subsets of Kaposi s sarcoma (KS) (i.e., sporadic, endemic, epidemic, and iatrogenic) have an association with human herpes virus 8 (HHV8), these subsets occur in patient populations with distinctive clinical features. To a variable degree men outnumber women in all subsets. OBJEC
Crusted scabies in association with human T-cell lymphotropic virus 1 [clinical conference]: J Cutan Med Surg. 1999 Jan;3(3):148-52. Unique Identifier : AIDSLINE MED/99236439; Bergman JN; Dodd WA; Trotter MJ; Oger JJ; Dutz JP; Division of Dermatology, The University of British Columbia,; Vancouver, Canada.; BACKGROUND: Human T-cell lymphotropic virus I (HTLV- 1) infection can lead to myelopathy/tropical spastic paresis and adult T-cell leukemia/lymphoma (ATLL). Infection with HTLV-1 has also been associated with clinically significant immunosuppression. Crusted scabies, also known as Norwegian scabies, is an uncommon pre
[Summer-type hypersensitivity pneumonitis with remarkable obstructive impairment of pulmonary function]: Nihon Kokyuki Gakkai Zasshi. 1998 Dec;36(12):1048-52. Unique Identifier : AIDSLINE MED/99164354; Iwakami S; Shiina K; Owada A; Hasunuma K; Sato K; Takahashi H; Dambara T; Miyamoto H; Uekusa T; Fukuchi Y; Department of Respiratory Medicine, Juntendo University School of; Medicine, Tokyo, Japan.; A 57-year-old-man was admitted because of persistent cough and progressive dyspnea over a period of 2 months. Examination revealed wheezing in both lungs, severe hypoxemia, and marked obstructive impairment of pulmonary function. A chest CT scan showed diffuse small nodular lesions with patchy air space opacifications
Hyperimmunoglobin E syndrome: a sign of TH1/TH2 imbalance?: Eur J Dermatol. 1999 Mar;9(2):129-31. Unique Identifier : AIDSLINE MED/99167710; Shirafuji Y; Matsuura H; Sato A; Kanzaki H; Katayama H; Arata J; Department of Dermatology, Okayama University Medical School,; Shikata-cho 2-5-1, Okayama 700-8558, Japan.; We report on a patient with hyperimmunoglobulin E syndrome, who developed pruritic vesiculopapules from the age of six months and also had recurrent episodes of skin abscesses and oral thrush . Serum IgE was extremely elevated at 59,514 IU/ml and specific IgE antibody to Staphyl
Repeatability of surface EMG variables during voluntary isometric contractions of the biceps brachii muscle.: J Electromyogr Kinesiol. 1999 Apr;9(2):105-19. Unique Identifier : AIDSLINE MED/99196347; Rainoldi A; Galardi G; Maderna L; Comi G; Lo Conte L; Merletti R; Centro di Bioingegneria, USAS-Politecnico di Torino, ASLI-Regione; Piemonte, Italy.; The repeatability of initial value and rate of change of mean spectral frequency (MNF), average rectified values (ARV) and muscle fiber conduction velocity (CV) was investigated in the dominant biceps brachii of ten normal subjects during sustained isometric voluntary contractions. Four levels of contraction were stud
Terminal exon definition occurs cotranscriptionally and promotes termination of RNA polymerase II.: Mol Cell. 1999 Mar;3(3):371-8. Unique Identifier : AIDSLINE MED/99214852; Dye MJ; Proudfoot NJ; Sir William Dunn School of Pathology, University of Oxford,; United Kingdom.; Analysis of nascent transcription from the human epsilon- and beta-globin genes shows that transcriptional termination occurs within 1.5 kb of the poly(A) site and is dependent on the presence of functional poly(A) signals. Even so, transcripts that have not been cleaved at the poly(A) site are detected up to the term
Identification of a major latent nuclear antigen, LNA-1, in the human herpesvirus 8 genome.: J Hum Virol. 1997 Nov-Dec;1(1):19-29. Unique Identifier : AIDSLINE MED/99211131; Kellam P; Boshoff C; Whitby D; Matthews S; Weiss RA; Talbot SJ; Institute of Cancer Research, Chester Beatty Laboratories,; London, United Kingdom.; OBJECTIVES: Human herpesvirus 8 (HHV-8) is strongly associated with all forms of Kaposi s sarcoma (KS) and with primary effusion lymphomas (PEL). KS patients sera are immunoreactive against discrete nuclear localizing antigens in PEL cell lines. This study sought to identify and characterize these nuclear localizing
Gp120 sequence variation in brain and in T-lymphocyte human immunodeficiency virus type 1 primary isolates.: J Hum Virol. 1997 Nov-Dec;1(1):3-18. Unique Identifier : AIDSLINE MED/99211130; Gartner S; McDonald RA; Hunter EA; Bouwman F; Liu Y; Popovic M; Department of Neurology, Johns Hopkins University School of; Medicine, Baltimore, Maryland, USA.; OBJECTIVE: We sought to identify genetic determinants within human immunodeficiency virus type 1 (HIV-1) gp120 that differentiate viral species in brain from those in lymphocytes. STUDY DESIGN/METHODS: Polymerase chain reaction (PCR) was used to amplify gp120 genes from paired brain and T-cell isolates from two infant
Correlation of tumor suppressor P53 RNA expression with human immunodeficiency virus disease in rapid and slow progressors.: J Hum Virol. 1997 Nov-Dec;1(1):30-6. Unique Identifier : AIDSLINE MED/99211132; McLinden RJ; Lewis B; Michael NL; Redfield RR; Birx DL; Kim JH; Department of Medicine, University of Maryland, Baltimore, USA.; OBJECTIVE: To determine the relation between P53 tumor suppressor RNA expression and human immunodeficiency virus (HIV) disease progression. STUDY DESIGN/METHODS: A quantitative assay of P53 RNA expression was used to analyze a cohort of HIV-negative persons. The assay was then used in longitudinal and cross-sectional
Mother-to-child transmission of human T-cell lymphotropic virus type I associated with prolonged breast-feeding.: J Hum Virol. 1997 Nov-Dec;1(1):37-44. Unique Identifier : AIDSLINE MED/99211133; Wiktor SZ; Pate EJ; Rosenberg PS; Barnett M; Palmer P; Medeiros D; Maloney EM; Blattner WA; Viral Epidemiology Branch, National Cancer Institute, Bethesda,; Maryland 20816, USA.; OBJECTIVES: We assessed the risk of transmitting human T-cell lymphotropic virus type I (HTLV-I) through breast-feeding. STUDY DESIGN/METHODS: To assess the risk of mother-to-child transmission of HTLV-I, 212 HTLV-I-seropositive women and 145 HTLV-I-seronegative women were enrolled in a prospective cohort study conduc
Diagnostic challenges for rapid human immunodeficiency virus assays. Performance using HIV-1 group O, HIV-1 group M, and HIV-2 samples.: J Hum Virol. 1997 Nov-Dec;1(1):45-51. Unique Identifier : AIDSLINE MED/99211134; Constantine NT; Zekeng L; Sangare AK; Gurtler L; Saville R; Anhary H; Wild C; Institute of Human Virology, University of Maryland, Baltimore; 21201, USA. constant@umbi.umd.edu; OBJECTIVE: We sought to determine the ability of seven rapid assays for human immunodeficiency virus (HIV) to detect antibodies in a panel of sera from individuals infected with different types and groups of HIV. STUDY DESIGN/METHODS: Sixty-eight well-characterized samples, including HIV-1 group O (24), several HIV-1
Tat toxoid: its potential role as an HIV vaccine [editorial; comment]: J Hum Virol. 1998 May-Jun;1(4):249-50. Unique Identifier : AIDSLINE MED/99211152; Lambert J
Stimulation of bystander T-cell proliferation by tumor necrosis factor produced by HIV-1-infected macrophages.: J Hum Virol. 1998 May-Jun;1(4):257-66. Unique Identifier : AIDSLINE MED/99211154; Godard CM; Chermann JC; Unite de Recherche sur les Retrovirus et Maladies Associees,; Parc Scientifique et Technologique de Luminy, Marseille, France.; u322@inserm-nacre.univ-mrs.fr; OBJECTIVE: Cocultivation of the CD4+CD95+ T-cell line (MT4) with monocyte-derived macrophages (MDMs) infected with the HIV-1 resulted in costimulation of proliferation and apoptosis after 20 hours of contact. This study sought to determine whether tumor necrosis factor (TNF) produced by HIV-1-infected MDMs was involve
Antibodies to the HIV-1 Tat protein correlated with nonprogression to AIDS: a rationale for the use of Tat toxoid as an HIV-1 vaccine [see comments]: J Hum Virol. 1998 May-Jun;1(4):282-92. Unique Identifier : AIDSLINE MED/99211157; Zagury JF; Sill A; Blattner W; Lachgar A; Le Buanec H; Richardson M; Rappaport J; Hendel H; Bizzini B; Gringeri A; Carcagno M; Criscuolo M; Burny A; Gallo RC; Zagury D; Universite Pierre et Marie Curie, Paris, France.; OBJECTIVES: To investigate which immune parameters, such as antibodies against HIV-1 specificities, or viral parameters, such as p24 antigenemia, are predictive of disease progression. STUDY DESIGN: We performed studies on serum collected from individuals exhibiting two extremes of disease evolution--67 fast progresso
Safety and immunogenicity of HIV-1 Tat toxoid in immunocompromised HIV-1-infected patients [see comments]: J Hum Virol. 1998 May-Jun;1(4):293-8. Unique Identifier : AIDSLINE MED/99211158; Gringeri A; Santagostino E; Muca-Perja M; Mannucci PM; Zagury JF; Bizzini B; Lachgar A; Carcagno M; Rappaport J; Criscuolo M; Blattner W; Burny A; Gallo RC; Zagury D; Hemophilia and Thrombosis Center Angelo Bianchi Bonomi, IRCCS; Maggiore Hospital, Milan, Italy. hemophilia_ctr@polic.cilea.it; OBJECTIVES: To antagonize the deleterious effects of the HIV-1 toxin extracellular Tat on uninfected immune cells, we developed a new strategy of anti-HIV-1 vaccine using an inactivated but immunogenic Tat (Tat toxoid). Tat toxoid has been assayed for safety and immunogenicity in seropositive patients. METHOD: The pha
Prevalence of a CCR5 gene 32-bp deletion in an Israeli cohort of HIV-1-infected and uninfected hemophilia patients.: J Hum Virol. 1998 May-Jun;1(4):299-301. Unique Identifier : AIDSLINE MED/99211159; Kantor R; Barzilai A; Varon D; Martinowitz U; Gershoni JM; Department of Internal Medicine E, Chaim Sheba Medical Center,; Tel-Hashomer, Israel. kantora@agri.huji.ac.il; OBJECTIVE: The recently discovered connection of chemokines and their receptors to HIV pathogenesis, and the description of the 32-bp deletion in the CCR5 gene (delta 32 CCR5), led to heightened excitement and numerous reports regarding their role in HIV transmission and disease progression. The populations in most of
HTLV-I serostatus of mothers of patients with adult T-cell leukemia and HTLV-I-associated myelopathy/tropical spastic paraparesis.: J Hum Virol. 1998 May-Jun;1(4):302-5. Unique Identifier : AIDSLINE MED/99211160; Bartholomew C; Jack N; Edwards J; Charles W; Corbin D; Cleghorn FR; Blattner WA; University of the West Indies, Department of Medicine, Port of; Spain, Trinidad.; OBJECTIVES: It has been shown that > 90% of mothers of HTLV-I-infected children were themselves carriers of HTLV-I. This study was designed to determine the HTLV-I serostatus of mothers of patients with adult T-cell leukemia (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), and to assess t
Evaluation of molecular parameters for routine assessment of viremia in patients with chronic hepatitis C who are undergoing antiviral therapy.: J Hum Virol. 1998 Jul-Aug;1(5):314-9. Unique Identifier : AIDSLINE MED/99211162; Kessler HH; Pierer K; Santner BI; Vellimedu SK; Stelzl E; Marth E; Fickert P; Stauber RE; Division of Clinical Molecular Diagnostics,; Karl-Franzens-University, Graz, Austria.; harald.kessler@kfunigraz.ac.at; OBJECTIVE: To define the usefulness of molecular parameters in patients with chronic hepatitis C who are undergoing antiviral therapy. Anti-hepatitis C virus (HCV) treatment was monitored by determination of serum HCV load and by presence of HCV RNA in peripheral blood mononuclear cells (PBMCs). STUDY DESIGN/METHODS:
HIV-1 nef mutations and clinical long-term nonprogression. A molecular epidemiology study.: J Hum Virol. 1998 Jul-Aug;1(5):320-7. Unique Identifier : AIDSLINE MED/99211163; Visco-Comandini U; Yun Z; Paganelli R; Orlandi P; Salotti A; Johansson B; Vahlne A; Sonnerborg A; Department of Immunology, Microbiology, Pathology and Infectious; Diseases, Karolinska Institute, Huddinge Hospital, Sweden.; UBVI@labd01.hs.sll.se; OBJECTIVES: To analyze HIV-1 nef gene mutations in a cohort of Italian and Swedish long-term nonprogressors (LTNP) and to investigate whether particular amino acid substitutions are associated with LTNP. STUDY DESIGN/METHODS: nef alleles from 21 LTNP and 8 progressor controls were amplified by polymerase chain reactio
Milk-borne transmission of HIV. Characterization of productively infected cells in breast milk and interactions between milk and saliva.: J Hum Virol. 1998 Jul-Aug;1(5):328-37. Unique Identifier : AIDSLINE MED/99211164; Southern SO; Department of Microbiology, University of Minnesota, Minneapolis; 55455, USA. sarka@lenti.med.umn.edu; OBJECTIVES: Definition of the cellular constituents of breast milk and infant saliva that are involved in milk-borne transmission of HIV infectivity. STUDY DESIGN/METHODS: Productively infected cells in colostrum and milk of HIV-1-seropositive mothers were identified by in situ hybridization and immunocytochemistry. A
Effect of splenectomy on T-cell subsets and plasma HIV viral titers in HIV-infected patients.: J Hum Virol. 1998 Jul-Aug;1(5):338-45. Unique Identifier : AIDSLINE MED/99211165; Bernard NF; Chernoff DN; Tsoukas CM; Immunodeficiency Treatment Center, McGill University Medical; Center, Montreal, Quebec, Canada. MCTL@musica.mcgill.ca; OBJECTIVE: In previous studies we have shown that removal of the spleen in HIV-infected people during the asymptomatic phase of disease results in slower time to AIDS and may also result in improved survival. In this paper, we examine whether splenectomy affects lymphocyte counts, T-cell subsets, and HIV plasma viremi
Transduction of CD34+ cells by a vesicular stomach virus protein G (VSV-G) pseudotyped HIV-1 vector. Stable gene expression in progeny cells, including dendritic cells.: J Hum Virol. 1998 Jul-Aug;1(5):346-52. Unique Identifier : AIDSLINE MED/99211166; Li X; Mukai T; Young D; Frankel S; Law P; Wong-Staal F; Department of Medicine, University of California, San Diego, La; Jolla, USA. fwongstaal@ucsd.edu; OBJECTIVE: To use HIV-1 vectors to mediate stable gene transfer into hematopoietic stem/progenitor cells. STUDY DESIGN/METHODS: Purified human CD34+ cells were transduced with HIV-1 vectors pseudotyped with VSV-G and subjected to colony-forming assays and differentiation in liquid culture. Transduction was determined
State of the HIV pandemic [editorial]: J Hum Virol. 1998 Nov-Dec;1(7):427-9. Unique Identifier : AIDSLINE MED/99211167; Essex M
Histone-mediated transfer and expression of the HIV-1 tat gene in Jurkat cells.: J Hum Virol. 1998 Nov-Dec;1(7):430-40. Unique Identifier : AIDSLINE MED/99211168; Demirhan I; Hasselmayer O; Chandra A; Ehemann M; Chandra P; Gustav-Embden Center of Biological Chemistry, Department of; Molecular Biology, Frankfurt University Medical School, Germany.; We studied the gene transfer efficiency of lipofection reagents in comparison to DEAE-Dextran. DOTAP, Dosper, and Lipofectin have lower transfection efficiency; Lipofectamine has a 2.5-fold better efficiency compared with DEAE-Dextran. We report a novel and highly efficient DNA transfer system based on the DNA-binding
Involvement of protein-DNA interaction in adeno-associated virus Rep78-mediated inhibition of HIV-1.: J Hum Virol. 1998 Nov-Dec;1(7):441-50. Unique Identifier : AIDSLINE MED/99211169; Kokorina NA; Santin AD; Li C; Hermonat PL; Department of Obstetrics and Gynecology, University of Arkansas; for Medical Sciences, Little Rock 72205, USA.; OBJECTIVE: It has been well documented by several laboratories that adeno-associated virus (AAV) is able to inhibit HIV-1 replication and gene expression. This effect has been mapped to the AAV-encoded Rep78 protein. However, the mechanism by which Rep78 is able to inhibit HIV-1 is unclear. As Rep78 is a DNA binding t
Fast genotypic detection of drug resistance mutations in the HIV-1 reverse transcriptase gene of treatment-naive patients.: J Hum Virol. 1998 Nov-Dec;1(7):451-6. Unique Identifier : AIDSLINE MED/99211170; Fontaine E; Lambert C; Servais J; Ninove D; Plesseria JM; Staub T; Arendt V; Kirpach P; Robert I; Schneider F; Hemmer R; Schmit JC; Laboratoire de Retrovirologie, Centre de Recherche; Public-Sante, Luxembourg.; OBJECTIVES: This study was performed to assess the frequency of drug resistance mutations in treatment-naive HIV-1-infected patients. STUDY DESIGN/METHODS: Frozen plasma samples from 135 treatment-naive HIV-infected adults were available from the first time the patients were seen for their infection in our center betw
Low peripheral blood viral HIV-2 RNA in individuals with high CD4 percentage differentiates HIV-2 from HIV-1 infection.: J Hum Virol. 1998 Nov-Dec;1(7):457-68. Unique Identifier : AIDSLINE MED/99211171; Berry N; Ariyoshi K; Jaffar S; Sabally S; Corrah T; Tedder R; Whittle H; Department of Virology, Windeyer Institute of Medical Sciences,; University College London Medical School, U.K.; OBJECTIVES: To elucidate why the virulence of HIV-1 and HIV-2 infections differ in West African populations. STUDY DESIGN/METHOD: Peripheral blood plasma virion RNA and cellular proviral DNA levels were measured in a cross-section of 59 HIV-1 and 49 HIV-2 singly infected individuals representing all stages of infectio
Role of the CCR5 delta 32 allele in resistance to HIV-1 infection in west Africa.: J Hum Virol. 1998 Nov-Dec;1(7):469-74. Unique Identifier : AIDSLINE MED/99211172; Kokkotou E; Philippon V; Gueye-Ndiaye A; Mboup S; Wang WK; Essex M; Kanki P; Department of Immunology and Infectious Diseases, Harvard School; of Public Health, Boston, Massachusetts 02115-6017, USA.; OBJECTIVE: To determine the frequency of the mutant CCR5 delta 32 allele in high-risk HIV-seronegative Africans as compared with the general African population, and to assess its in vitro protective efficacy against HIV-1 infection. STUDY DESIGN: In the homozygous form, the CCR5 delta 32 allele confers resistance to m
TORCH testing in HIV-infected women.: Clin Obstet Gynecol. 1999 Mar;42(1):149-62; quiz 174-5. Unique Identifier : AIDSLINE MED/99172963; Helfgott A; Department of Obstetrics and Gynecology, University of; Texas-Houston Medical School, LBJ Hospital 77026, USA.; The issue of TORCH testing in pregnant women infected with the HIV virus remains confusing, even more so than it is in the non-HIV-infected gravida. Unfortunately, the data presented in this article make the recommendations of how to test for these various infections in pregnancy that much more difficult. Patients who
[Serial MRI findings in patients with CNS cryptococcosis]: Unique Identifier : AIDSLINE MED/99177762; Kumazawa K; Yamada T; Nakamori T; Hoshino A; Terao S; Mitsuma T; We reported the serial magnetic resonance imaging (MRI) findings of two patients with central nervous system (CNS) cryptococcal infection without AIDS. The diagnosis of CNS cryptococcosis was made by visualizing the fungi in the CSF with the India ink test, detecting cryptococcal an
[Antigenicity of nine synthetic peptides of human immunodeficiency virus]: Chung Hua Nei Ko Tsa Chih. 1997;36(2):105-7. Unique Identifier : AIDSLINE MED/99029113; Mao P; He H; Hong S; Department of Virology, 302 Hospital of PLA, Beijing.; To establish a ELISA method to detect the infection of human immunodeficiency virus (HIV), we synthesized nine peptides ranging in length between 10-27 amino acid (aa) of HIV located in the regions of gp41, p24 of HIV-1 and gp36 of HIV-2, according to the published amino acid sequence and the position of antigenic det
[German-Austrian recommendations for post-exposure prophylaxis after HIV infection (letter)]: Dtsch Med Wochenschr. 1999 Mar 26;124(12):373. Unique Identifier : AIDSLINE MED/99230989; Seuffer RH
Structural basis for the specificity of the initiation of HIV-1 reverse transcription.: EMBO J. 1999 Feb 15;18(4):1038-48. Unique Identifier : AIDSLINE MED/99146920; Isel C; Westhof E; Massire C; Le Grice SF; Ehresmann B; Ehresmann C; Marquet R; Unite Propre de Recherche No. 9002 du Centre National de la; Recherche Scientifique, Institut de Biologie Moleculaire et; Cellulaire, 15 rue Rene Descartes, 67084 Strasbourg Cedex,; France.; Initiation of human immunodeficiency virus type 1 (HIV-1) reverse transcription requires specific recognition of the viral genome, tRNA3Lys, which acts as primer, and reverse transcriptase (RT). The specificity of this ternary complex is mediated by intricate interactions between HIV-1 RNA and tRNA3Lys, but remains po
Head-to-tail dimers and interdomain flexibility revealed by the crystal structure of HIV-1 capsid protein (p24) complexed with a monoclonal antibody Fab.: EMBO J. 1999 Mar 1;18(5):1124-36. Unique Identifier : AIDSLINE MED/99164080; Berthet-Colominas C; Monaco S; Novelli A; Sibai G; Mallet F; Cusack S; European Molecular Laboratory Biology, Grenoble Outstation,; B.P.156X, F-38042 Grenoble Cedex 9, France.; The crystal structure of an intact molecule of HIV-1 capsid protein (p24) in complex with a monoclonal antibody fragment recognizing an epitope on the C-terminal domain has been determined at 3 A resolution. The helical N- and C-terminal domains of p24 are linked by an extended peptide forming a flexibly linked dumb-b
Stimulation of Tat-associated kinase-independent transcriptional elongation from the human immunodeficiency virus type-1 long terminal repeat by a cellular enhancer.: EMBO J. 1999 Mar 1;18(5):1378-86. Unique Identifier : AIDSLINE MED/99164103; West MJ; Karn J; Medical Research Council, Laboratory of Molecular Biology, Hills; Road, Cambridge, CB2 2QH, UK.; The human immunodeficiency virus type-1 (HIV-1) long terminal repeat (LTR) initiates transcription efficiently but produces only short transcripts in the absence of the trans-activator protein, Tat. To determine whether a cellular enhancer could provide the signals required to recruit an elongation-competent polymeras
Intracellular degradation of the HIV-1 envelope glycoprotein. Evidence for, and some characteristics of, an endoplasmic reticulum degradation pathway.: Eur J Biochem. 1999 Mar;260(2):482-9. Unique Identifier : AIDSLINE MED/99195489; Courageot J; Fenouillet E; Bastiani P; Miquelis R; Laboratoire de Biochimie, Ingenierie des Proteines, Institut; Federatif Jean Roche, Faculte de Medecine-Nord, Marseille,; France.; Analysis of the fate of HIV-1 envelope protein gp160 (Env) has shown that newly synthesized proteins may be degraded within the biosynthetic pathway and that this degradation may take place in compartments other than the lysosomes. The fate of newly synthesized Env was studied in living BHK-21 cells with the recombina
Increased discriminative stimulus potency of phencyclidine in C57B1/6 mice infected with the LP-BM5 retrovirus.: Eur J Pharmacol. 1999 Feb 12;367(1):1-5. Unique Identifier : AIDSLINE MED/99180294; English JA; Bruce KH; Paul IA; Department of Psychiatry, University of Mississippi Medical; Center, Jackson 39216-4505, USA.; Drug discrimination procedures in mice are used to study the neuropharmacology of a wide variety of drugs. In C57 B1/6 mice, infection with the LP-BM5 murine leukemia virus leads to a syndrome (murine acquired immunodeficiency syndrome-MAIDS) characterized by immunocompromise, neurochemical alterations, and learning a
Impact of chronic liver disease due to hepatitis viruses as cause of hospital admission and death in HIV-infected drug users.: Eur J Epidemiol. 1999 Jan;15(1):1-4. Unique Identifier : AIDSLINE MED/99196624; Soriano V; Garcia-Samaniego J; Valencia E; Rodriguez-Rosado R; Munoz F; Gonzalez-Lahoz J; Service of Infectious Diseases, Centro de Investigaciones; Clinicas, Instituto de Salud Carlos III, Madrid, Spain.; vsoriano@dragonet.es; The life expectancy of HIV-positive individuals has been prolonged in recent years, as a consequence of the wide use of antiretroviral drugs and primary prophylaxis for the most common opportunistic infections. In HIV-positive persons infected parenterally, chronic viral liver disease (CVLD), mainly that caused by hep
When do HIV-infected persons start with antiretroviral therapy? A retrospective analysis of patients' monitoring and treatment status in general practice, as compared with the 1991 Dutch HIV treatment guidelines.: Fam Pract. 1998 Dec;15(6):525-8. Unique Identifier : AIDSLINE MED/99176677; Reedijk M; Wigersma L; Mohrs J; OBJECTIVE: We aimed to compare, in a sample of Amsterdam general practices, the monitoring and treatment status of HIV-infected patients according to the 1991 Dutch consensus guidelines for antiretroviral treatment of HIV-infection, which advise that therapy be started at a peripheral blood CD4+ cell count of
Phase variations of the Mycoplasma penetrans main surface lipoprotein increase antigenic diversity.: Infect Immun. 1999 Apr;67(4):1569-78. Unique Identifier : AIDSLINE GENBANK/AJ006699; Neyrolles O; Chambaud I; Ferris S; Prevost MC; Sasaki T; Montagnier L; Blanchard A; Unite d'Oncologie Virale, Institut Pasteur, 75724 Paris Cedex; 15, France.; Mycoplasma penetrans is a recently identified mycoplasma, isolated from urine samples collected from human immunodeficiency virus (HIV)-infected patients. Its presence is significantly associated with HIV infection. The major antigen recognized during natural and experimental infections is an abundant P35 lipoprotein
Interleukin-10 and antigen-presenting cells actively suppress Th1 cells in BALB/c mice infected with the filarial parasite Brugia pahangi.: Unique Identifier : AIDSLINE MED/99184976; Osborne J; Devaney E; Infection with the third-stage larvae (L3) of the filarial nematode Brugia results in a Th2-biased immune response in mice and humans. Previously we have shown that the production of interleukin 4 (IL-4) is critical for down-regulating polyclonal Th1 responses in L3-infected mice. However, the in vitro neutralization
Interleukin-12 production is required for chlamydial antigen-pulsed dendritic cells to induce protection against live Chlamydia trachomatis infection.: Infect Immun. 1999 Apr;67(4):1763-9. Unique Identifier : AIDSLINE MED/99185000; Lu H; Zhong G; Molecular Immunology Section, Department of Medical Microbiology,; University of Manitoba, Winnipeg, Manitoba R3E 0W3, Canada.; Immunization with dendritic cells pulsed ex vivo with antigens has been successfully used to elicit primary antigen-specific immune responses. We report that mouse bone marrow-derived dendritic cells pulsed with inactivated chlamydial organisms induced strong protection against live chlamydial infection in a mouse lun
Role of gamma interferon in cellular immune response against murine Encephalitozoon cuniculi infection.: Infect Immun. 1999 Apr;67(4):1887-93. Unique Identifier : AIDSLINE MED/99185016; Khan IA; Moretto M; Department of Medicine and Microbiology, Dartmouth Medical; School, Lebanon, New Hampshire 03756, USA.; Imtiaz.Khan@dartmouth.edu; Microsporidia are obligate intracellular protozoan parasites that cause a wide variety of opportunistic infection in patients with AIDS. Because it is able to grow in vitro, Encephalitozoon cuniculi is currently the best-studied microsporidian. T cells mediate protective immunity against this parasite. Splenocytes obt
Geographical clustering of human T-cell lymphotropic virus type I in Guadeloupe, an endemic Caribbean area.: Int J Cancer. 1999 May 5;81(3):330-4. Unique Identifier : AIDSLINE MED/99224650; Rouet F; Rabier R; Foucher C; Chancerel B; Agis F; Strobel M; Etablissement de Transfusion Sanguine, Hopital Ricou,; Pointe-a-Pitre, Guadeloupe, France.; Between January 1989 and December 1996, 59,426 blood donors from Guadeloupe (French West Indies) were screened for antibodies to human T-cell lymphotropic virus type I (HTLV-I). Of these, 195 were confirmed as being positive for HTL
Interleukin-12-secreting human papillomavirus type 16-transformed cells provide a potent cancer vaccine that generates E7-directed immunity.: Int J Cancer. 1999 May 5;81(3):428-37. Unique Identifier : AIDSLINE MED/99224664; Hallez S; Detremmerie O; Giannouli C; Thielemans K; Gajewski TF; Burny A; Leo O; Departement de Biologie Moleculaire, Universite Libre de; Bruxelles, Rhode-St Genese, Belgium. shallez@dbm.ulb.ac.be; The development of a vaccine that would be capable of preventing or curing the (pre)cancerous lesions induced by genital oncogenic human papillomaviruses (HPVs) is the focus of much research. Many studies are presently evaluating vaccines based on the viral E6 and E7 oncoproteins, both of which are continually express
[An important task even in the HAART era (High Activity Anti-Retroviral Therapy). Infection management in HIV-patients]: Internist (Berl). 1999 Mar;40(3 Suppl Infektions):1-4. Unique Identifier : AIDSLINE MED/99219007
Access and use of medications in HIV disease.: Health Serv Res. 1999 Apr;34(1 Pt 1):123-44. Unique Identifier : AIDSLINE MED/99216038; Smith SR; Kirking DM; University of North Carolina School of Pharmacy, Division of; Pharmaceutical Policy and Evaluative Sciences, Chapel Hill; 27599-7360, USA.; OBJECTIVE: To examine if measures of access to medical care are associated with outpatient use of antiretroviral and Pneumocystis carinii pneumonia (PCP) medications among a cohort of individuals with HIV disease. DATA SOURCES: Adults who participated in a series of up to six interviews as part of the AIDS Costs and S
Conditional Length of Stay.: Health Serv Res. 1999 Apr;34(1 Pt 2):349-63. Unique Identifier : AIDSLINE MED/99213772; Silber JH; Rosenbaum PR; Koziol LF; Sutaria N; Marsh RR; Even-Shoshan O; Center for Outcomes Research, Children's Hospital of; Philadelphia, PA 19104-4318, USA.; OBJECTIVE: To develop and test a new outcome measure, Conditional Length of Stay (CLOS), to assess hospital performance when deaths are rare and complication data are not available. DATA SOURCES: The 1991 and 1992 MedisGroups National Comparative Data Base. STUDY DESIGN: We use engineering reliability theory tradition
Activation of serum response factor by RhoA is mediated by the nuclear factor-kappaB and C/EBP transcription factors.: J Biol Chem. 1999 Mar 26;274(13):8506-15. Unique Identifier : AIDSLINE MED/99185067; Montaner S; Perona R; Saniger L; Lacal JC; Instituto de Investigaciones Biomedicas, Consejo Superior de; Investigaciones Cientificas, Madrid, Spain.; The activity of the transcription factor NF-kappaB can be modulated by members of the Rho family of small GTPases (Perona, R., Montaner, S., Saniger, L., Sanchez-Perez, I., Bravo, R., and Lacal, J. C. (1997) Genes Dev. 11, 463-475). Ectopic expression of RhoA, Rac1, and Cdc42Hs proteins induces the translocation of NF
Leukotriene binding, signaling, and analysis of HIV coreceptor function in mouse and human leukotriene B4 receptor-transfected cells.: J Biol Chem. 1999 Mar 26;274(13):8597-603. Unique Identifier : AIDSLINE MED/99185079; Martin V; Ronde P; Unett D; Wong A; Hoffman TL; Edinger AL; Doms RW; Funk CD; Center for Experimental Therapeutics, University of Pennsylvania,; Philadelphia, Pennsylvania 19104, USA.; The mouse leukotriene B4 receptor (m-BLTR) gene was cloned. Membrane fractions of human embryonic kidney 293 cells stably expressing m-BLTR demonstrated a high affinity and specific binding for leukotriene B4 (LTB4, Kd = 0.24 +/- 0.03 nM). In competition binding experiments, LTB4 was the most potent competitor (Ki = 0
Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus.: J Biol Chem. 1999 Mar 26;274(13):8875-85. Unique Identifier : AIDSLINE MED/99185115; Oppermann M; Mack M; Proudfoot AE; Olbrich H; Department of Immunology, University of Gottingen, 37075; Gottingen, Germany. mopperm@gwdg.de; The binding of CC chemokines to CC chemokine receptor 5 (CCR5) triggers cellular responses that, generally, are only transient in nature. To explore the potential role of G protein-coupled receptor kinases (GRKs) in the regulation of CCR5, we performed phosphorylation experiments in a rat basophilic leukemia cell line
Incorporation of Vpr into human immunodeficiency virus type 1 requires a direct interaction with the p6 domain of the p55 gag precursor.: J Biol Chem. 1999 Mar 26;274(13):9083-91. Unique Identifier : AIDSLINE MED/99185142; Bachand F; Yao XJ; Hrimech M; Rougeau N; Cohen EA; Laboratoire de retrovirologie humaine, Departement de; Microbiologie et Immunologie, Faculte de Medecine, Universite; de Montreal, Montreal, Quebec H3C 3J7, Canada.; The 96-amino acid Vpr protein is the major virion-associated accessory protein of the human immunodeficiency virus type 1 (HIV-1). As Vpr is not part of the p55 Gag polyprotein precursor (Pr55(gag)), its incorporation requires an anchor to associate with the assembling viral particles. Although the molecular mechanism
Identification of peroxisomal acyl-CoA thioesterases in yeast and humans.: J Biol Chem. 1999 Apr 2;274(14):9216-23. Unique Identifier : AIDSLINE GENBANK/AF124265; Jones JM; Nau K; Geraghty MT; Erdmann R; Gould SJ; Department of Biological Chemistry, The Johns Hopkins University; School of Medicine, Baltimore, Maryland 21205, USA.; A computer-based screen of the Saccharomyces cerevisiae genome identified YJR019C as a candidate oleate-induced gene. YJR019C mRNA levels were increased significantly during growth on fatty acids, suggesting that it may play a role in fatty acid metabolism. The YJR019C product is highly similar to tesB, a bacterial ac
Epitope mapping of CCR5 reveals multiple conformational states and distinct but overlapping structures involved in chemokine and coreceptor function.: J Biol Chem. 1999 Apr 2;274(14):9617-26. Unique Identifier : AIDSLINE MED/99194814; Lee B; Sharron M; Blanpain C; Doranz BJ; Vakili J; Setoh P; Berg E; Liu G; Guy HR; Durell SR; Parmentier M; Chang CN; Price K; Tsang M; Doms RW; Department of Pathology and Laboratory Medicine, University of; Pennsylvania, Philadelphia, Pennsylvania 19104, USA.; The chemokine receptor CCR5 is the major coreceptor for R5 human immunodeficiency virus type-1 strains. We mapped the epitope specificities of 18 CCR5 monoclonal antibodies (mAbs) to identify domains of CCR5 required for chemokine binding, gp120 binding, and for inducing conformational changes in Env that lead to memb
Altered expression profile of the surface glycopeptidolipids in drug-resistant clinical isolates of Mycobacterium avium complex.: J Biol Chem. 1999 Apr 2;274(14):9778-85. Unique Identifier : AIDSLINE MED/99194833; Khoo KH; Jarboe E; Barker A; Torrelles J; Kuo CW; Chatterjee D; Institute of Biological Chemistry, Academia Sinica, Nankang,; Taipei 115, Taiwan, Republic of China.; Members of the Mycobacterium avium complex are the most frequently encountered opportunistic bacterial pathogens among patients in the advanced stage of AIDS. Two clinical isolates of the same strain, numbers 397 and 417, were obtained from an AIDS patient with disseminated M. avium complex infection before and after
Pharmacokinetics and tolerability of intravenous trecovirsen (GEM 91), an antisense phosphorothioate oligonucleotide, in HIV-positive subjects.: J Clin Pharmacol. 1999 Jan;39(1):47-54. Unique Identifier : AIDSLINE MED/99142173; Sereni D; Tubiana R; Lascoux C; Katlama C; Taulera O; Bourque A; Cohen A; Dvorchik B; Martin RR; Tournerie C; Gouyette A; Schechter PJ; Service de Medecine Interne, Hopital Cochin, Paris, France.; Trecovirsen, a 25-mer antisense phosphorothioate oligonucleotide targeted at the gag site of the HIV gene, was administered to HIV-positive volunteers as an i.v. infusion. Single doses ranged from 0.1 to 2.5 mg/kg in an ascending escalation in cohorts of 6 to 12 subjects. Plasma trecovirsen concentrations and pharmaco
Sexual behavior and AIDS-related knowledge among community college students in Orange County, California.: J Community Health. 1999 Feb;24(1):29-43. Unique Identifier : AIDSLINE MED/99155671; Shapiro J; Radecki S; Charchian AS; Josephson V; College of Medicine, University of California, Irvine, USA.; Whereas college students are not identified as a high-risk group for acquiring the HIV infection, they exhibit high-risk behaviors consistent with their age group, including multiple sexual partners and high rates of unprotected intercourse. This study was conducted to determine levels of HIV-related sexual behavior,
Soluble tumor necrosis factor receptors in chronic hepatitis C: a correlation with histological fibrosis and activity.: J Hepatol. 1999 Feb;30(2):185-91. Unique Identifier : AIDSLINE MED/99165463; Zylberberg H; Rimaniol AC; Pol S; Masson A; De Groote D; Berthelot P; Bach JF; Brechot C; Zavala F; Unite d'Hepatologie, Hopital Necker, Paris, France.; BACKGROUND/AIMS: Tumor necrosis factor-alpha (TNF) is a mediator of inflammation and cellular immune response. Soluble TNF receptors (sTNFR) sTNF-R55 and sTNF-R75, which compete with cellular receptors for the binding of TNF, have been detected at high levels in infectious diseases including human immunodeficiency vir
Retrospective analysis of the impact of HIV infection and alcohol use on chronic hepatitis C in a large cohort of drug users [letter]: Unique Identifier : AIDSLINE MED/99165489; Bonacini M
HIV-1-induced neuronal injury in the developing brain.: J Leukoc Biol. 1999 Apr;65(4):453-7. Unique Identifier : AIDSLINE MED/99219267; Epstein LG; Gelbard HA; Department of Neurology, University of Rochester, New York, USA.; L-epstein@nwu.edu; HIV-1 infection of the nervous system causes neuronal injury and death, resulting in cognitive, motor, and behavioral dysfunction in both adults and children. In infants a characteristic feature of HIV-1 infection is impaired brain growth resulting in secondary microcephaly with onset between 2 and 4 months of age. Th
Molecular pathway involved in HIV-1-induced CNS pathology: role of viral regulatory protein, Tat.: J Leukoc Biol. 1999 Apr;65(4):458-65. Unique Identifier : AIDSLINE MED/99219268; Rappaport J; Joseph J; Croul S; Alexander G; Del Valle L; Amini S; Khalili K; Center for NeuroVirology and NeuroOncology, MCP Hahnemann; University, Philadelphia, Pennsylvania 19102, USA.; The broad range of histological lesions associated with HIV-1 are somewhat subtle relative to the clinical manifestations that occur as a result of HIV infection. Although it is clear that HIV has a causative role in CNS disease, dementia appears to be a consequence of the infiltra
The SIV-infected rhesus monkey model for HIV-associated dementia and implications for neurological diseases.: J Leukoc Biol. 1999 Apr;65(4):466-74. Unique Identifier : AIDSLINE MED/99219269; Rausch DM; Murray EA; Eiden LE; Office of AIDS Research, National Institute of Mental Health,; Bethesda, Maryland 20892-9623, USA. dr89b@nih.gov; The neuropathogenesis of human immunodeficiency virus (HIV)-associated dementia has remained elusive, despite identification of HIV as the causal agent. Although a number of contributing factors have been identified, the series of events that culminate in motor and cognitive impair
Do alcohol and cocaine abuse alter the course of HIV-associated dementia complex?: J Leukoc Biol. 1999 Apr;65(4):475-81. Unique Identifier : AIDSLINE MED/99219270; Tyor WR; Middaugh LD; Department of Neurology, Medical University of South Carolina,; Charleston 29425, USA. tyorwr@musc.edu; Although psychoactive drugs are commonly used by AIDS patients, it is unclear whether commonly abused drugs, such as cocaine and ethanol, affect the course of HIV-associated dementia (HADC). Epidemiological studies have resulted in conflicting conclusions as to what role, if any, a
Proton magnetic resonance spectroscopy pattern of progressive multifocal leukoencephalopathy in AIDS.: J Neurol Neurosurg Psychiatry. 1999 Apr;66(4):520-3. Unique Identifier : AIDSLINE MED/99215611; Iranzo A; Moreno A; Pujol J; Marti-Fabregas J; Domingo P; Molet J; Ris J; Cadafalch J; Department of Neurology, Santa Creu i Sant Pau Hospital,; Autonomous University of Barcelona, Spain.; The objective was to determine whether the use of intermediate echo times (135 ms) in proton magnetic resonance spectroscopy (1H-MRS) detects a homogenous pattern in progressive multifocal leukoencephalopathy (PML) in HIV-1 infected people, and to confirm the results of previous studies. Six patients infected with HIV
Hypothesis on the pathogenesis of vacuolar myelopathy, dementia, and peripheral neuropathy in AIDS [letter]: J Neurol Neurosurg Psychiatry. 1999 Apr;66(4):554. Unique Identifier : AIDSLINE MED/99215628; Di Rocco A; Werner P
A molecular-field-based similarity study of non-nucleoside HIV-1 reverse transcriptase inhibitors.: J Comput Aided Mol Des. 1999 Jan;13(1):79-93. Unique Identifier : AIDSLINE MED/99187466; Mestres J; Rohrer DC; Maggiora GM; Pharmacia & Upjohn Inc., Kalamazoo, MI 49001, USA.; This article describes a molecular-field-based similarity method for aligning molecules by matching their steric and electrostatic fields and an application of the method to the alignment of three structurally diverse non-nucleoside HIV-1 reverse transcriptase inhibitors. A brief description of the method, as implemen
Prevalence of Helicobacter pylori infection detected by serology and 13C-urea breath test in HIV-1 perinatally infected children.: J Pediatr Gastroenterol Nutr. 1999 Mar;28(3):301-6. Unique Identifier : AIDSLINE MED/99165055; Lionetti P; Amarri S; Silenzi F; Galli L; Cellini M; de Martino M; Vierucci A; Dipartimento di Pediatria Universita di Firenze, Italy.; BACKGROUND: Conflicting results have been reported in adults with human immunodeficiency virus (HIV-1) who were investigated for Helicobacter pylori infection. Most studies indicate a lower prevalence than is found in the general population. The purposes of this study were to evaluate H. pylori prevalence by noninvasi
Cyclosporine for rectoperineal fistula in a human immunodeficiency virus-infected child.: J Pediatr Gastroenterol Nutr. 1999 Mar;28(3):333-5. Unique Identifier : AIDSLINE MED/99165063; Caselli D; Maccabruni A; Beluffi G; Minoli L; Department of Paediatrics, University of Pavia, Istituto di; Ricovero e Cura a Carattere Scientifico Policlinico S. Matteo,; Italy.
The role of the iminium bond in the inhibition of reverse transcriptase by quaternary benzophenanthridines.: J Pharm Pharmacol. 1998 Nov;50(11):1307-15. Unique Identifier : AIDSLINE MED/99093146; Kerry MA; Duval O; Waigh RD; Mackay SP; School of Health Sciences, University of Sunderland, Tyne and; Wear, UK.; The quaternary benzo[c]phenanthridines fagaronine, nitidine and O-methylfagaronine have been reviewed as potential antitumour and antiviral agents. Their mode of action has not been established, but their ability to bind with DNA by intercalation is believed to be involved. Of the three synthetic analogues of O-methyl
Anti-HIV activity and mechanism of action of macrocyclic diamide SRR-SB3.: J Pharm Pharmacol. 1998 Dec;50(12):1339-42. Unique Identifier : AIDSLINE MED/99160211; Mahmood N; Jhaumeer-Lauloo S; Sampson J; Houghton PJ; The Centre for Bioactivity Screening of Natural Products,; Department of Pharmacy, King's College London, UK.; The importance of cyclic compounds as anti-cancer and anti-viral agents has been recognized for some time. We have studied a series of macrocyclic amide derivatives for activity against HIV infection of T lymphocytes in-vitro. Compounds containing aromatic rings and sulphur atoms were generally active, however the sel
Anxiety and depression among HIV-infected heterosexuals--a report from India.: J Psychosom Res. 1998 Nov;45(5):401-9. Unique Identifier : AIDSLINE MED/99050897; Chandra PS; Ravi V; Desai A; Subbakrishna DK; Department of Psychiatry, National Institute of Mental Health &; Neurosciences, Bangalore, India. chandra@nimhans.ren.nic.in; The aim of the study was to study factors related to anxiety, depression, and suicidal ideation among HIV-seropositive heterosexuals soon after being tested for their HIV status for the first time. Anxiety, depression, and suicidal ideation were assessed among 51 HIV-seropositive heterosexual men and women with variou
Asymmetric recognition of psoralen interstrand crosslinks by the nucleotide excision repair and the error-prone repair pathways.: J Mol Biol. 1999 Mar 12;286(5):1379-87. Unique Identifier : AIDSLINE MED/99165774; Barre FX; Asseline U; Harel-Bellan A; Institut de Recherche sur le Cancer, CNRS UPR 9079, 7 rue Guy; Moquet, Villejuif, 94801, France.; Psoralen is an asymmetric photoreactive intercalator with a furane and a pyrone side. When intercalated at 5 -TpA-3 sites and upon UVA irradiation, the psoralen can react with the thymine residues on both strands, introducing an interstrand crosslink. Using psoralen-coupled triple-helix-forming oligonucleotides, psor
HIV testing after implementation of name-based reporting [letter; comment]: JAMA. 1999 Apr 21;281(15):1377-8; discussion 1379-80. Unique Identifier : AIDSLINE MED/99231401; Aragon R; Myers J
HIV testing after implementation of name-based reporting [letter; comment]: JAMA. 1999 Apr 21;281(15):1378; discussion 1379-80. Unique Identifier : AIDSLINE MED/99231402; Woods WJ; Binson D; Morin S; Dilley JW
HIV testing after implementation of name-based reporting [letter; comment]: JAMA. 1999 Apr 21;281(15):1378-9; discussion 1379-80. Unique Identifier : AIDSLINE MED/99231403; Solomon L; Benjamin G; Wasserman M
HIV testing after implementation of name-based reporting [letter]: JAMA. 1999 Apr 21;281(15):1379-80. Unique Identifier : AIDSLINE MED/99231404; Paul SM; Cross H; Costa S
Extracellular water: sodium bromide dilution estimates compared with other markers in patients with acquired immunodeficiency syndrome.: JPEN J Parenter Enteral Nutr. 1999 Mar-Apr;23(2):61-6. Unique Identifier : AIDSLINE MED/99180031; Kim J; Wang Z; Gallagher D; Kotler DP; Ma K; Heymsfield SB; Obesity Research Center and Body Composition Unit, St; Luke's/Roosevelt Hospital, College of Physicians and Surgeons,; Columbia University, New York, New York, USA.; Extracellular fluid and closely related extracellular water (ECW) provide information on nutritional status in health and disease. Although various methods exist for ECW determination, little is known about their comparability in patients with wasting diseases such as acquired immunodeficiency syndrome (AIDS). One pra
[The molecular mechanisms governing T cell development in the thymus]: Nippon Rinsho. 1999 Feb;57(2):267-72. Unique Identifier : AIDSLINE MED/99177715; Kimura M; Nakayama T; Department of Molecular Immunology, Graduate School of Medicine,; Chiba University.; Intracellular signaling events required for T cell development in the thymus have been investigated using various gene deficient and transgenic mice. Here, we summarize and discuss the recent results. Immature thymocytes immigrated from bone marrow are found to be committed to lymphoid lineage. First, the lymphoid pro
[Retroviruses and autoimmune diseases]: Nippon Rinsho. 1999 Feb;57(2):310-5. Unique Identifier : AIDSLINE MED/99177722; Fugo K; Yoshiki T; 1st Department of Pathology, Hokkaido University School of; Medicine.; Various genetic factors and environmental factors are intricately intertwined in the pathomechanism of autoimmune diseases. Retroviruses, represented by HTLV-I and HIV, are known to relate to autoimmune disorders. However, the pathogenetic role of retrovirus and the relationship between retrovirus and autoimmune disea
[Practice and research of forensic medicine learned from the dead]: Nippon Hoigaku Zasshi. 1998 Oct;52(5):277-85. Unique Identifier : AIDSLINE MED/99177698; Tsunenari S; Department of Forensic Medicine, Kumamoto University School of; Medicine, Japan.; Practice and Research of Forensic Medicine Learned from the Dead is presented by looking back my 29 years carrier as a forensic pathologist. After joining in Department of Forensic Medicine, Kumamoto University in 1969, I had spent several happy years with studying on postmortem corneal clouding. Soon I began to hav
[Current status and perspectives on the development of rifamycin derivative antibiotics]: Kekkaku. 1999 Jan;74(1):53-61. Unique Identifier : AIDSLINE MED/99166028; Hidaka T; Takasago Research Laboratories, Kaneka Corporation, Hyogo, Japan.; Rifampicin (RFP) was developed as one of the anti-tuberculosis drugs in 1966 and has been used for almost 30 years. Establishment of combination therapy using RFP has been contributing to the treatment/eradication of tuberculosis. A number of rifamycin derivatives, as
Insurance and inpatient utilization for HIV: better answers, still further questions [editorial]: Med Care. 1999 Apr;37(4):325-8. Unique Identifier : AIDSLINE MED/99228000; Wu AW
Urethral Trichomonas vaginalis infection and HIV-1 transmission [letter]: Lancet. 1997 Oct 11;350(9084):1076. Unique Identifier : AIDSLINE MED/99228569; Jackson DJ; Rakwar JP; Bwayo JJ; Kreiss JK; Moses S
AIDS doctors push for live-virus vaccine trials [news]: Lancet. 1997 Oct 11;350(9084):1082. Unique Identifier : AIDSLINE MED/99228575; McCarthy M
HIV screening launched in Ireland [news]: Lancet. 1997 Oct 11;350(9084):1084. Unique Identifier : AIDSLINE MED/99228577; Birchard K
Tackling mother-to-child HIV in Cote d'Ivoire [news]: Lancet. 1997 Oct 11;350(9084):1084. Unique Identifier : AIDSLINE MED/99228578; Feinmann J
Brazilian haematologist sacked for speaking out over quality control [news]: Lancet. 1997 Oct 11;350(9084):1085. Unique Identifier : AIDSLINE MED/99228579; Csillag C
Should assays drive science or vice versa? [letter; comment]: Lancet. 1997 Oct 11;350(9084):1108. Unique Identifier : AIDSLINE MED/99228602; Johnston MI; Goudsmit J
Elective caesarean section for prevention of vertical transmission of HIV-1 infection [comment]: Lancet. 1999 Mar 27;353(9158):1030-1. Unique Identifier : AIDSLINE MED/99213437; Hudson CN; Department of Gynaecology, St Bartholomew's Hospital, London, UK.
A pill a day, or two, for hepatitis B?: Lancet. 1999 Mar 27;353(9158):1032-3. Unique Identifier : AIDSLINE MED/99213439; Dusheiko G; Department of Medicine, Royal Free and University College School; of Medicine, London, UK.
Elective caesarean-section versus vaginal delivery in prevention of vertical HIV-1 transmission: a randomised clinical trial. The European Mode of Delivery Collaboration [see comments]: Lancet. 1999 Mar 27;353(9158):1035-9. Unique Identifier : AIDSLINE MED/99213441; BACKGROUND: Results from observational studies suggest that caesarean-section delivery may reduce the risk of mother-to-child transmission of HIV-1 infection in comparison with vaginal delivery. We carried out a randomised clinical trial to address this issue and to assess the extent of postdelivery complications. MET
Site-directed polyethylene glycol modification of trichosanthin: effects on its biological activities, pharmacokinetics, and antigenicity.: Life Sci. 1999;64(14):1163-75. Unique Identifier : AIDSLINE MED/99224984; He XH; Shaw PC; Xu LH; Tam SC; Department of Physiology, The Chinese University of Hong Kong,; Shatin, NT.; Trichosanthin (TCS), a type I ribosome-inactivating protein (RIP), was modified with polyethylene glycol (PEG) in order to reduce its antigenicity and prolong its half-life. Computer modeling identified three potential antigenic sites namely Q219, K173 and S7. By site-directed mutagenesis, these sites were changed int
Effects of vesnarinone on cytokine production and activation of murine microglia.: Life Sci. 1999;64(14):1197-203. Unique Identifier : AIDSLINE MED/99224987; Suzumura A; Sawada M; Department of Neurology, Nara Medical University, Kashihara,; Japan.; Tumor necrosis factor alpha (TNF alpha) is considered to play a critical role in the development of various pathological processes in the central nervous system (CNS), such as neuronal degeneration, demyelination and gliosis. In order to search for agents which suppress TNF alpha production in the CNS for future treat
[HIV infection. Virus resistance: development and prevention]: Med Monatsschr Pharm. 1999 Mar;22(3):86-8. Unique Identifier : AIDSLINE MED/99232814; Link R; Miller V; Fatkenheuer G; Manegold C; Harrer T
HIV Tat represses transcription of the beta 2-microglobulin promoter.: Mol Immunol. 1998 Dec;35(18):1171-8. Unique Identifier : AIDSLINE MED/99213483; Carroll IR; Wang J; Howcroft TK; Singer DS; Molecular Regulation Section, Experimental Immunology Branch,; National Cancer Institute, NIH, Bethesda, MD 20892, USA.; The MHC class I complex, which binds and presents peptide antigen, is composed of a class I heavy chain and the beta2-microglobulin light chain. HIV-1, which induces a profound immunodeficiency in infected individuals, encodes proteins that cause decreased expression of class I heavy chain. We now report that the HIV
Discontinuation of primary prophylaxis against Pneumocystis carinii pneumonia in HIV-1-infected adults treated with combination antiretroviral therapy. Swiss HIV Cohort Study [see comments]: N Engl J Med. 1999 Apr 29;340(17):1301-6. Unique Identifier : AIDSLINE MED/99219763; Furrer H; Egger M; Opravil M; Bernasconi E; Hirschel B; Battegay M; Telenti A; Vernazza PL; Rickenbach M; Flepp M; Malinverni R; HIV-Sprechstunde, Inselspital Bern, Switzerland.; BACKGROUND: It is unclear whether primary prophylaxis against Pneumocystis carinii pneumonia can be discontinued in patients infected with the human immunodeficiency virus (HIV) who are successfully treated with combination antiretroviral therapy. We prospectively studied the safety of stopping prophylaxis among patie
Images in clinical medicine. Indinavir crystalluria.: N Engl J Med. 1999 Apr 29;340(17):1329. Unique Identifier : AIDSLINE MED/99219767; Tsao JW; Kogan SC; University of California, San Francisco 94143, USA.
Does Pneumocystis carinii prophylaxis still need to be lifelong? [editorial; comment]: N Engl J Med. 1999 Apr 29;340(17):1356-8. Unique Identifier : AIDSLINE MED/99219771; Masur H; Kaplan J
Cryptococcus meningoencephalitis in AIDS: parenchymal and meningeal forms.: Neuroradiology. 1999 Feb;41(2):129-33. Unique Identifier : AIDSLINE MED/99189015; Berkefeld J; Enzensberger W; Lanfermann H; Institut fur Neuroradiologie, Klinikum der; Johann-Wolfgang-Goethe Universitat, Frankfurt am Main, Germany.; Berkefeld@em.uni-frankfurt.de; CT and MRI in one case of Cryptococcus neoformans infection showed contrast-enhancing parenchymal lesions resembling granulomata or abscesses. After an initial phase without contrast enhancement, the full extent of the lesions was visible within 2 weeks of presentation. The enhancing masses were assumed to represent i
Gaining ground in progressive multifocal leukoencephalopathy [editorial; comment]: Neurology. 1999 Feb;52(3):440-1. Unique Identifier : AIDSLINE MED/99148635; Dolin R
Plasma viral load and CD4 lymphocytes predict HIV-associated dementia and sensory neuropathy.: Neurology. 1999 Feb;52(3):607-13. Unique Identifier : AIDSLINE MED/99148663; Childs EA; Lyles RH; Selnes OA; Chen B; Miller EN; Cohen BA; Becker JT; Mellors J; McArthur JC; School of Hygiene and Public Health, The Johns Hopkins; University, Baltimore, MD, USA.; OBJECTIVE: To determine the predictive value of plasma HIV RNA and CD4 lymphocytes for HIV-associated dementia and sensory neuropathy. METHODS: A total of 1,604 AIDS-free HIV seropositive men from the Multicenter AIDS Cohort Study were followed over a 10-year period (1985 to 1995).
HAART improves prognosis in HIV-associated progressive multifocal leukoencephalopathy [see comments]: Neurology. 1999 Feb;52(3):623-5. Unique Identifier : AIDSLINE MED/99148666; Clifford DB; Yiannoutsos C; Glicksman M; Simpson DM; Singer EJ; Piliero PJ; Marra CM; Francis GS; McArthur JC; Tyler KL; Tselis AC; Hyslop NE; Department of Neurology, Washington University School of; Medicine, St. Louis, MO, USA. cliffordd@neuro.wustl.edu; Introduction of highly active antiretroviral therapy (HAART) has been associated with many changes in the complications of human immunodeficiency virus (HIV) infection. A cohort of 25 HIV patients with progressive multifocal leukoencephalopathy (PML) treated with HAART experienced a median survival of >46 weeks. This
Role of T cells in murine IgA nephropathy.: Nephrol Dial Transplant. 1999;14 Suppl 1:12-3. Unique Identifier : AIDSLINE MED/99156183; Nagasawa R; Maruyama N; Imasawa T; Mitarai T; Division of Haemodialysis, Saitama Medical Centre, Saitama; Medical School, Japan.
Methycillin-resistant Staphylococcus aureus-related glomerulonephritis.: Nephrol Dial Transplant. 1999;14 Suppl 1:17-8. Unique Identifier : AIDSLINE MED/99156185; Kobayashi M; Koyama A; Department of Nephrology, Tokyo Medical University Kasumigaura; Hospital, Ibaraki, Japan.
Cytokine network and resident renal cells in glomerular diseases.: Nephrol Dial Transplant. 1999;14 Suppl 1:22-6. Unique Identifier : AIDSLINE MED/99156187; Schena FP; Institute of Nephrology, University of Bari, Polyclinic, Italy.; This review has highlighted the cytokine network which is involved in renal damage from an initial, even transient, stage to extensive glomerular and tubulointerstitial sclerosis. Studies of a variety of different proliferative glomerulonephritides have documented the prominent role of macrophages in infiltrating mesa
Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1.: Pflugers Arch. 1999 Mar;437(4):538-46. Unique Identifier : AIDSLINE MED/99190753; Barcova M; Speth C; Kacani L; Uberall F; Stoiber H; Dierich MP; Institute for Hygiene, University of Innsbruck, Fritz-Pregl-Str.; 3, A-6020 Innsbruck, Austria.; Our previous results show that recombinant gp41 (aa565-647), the extracellular domain of HIV-1 transmembrane glycoprotein, stimulates interleukin-10 (IL-10) production in human monocytes. The signal cascade transducing this effect is not yet clear. In this study, we examined whether gp41-induced IL-10 up-regulation is
Localised upper airway obstruction in a patient with acquired immunodeficiency syndrome.: Postgrad Med J. 1998 Oct;74(876):604-6. Unique Identifier : AIDSLINE MED/99227801; D'Arsigny CL; Ford S; O'Donnell DE; Department of Medicine, Queen's University, Ontario, Canada.; We describe a case of rapidly progressive upper airway obstruction due to tracheal Pseudomonas abscesses in a patient with acquired immunodeficiency syndrome. The case highlights the aggressive nature of Pseudomonas infections and the difficulty of eradicating this organism in patients infected with the human immunode
[Bacteremia in tuberculosis and other mycobacterial infections]: Probl Tuberk. 1999;(1):54-9. Unique Identifier : AIDSLINE MED/99215401; Puzanov VA; Kosareva MV
Molecular dynamics study of the proposed beta-hairpin form of the switch domain from HIV1 gp120 alone and complexed with an inhibitor of CD4 binding.: Proteins. 1999 Feb 1;34(2):197-205. Unique Identifier : AIDSLINE MED/99144953; Graf von Stosch A; von der Lieth CW; Reed J; Department of Pathochemistry, German Cancer Research Center,; Heidelberg, Germany.; The strong tendency of beta-hairpin peptides to aggregate can prevent their structural resolution. The polar form of the switch peptide (LAV 15mer) at the CD4-binding domain of HIV1 gp120 is such a peptide, and NMR investigations of its interaction with a class of CD4-binding inhibitors developed in this laboratory ha
Analysis of domain motions in large proteins.: Proteins. 1999 Feb 15;34(3):369-82. Unique Identifier : AIDSLINE MED/99146628; Hinsen K; Thomas A; Field MJ; Laboratoire de Dynamique Moleculaire, Institut de Biologie; Structurale--Jean-Piere Ebel, Grenoble, France.; hinsen@cnrs-orleans.fr; We present a new approach for determining dynamical domains in large proteins, either based on a comparison of different experimental structures, or on a simplified normal mode calculation for a single conformation. In a first step, a deformation measure is evaluated for all residues in the protein; a high deformation
Estimating the proportion of treatment effect explained by a surrogate marker [letter]: Stat Med. 1999 Jan 15;18(1):107-9. Unique Identifier : AIDSLINE MED/99144507; Flandre P; Saidi Y
Classifying individuals based on predictors of random effects. Multicenter AIDS Cohort Study.: Stat Med. 1999 Jan 15;18(1):35-52. Unique Identifier : AIDSLINE MED/99144502; Lyles RH; Xu J; Department of Epidemiology, Johns Hopkins School of Hygiene and; Public Health, Baltimore, MD 21205, USA. rlyles@jhsph.edu; Often one wishes to describe individuals according to whether their average exposure over a period of time is above or below some meaningful threshold. In this article, we treat predictors of random effects as diagnostic tools to aid in such classification, given that the true unobservable mean exposure for each of a
A Markov model for measuring vaccine efficacy for both susceptibility to infection and reduction in infectiousness for prophylactic HIV vaccines.: Stat Med. 1999 Jan 15;18(1):53-68. Unique Identifier : AIDSLINE MED/99144503; Longini IM Jr; Hudgens MG; Halloran ME; Sagatelian K; Department of Biostatistics, Rollins School of Public Health,; Emory University, Atlanta, GA 30322, USA.; We use a discrete-time non-homogeneous Markov chain to model data from augmented human immunodeficiency virus (HIV) vaccine trials. For this design, the study population consists of primary participants some of whom have steady sexual partners who are also enrolled to augment the trial. The state space consists of the
[Reiter's syndrome and human immunodeficiency virus infection]: Rev Hosp Clin Fac Med Sao Paulo. 1998 Jul-Aug;53(4):202-4. Unique Identifier : AIDSLINE MED/99121257; de Mello e Silva AC; Boulos M; Faculdade de Medicina da Universidade de Sao Paulo.; The increase of rheumatic disorders in HIV infected has been known for the last decade with special emphasis on Reiter s Syndrome. In spite of common sources of HIV and other microorganisms being important in the pathogenesis of Reiter s Syndrome, severe immunodeficiency may be important in the development of rheumati
Comparison of 3 quantitative HCV RNA assays--accuracy of baseline viral load to predict treatment outcome in chronic hepatitis C.: Scand J Infect Dis. 1998;30(5):441-6. Unique Identifier : AIDSLINE MED/99163923; Reichard O; Norkrans G; Fryden A; Braconier JH; Sonnerborg A; Weiland O; Department of Infectious Diseases, Danderyd University Hospital,; Karolinska Institutet, Stockholm, Sweden.; The correlation between 3 assays for hepatitis C virus (HCV) RNA quantification and their respective accuracy in predicting the response to interferon and interferon/ribavirin therapy was evaluated by analysing pre-treatment sera from 100 patients. A total of 97%, 100%, and 98% of the patients tested positive by the b
Hepatitis C virus-infected, HCV-RNA-negative patients with bleeding disorders--relationship to age, HIV and treatment.: Scand J Infect Dis. 1998;30(5):455-8. Unique Identifier : AIDSLINE MED/99163926; Schulman S; Von Sydow M; Petrini P; Fahlstadius P; Department of Medicine, Karolinska Hospital, Stockholm, Sweden.; All 155 anti-hepatitis C-virus (HCV) positive patients with haemostatic disorders at our unit were tested for HCV-RNA in order to determine the prevalence of a negative result. The patients were also characterized in order to find predictors for a negative HCV-RNA test. The prevalence of a negative HCV-RNA test was 15
Changes in small intestinal structure and function in HIV-infected patients with chronic diarrhoea.: Scand J Infect Dis. 1998;30(5):459-63. Unique Identifier : AIDSLINE MED/99163927; Oktedalen O; Skar V; Dahl E; Serck-Hanssen A; Department of Medicine and Pathology, Ullevaal University; Hospital, Oslo, Norway.; Human immunodeficiency virus (HIV) is often combined with unexplainable diarrhoea and weight loss. This study was designed to see if changes in the intestinal mucosal structure could explain the malabsorption found in HIV-infected patients with diarrhoea. Twenty acquired immunodeficiency system (AIDS) patients, 19 men
Low levels of IgG antibodies against pneumocystis carinii among HIV-infected patients.: Scand J Infect Dis. 1998;30(5):495-9. Unique Identifier : AIDSLINE MED/99163935; Laursen AL; Andersen PL; Department of Infectious Diseases, Marselisborg Hospital,; University of Aarhus, Denmark.; IgG antibodies against Pneumocystis carinii (P. carinii) were detected by an ELISA method using urea-extracted material from human and rat P. carinii as the antigen. Carbohydrate formed a major part of the antigen responsible for reactivity in the ELISA assay, since periodate treatment reduced the reactivity of most s
Arthritis due to mycobacterium fortuitum.: Scand J Infect Dis. 1998;30(5):525-7. Unique Identifier : AIDSLINE MED/99163943; Butt AA; Janney A; Department of Medicine, Louisiana State University Medical; Center, New Orleans, USA.; Mycobacterium fortuitum is classified as a rapidly growing mycobacterium (RGM) according to the Runyon classification. RGM are increasingly being recognized as human pathogens. Joint infection due to M. fortuitum is a rare, but serious disease. This report describes a patient with acquired immunodeficiency syndrome (A
A rare case of cotrimoxazole-induced eosinophilic aseptic meningitis in an HIV-infected patient.: Scand J Infect Dis. 1998;30(5):530-1. Unique Identifier : AIDSLINE MED/99163945; Patey O; Lacheheb A; Dellion S; Zanditenas D; Jungfer-Bouvier F; Lafaix C; Service de Medecine Interne, Maladies Infectieuses et; Tropicales, Villeneuve St Georges, France.; A case of cotrimoxazole-induced meningoencephalitis in an HIV-infected patient without signs of AIDS is reported. The patient developed an apparently generalized seizure, of cotrimoxazole, 1 month after first taking a dose of this drug and a febrile coma after a second dose 3 weeks later. Lumbar puncture revealed eosi
In the company of friends: peer influence on Thai male extramarital sex.: Soc Sci Med. 1998 Dec;47(12):1993-2011. Unique Identifier : AIDSLINE MED/99173564; Vanlandingham M; Knodel J; Saengtienchai C; Pramualratana A; Department of Preventive Medicine and Community Health,; University of Texas Medical Branch, Galveston 77555-1153, USA.; mvanland@utmb.edu; We explore some of the key social dynamics underlying patterns of male extramarital heterosexual behavior in Thailand . We analyze transcripts of focus group discussions and focused individual interviews conducted during 1993 and 1994 with married men and women living in both urba
The social impact of HIV testing: a comparative analysis of Britain and Sweden.: Soc Sci Med. 1999 Feb;48(3):293-300. Unique Identifier : AIDSLINE MED/99174895; Danziger R; Department of Public Health and Policy, London School of Hygiene; and Tropical Medicine, UK. r.danziger@lshtm.ac.uk; The role of HIV testing in the primary prevention of HIV is as yet unclear. Whereas most outcome evaluations have tended to focus on the impact of HIV testing and counselling on individuals risk behaviours, this paper argues for a fresh perspective on HIV testing which takes into account its social impact. To illustr
Pre-test counselling for HIV--short and friendly please [letter]: S Afr Med J. 1999 Jan;89(1):11-2. Unique Identifier : AIDSLINE MED/99169547; Mankazana M
The costing of HIV/AIDS--without a clue?: S Afr Med J. 1999 Jan;89(1):33-4. Unique Identifier : AIDSLINE MED/99169557; van der Linde I
Cheaper to manage HIV than to treat AIDS--the Medscheme experience.: S Afr Med J. 1999 Jan;89(1):34-5. Unique Identifier : AIDSLINE MED/99169558; Cowlin J
[Central nervous system lymphoma]: Sangre (Barc). 1998 Dec;43(6):527-33. Unique Identifier : AIDSLINE MED/99189684; Cristobal CB; Universidad Complutense de Madrid.
Community education for stroke awareness: An efficacy study.: Stroke. 1999 Apr;30(4):720-3. Unique Identifier : AIDSLINE MED/99205321; Stern EB; Berman M; Thomas JJ; Klassen AC; Program in Occupational Therapy, Department of Physical Medicine; and Rehabilitation, University of Minnesota, Minneapolis, Minn.; 55455, USA.Stern001@tc.umn.edu; BACKGROUND AND PURPOSE: This study examined the effectiveness of a slide/audio community education program aimed at increasing knowledge of stroke risk factors, stroke warning signs, and action needed when stroke warning signs occur. The program targets audiences at higher risk for stroke, especially individuals who a
Cerebral vasculopathy in HIV infection revealed by transcranial Doppler: A pilot study.: Unique Identifier : AIDSLINE MED/99205337; Brilla R; Nabavi DG; Schulte-Altedorneburg G; Kemeny V; Reichelt D; Evers S; Schiemann U; Husstedt IW; BACKGROUND AND PURPOSE: There is growing evidence for affection of cerebral vessels during human immunodeficiency virus (HIV) infection. We prospectively evaluated cerebrovascular reserve capacity (CRC) in HIV-seropositive patients by transcranial Doppler sonography (TCD) after systemic administration of acetazolamide
Co-trimoxazole and stavudine interference in a high-performance liquid chromatographic analysis for didanosine in human plasma.: Ther Drug Monit. 1998 Dec;20(6):669-72. Unique Identifier : AIDSLINE MED/99068874; Hoetelmans RM; Profijt M; Meenhorst PL; Mulder JW; van Heeswijk RP; Beijnen JH; Department of Pharmacy and Pharmacology, Slotervaart Hospital,; Amsterdam, The Netherlands.; Recently, the authors were confronted with interference of stavudine and co-trimoxazole when analyzing the antiretroviral drug didanosine (ddI) in plasma of HIV-1-infected patients using reverse-phase high-performance liquid chromatography with ultrav
Sodium stibogluconate (pentostan) overdose in a patient with acquired immunodeficiency syndrome.: Ther Drug Monit. 1998 Dec;20(6):714-6. Unique Identifier : AIDSLINE MED/99068882; Reymond JM; Desmeules J; Medical Clinic 1, Department of Internal Medicine, Geneva; University Hospital, Switzerland.; A 32-year-old man with acquired immunodeficiency syndrome (AIDS) admitted to the hospital for treatment of visceral leishmaniasis was inadvertently given 10 times the prescribed first dose of sodium stibogluconate ([Sb] 6.5 g instead of 0.65 g). He experienced no immediate major toxicity during the first 48 hours, but
[Carriers of Staphylococcus aureus as a source of nosocomial infections. Epidemiological and prophylactic aspects]: Ugeskr Laeger. 1999 Mar 15;161(11):1580-4. Unique Identifier : AIDSLINE MED/99218718; Kolmos HJ; Klinisk mikrobiologisk afdeling, H:S Hvidovre Hospital.; 20% of the normal population are nasal carriers of Staphylococcus aureus (Sa), and the carrier rate is even higher in insulin dependent diabetics, intravenous drug addicts, patients on haemo- and peritoneal dialysis, and HIV infected patients. Nasal Sa carriers have an increased risk of Sa infections following invasiv
[Antiretroviral treatment (editorial)]: Ugeskr Laeger. 1999 Mar 22;161(12):1731. Unique Identifier : AIDSLINE MED/99227414; Nielsen HI
[Anesthesiologic aspects in patients with HIV infections]: Ugeskr Laeger. 1999 Mar 22;161(12):1744-6. Unique Identifier : AIDSLINE MED/99227418; Laursen SB; Nielsen TL; Jacobsen E; H:S Rigshospitalet,epidemiafdeling M.; A review of anaesthesia for patients with HIV-infection is given. The use of new antiretroviral drug combinations to treat HIV-infection may result in longer survival, and therefore more cases of HIV-positive patients who undergo surgery and require anaesthetic services. Clinical manifestations of the HIV infection in
[Experiences with antiretroviral combination therapy]: Ugeskr Laeger. 1999 Mar 22;161(12):1747-51. Unique Identifier : AIDSLINE MED/99227419; Justesen US; Mygind LH; Pedersen SS; Pedersen C; Odense Universitetshospital, medicinsk afdeling C.; The purpose of the study was to evaluate the efficacy of treating of HIV infected patients with two nucleoside analogues and one protease inhibitor in clinical practice. Sixty-one patients were included and followed with respect to plasma HIV-RNA, CD4 cell count and side effects up to one year. Median plasma HIV-RNA w
[Treatment of HIV infections and AIDS with protease inhibitor and two nucleoside analogs]: Ugeskr Laeger. 1999 Mar 22;161(12):1751-4. Unique Identifier : AIDSLINE MED/99227420; Jensen-Fangel S; Larsen L; Thomsen HF; Nielsen LP; Black FT; Obel N; Arhus Universitetshospital, Marselisborg Hospital, medicinsk; epidemisk afdeling A.; Until December 31st 1997, 163 HIV/AIDS patients were treated with HAART at the Department of Infectious Diseases, Aarhus University Hospital. The patients mainly received a combination of zidovudine, lamivudine and saquinavir. They were observed for an average period of 375 days. HAART was found to increase the amount
[Cell tropism of HIV]: Uirusu. 1998 Dec;48(2):153-61. Unique Identifier : AIDSLINE MED/99177772; Koyanagi Y; Department of Microbiology and Molecular Virology, Tokyo Medical; and Dental University, Japan.
[Rudolf-Virchow Prize 1998. Award lecture. Toxoplasmosis: a model infection for studying systemic and intracerebral immune reactions]: Unique Identifier : AIDSLINE MED/99195117; Deckert-Schluter M; Toxoplasmosis has gained particular attention in the AIDS era as the most common opportunistic encephalitis in HIV-infected patients. Since there are important parallels between the human and rodent infection, experimental murine toxoplasmosis is widely used to study the immune reactions to this protozoal parasite. Or
AAP policy on children with HIV-infected parents. American Academy of Pediatrics [news]: Am Fam Physician. 1999 Apr 1;59(7):2022-3. Unique Identifier : AIDSLINE MED/99223414; Rose VL
An ethnographic comparison of HIV risk behaviors among heroin and methamphetamine injectors.: Am J Drug Alcohol Abuse. 1999 Feb;25(1):1-23. Unique Identifier : AIDSLINE MED/99176861; Zule WA; Desmond DP; Department of Psychiatry, The University of Texas Health Science; Center at San Antonio, USA.; Drug injection and other practices affecting the risk of human immunodeficiency virus (HIV) infection were studied among 154 heroin users and 45 methamphetamine users in San Antonio, Texas. Amphetamine users were younger, mostly white, and had less-severe drug dependence. Heroin users had significantly higher levels o
Depressive symptoms, drug network, and their synergistic effect on needle-sharing behavior among street injection drug users.: Am J Drug Alcohol Abuse. 1999 Feb;25(1):117-27. Unique Identifier : AIDSLINE MED/99176867; Mandell W; Kim J; Latkin C; Suh T; Department of Mental Hygiene, Johns Hopkins University School of; Hygiene and Public Health, Baltimore, Maryland, USA.; In this study, we examined the relationship between depressive symptoms and needle-sharing behavior in a community sample of intravenous drug users (N = 499) in Baltimore, Maryland. Based on the polytomous logistic regression, higher depressive symptoms were positively associated both with needle sharing after cleanin
Women inmates' risky sex and drug behaviors: are they related?: Am J Drug Alcohol Abuse. 1999 Feb;25(1):129-49. Unique Identifier : AIDSLINE MED/99176868; Cotten-Oldenburg NU; Jordan BK; Martin SL; Kupper L; AIDS/STD Prevention Services Section, Minnesota Department of; Health, Minneapolis 55440-9441, USA.; The large concentration of female illicit drug users in state correctional facilities prompted an examination of the associations among different types of drug use and sexual risk factors related to human immunodeficiency virus (HIV) among women inmates. A consecutive sample of 805 women felons admitted to the North C
Absence of age-related increase in systolic blood pressure in ambulatory patients with HIV infection.: Am J Med Sci. 1999 Apr;317(4):232-7. Unique Identifier : AIDSLINE MED/99225083; Mattana J; Siegal FP; Sankaran RT; Singhal PC; Department of Medicine, Long Island Jewish Medical Center, New; Hyde Park, New York 11040, USA.; BACKGROUND: Systolic blood pressure is well known to increase significantly with age and is strongly correlated with stroke and coronary artery disease. We and other investigators have reported a low prevalence of hypertension in subgroups of patients with HIV infection. In the present study, we examined an ambulatory
Hygienic practices of consultant anaesthetists: a survey in the north-west region of the UK.: Anaesthesia. 1999 Jan;54(1):13-8. Unique Identifier : AIDSLINE MED/99225839; el Mikatti N; Dillon P; Healy TE; Anaesthetic Department of TU 3, South Manchester University; Hospital NHS Trust, Withington Hospital, UK.; Questionnaires were distributed to all 213 consultant anaesthetists in the North-We