1999

[Lymphoid hyperplasia associated with human immunodeficiency virus and Epstein-Barr virus; relationship with lymphomatous pathology]: Ann Pathol. 1998 Oct;18(4):325-30. Unique Identifier : AIDSLINE MED/99044466; Raphael M; Asso-Bonnet M; el Mansouri S; Martin A; Service d'Hematologie Biologique, Hopital Avicenne, Bobigny.
Hepatitis C virus genotypes and the influence of the induction of immunosuppression with anti-thymocyte globulin (ATG) on chronic hepatitis in renal graft recipients.: Unique Identifier : AIDSLINE MED/98329662; Rodrigues A; Pinho L; Lobato L; Queiros A; Castro R; Daniel M; Dias L; Henriques AC; Sarmento A; Guimaraes S; Hepatitis C virus (HCV) exhibits a dramatic genetic variability and several mechanisms of immunological response are unable to control hepatic and extrahepatic replication. Genotype 1 b is associated with more severe clinical manifestations and is less responsive to interferon. In addition, we have reported an increas
CD4+ and CD8+ T cell subset distribution in the blood of small-bowel-grafted rats: modification during graft-versus-host disease.: Transpl Int. 1998;11 Suppl 1:S467-71. Unique Identifier : AIDSLINE MED/98329743; Marni A; Forti D; Fulgenzi A; Corsi M; Cazzulani A; Ferrero ME; Department of Surgery Pizzamiglio II, Ospedale Niguarda, Milan,; Italy.; We studied the modifications of blood T cell distribution following small-bowel allografting in rats under different experimental conditions. Group 1: ACI (RT1a) rats were used as small-bowel donors for ACI x Wistar (RT1y) F1 hybrid rats (WAF1) in which graft-versus-host disease (GVHD) developed. Group 2: WAF1 rats we
Balancing the Th1/Th2 concept in multiple sclerosis.: Immunol Today. 1998 Nov;19(11):489-90. Unique Identifier : AIDSLINE MED/99035945; Laman JD; Thompson EJ; Kappos L; Dept of Immunology, Erasmus University Rotterdam.; Laman@immu.fgg.eur.nl
HIV infection: how effective is drug combination treatment?: Immunol Today. 1998 Nov;19(11):528-32. Unique Identifier : AIDSLINE MED/99035955; Grossman Z; Feinberg M; Kuznetsov V; Dimitrov D; Paul W; NIH Office of AIDS Research, Bethesda, MD 20892, USA.; wepaul@nih.gov; The rate of decline of plasma HIV RNA in patients treated with anti-retroviral drugs has been postulated to reflect the half-lives of previously HIV-infected cells. Here, Zvi Grossman and colleagues argue that the observed decline is explained by the kinetics of ongoing infection cycles. Residual cell-to-cell infectio
Pertussis infection and vaccination induces Th1 cells [letter]: Immunol Today. 1998 Nov;19(11):534. Unique Identifier : AIDSLINE MED/99035957; Brady MT; Mahon BP; Mills KH
Sexual and mother-to-child transmission of the human immunodeficiency virus type 1: a review.: Am J Reprod Immunol. 1998 Sep;40(3):183-6. Unique Identifier : AIDSLINE MED/98436854; Chermann JC; INSERM Unite de Recherche sur les Retrovirus et Maladies,; Technologique de Luminy, Marseille, France.; PROBLEM: Sexual and mother-to-child transmission of the human immunodeficiency virus (HIV) type 1 occurs only with a low percentage of infection. Many instances of sexual intercourse result in no transmission, and only 20% of children are infected from seropositive mothers (3% in mothers treated with azidothymidine).
The radiology of the thoracic manifestations of AIDS.: Crit Rev Diagn Imaging. 1998 Aug;39(4):259-338. Unique Identifier : AIDSLINE MED/98431722; Oldham SA; Barron B; Munden RF; Lamki N; Lamki L; Department of Radiology, University of Texas Houston Health; Science Center 77030, USA.; The thoracic manifestations of AIDS have undergone a gradual metamorphosis, partly due to more awareness about the disease leading to earlier diagnoses and partly due to the fact that research has produced more effective prophylaxis as well as treatment for these patients. Many patients now demonstrate partial or comp
Acute pancreatitis: the role of diagnostic imaging.: Crit Rev Diagn Imaging. 1998 Sep;39(5):339-63. Unique Identifier : AIDSLINE MED/99007960; Dalzell DP; Scharling ES; Ott DJ; Wolfman NT; Department of Radiology, Wake Forest University School of; Medicine, Winston-Salem, N.C 27157-1088, USA.; In the U.S., acute pancreatitis is usually caused by excessive consumption of ethanol or by biliary stone disease. Major pathologic finding and complications include fluid collections within the organ or the adjacent peripancreatic tissues, pseudocysts, pancreatic necrosis, pseudoaneurysm, and abscess formation. Radio
HIV and the family.: J Pierre Fauchard Acad. 1994 Dec;8(4):126. Unique Identifier : AIDSLINE MED/99073063
AIDS cases soar in past year.: J Pierre Fauchard Acad. 1994 Dec;8(4):127-9. Unique Identifier : AIDSLINE MED/99073064; Around 1.5 million people developed AIDS between mid-1993 and mid-1994--three times as many as in the previous 12 months, according to estimates released by GPA on 1 July. About 200,000 of the new cases are thought to be in south and southeast Asia, more than eight times as many as occurred in that region during the p
Ten points for world AIDS day 1994 AIDS and the family.: J Pierre Fauchard Acad. 1994 Dec;8(4):130. Unique Identifier : AIDSLINE MED/99073065
Sexual behaviour research and HIV/AIDS.: J Pierre Fauchard Acad. 1994 Dec;8(4):131-2. Unique Identifier : AIDSLINE MED/99073066; To design effective ways of reducing HIV transmission through sexual intercourse, which accounts for about 90% of all infections among adults and adolescents, we need to know more about how sex occurs and is understood in different cultures. Dr Peter Aggleton, who leaves GPA this summer after two years as head of its
HIV. Genetic effects on immunity immunity to infection. Web alert.: Unique Identifier : AIDSLINE MED/98390150; Greaves DR; Sir William Dunn School of Pathology, Oxford, UK.
Preparing for HIV vaccines that induce cytotoxic T lymphocytes [editorial]: Curr Opin Immunol. 1998 Aug;10(4):379-81. Unique Identifier : AIDSLINE MED/98390151; McMichael A
HIV-2 and T cell recognition.: Curr Opin Immunol. 1998 Aug;10(4):382-7. Unique Identifier : AIDSLINE MED/98390152; Whittle HC; Ariyoshi K; Rowland-Jones S; MRC Laboratories, The Gambia, West Africa. whittle@commit.gm; HIV-2 is less pathogenic and less transmissible than HIV-1. Recent research in relation to deletions in the HIV nef gene and to immune cross-reactions between infections by HIV-2, HIV-1 and simian immunodeficiency virus suggests that T cell recognition and the control of viral replication may be more efficient in HIV-
Cross-clade T cell recognition of HIV.1.: Curr Opin Immunol. 1998 Aug;10(4):388-92. Unique Identifier : AIDSLINE MED/98390153; Gotch F; Department of Immunology, Chelsea and Westminster Hospital,; London, UK.; Despite considerable advances in antiviral therapy for HIV infection, successful global intervention will require an effective vaccine. Current evidence suggests that cytotoxic T lymphocyte responses will be an important component of such vaccination. Recent evidence suggests that cytotoxic T lymphocytes raised agains
Protective immunity induced by live attenuated simian immunodeficiency virus.: Curr Opin Immunol. 1998 Aug;10(4):436-43. Unique Identifier : AIDSLINE MED/98390160; Johnson RP; Desrosiers RC; Division of Immunology, New England Regional Primate Research; Center, Harvard Medical School, Southborough, MA 01772, USA.; pjohnson@warren.med.harvard.edu; Lack of information on the mechanisms of protective immunity to AIDS virus infection represents a major obstacle to the development of a rational strategy for an effective HIV vaccine. In macaques, immunization with live attenuated simian immunodeficiency viruses has induced the most potent protective immunity and con
Therapeutic vaccination against chronic viral infection: the importance of cooperation between CD4+ and CD8+ T cells.: Curr Opin Immunol. 1998 Aug;10(4):444-9. Unique Identifier : AIDSLINE MED/98390161; Zajac AJ; Murali-Krishna K; Blattman JN; Ahmed R; Emory Vaccine Center, Emory University School of Medicine,; Atlanta, GA 30322, USA.; The goal of therapeutic vaccination is to elicit an antiviral immune response within persistently infected individuals and consequently eradicate the infection. CD8+ T cells are potent mediators of viral clearance; however, during chronic infections CD4+ T cell help is required to sustain antiviral CD8+ T cell activit
Cytotoxic T cell responses to intracellular pathogens.: Curr Opin Immunol. 1998 Aug;10(4):471-7. Unique Identifier : AIDSLINE MED/98390165; Stenger S; Modlin RL; Institut fur Klinische Mikrobiologie, Immunologie und Hygiene,; Universitat Erlangen, Germany.; Host defense against intracellular pathogens is thought to require cytotoxic T cells. Recent studies have investigated the impact of host cell lysis and cytokine production by cytotoxic T lymphocytes on the fate of intracellular pathogens. The identification of two mechanisms of lysis induced by cytotoxic T lymphocyte
Adaptation to promiscuous usage of CC and CXC-chemokine coreceptors in vivo correlates with HIV-1 disease progression.: AIDS. 1998 Sep 10;12(13):F137-43. Unique Identifier : AIDSLINE MED/98435802; Xiao L; Rudolph DL; Owen SM; Spira TJ; Lal RB; HIV/Retrovirus Diseases Branch, Division of AIDS, STD, and TB; Laboratory Research, National Center for Infectious Diseases,; Centers for Disease Control and Prevention, Public Health; Services, US Department of Health and Human Serv.; OBJECTIVE: To study coreceptor usage of sequential primary HIV-1 isolates in a longitudinal follow-up cohort of HIV-1-infected men to understand its contribution to pathogenesis of HIV disease. DESIGN: Viral coreceptor usage of sequential primary isolates from HIV-1-infected individuals was examined at various timepoi
Target cell availability and the successful suppression of HIV by hydroxyurea and didanosine [editorial]: AIDS. 1998 Sep 10;12(13):1567-70. Unique Identifier : AIDSLINE MED/98435803; De Boer RJ; Boucher CA; Perelson AS
Cost-effectiveness and cost-benefit in the prevention of mother-to-child transmission of HIV in developing countries. Ghent International Working Group on Mother-to-Child Transmission of HIV [editorial; comment]: AIDS. 1998 Sep 10;12(13):1571-80. Unique Identifier : AIDSLINE MED/98435804; Newell ML; Dabis F; Tolley K; Whynes D
Prognostic significance of plasma markers of immune activation, HIV viral load and CD4 T-cell measurements.: AIDS. 1998 Sep 10;12(13):1581-90. Unique Identifier : AIDSLINE MED/98435805; Fahey JL; Taylor JM; Manna B; Nishanian P; Aziz N; Giorgi JV; Detels R; Department of Microbiology and Immunology, Center for; Interdisciplinary Research in Immunology and Disease, UCLA School; of Medicine, Los Angeles, California 90095-1747, USA.; OBJECTIVE: To evaluate the prognostic significance for AIDS occurrence of plasma levels of immune activation markers in comparison with and in conjunction with HIV viral load and CD4 T-cell measurements. DESIGN: A retrospective analysis was conducted of three plasma activation markers, the soluble tumor necrosis facto
Neutralizing antibodies are positively associated with CD4+ T-cell counts and T-cell function in long-term AIDS-free infection.: AIDS. 1998 Sep 10;12(13):1591-600. Unique Identifier : AIDSLINE MED/98435806; Carotenuto P; Looij D; Keldermans L; de Wolf F; Goudsmit J; Department of Human Retrovirology, Academic Medical Centre,; University of Amsterdam, The Netherlands.; OBJECTIVES: To assess the dynamics of neutralizing antibodies (NAb) in long-term AIDS-free HIV-1-infected subjects and establish correlations with known markers of disease progression. DESIGN: Cross-sectional study using sera collected from long-term non-progressors (LTNP) 8 years after seroconversion or study entry.
Change in fluconazole susceptibility patterns and genetic relationship among oral Candida albicans isolates.: AIDS. 1998 Sep 10;12(13):1601-10. Unique Identifier : AIDSLINE MED/98435807; Diaz-Guerra TM; Martinez-Suarez JV; Laguna F; Valencia E; Rodriguez-Tudela JL; Unidad de Micologia, Centro Nacional de Microbiologia,; Majadahonda, Instituto de Salud Carlos III, Madrid, Spain.; OBJECTIVE: To assess the genetic homogeneity or heterogeneity within each set of Candida albicans isolates colonizing/infecting the oral cavities of HIV-infected patients undergoing azole therapy when changes in susceptibility to fluconazole were detected. DESIGN: Fourteen HIV-positive patients suffering recurrent epi
HIV protease genotype and viral sensitivity to HIV protease inhibitors following saquinavir therapy.: AIDS. 1998 Sep 10;12(13):1611-8. Unique Identifier : AIDSLINE MED/98435808; Craig C; Race E; Sheldon J; Whittaker L; Gilbert S; Moffatt A; Rose J; Dissanayeke S; Chirn GW; Duncan IB; Cammack N; Roche Discovery Welwyn, Welwyn Garden City, Herts, UK.; OBJECTIVE: To examine the relationship between HIV protease genotype and altered protease inhibitor sensitivity of isolates from patients after therapy with saquinavir (SQV) in its hard gelatin formulation. DESIGN: Forty-one post-therapy isolates and corresponding baseline samples were obtained from 37 patients in fou
Suppression of plasma viral load below 20 copies/ml is required to achieve a long-term response to therapy.: AIDS. 1998 Sep 10;12(13):1619-24. Unique Identifier : AIDSLINE MED/98435809; Raboud JM; Montaner JS; Conway B; Rae S; Reiss P; Vella S; Cooper D; Lange J; Harris M; Wainberg MA; Robinson P; Myers M; Hall D; Canadian HIV Trials Network and Centre for Excellence in; HIV/AIDS, St Paul's Hospital/University of British Columbia,; Vancouver.; BACKGROUND: Current guidelines state that the goal of antiretroviral therapy for HIV-infected individuals is to suppress plasma viral load (pVL) to below 400 copies/ml. METHODS: Predictors of achieving and maintaining pVL suppression were examined in a randomized trial of combinations of zidovudine,
Treatment response and durability of a double protease inhibitor therapy with saquinavir and ritonavir in an observational cohort of HIV-1-infected individuals.: AIDS. 1998 Sep 10;12(13):1625-30. Unique Identifier : AIDSLINE MED/98435810; Kaufmann GR; Duncombe C; Cunningham P; Beveridge A; Carr A; Sayer D; French M; Cooper DA; Centre for Immunology, St Vincent's Hospital, Sydney, NSW,; Australia.; OBJECTIVE: To evaluate treatment response, durability and tolerance of a four-drug regimen including saquinavir and ritonavir in combination with either zidovudine/lamivudine or stavudine
Clinical outcome and predictive factors of failure of highly active antiretroviral therapy in antiretroviral-experienced patients in advanced stages of HIV-1 infection.: AIDS. 1998 Sep 10;12(13):1631-7. Unique Identifier : AIDSLINE MED/98435811; d'Arminio Monforte A; Testa L; Adorni F; Chiesa E; Bini T; Moscatelli GC; Abeli C; Rusconi S; Sollima S; Balotta C; Musicco M; Galli M; Moroni M; Institute of Infectious and Tropical Diseases, University of; Milan, Italy.; OBJECTIVE: To verify the effectiveness of highly active antiretroviral therapy (HAART) and to identify any factors predictive of clinical outcome in a clinical setting. DESIGN: Observational study. METHODS: Treatment failure (i.e., the occurrence of new or recurrent AIDS-defining events, death or any definitive discon
The relative prognostic value of plasma HIV RNA levels and CD4 lymphocyte counts in advanced HIV infection.: AIDS. 1998 Sep 10;12(13):1639-43. Unique Identifier : AIDSLINE MED/98435812; Cozzi Lepri A; Katzenstein TL; Ullum H; Phillips AN; Skinhoj P; Gerstoft J; Pedersen BK; Royal Free Centre for HIV Medicine & Department of Primary Care; and Population Sciences, Royal Free and University College; Medical School, University College London, UK.; OBJECTIVE: It has been suggested that the plasma HIV RNA level is a better predictor of AIDS and death than the CD4 lymphocyte count. We assessed whether the prognostic value of plasma virus levels was different according to the CD4 count. DESIGN: Prospective cohort study of HIV-infected patients followed for a median
The effect of protease inhibitors on weight and body composition in HIV-infected patients.: AIDS. 1998 Sep 10;12(13):1645-51. Unique Identifier : AIDSLINE MED/98435813; Silva M; Skolnik PR; Gorbach SL; Spiegelman D; Wilson IB; Fernandez-DiFranco MG; Knox TA; Department of Community Health, Tufts University School of; Medicine, and the New England Medical Center Hospitals, Boston,; Massachusetts 02111, USA.; OBJECTIVES: To determine the nutritional changes that occur in HIV-infected patients receiving protease inhibitor (PI) therapy and to determine the effects of PI treatment on physical functioning and health perceptions in patients with HIV infection. DESIGN: Longitudinal data analysis of 38 patients from a large Nutri
Effects of vitamin E and C supplementation on oxidative stress and viral load in HIV-infected subjects.: AIDS. 1998 Sep 10;12(13):1653-9. Unique Identifier : AIDSLINE MED/98435814; Allard JP; Aghdassi E; Chau J; Tam C; Kovacs CM; Salit IE; Walmsley SL; Department of Medicine, University of Toronto, Ontario, Canada.; OBJECTIVES: The HIV-infected population is known to be oxidatively stressed and deficient in antioxidant micronutrients. Since in vitro replication of HIV is increased with oxidative stress, this study assessed the effect of antioxidant vitamin supplementation on lipid peroxidation, a measure of oxidative stress, and
Mycobacterium xenopi in HIV-infected patients: an emerging pathogen.: AIDS. 1998 Sep 10;12(13):1661-6. Unique Identifier : AIDSLINE MED/98435815; Juffermans NP; Verbon A; Danner SA; Kuijper EJ; Speelman P; Department of Internal Medicine, University of Amsterdam, The; Netherlands.; BACKGROUND: Mycobacterium xenopi is associated with pulmonary disease in patients with loss of local or general host defence. OBJECTIVES: To determine the occurrence of M. xenopi in our hospital during 1987-1992 and 1993-1996, as well as the association of M. xenopi with HIV infection in 1993-1996; to evaluate the cli
Taste and smell complaints in HIV-infected patients.: AIDS. 1998 Sep 10;12(13):1667-74. Unique Identifier : AIDSLINE MED/98435816; Heald AE; Pieper CF; Schiffman SS; Department of Medicine, Duke University Medical Center, Durham,; North Carolina 27710, USA.; OBJECTIVES: To define the scope of taste and smell (chemosensory) complaints amongst HIV-infected persons in the study population; to evaluate the clinical factors associated with chemosensory complaints; and to determine the impact of chemosensory complaints on quality of life. DESIGN: Cross-sectional survey. SETTING
Antiretroviral drugs as a public health intervention for pregnant HIV-infected women in rural South Africa: an issue of cost-effectiveness and capacity [see comments]: AIDS. 1998 Sep 10;12(13):1675-82. Unique Identifier : AIDSLINE MED/98435817; Wilkinson D; Floyd K; Gilks CF; Centre for Epidemiological Research in Southern Africa, Medical; Research Council, Mtubatuba.; OBJECTIVE: To estimate cost-effectiveness and capacity requirements for providing antiretroviral drugs to pregnant HIV-infected women in rural South Africa . SETTING: Hlabisa health district, where HIV prevalence among pregnant women was 26.0% in 1997. METHODS: Calculation of the n
Pneumococcal vaccination in HIV-1-infected adults in Uganda: humoral response and two vaccine failures.: AIDS. 1998 Sep 10;12(13):1683-9. Unique Identifier : AIDSLINE MED/98435818; French N; Gilks CF; Mujugira A; Fasching C; O'Brien J; Janoff EN; Medical Research Council Programme on AIDS in Uganda, Uganda; Virus Research Institute, Entebbe.; OBJECTIVES: To assess the feasibility of establishing a pneumococcal vaccine trial among HIV-1-infected adults in Uganda and to characterize their responses to 23-valent pneumococcal polysaccharide vaccine. DESIGN: An open-label pilot trial to assess recruitment and compliance of H
Effects of age at seroconversion and baseline HIV RNA level on the loss of CD4+ cells among persons with hemophilia. Multicenter Hemophilia Cohort Study.: AIDS. 1998 Sep 10;12(13):1691-7. Unique Identifier : AIDSLINE MED/98435819; Touloumi G; Hatzakis A; Rosenberg PS; O'Brien TR; Goedert JJ; Department of Hygiene and Epidemiology, Athens University Medical; School, Greece.; OBJECTIVE: To assess the impact of age at seroconversion and HIV RNA level in serum during early chronic infection on the initial values and subsequent trends (slopes) of CD4+ lymphocyte counts. DESIGN AND METHODS: In a cohort of 137 HIV-1-positive hemophiliacs with well-estimated dates of seroconversion, baseline HIV
Bacterial vaginosis and disturbances of vaginal flora: association with increased acquisition of HIV.: Unique Identifier : AIDSLINE MED/98435820; Taha TE; Hoover DR; Dallabetta GA; Kumwenda NI; Mtimavalye LA; Yang LP; Liomba GN; Broadhead RL; Chiphangwi JD; Miotti PG
Declining HIV-2 prevalence and incidence among men in a community study from Guinea-Bissau.: Unique Identifier : AIDSLINE MED/98435821; Larsen O; da Silva Z; Sandstrom A; Andersen PK; Andersson S; Poulsen AG; Melbye M; Dias F; Naucler A; Aaby P; Projecto de Saude de Bandim, Bissau, Guinea-Bissau.; OBJECTIVE: To assess the present level of HIV-2 infection in an adult population in Bissau and to evaluate sex and age-specific changes in HIV-2 prevalence and incidence between 1987 and 1996. DESIGN AND METHODS: Sex and age-specific changes in HIV-2 prevalence were evaluated comparing a survey from 1987 in a sample o
Highly active antiretroviral therapy leads to a significant but delayed increase of CD45RA+ T-helper cells [letter]: AIDS. 1998 Sep 10;12(13):1715-6. Unique Identifier : AIDSLINE MED/98435822; Degen O; Stellbrink HJ; Lauer J; van Lunzen J
Complete regression of AIDS-related Kaposi's sarcoma-associated human herpesvirus-8 during therapy with indinavir [letter]: AIDS. 1998 Sep 10;12(13):1717-9. Unique Identifier : AIDSLINE MED/98435823; Martinelli C; Zazzi M; Ambu S; Bartolozzi D; Corsi P; Leoncini F
Herpes zoster infection in HIV-seropositive patients associated with highly active antiretroviral therapy [letter]: AIDS. 1998 Sep 10;12(13):1719-20. Unique Identifier : AIDSLINE MED/98435824; Aldeen T; Hay P; Davidson F; Lau R
Progressive multifocal leukoencephalopathy following initiation of highly active antiretroviral therapy [letter]: AIDS. 1998 Sep 10;12(13):1720-2. Unique Identifier : AIDSLINE MED/98435825; Mayo J; Collazos J; Martinez E
Acute hepatitis in HIV-infected patients during ritonavir treatment [letter]: AIDS. 1998 Sep 10;12(13):1722-4. Unique Identifier : AIDSLINE MED/98435826; Arribas JR; Ibanez C; Ruiz-Antoran B; Pena JM; Esteban-Calvo C; Frias J; Vazquez JJ; Gonzalez-Garcia JJ
Bacterial lipopolysaccharide is a potent inhibitor of HIV-1 replication in T lymphocytes and macrophages [letter]: AIDS. 1998 Sep 10;12(13):1724-6. Unique Identifier : AIDSLINE MED/98435827; Alfano M; Schmidtmayerova H; Bukrinsky M
Use of highly sensitive assays for the evaluation of post-exposure HIV prophylaxis [letter]: AIDS. 1998 Sep 10;12(13):1726-7. Unique Identifier : AIDSLINE MED/98435828; Schockmel GA; Balavoine JF; Yerly S; Perrin L
Performance of an ultrasensitive assay to test undetectable viral load specimens using the branched DNA assay [letter]: AIDS. 1998 Sep 10;12(13):1727-9. Unique Identifier : AIDSLINE MED/98435829; de Mendoza C; Holguin A; Soriano V
Comparison of zidovudine phosphorylation in lymph nodes and peripheral blood mononuclear cells in HIV-infected patients. DATRI 012 Study Group [letter]: AIDS. 1998 Sep 10;12(13):1729-31. Unique Identifier : AIDSLINE MED/98435830; Peter K; Lalezari JP; Pearl JM; Thevanayagam L; Gambertoglio JG
Increased susceptibility to HIV-1 infection of peripheral blood mononuclear cells from chronically immune-activated individuals [letter]: AIDS. 1998 Sep 10;12(13):1731-3. Unique Identifier : AIDSLINE MED/98435831; Shapira-Nahor O; Kalinkovich A; Weisman Z; Greenberg Z; Nahmias J; Shapiro M; Panet A; Bentwich Z
Social marketing sexually transmitted disease and HIV prevention: a consumer-centered approach to achieving behaviour change.: AIDS. 1998;12 Suppl 2:S1-9. Unique Identifier : AIDSLINE MED/99006842; Lamptey PR; Price JE; Family Health International, Arlington, Virginia, USA.; This paper proposes that international sexually transmitted disease (STD)/HIV prevention efforts might be enhanced by the application of social marketing principles. It first outlines the conceptual basis of social marketing approaches to health behaviour change generally and then explores key issues and opportunities
Field experiences: measuring capacity building efforts in HIV/AIDS prevention programmes.: AIDS. 1998;12 Suppl 2:S109-17. Unique Identifier : AIDSLINE MED/99006854; Kotellos KA; Amon JJ; Benazerga WM; Division of HIV/AIDS, Family Health International, Arlington,; Virginia, USA.; OBJECTIVE: To present a theoretical and practical means for the evaluation of organizational and institutional development (capacity building) in HIV/AIDS prevention programmes in developing countries. METHODS: Multiple frameworks, methodologies and paradigms for the evaluation of organizational and institutional deve
The affordability of antiretroviral therapy in developing countries: what policymakers need to know.: AIDS. 1998;12 Suppl 2:S11-8. Unique Identifier : AIDSLINE MED/99006843; Forsythe SS; AIDSCAP/Family Health International.; OBJECTIVE: The objective of this paper is to assist policymakers in developing countries and international donors by providing an outline of economic information needed to make a decision regarding the purchase of drugs to provide highly active antiretroviral therapy (HAART). DESIGN: The following paper: (i) reviews e
Targeted intervention research studies on sexually transmitted diseases (STD): methodology, selected findings and implications for STD service delivery and communications.: AIDS. 1998;12 Suppl 2:S119-26. Unique Identifier : AIDSLINE MED/99006855; Field ML; Price J; Niang C; N'tcha J; Zwane IT; Lurie M; Nxumalo M; Dialmy A; Manhart L; Gebre A; Saidel T; Dallabetta G; Family Health International, Arlington, Virginia, USA.; OBJECTIVE: To report the findings of qualitative studies designed for use in improving sexually transmitted disease (STD) programs. The studies explore illness conceptions and treatment behaviors for STD in five African countries. These targeted intervention research (TIR) studies were performed on clinic-based and co
Beyond the dichotomy: linking HIV prevention with care.: AIDS. 1998;12 Suppl 2:S19-26. Unique Identifier : AIDSLINE MED/99006844; MacNeil JM; Anderson S; AIDSCAP Project of Family Health International, Arlington, VA; 22201, USA.; In the past decade, the global strategy against AIDS has focused primarily upon prevention. Regardless of the effectiveness of prevention efforts being made today and advances in treatments, the numbers of persons infected globally continues to grow at an alarming rate, especially in developing countries. With numbers
AVERT: a user-friendly model to estimate the impact of HIV/sexually transmitted disease prevention interventions on HIV transmission.: AIDS. 1998;12 Suppl 2:S27-35. Unique Identifier : AIDSLINE MED/99006845; Rehle TM; Saidel TJ; Hassig SE; Bouey PD; Gaillard EM; Sokal DC; AIDS Control and Prevention Project, Family Health International,; Arlington, Virginia, USA.; OBJECTIVE: To introduce the newly developed AVERT model by describing the purpose, logic, advantages and limitations of the model, to validate the model s estimates against seroconversion data from a large randomized controlled trial, and to provide practical examples of its applications. DESIGN: Static, deterministic
HIV risk behavioral surveillance: a methodology for monitoring behavioral trends.: AIDS. 1998;12 Suppl 2:S37-46. Unique Identifier : AIDSLINE MED/99006846; Mills S; Saidel T; Bennett A; Rehle T; Hogle J; Brown T; Magnani R; AIDS Control and Prevention Project, Family Health International,; Bangkok, Thailand. smills@fhibkk.org; OBJECTIVE: This article summarizes issues and recommendations for conducting HIV risk behavioral surveillance surveys (BSS) based on experiences from ten BSS projects in eight countries in Asia and Africa. BACKGROUND: BSS consists of systematic and repeated cross-sectional surveys of HIV and sexually transmitted disea
Evolution of socioeconomic impact assessments of HIV/AIDS.: AIDS. 1998;12 Suppl 2:S47-55. Unique Identifier : AIDSLINE MED/99006847; Forsythe S; Rau B; Policy Unit of AIDSCAP/Family Health International.; OBJECTIVE: The objective of this paper is to describe how and why socioeconomic impact assessments, as applied to HIV/AIDS in developing countries, have evolved over time and to discuss the direction that this field should be taking in the future. DESIGN: This paper involves a review of existing literature and incorpo
Indicators and the measurement of STD case management in developing countries. STD PI6&7 Working Group.: Unique Identifier : AIDSLINE MED/99006848
Improving sexually transmitted disease management in the private sector: the Jamaica experience.: Unique Identifier : AIDSLINE MED/99006849; Green M
Cost of providing sexually transmitted disease services in Bangkok.: AIDS. 1998;12 Suppl 2:S73-80. Unique Identifier : AIDSLINE MED/99006850; Forsythe S; Mangkalopakorn C; Chitwarakorn A; Masvichian N; HIV/AIDS Work Programme, Liverpool School of Tropical Medicine,; UK.; OBJECTIVE: The main purpose of this study was to assess the economic costs of sexually transmitted disease (STD) treatment and to identify opportunities for sustaining Bangkok s STD clinics. DESIGN: A cost analysis was used to assess the resources required to provide (i) STD services, (ii) additional services at STD c
The role of pharmacists in HIV/STD prevention: evaluation of an STD syndromic management intervention in Nepal.: AIDS. 1998;12 Suppl 2:S81-7. Unique Identifier : AIDSLINE MED/99006851; Tuladhar SM; Mills S; Acharya S; Pradhan M; Pollock J; Dallabetta G; New ERA, Kathmandu, Nepal.; OBJECTIVE: To evaluate the effects of a pilot sexually transmitted disease (STD) syndromic case management training for pharmacists in Nepal on STD drug dispensing behavior, HIV/STD prevention communication, and condom promotion and
Is HIV/STD control in Jamaica making a difference?: AIDS. 1998;12 Suppl 2:S89-98. Unique Identifier : AIDSLINE MED/99006852; Figueroa JP; Brathwaite AR; Wedderburn M; Ward E; Lweis-Bell K; Amon JJ; Williams Y; Williams E; Ministry of Health, Kingston, Jamaica.; OBJECTIVE: To assess the impact of the comprehensive HIV/STD Control Program established in Jamaica since the late 1980s on the HIV/AIDS epidemic. METHODS: AIDS case reports, HIV testing of blood donors, antenatal clinic attenders (ANC), food service workers, sexually transmitted
Applying social, behavioral and evaluation research to developing country HIV prevention programs.: AIDS. 1998;12 Suppl 2:S99-108. Unique Identifier : AIDSLINE MED/99006853; MacNeil JM; Hogle J; Family Health International's AIDSCAP Project, Arlington,; Virginia, USA.; OBJECTIVE: To examine the role that social, behavioral and evaluation research played in a 6-year global HIV prevention program working in 45 developing countries. METHODS: Computerized review of project database inventories: 320 research abstracts, 591 subproject abstracts, on-line literature search of project peer-r
Synthesis and in vitro antimicrobial and antitumoral screening of novel lipophilic isoniazid analogues. VI.: Boll Chim Farm. 1998 Jul-Aug;137(7):267-76. Unique Identifier : AIDSLINE MED/99011574; Vigorita MG; Ottana R; Maccari R; Monforte F; Bisignano G; Pizzimenti FC; Dipartimento Farmaco-chimico, Universita di Messina, Italy.; Various kinds of lipophilic analogues of isonicotinic acid hydrazide (Isoniazid) were synthesized and in vitro explored in a search for antimycobacterial agents with extended activity spectrum against pathogens responsible for the AIDS-associated diseases. The primary in vitro screening showed that a) isonicotinoylhyd
AIDS-related malignancies.: Ann Med. 1998 Aug;30(4):323-44. Unique Identifier : AIDSLINE MED/98455152; Smith C; Lilly S; Mann KP; Livingston E; Myers S; Lyerly HK; Miralles GD; Department of Medicine, Duke University Medical Center, Durham,; NC 27710, USA.; In the US over one million persons are currently infected with the HIV, over half a million have had AIDS, and over 300,000 have died from AIDS. Worldwide, it is estimated that more than 17 million people are currently infected with HIV, and over 1,200,000 cases of AIDS have been reported to the
PCR for HBV, HCV and HIV-1 experiences and first results from a routine screening programme in a large blood transfusion service.: Biologicals. 1998 Jun;26(2):101-4. Unique Identifier : AIDSLINE MED/99030780; Schottstedt V; Tuma W; Bunger G; Lefevre H; Red Cross Blood Transfusion Service North-Rhine Westfalia,; Germany.; We adapted the PCR method to screen up to 3000 blood donations per day for hepatitis B, hepatitis C and HIV-1 virus contamination. Up to 600 aliquots (average 418 donations) are pooled by using an automatic sample processor with disposable tips (validated to avoid contamination) taken from blood donations which are se
Inactivation of viruses by beta-propiolactone in human cryo poor plasma and IgG concentrates.: Unique Identifier : AIDSLINE MED/99030788; Scheidler A; Rokos K; Reuter T; Ebermann R; Pauli G; Virus inactivation by cold treatment with beta-propiolactone
Emergence of new viral infections: implications for the blood supply.: Biologicals. 1998 Jun;26(2):77-84. Unique Identifier : AIDSLINE MED/99030776; Nathanson N; Department of Microbiology, University of Pennsylvania Medical; Center, 263 Clinical Research Building, Philadelphia, PA; 19104-6146, USA.; New viral infections of humans appear to be emerging at an increasing tempo, probably due to technological developments and societal changes that have enhanced the ability of viruses to invade and spread within the human population. Emergence can be due to several discrete phenomena. Existing viruses of humans continu
Surveillance for transfusion-transmitted viral infections in the United States.: Biologicals. 1998 Jun;26(2):85-8. Unique Identifier : AIDSLINE MED/99030777; Chamberland ME; Centers for Disease and Prevention, Division of Viral and; Rickettsial Diseases, Atlanta, GA 30333, USA.; Surveillance is part of a multi-faceted programme to monitor the safety of the U. S. blood supply. The Centers for Disease Control and Prevention administers several national surveillance programmes, including pathogen- and disease-specific systems (e.g. human immunodeficiency virus, hepatitis) and programmes that foc
[Mental and physical impairment, socio-economic resources and care strategies in people with HIV infection]: Ann Ig. 1998 May-Jun;10(3):189-99. Unique Identifier : AIDSLINE MED/99050538; Mancinelli S; Palombi L; Liotta G; Doro Altan A; Riccardi F; Narciso P; Marazzi MC; Catt. di Igiene, Universita di Tor Vergata, Roma.
NMR study and comparison of the antigenic properties of a peptide recognized by two HIV-1 neutralizing antibodies.: J Mol Recognit. 1997 Nov-Dec;10(6):256-61. Unique Identifier : AIDSLINE MED/98443588; Tsang P; Mu X; Wu G; Durda PJ; Department of Chemistry, University of Cincinnati, OH 45221-0172,; USA.; Fab-peptide complexes formed between a 15 residue peptide derived from the HIV-1 gp120 V3 loop and two of its cognate monoclonal antibodies, 5023A and 5025A, were studied using isotope-edited solution nuclear magnetic resonance (NMR) techniques. Since these antibodies neutralize HIV-1 virus with different strain speci
The role of dendritic cells in the infection of CD4+ T cells with the human immunodeficiency virus: use of dendritic cells from individuals homozygous for the delta32CCR5 allele as a model.: AIDS Res Hum Retroviruses. 1998 Sep 1;14(13):1109-13. Unique Identifier : AIDSLINE MED/98407600; Dybul M; Weissman D; Rubbert A; Machado E; Cohn M; Ehler L; O'Callahan M; Mizell S; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda,; Maryland 20892, USA.; Despite exposure to multiple strains of both macrophage (M)-tropic and T cell (T)-tropic HIV, primary infection is largely restricted to relatively homogeneous M-tropic virus. Since dendritic cells (DCs) play a pivotal role in the early events of HIV infection, several studies have focused on the role of DCs in this r
Molecular characterization of five neutralizing anti-HIV type 1 antibodies: identification of nonconventional D segments in the human monoclonal antibodies 2G12 and 2F5.: AIDS Res Hum Retroviruses. 1998 Sep 1;14(13):1115-28. Unique Identifier : AIDSLINE MED/98407601; Kunert R; Ruker F; Katinger H; Institute of Applied Microbiology, University of Agricultural; Sciences, Vienna, Austria.; We have stabilized a panel of 33 hybridomas producing human monoclonal antibodies (MAbs) against HIV-1 gp160 and p24. Five of these antibodies were able to neutralize different HIV-1 isolates, and two of them (2F5 and 2G12) revealed remarkable potential to neutralize primary virus isolates of different clades in sever
Effect of major deletions in the V1 and V2 loops of a macrophage-tropic HIV type 1 isolate on viral envelope structure, cell entry, and replication.: AIDS Res Hum Retroviruses. 1998 Sep 1;14(13):1129-39. Unique Identifier : AIDSLINE MED/98407602; Stamatatos L; Wiskerchen M; Cheng-Mayer C; Aaron Diamond AIDS Research Center, The Rockefeller University,; New York, New York 10021, USA.; Two HIV-1 envelope mutant proteins were generated by introducing deletions in the first and second hypervariable gp120 regions (V1 and V2 loops, respectively) of a macrophage-tropic primary HIV-1 isolate, SF162, to study the effect of the deleted sequences on envelope structure, viral entry, and replication potentials
Cell-associated viral RNA expression during acute infection with HIV type 1.: AIDS Res Hum Retroviruses. 1998 Sep 1;14(13):1141-9. Unique Identifier : AIDSLINE MED/98407603; Riggs NL; Little SJ; Richman DD; Guatelli JC; Department of Medicine, University of California San Diego, La; Jolla 92093, USA.; The mechanism of decline in viremia following acute infection with HIV is unknown. To characterize this process virologically, the expression of viral RNAs was analyzed in samples of peripheral blood mononuclear cells (PBMCs) from a patient who experienced a 100-fold decline in plasma viremia over a 13-day period prio
Optimization of polymerase chain reaction for detection of HIV type 2 DNA.: AIDS Res Hum Retroviruses. 1998 Sep 1;14(13):1151-6. Unique Identifier : AIDSLINE MED/98407604; Walther L; Grankvist O; Mirzai B; da Silva Z; Fredlund H; Biberfeld G; Thorstensson R; Swedish Institute for Infectious Disease Control and Microbiology; and Tumor Biology Center, Karolinska Institute, Stockholm.; The aim of this study was to increase the sensitivity of an earlier version of an HIV-2 nested PCR assay based on primers in the gag, pol, LTR, and env regions. The assay was first optimized with regard to concentrations of dNTP, MgCl2, and primers, using a method that allowed optimization of all three parameters in o
Antibodies to the HIV type 2 core protein p26 and Vpx: association with disease progression.: AIDS Res Hum Retroviruses. 1998 Sep 1;14(13):1157-62. Unique Identifier : AIDSLINE MED/98407605; Popper SJ; Sankale JL; Thior I; Siby T; Marlink RG; Mboup S; Essex M; Kanki PJ; Harvard AIDS Institute, Harvard School of Public Health, Boston,; Massachusetts 02115, USA.; A longitudinal cohort study was conducted to define the prevalence and temporal pattern of antibody response to the HIV-2 virion-associated proteins p26gag and Vpx. One hundred and forty-one asymptomatic HIV-2-infected women were enrolled, and followed for up to 11 years. Eighty-one percent of the subjects had antibod
SIV-associated nephropathy in rhesus macaques infected with lymphocyte-tropic SIVmac239.: AIDS Res Hum Retroviruses. 1998 Sep 1;14(13):1163-80. Unique Identifier : AIDSLINE MED/98407606; Gattone VH 2nd; Tian C; Zhuge W; Sahni M; Narayan O; Stephens EB; Department of Anatomy and Cell Biology, University of Kansas; Medical Center, Kansas City 66160, USA.; We examined the renal pathology and viral genetic changes following inoculation of six rhesus macaques with lymphocyte-tropic SIVmac239. Portions of the renal cortex were sieved into glomerular and tubulointerstitial (TI) fractions and examined for SIVmac sequences by PCR and for p27 core antigen. SIVmac sequences wer
Phenotypic changes in peripheral blood monocytes of cynomolgus monkeys acutely infected with simian immunodeficiency virus.: Unique Identifier : AIDSLINE MED/98407607; Otani I; Akari H; Nam KH; Mori K; Suzuki E; Shibata H; Doi K; Terao K; Yosikawa Y; Tsukuba Primate Center, National Institute of Infectious; Diseases, Ibaraki, Japan.; The quantitative and phenotypic changes of peripheral blood monocytes during the acute stage of simian immunodeficiency virus infection were investigated. We inoculated intravenously three cynomolgus monkeys (Macaca fascicularis) with 100 TCID50 of SIVmac239 and collected whole blood twice a week until 35 days postino
Mechanisms of protection induced by attenuated simian immunodeficiency virus. II. Lymphocyte depletion does not abrogate protection.: AIDS Res Hum Retroviruses. 1998 Sep 1;14(13):1187-98. Unique Identifier : AIDSLINE MED/98407608; Stebbings R; Stott J; Almond N; Hull R; Lines J; Silvera P; Sangster R; Corcoran T; Rose J; Cobbold S; Gotch F; McMichael A; Walker B; Division of Immunobiology, National Institute for Biological; Standards and Control, South Mimms, Potters Bar, Herts, UK.; To determine the role that cellular immune responses play in the protection conferred by vaccination with attenuated SIVmac32H (pC8), we have attempted to deplete macaques of their CD8+ cells prior to challenge with wild-type SIVmac32H (pJ5). In two of four pC8-infected macaques, N109 and N112, a transient partial dep
Sequence analysis of the first HTLV-I infection in Germany without relations to endemic areas.: AIDS Res Hum Retroviruses. 1998 Sep 1;14(13):1199-203. Unique Identifier : AIDSLINE MED/98407609; Ellerbrok H; Fleischer C; Salemi M; Reinhardt P; Ludwig WD; Vandamme AM; Pauli G; Department of Virology, Robert Koch Institut, Berlin, Germany.; In most parts of Europe only a limited number of sporadic cases of HTLV-I infections have been identified. So far, the few cases found in Germany have always been linked to individuals with relations to endemic areas. Here we report the first HTLV-I infection from a German ATL pat
Molecular epidemiological analysis of human immunodeficiency virus type 1 in Newfoundland, Canada.: AIDS Res Hum Retroviruses. 1998 Sep 1;14(13):1205-9. Unique Identifier : AIDSLINE MED/98407610; Montpetit ML; Ratnam S; Campbell C; Gleeson T; Donovan C; Tollefson J; National Laboratory for HIV Genetics, Bureau of HIV/AIDS and; STDs, Laboratory Centre for Disease Control, Health Canada,; Ottawa, Ontario.
Long-term nonprogression in HIV infection: methodological issues and scientific priorities. Report of an international European community-National Institutes of Health Workshop, The Royal Society, London, England, November 27-29, 1995. Scientific Coordinating Committee.: AIDS Res Hum Retroviruses. 1998 Sep 20;14(14):1211-28. Unique Identifier : AIDSLINE MED/98435933; Easterbrook PJ; Schrager LK; HIV Epidemiology Unit, Imperial College School of Medicine,; Chelsea and Westminster Hospital, London, UK.
Association between a defective CCR-5 gene and progression to disease in HIV infection.: AIDS Res Hum Retroviruses. 1998 Sep 20;14(14):1229-34. Unique Identifier : AIDSLINE MED/98435934; Balfe P; Churcher Y; Penny M; Easterbrook PJ; Goodall RL; Galpin S; Gotch F; Daniels RS; McKeating JA; Department of Virology, UCLMS, London, UK. p.balfe@ucl.ac.uk; We measured the effect(s) of CCR-5 genotype on disease progression by studying the frequency of a defective CCR-5 delta32 allele within a cohort of long-term infected individuals. An elevated frequency of CCR-5 delta32 heterozygotes within the cohort compared with a control population of blood donors was observed. An
Primary intestinal epithelial cells can be infected with laboratory-adapted strain HIV type 1 NDK but not with clinical primary isolates.: AIDS Res Hum Retroviruses. 1998 Sep 20;14(14):1235-8. Unique Identifier : AIDSLINE MED/98435935; Chenine AL; Matouskova E; Sanchez G; Reischig J; Pavlikova L; LeContel C; Chermann JC; Hirsch I; INSERM U322, Unite de Recherches sur les Retrovirus et maladies; associees, Marseille, France.; Infectivities of HIV-1 primary isolates and laboratory-adapted strains were compared in primary fetal enterocytes and the colonic epithelial cell line HT29. Infection by two laboratory strains, HIV-1 NDK and HIV-1 NDK(A4), which were adapted on CEM and HT29 cells, respectively, produced significant amounts of virus in
Potent inhibition of HIV type 1 replication by an antiinflammatory alkaloid, cepharanthine, in chronically infected monocytic cells.: Unique Identifier : AIDSLINE MED/98435936; Okamoto M; Ono M; Baba M; Division of Human Retroviruses, Center for Chronic Viral; Diseases, Faculty of Medicine, Kagoshima University, Sakuragaoka,; Japan.; Cepharanthine is a biscoclaurine alkaloid isolated from Stephania cepharantha Hayata and has been shown to have antiinflammatory, antiallergic, and immunomodulatory activities in vivo. As several inflammatory cytokines and oxidative stresses are involved in the pathogenesis of HIV-1 infection, we investigated the inhi
Replication-defective HIV as a vaccine candidate.: AIDS Res Hum Retroviruses. 1998 Sep 20;14(14):1247-52. Unique Identifier : AIDSLINE MED/98435937; Tung FY; Rinaldo CR Jr; Montelaro RC; Department of Infectious Disease and Microbiology, University of; Pittsburgh, Pennsylvania 15261, USA.; Live attenuated vaccines prepared from simian immunodeficiency virus (SIV) have provided the best protective immunity in challenge experiments. In animals vaccinated with attenuated SIV, immune responses may be elicited owing to endogenous expression of native SIV proteins and/or antigen presentation in the native rep
Production and characterization of SIV envelope-specific rhesus monoclonal antibodies from a macaque asymptomatically infected with a live SIV vaccine.: AIDS Res Hum Retroviruses. 1998 Sep 20;14(14):1253-62. Unique Identifier : AIDSLINE MED/98435938; Robinson JE; Cole KS; Elliott DH; Lam H; Amedee AM; Means R; Desrosiers RC; Clements J; Montelaro RC; Murphey-Corb M; Department of Pediatrics, Tulane University Medical School, New; Orleans, Louisiana 70112, USA.; Five rhesus monoclonal antibodies (RhMAbs) were produced by rhesus EBV transformation of peripheral blood B cells from a rhesus macaque that had been asymptomatically infected with an attenuated, macrophage-tropic SIV strain, 17E-Cl. These MAbs recognized conformation-dependent epitopes on SIV gp120 and could not be m
HIV peptide conjugated to heat-killed bacteria promotes antiviral responses in immunodeficient mice.: AIDS Res Hum Retroviruses. 1998 Sep 20;14(14):1263-9. Unique Identifier : AIDSLINE MED/98435939; Scott DE; Golding H; Huang LY; Inman J; Golding B; Laboratory of Plasma Derivatives, Division of Hematology, Center; for Biologics Evaluation and Research, U.S. Food and Drug; Administration, Bethesda, Maryland 20892, USA.; Enhancement of immunity in the setting of HIV infection is difficult owing to loss of functional CD4+ T cells. The MHC class II-deficient mouse (II-/-) environment simulates that of the immunocompromised HIV-infected individual, since these mice have low CD4+ T cell numbers, defective CD4-dependent responses, and are
Functional and molecular characterization of human monoclonal antibody reactive with the immunodominant region of HIV type 1 glycoprotein 41.: AIDS Res Hum Retroviruses. 1998 Sep 20;14(14):1271-80. Unique Identifier : AIDSLINE GENBANK/AF059200; Cavacini LA; Emes CL; Wisnewski AV; Power J; Lewis G; Montefiori D; Posner MR; Department of Medicine, Beth Israel Deaconess Medical Center and; Harvard Medical School, Boston, Massachusetts 02215, USA.; lcavacin@bidmc.harvard.edu; The immunoreactivity, functional activity, and molecular features of a human monoclonal antibody (HMAb), F240, from an HIV-1-infected individual have been studied. Flow cytometric analysis demonstrated that F240 is reactive with cells infected with a broad range of laboratory isolates but not with uninfected cells. Re
Molecular characterization of the envelope transmembrane glycoprotein of 13 new human immunodeficiency virus type 1 group O strains from six different African countries.: AIDS Res Hum Retroviruses. 1998 Sep 20;14(14):1281-5. Unique Identifier : AIDSLINE GENBANK/Y09780; Bibollet-Ruche F; Peeters M; Mboup S; Ekaza E; Gandji R; Torimiro J; Mpoudi EN; Amblard J; Dibanga G; Saidou M; Esu-Williams E; Vanden Haesevelde M; Saman E; Delaporte E; Project SIDAK, Laboratoire Retrovirus, ORSTOM, Montpellier,; France.
A novel glycoprotein 120 sequence from an HIV type 1 isolate of the A clade identified in North Uganda.: AIDS Res Hum Retroviruses. 1998 Sep 20;14(14):1287-9. Unique Identifier : AIDSLINE GENBANK/AF062521; Buonaguro L; Buonaguro FM; Russo F; Tornesello ML; Beth-Giraldo E; Wagner R; Wolf H; Giraldo G; Division of Viral Oncology and AIDS Reference Center, Istituto; Nazionale Tumori Fond. G. Pascale, Naples, Italy.
HIV type 1 C2V3 env diversity among Belgian individuals.: AIDS Res Hum Retroviruses. 1998 Sep 20;14(14):1291-6. Unique Identifier : AIDSLINE +; Heyndrickx L; Janssens W; Coppens S; Vereecken K; Willems B; Fransen K; Colebunders R; Vandenbruaene M; van der Groen G; Department of Microbiology, Institute of Tropical Medicine,; Antwerp, Belgium.
The subtypes of HIV type 1 in Greece.: AIDS Res Hum Retroviruses. 1998 Sep 20;14(14):1297-8. Unique Identifier : AIDSLINE GENBANK/AJ224956; Papa A; Adwan G; Kouidou S; Clewley JP; Alexiou S; Malisiovas N; Ntoutsos I; Kiosses B; Antoniadis A; Department of Microbiology, School of Medicine, Aristotelian; University of Thessaloniki, Greece.
Extreme founder effect in an HIV type 1 subtype A epidemic among drug users in Svetlogorsk, Belarus.: AIDS Res Hum Retroviruses. 1998 Sep 20;14(14):1299-303. Unique Identifier : AIDSLINE +; Lukashov VV; Karamov EV; Eremin VF; Titov LP; Goudsmit J; Department of Human Retrovirology, Academic Medical Center,; University of Amsterdam, The Netherlands.
Treatment of HIV infection with cytoreductive agents.: AIDS Res Hum Retroviruses. 1998 Oct 10;14(15):1305-13. Unique Identifier : AIDSLINE MED/99002720; Smith C; Lilly S; Miralles GD; Department of Medicine, Duke University Medical Center, Durham,; North Carolina 27710, USA.; Advances in antiretroviral therapy have resulted in significant improvement in virological markers and clinical end points. However, studies have demonstrated that HIV can be recovered from patients in whom HIV RNA has been undetectable for prolonged periods of time, suggesting that the elimination half-life of latent
Phosphorylation of triciribine is necessary for activity against HIV type 1.: AIDS Res Hum Retroviruses. 1998 Oct 10;14(15):1315-22. Unique Identifier : AIDSLINE MED/99002721; Ptak RG; Borysko KZ; Porcari AR; Buthod JL; Holland LE; Shipman C Jr; Townsend LB; Drach JC; Department of Biologic and Materials Sciences, School of; Dentistry, University of Michigan, Ann Arbor 48109-1078, USA.; Triciribine (TCN) is a tricyclic nucleoside with known antineoplastic and antiviral activity. It is a potent and selective inhibitor of HIV-1 and HIV-2, including strains known to be resistant to AZT or TIBO. TCN is phosphorylated to its 5 -monophosph
Molecular cloning and expression of rhesus macaque and sooty mangabey interleukin 16: biologic activity and effect on simian immunodeficiency virus infection and/or replication.: AIDS Res Hum Retroviruses. 1998 Oct 10;14(15):1323-8. Unique Identifier : AIDSLINE MED/99002722; Lee ME; Adams JW; Villinger F; Brar SS; Meadows M; Bucur SZ; Lackey DA 3rd; Brice GT; Cruikshank WW; Ansari AA; Hillyer CD; Department of Pathology and Laboratory Medicine and the Winship; Cancer Center, Emory University School of Medicine, Atlanta,; Georgia 30329, USA.; Interleukin 16 (IL-16) has been shown to diminish HIV and SIV replication through inhibition of HIV and SIV mRNA transcription. To evaluate its role further, we compared IL-16 cloned from disease-susceptible rhesus macaques and disease-resistant sooty mangabeys. Recombinant rhesus macaque (rr) IL-16 was compared with
Impairment of excitatory amino acid transport in astroglial cells infected with the human immunodeficiency virus type 1.: AIDS Res Hum Retroviruses. 1998 Oct 10;14(15):1329-39. Unique Identifier : AIDSLINE MED/99002723; Kort JJ; Department of Medicine, Albany Medical College, New York 12208,; USA.; Perturbation of astrocyte functions by HIV-1 infection may contribute to the pathogenesis of AIDS dementia complex (ADC). The present study investigated the possibility that astroglial transport of glutamate and aspartate, the major excitatory amino acids (EAAs) in the mammalian ce
Lack of in vitro anti-gp160 antibody production is a correlate of nonprogression among HIV type 1-infected individuals.: AIDS Res Hum Retroviruses. 1998 Oct 10;14(15):1341-3. Unique Identifier : AIDSLINE MED/99002724; Rusconi S; Santambrogio S; Di Marco A; Colombo MC; Citterio P; Adorni F; Galli M; Istituto di Malattie Infettive e Tropicali, Universita di; Milano, Ospedale Luigi Sacco, Milan, Italy.; The aim of our study was to investigate the possible correlation of in vitro antibody production (IVAP) directed to the gp160 protein of HIV-1 with CD4+ slopes, plasma viremia, and disease progression in long-term nonprogressors (LTNPs). Nineteen subjects with a long-term nonprogressive HIV-1 infection were studied an
Mucosal antibody expression following rapid SIV(Mne) dissemination in intrarectally infected Macaca nemestrina.: AIDS Res Hum Retroviruses. 1998 Oct 10;14(15):1345-56. Unique Identifier : AIDSLINE MED/99002725; Kuller L; Thompson J; Watanabe R; Iskandriati D; Alpers CE; Morton WR; Agy MB; Washington Regional Primate Research Center, University of; Washington, Seattle 98195-7330, USA.; The early kinetics of antibody expression following transmucosal infection by SIV(Mne) were examined in several mucosal compartments in Macaca nemestrina. Five male-female pairs of macaques were inoculated intrarectally with SIV(Mne) E11S, a biological clone, and serially euthanized at 1, 2, 4, 8, and 12 weeks postino
Genital infection of female chimpanzees with human immunodeficiency virus type 1.: AIDS Res Hum Retroviruses. 1998 Oct 10;14(15):1357-67. Unique Identifier : AIDSLINE MED/99002726; Girard M; Mahoney J; Wei Q; van der Ryst E; Muchmore E; Barre-Sinoussi F; Fultz PN; Institut Pasteur, Paris, France.; To develop an animal model for mucosal HIV-1 infection, adult chimpanzees were inoculated without trauma by depositing the virus inoculum at the entrance to the cervical canal with a rigid catheter to which flexible tubing was attached. By this procedure, persistent infections were established in some chimpanzees with
Comparative analysis of humoral immune responses to HIV type 1 envelope glycoproteins in mice immunized with a DNA vaccine, recombinant Semliki Forest virus RNA, or recombinant Semliki Forest virus particles.: AIDS Res Hum Retroviruses. 1998 Oct 10;14(15):1369-77. Unique Identifier : AIDSLINE MED/99002727; Brand D; Lemiale F; Turbica I; Buzelay L; Brunet S; Barin F; Laboratoire de Virologie, EP CNRS 117, Universite Francois; Rabelais, Tours, France.; The Semliki Forest virus (SFV) system seems to be a useful new approach for generating effective immune responses against HIV-1 in animal models. We evaluated this system by comparing the humoral immune responses raised in mice immunized against the HIV-1 envelope with the SFV system, a DNA vaccine, and a recombinant
Genetic and serologic characterization of HIV type 1 prevailing in Myanmar (Burma).: AIDS Res Hum Retroviruses. 1998 Oct 10;14(15):1379-85. Unique Identifier : AIDSLINE MED/99002728; Kusagawa S; Sato H; Watanabe S; Nohtomi K; Kato K; Shino T; Thwe M; OO KY; Lwin S; Mra R; Kywe B; Yamazaki S; Takebe Y; Laboratory of Molecular Virology and Epidemiology, AIDS Research; Center, National Institute of Infectious Diseases, Tokyo, Japan.; To study the molecular epidemiology of HIV-1 spread in Myanmar and the interplay with the epidemic in surrounding Southeast Asian countries, we determined the HIV-1 subtypes prevailing in Myanmar. Thirty HIV-positive blood specimens were sampled in the capital city, Yangon, and an
Characterization of the V3 region of HIV type 1 isolates from Morocco.: AIDS Res Hum Retroviruses. 1998 Oct 10;14(15):1387-9. Unique Identifier : AIDSLINE GENBANK; Abid M; Luo CC; Sekkat S; De Latore N; Mansour H; Holloman-Candal D; Rayfield M; Benslimane A; Institute Pasteur du Maroc, Casablanca, Morocco.
Characterization of HIV type 1 gp120 V3 region sequences from Ugandan infants.: AIDS Res Hum Retroviruses. 1998 Oct 10;14(15):1391-5. Unique Identifier : AIDSLINE +; Mellquist JL; Bowman B; Kasturi L; Guay L; Kataaha P; Mmiro F; Ndugwa C; Jackson JB; Eshleman SH; Department of Pathology, Case Western Reserve University School; of Medicine, Cleveland, Ohio 44106, USA.
Clinical effects of human macrophage inflammatory protein-1 alpha MIP-1 alpha (LD78) administration to humans: a phase I study in cancer patients and normal healthy volunteers with the genetically engineered variant, BB-10010.: Eur J Cancer. 1998 Jun;34(7):1023-9. Unique Identifier : AIDSLINE MED/99066312; Marshall E; Howell AH; Powles R; Hunter MG; Edwards M; Wood LM; Czaplewski L; Puttick R; Warrington S; Boyce M; Testa N; Dexter TM; Lord BI; Millar A; CRC Department of Medical Oncology, Christie Hospital,; Manchester, U.K.; BB-10010 is a genetically engineered variant of human macrophage inflammatory protein-1 alpha (hMIP-1 alpha) with improved pharmaceutical formulation properties. Although initially described as a pro-inflammatory cytokine, it is now recognised that hMIP-1 alpha has additional effects on haemopoietic stem cell cycling
Bone and joint infections in children.: Curr Opin Rheumatol. 1998 Sep;10(5):494-7. Unique Identifier : AIDSLINE MED/98419004; Spencer CH; Department of Pediatrics, La Rabida Children's Hospital and; Research Center/University of Chicago, IL 60649, USA.; Recent reports of joint and bone infections in children have provided several new insights into prompt and accurate diagnosis of these potentially destructive processes. In the HIV era, some reports have focused specifically on musculoskeletal infections at unusual sites with unusual organisms. Other reports further d
The importance of simple/rapid assays in HIV testing.: Wkly Epidemiol Rec. 1998 Oct 16;73(42):321-6. Unique Identifier : AIDSLINE MED/99020009
The geographical distribution of Kaposi's sarcoma and of lymphomas in Africa before the AIDS epidemic.: Br J Cancer. 1998 Dec;78(11):1521-8. Unique Identifier : AIDSLINE MED/99052306; Cook-Mozaffari P; Newton R; Beral V; Burkitt DP; CRC Cancer Epidemiology Research Group, Department of Public; Health, Radcliffe Infirmary, University of Oxford, UK.; Estimated incidence rates are presented for three human immunodeficiency virus (HIV)-associated cancers [Kaposi s sarcoma (KS), Burkitt s lymphoma (BL) and other non-Hodgkin s lymphomas (NHLs)] from across the African continent, based on data collected before the HIV epidemic. Mapping of the rates and comparisons with
Can social cognitive models contribute to the effectiveness of HIV-preventive behavioural interventions? A brief review of the literature and a reply to Joffe (1996; 1997) and Fife-Schaw (1997).: Br J Med Psychol. 1998 Sep;71 ( Pt 3):297-310. Unique Identifier : AIDSLINE MED/98402260; Abraham C; Sheeran P; Orbell S; School of Social Sciences, University of Sussex, Falmer,; Brighton, UK.; A recent debate in the British Journal of Medical Psychology has considered the role of social cognitive models, such as the theory of reasoned action and the theory of planned behaviour, in understanding HIV-preventive behaviour. In this paper we clarify some of the assumptions involved in applications of social cogn
Quinolone photoallergy: photosensitivity dermatitis induced by systemic administration of photohaptenic drugs.: J Dermatol Sci. 1998 Sep;18(1):1-10. Unique Identifier : AIDSLINE MED/98418428; Tokura Y; Department of Dermatology, Hamamatsu University School of; Medicine, Japan. tokuray@hama-med.ac.jp; Quinolone antibacterial agents are well known to elicit photosensitivity as a side effect. The photoallergenicity of fluoroquinolones, the representative quinolone derivatives, is mainly derived from their photohaptenic moiety. When epidermal cells are irradiated with ultraviolet A light in the presence of fluoroquino
Search for human T-lymphotropic virus type I carriers among northeastern Chinese.: J Dermatol Sci. 1998 Sep;18(1):30-4. Unique Identifier : AIDSLINE MED/98418431; Geng L; Zai N; Xiao Y; Song F; Tanaka A; Lou H; Sonoda S; Kanzaki T; Department of Dermatology, Kagoshima University Faculty of; Medicine, Japan.; Human T-lymphotropic virus type I (HTLV-I) is thought to be the causative agent of adult T-cell leukemia/ lymphoma (ATL). This virus infection is endemic in southwestern Japan , parts of Africa and the Caribbean Islands. We examined sera of 1645 subjects of Liaoning province, northea
Bacterial translocation and T-lymphocyte populations in experimental short-bowel syndrome.: Eur J Pediatr Surg. 1998 Aug;8(4):247-50. Unique Identifier : AIDSLINE MED/98456480; Aldazabal P; Eizaguirre I; Barrena MJ; Garcia-Arenzana JM; Ariz C; Cuadrado E; Hospital Na Sa de Aranzazu, San Sebastian, Spain.; Bacterial translocation (BT) accounts in part for sepsis in short-bowel syndrome in which total parenteral nutrition (TPN) is routinely necessary. TPN per se facilitates BT and it has been suggested that decreased T-lymphocyte populations (TLP) in newborn rabbits and nude mice promote BT as well. We have tested the
Molecular cloning and sequencing of feline stromal cell-derived factor-1 alpha and beta.: Eur J Immunogenet. 1998 Aug;25(4):303-5. Unique Identifier : AIDSLINE MED/98450506; Nishimura Y; Miyazawa T; Ikeda Y; Izumiya Y; Nakamura K; Cai JS; Sato E; Kohmoto M; Mikami T; Department of Veterinary Microbiology, Graduate School of; Agricultural and Life Sciences, University of Tokyo, Japan.; The stromal cell-derived factor-1 alpha and beta (SDF-1 alpha/beta) are the ligands of fusin/CXCR4, the co-receptors of human immunodeficiency virus type 1 and the feline immunodeficiency virus. We cloned the cDNA of feline SDF-1 alpha/beta. The open reading frames of feline SDF-1 alpha/beta were 267/279 base pairs an
Phenotypic mechanism of HIV-1 resistance to 3'-azido-3'-deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase.: Biochemistry. 1998 Nov 10;37(45):15908-17. Unique Identifier : AIDSLINE MED/99060068; Arion D; Kaushik N; McCormick S; Borkow G; Parniak MA; Lady Davis Institute for Medical Research, McGill University AIDS; Centre, Sir Mortimer B. Davis-Jewish General Hospital, Montreal,; Quebec, Canada.; The multiple mutations associated with high-level AZT resistance (D67N, K70R, T215F, K219Q) arise in two separate subdomains of the viral reverse transcriptase (RT), suggesting that these mutations may contribute differently to overall resistance. We
Skills training for pregnancy and AIDS prevention in Anglo and Latino youth [see comments]: J Adolesc Health. 1998 Sep;23(3):139-49. Unique Identifier : AIDSLINE MED/98398124; Hovell M; Blumberg E; Sipan C; Hofstetter CR; Burkham S; Atkins C; Felice M; Graduate School of Public Health, San Diego State University,; California 92182, USA.; PURPOSE: This study tested social skills training (SST), didactic training (DT), and no training (NT) on adolescents social skills for resisting peer pressure to engage in acquired immunodeficiency syndrome (AIDS) and pregnancy risk behavior. METHODS: A total of 307 Latino and Anglo youth ages 13-18 years were assign
Condom use by Hispanic and African-American adolescent girls who use hormonal contraception.: J Adolesc Health. 1998 Oct;23(4):205-11. Unique Identifier : AIDSLINE MED/98434120; Roye CF; Hunter-Bellevue School of Nursing, New York, New York 10010, USA.; PURPOSE: The purpose of the present study was to examine condom use by teens who use hormonal contraceptives [i.e., Depo-Provera, Norplant, or oral contraceptives (OCs)]. METHODS: This is a cross-sectional study of 578 Hispanic and African-American female adolescents between the ages of 12 and 21 years who came to a r
Adolescent health care experience of gay, lesbian, and bisexual young adults.: J Adolesc Health. 1998 Oct;23(4):212-20. Unique Identifier : AIDSLINE MED/98434121; Allen LB; Glicken AD; Beach RK; Naylor KE; Department of Pediatrics, School of Medicine, University of; Colorado Health Sciences Center, Denver 80262, USA.; METHODS: Subjects were 102 self-identified gay, lesbian, and bisexual youth aged 18-23 years. A confidential self-administered survey elicited demographic information, sexual orientation information, health care experiences, subjects understanding of medical confidentiality during ages 14-18 years, and their suggesti
The sexual practices of Asian and Pacific Islander high school students.: J Adolesc Health. 1998 Oct;23(4):221-31. Unique Identifier : AIDSLINE MED/98434122; Schuster MA; Bell RM; Nakajima GA; Kanouse DE; RAND, Santa Monica, California 90407-2138, USA.; PURPOSE: To describe the sexual behaviors, beliefs, and attitudes of Asian and Pacific Islander California high school students and to compare them to other racial/ethnic groups. METHODS: Data were collected from an anonymous self-administered survey of 2026 ninth to 12th graders in a Los Angeles County school distric
Polymorphisms in the human CC chemokine receptor-3 gene.: Biochim Biophys Acta. 1998 Nov 8;1442(2-3):170-6. Unique Identifier : AIDSLINE MED/99023738; Zimmermann N; Bernstein JA; Rothenberg ME; Division of Pulmonary Medicine, Allergy and Clinical Immunology,; Department of Pediatrics, Children's Hospital Medical Center,; 3333 Burnet Avenue, Cincinnati, OH 45229, USA.; CC chemokine receptor (CCR)-3 is a seven-transmembrane-spanning G-protein-coupled receptor (GPCR) that is involved in the recruitment of inflammatory cells in allergic responses and acts as a co-receptor for entry of HIV into cells. Selected polymorphisms in GPCRs have been shown to have dramatic effects on the manife
Feasibility of named antenatal HIV screening in an inner city population.: Unique Identifier : AIDSLINE MED/99046410; Dennison B; Kennedy J; Tilling K; Wolfe CD; Chrystie IL; Banatvala JE; The object of this study was to assess the resource use, feasibility, uptake and consumers perspective of introducing routine named human immunodeficiency virus (HIV) testing into an inner city hospital antenatal clinic (St Thomas Hospital, part of Guy s and St Thomas Hospital Trust). Following the introduction of a
Changing HIV infection rates and risk in an African-American community cohort.: AIDS Care. 1998 Jun;10(3):267-81. Unique Identifier : AIDSLINE MED/99046411; Brunswick AF; Flory MJ; Columbia University, New York, NY 10032, USA.; This longitudinal study of a homogeneously urban African-American community cohort drawn from the metropolitan New York area (USA) analyzed three-year change in HIV-1 antibody prevalence and self-reported risk practices separately for men and women. Specifically, risk practices reported on personal interviews and resu
Is acculturation associated with sexual risk behaviours? An investigation of HIV-positive Latino men and women.: AIDS Care. 1998 Jun;10(3):283-95. Unique Identifier : AIDSLINE MED/99046412; Marks G; Cantero PJ; Simoni JM; Department of Preventive Medicine, University of Southern; California, USA.; This cross-sectional study of 226 HIV-positive Latino men and women sampled and assessed at an outpatient HIV clinic in Los Angeles examined the associations among acculturation, use of a substance before sex, and unsafe sexual behaviour. As acculturation increased, men and women were increasingly likely to have engag
Medication adherence strategies for drug abusers with HIV/AIDS.: AIDS Care. 1998 Jun;10(3):297-312. Unique Identifier : AIDSLINE MED/99046413; Sorensen JL; Mascovich A; Wall TL; DePhilippis D; Batki SL; Chesney M; San Francisco General Hospital, USA. james@itsa.ucsf.edu; This paper describes two clinical techniques aiming to improve adherence to medications for HIV/AIDS in methadone maintenance patients. The first technique, providing on-site dispensing of antiretroviral medications, enhanced medication adherence but did not produce enduring effects beyond the time of the intervention
A qualitative investigation into an HIV outbreak among injection drug users in Vancouver, British Columbia.: AIDS Care. 1998 Jun;10(3):313-21. Unique Identifier : AIDSLINE MED/99046414; Harvey E; Strathdee SA; Patrick DM; Ofner M; Archibald CP; Eades G; O'Shaughnessy MV; St. Paul's Hospital, Vancouver, Canada.; The proportion of injection drug users (IDUs) testing positive for Human Immunodeficiency Virus (HIV) in British Columbia has increased from 3 to 7% since January 1993 (Patrick et al., 1997). We conducted a qualitative study as a first step in a case control investigation aimed at identifying risk factors associated w
Whose health is it? The views of injecting drug users with HIV infection and their professional carers.: AIDS Care. 1998 Jun;10(3):323-8. Unique Identifier : AIDSLINE MED/99046415; Carretero MD; Chiswick A; Catalan J; Neurosciences and Psychological Medicine Division, Imperial; College School of Medicine, Psychological Medicine Unit, Chelsea; and Westminster Hospital, London, UK.; The views about autonomy in medical treatment of people with HIV infection (who had acquired it via the injection of drugs) and their professional carers were investigated using a standardized self-report instrument. Forty-two patients and 61 staff were entered in the study. Patients and staff reported strong endorsem
Factors associated with changes in sex behaviour among drug users in Puerto Rico.: AIDS Care. 1998 Jun;10(3):329-38. Unique Identifier : AIDSLINE MED/99046416; Robles RR; Marrero CA; Matos TD; Colon HM; Finlinson HA; Reyes JC; Sahai H; Research Institute, Mental Health and Anti-Addiction Services; Administration, San Juan, Puerto Rico.; Despite available strategies to prevent sex risk behaviours in Puerto Rico , heterosexual transmission of HIV continues to increase. Since 1990, heterosexual contact has been the fastest growing infection risk category among the island s general population, and the primary transe
Close relationships and safer sex among HIV-infected men with haemophilia.: AIDS Care. 1998 Jun;10(3):339-54. Unique Identifier : AIDSLINE MED/99046417; Norman LR; Kennedy M; Parish K; Division of HIV/AIDS Prevention, Centers for Disease Control and; Prevention, Atlanta, GA 30333, USA.; The present study sought to inform future behavioural intervention efforts by obtaining information from HIV-positive heterosexual men with haemophilia about their attitudes towards close relationships, attitudes towards risk reduction practices, and actual risk reduction practices. HIV-infected males with haemophiliae
Subjective HIV attribution theories, coping and psychological functioning among homosexual men with HIV.: AIDS Care. 1998 Jun;10(3):355-63. Unique Identifier : AIDSLINE MED/99046418; Clement U; Schonnesson LN; Heidelberg Institute of Systemic Research, Germany.; cw8@popix.ur2.uni-heidelberg.de; Facing a traumatic event, such as being diagnosed with HIV, the individual tries to find an explanation why the traumatic event happened. One way to answer that question is through attributions. The purpose of this study was to examine subjective attribution theories for HIV (internal/self-blame, external/blaming othee
Barriers to care among persons living with HIV/AIDS in urban and rural areas.: AIDS Care. 1998 Jun;10(3):365-75. Unique Identifier : AIDSLINE MED/99046419; Heckman TG; Somlai AM; Peters J; Walker J; Otto-Salaj L; Galdabini CA; Kelly JA; Department of Psychiatry and Behavioral Medicine, Medical College; of Wisconsin, Milwaukee 53226, USA.; People living with HIV disease, particularly those in small towns and rural areas, face many barriers that prevent them from receiving important life-care services. We developed the Barriers to Care Scale (BACS) to delineate the problem severity of factors that impede care and service provision among a sample of 226 me
Knowledge and attitudes about AIDS among deaf and hard of hearing persons.: AIDS Care. 1998 Jun;10(3):377-86. Unique Identifier : AIDSLINE MED/99046420; Woodroffe T; Gorenflo DW; Meador HE; Zazove P; University of Cincinnati, Ohio.; We investigated whether the public information being dispensed about Acquired Immunodeficiency Syndrome (AIDS) reaches Deaf and Hard of Hearing (D&HH) persons to the same extent as the rest of the American population. Using a self-administered written survey, modified so that D&HH persons whose primary language
Injection drug users as social actors: a stigmatized community's participation in the syringe exchange programmes of New York City.: AIDS Care. 1998 Aug;10(4):397-408. Unique Identifier : AIDSLINE MED/99046400; Henman AR; Paone D; Des Jarlais DC; Kochems LM; Friedman SR; Chemical Dependency Institute, New York, NY 10003, USA.; In 1992, New York State Department of Health regulations provided for fully legal syringe exchange programmes in the state. The policies and procedures mandated that: Each program must seek to recruit ... for inclusion on its advisory board ... program participants ... Programs are also urged to establish other advis
The validation of statements by IDUs based on the analysis of blood traces on their used syringes.: AIDS Care. 1998 Aug;10(4):409-14. Unique Identifier : AIDSLINE MED/99046401; Menoyo C; Lamikiz E; Zulaika D; Urcelai A; Zubia I; Martinez De Pancorbo M; Basque Country AIDS Prevention and Control Plan, Department of; Health of the Basque Government, San Sebastian, Spain.; The objective of this study was to study the correlation between statements made by injecting drug users (IDUs) and the analytical observation of their used syringes, with regard to needle and syringe non-sharing and HIV serology. A survey was carried out on 137 IDUs participating in different needle exchange programm
Partner notification with HIV-infected drug users: results of formative research.: AIDS Care. 1998 Aug;10(4):415-29. Unique Identifier : AIDSLINE MED/99046402; Rogers SJ; Tross S; Doino-Ingersol J; Weisfuse I; Academy for Educational Development (AED), Washington DC 20037,; USA.; The authors conducted formative research on the use of partner notification with HIV-infected drug users (i.e. those who use/abuse injectable drugs, crack or cocaine) in order to guide the development of an effective intervention for this population in New York City. Structured focus group and personal interviews were
Acceptability of voluntary HIV testing with counselling in a rural village in Kagera, Tanzania.: AIDS Care. 1998 Aug;10(4):431-9. Unique Identifier : AIDSLINE MED/99046403; Killewo JZ; Kwesigabo G; Comoro C; Lugalla J; Mhalu FS; Biberfeld G; Wall S; Sandstrom A; Muhimbili University College of Health Sciences, Dar es Salaam,; Tanzania. jkillewo@muchs.ac.tz; A pilot study on acceptability of voluntary HIV testing with counselling was performed in a rural village in Kagera, Tanzania as a potential intervention against HIV transmission. Village residents were prepared by their leaders and subsequently invited to health education group
Occupational risk of HIV infection among western health care professionals posted in AIDS endemic areas.: AIDS Care. 1998 Aug;10(4):441-52. Unique Identifier : AIDSLINE MED/99046404; de Graaf R; Houweling H; van Zessen G; Netherlands Institute of Mental Health and Addiction, Utrecht,; The Netherlands.; In this study on occupational risks of HIV infection among 99 Dutch medics working in AIDS endemic areas, 61% reported percutaneous exposures during an average stay of 21 months. The mean number of injuries was lower among physicians (2.0 versus 3.9 per year) and higher among nurses (1.9 versus 1.2) than in previous r
Health service utilization in London's African migrant communities: implications for HIV prevention.: AIDS Care. 1998 Aug;10(4):453-62. Unique Identifier : AIDSLINE MED/99046405; McMunn AM; Mwanje R; Paine K; Pozniak AL; Academic Department of Genitourinary Medicine, King's College; School of Medicine & Dentistry, London, UK.; The objective of this study was to examine health service utilization in relation to HIV/AIDS prevention in Ugandan migrants living in southeast London. A cross-sectional survey was carried out, with face-to-face interviews using a semi-structured questionnaire about knowledge and use of health services, receipt of he
Sexual HIV risk behaviour among men who have sex with both men and women.: AIDS Care. 1998 Aug;10(4):463-71. Unique Identifier : AIDSLINE MED/99046406; Weatherburn P; Hickson F; Reid DS; Davies PM; Crosier A; University of Portsmouth, London, UK.; The aim of this study was to describe the sexual behaviour of men who had sex with both men and women in the preceding five years (behaviourally bisexual men), specifically to examine their needs in relation to HIV prevention. Anonymous telephone interviews were carried out with respondents recruited though advertisem
HIV infection among foreign people involved in HIV-related risk activities and attending an HIV reference centre in Rome: the possible role of counselling in reducing risk behaviour.: AIDS Care. 1998 Aug;10(4):473-80. Unique Identifier : AIDSLINE MED/99046407; Spizzichino L; Casella P; Zaccarelli M; Rezza G; Venezia S; Gattari P; Drug Treatment Centre RM/E, Santo Spirito Hospital, Rome, Italy.; Between September 1993 and December 1995, 528 foreign individuals at risk of HIV infection attended the drug treatment centre located in the Santo Spirito Hospital in Rome, undergoing medical examination, HIV testing and counselling. The geographic distribution showed that the majority of the participants were from So
The integration of informal care, case management and community-based services for persons with HIV/AIDS.: AIDS Care. 1998 Aug;10(4):481-503. Unique Identifier : AIDSLINE MED/99046408; London AS; LeBlanc AJ; Aneshensel CS; Department of Sociology, Kent State University, Ohio 44242-0001,; USA. alondon@kent.edu; This research examines the integration of informal and formal care for persons with HIV/AIDS. Data come from a panel survey of informal HIV/AIDS caregivers (N = 642) and are analyzed using a modified version of the Behavioral Model that allows for inclusion of predisposing, enabling and need characteristics of persons
Transgender HIV prevention: a qualitative needs assessment.: AIDS Care. 1998 Aug;10(4):505-25. Unique Identifier : AIDSLINE MED/99046409; Bockting WO; Robinson BE; Rosser BR; Department of Family Practice and Community Health, Medical; School, University of Minnesota, USA. bockt001@gold.tc.umn.edu; Although clinical experience and preliminary research suggest that some transgender people are at significant risk for HIV, this stigmatized group has so far been largely ignored in HIV prevention. As part of the development of HIV prevention education targeting the transgender population, focus groups of selected tra
Managing HIV among serodiscordant heterosexual couples: serostatus, stigma and sex.: AIDS Care. 1998 Oct;10(5):533-48. Unique Identifier : AIDSLINE MED/99046391; van der Straten A; Vernon KA; Knight KR; Gomez CA; Padian NS; Center for AIDS Prevention Studies, University of California San; Francisco 94105, USA. avdstraten@psg.ucsf.edu; A qualitative study was conducted with 28 men and women in HIV-serodiscordant couples to explore the management of HIV in their relationship. Content analysis of the interviews revealed the role of serostatus and stigma in shaping partners experience of HIV, sex and risk. Partners differing serostatus often created
Factors associated with HIV-infected women's delay in seeking medical care.: AIDS Care. 1998 Oct;10(5):549-62. Unique Identifier : AIDSLINE MED/99046392; Raveis VH; Siegel K; Gorey E; Columbia University, School of Public Health, Division of; Sociomedical Sciences, New York, NY 10032, USA. vhr1@columbia.edu; Data from an investigation of HIV-infected African-American, Puerto Rican and non-Hispanic white women s treatment behaviour and decision-making are presented. Findings are based on a thematic analysis of the narrative accounts of 31 women who exhibited significant delay in seeing a physician about their HIV infection
HIV testing for HIV prevention: a comparative analysis of policies in Britain, Hungary and Sweden.: AIDS Care. 1998 Oct;10(5):563-70. Unique Identifier : AIDSLINE MED/99046393; Danziger R; Health Services Research Unit, London School of Hygiene and; Tropical Medicine, UK. r.danziger@lshtm.ac.uk; This paper compares policies on named HIV testing in the context of HIV prevention in Britain, Hungary and Sweden , and considers the extent to which these policies are based on evidence of effect
Sexual and reproductive health among primary and secondary school pupils in Mwanza, Tanzania: need for intervention.: AIDS Care. 1998 Oct;10(5):571-82. Unique Identifier : AIDSLINE MED/99046394; Matasha E; Ntembelea T; Mayaud P; Saidi W; Todd J; Mujaya B; Tendo-Wambua L; African Medical & Research Foundation (AMREF), Mwanza, Tanzania.; A cross-sectional questionnaire survey was conducted among 892 randomly selected pupils, aged 12 and above, attending 18 primary schools (PS) and five secondary schools (SS) in four communities of Mwanza Region in Tanzania . The goals were to assess the level of knowledge adolesce
AIDS-related illness trajectories in Mexico: findings from a qualitative study in two marginalized communities.: AIDS Care. 1998 Oct;10(5):583-98. Unique Identifier : AIDSLINE MED/99046395; Castro R; Orozco E; Eroza E; Manca MC; Hernandez JJ; Aggleton P; Centro Regional de Investigaciones Multidisciplinarias/UNAM,; Cuernavaca, Mexico. rcastro@servidor.unam.mx; This paper describes findings from a recent study examining how people affected directly and indirectly by the HIV/AIDS epidemic cope with HIV-related illness in Mexico. One-hundred-and-thirteen in-depth interviews were conducted with key informants in two contrasting communities: Ciudad Netzahualcoyotl (an economical
HIV serostatus disclosure among gay and bisexual men in four American cities: general patterns and relation to sexual practices.: AIDS Care. 1998 Oct;10(5):599-610. Unique Identifier : AIDSLINE MED/99046396; Wolitski RJ; Rietmeijer CA; Goldbaum GM; Wilson RM; Behavioral Intervention Research Branch, Centers for Disease; Control and Prevention, Atlanta, GA 30333, USA. rywl@cdc.gov; The present study examined patterns of serostatus disclosure among previously untested HIV-seropositive and HIV-seronegative gay and bisexual men recruited from four American cities (n = 701). Six months after learning their HIV serostatus, 97% of study participants had disclosed their test results to at least one oth
Reducing financial barriers to HIV-related medical care: does the Ryan White CARE Act make a difference?: AIDS Care. 1998 Oct;10(5):611-6. Unique Identifier : AIDSLINE MED/99046397; Marx R; Chang SW; Park MS; Katz MH; San Francisco Department of Public Health AIDS Office, California; 94102-6033, USA. rani_marx@dph.sf.ca.us; We evaluated whether the Ryan White CARE Act, which funds medical care and supportive services for low-income HIV-infected persons, equalizes health service use in San Francisco. Clients at nine CARE (n = 300) and four non-CARE (n = 172) funded sites completed self-administered questionnaires. There were no significan
Is access to medical care associated with receipt of HIV testing and counselling?: AIDS Care. 1998 Oct;10(5):617-28. Unique Identifier : AIDSLINE MED/99046398; Mosen DM; Wenger NS; Shapiro MF; Andersen RM; Cunningham WE; Department of Medicine, School of Medicine, University of; California, Los Angeles 90095, USA.; Lack of timely HIV testing leads to missed prevention opportunities and poor prevention counselling may be related to further disease spread. We examined the association of self-reported access to medical care with receiving HIV testing and preventive counselling services among a sample of patients with HIV disease pr
Impact of diarrhoea and faecal incontinence on the daily life of HIV-infected patients.: AIDS Care. 1998 Oct;10(5):629-37. Unique Identifier : AIDSLINE MED/99046399; Snijders F; de Boer JB; Steenbergen B; Schouten M; Danner SA; van Dam FS; Division of Infectious Diseases, Tropical Medicine and AIDS,; Academic Medical Center, University of Amsterdam, The; Netherlands.; Diarrhoea in HIV-1 infected persons is an important clinical problem. To improve care and counselling, information about the way, and the extent to which, diarrhoea influences the daily life of these patients can be useful. A cross-sectional descriptive study was performed at the HIV infection clinic of three major ho
Cancer in AIDS.: Curr Opin Oncol. 1998 Sep;10(5):B160-3. Unique Identifier : AIDSLINE MED/99016505
AIDS-related malignancies [editorial]: Curr Opin Oncol. 1998 Sep;10(5):403-4. Unique Identifier : AIDSLINE MED/99016491; Scadden DT
Kaposi's sarcoma herpesvirus as a new paradigm for virus-induced oncogenesis.: Curr Opin Oncol. 1998 Sep;10(5):405-12. Unique Identifier : AIDSLINE MED/99016492; Whitby D; Boshoff C; Chester Beatty Laboratories, Institute of Cancer Research,; London, UK.; Seroepidemiologic studies show that Kaposi s sarcoma herpesvirus (KSHV) is more prevalent in those populations at higher risk to develop Kaposi s sarcoma (KS). Anti-KSHV antibody titer is also higher in those who develop KS. KSHV is a sexually transmitted disease among homosexual men, but other routes of transmission
Emerging treatments for epidemic (AIDS-related) Kaposi's sarcoma.: Curr Opin Oncol. 1998 Sep;10(5):413-21. Unique Identifier : AIDSLINE MED/99016493; McGarvey ME; Tulpule A; Cai J; Zheng T; Masood R; Espina B; Arora N; Smith DL; Gill PS; University of Southern California, Los Angeles Department of; Medicine and Pathology, Norris Cancer Hospital and Research; Institute 90033, USA.; Kaposi s sarcoma (KS) is an opportunistic tumor that develops with increased frequency (100,000-fold) after HIV infection. KS causes significant morbidity from mucocutaneous involvement and mortality from complications of visceral sites of disease such as the lungs, gastrointestinal tract, and the liver. Progressive u
Advances and future challenges in non-Hodgkin's lymphoma.: Curr Opin Oncol. 1998 Sep;10(5):422-7. Unique Identifier : AIDSLINE MED/99016494; Klencke B; Kaplan L; University of California, San Francisco, Mount Zion Cancer; Center, San Francisco 94115, USA.; The mortality and morbidity burden of Non-Hodgkin s lymphoma (NHL) is increasing within the human immunodeficiency virus- (HIV-) infected population. Recent improvements in HIV management has meant overall reductions in deaths, especially those due to opportunistic infections, and while the outcome of HIV-related NHL
Anti-HIV type 1 activity of wild-type and functional defective RANTES intrakine in primary human lymphocytes.: Hum Gene Ther. 1998 Sep 20;9(14):2005-18. Unique Identifier : AIDSLINE MED/98430728; Yang AG; Zhang X; Torti F; Chen SY; Department of Cancer Biology, Comprehensive Cancer Center, Wake; Forest University School of Medicine, Winston-Salem, NC 27157,; USA.; We have developed a genetic intrakine strategy to inactivate the CC-chemokine receptor 5 (CCR-5), the principal coreceptor for macrophage (M)-tropic HIV-1 viruses (Yang et al, 1997). The inactivation of CCR5 was achieved by targeting a modified CC-chemokine (RANTES) to the lumen of the endoplasmic reticulum (ER) to
Synthetic neoglycolipids for biological applications: correlation between their structures and their interactions with membrane proteins.: Biochimie. 1998 May-Jun;80(5-6):483-7. Unique Identifier : AIDSLINE MED/98455708; Rico-Lattes I; Gouzy MF; Andre-Barres C; Guidetti B; Lattes A; Laboratoire des IMRCP, UMR-CNRS 5623, Universite Paul-Sabatier,; Toulouse, France.; Synthetic glycolipids are of interest for their biological applications requiring interactions with membrane proteins. Depending on their structures, new series of glycolipids have applications in extraction of membrane proteins or medical applications as mimics of natural ligands of proteins.
Type-specific serological testing for herpes simplex infection.: Int J STD AIDS. 1998 Sep;9(9):497-500. Unique Identifier : AIDSLINE MED/98435961; Kinghorn GR; Department of Genitourinary Medicine, Royal Hallamshire Hospital,; Sheffield, UK.
Sexually transmitted organisms in children and child sexual abuse.: Int J STD AIDS. 1998 Sep;9(9):501-10; quiz 510-1. Unique Identifier : AIDSLINE MED/98435962; Robinson AJ; Department of Genitourinary Medicine, Mortimer Market Centre,; London, UK.
Financing HIV service provision in England: estimated impact of the cost of antiretroviral combination therapy.: Int J STD AIDS. 1998 Sep;9(9):512-7. Unique Identifier : AIDSLINE MED/98435963; Beck EJ; Tolley K; Department of Epidemiology and Public Health, Imperial College; School of Medicine at St Mary's, London, UK.; The objective of this study was to provide population-based estimates on the cost of HIV service provision in England and the use of dual or triple antiretroviral combination therapy . Contemporary cost estimates of treating HIV-infected individuals by clinical stage of
Bronchopulmonary Kaposi's sarcoma in 106 HIV-1 infected patients.: Int J STD AIDS. 1998 Sep;9(9):518-25. Unique Identifier : AIDSLINE MED/98435964; Hannon FB; Easterbrook PJ; Padley S; Boag F; Goodall R; Phillips RH; Department of Radiotherapy and Oncology, Chelsea and Westminster; Hospital, London, UK.; The objectives of this study were to describe the clinical and radiological features at presentation, and the natural history of HIV-related bronchopulmonary Kaposi s sarcoma. A retrospective review of medical records and chest radiographs was performed in 106 HIV-infected homosexual men with bronchopulmonary Kaposi s
Vulvovaginal candidiasis in female sex workers.: Int J STD AIDS. 1998 Sep;9(9):526-30. Unique Identifier : AIDSLINE MED/98435965; Otero L; Palacio V; Carreno F; Mendez FJ; Vazquez F; Service of Microbiology, Hospital of Cabuenes, Gijon, Spain.; Vulvovaginal candidiasis is a frequent inflammatory process in women but it has not been widely studied in female sex workers (FSWs). To estimate the frequency of Candida species infection in FSWs and to identify related risk factors and clinical findings, we carried out a retrospective study of 1923 FSWs over 11 year
Clinical and in situ cellular responses to Haemophilus ducreyi in the presence or absence of HIV infection.: Int J STD AIDS. 1998 Sep;9(9):531-6. Unique Identifier : AIDSLINE MED/98435966; King R; Choudhri SH; Nasio J; Gough J; Nagelkerke NJ; Plummer FA; Ndinya-Achola JO; Ronald AR; Department of Medical Microbiology, University of Nairobi, Kenya,; Africa.; We aimed to determine if the clinical and histological features of chancroid are altered by HIV infection. Male patients presenting to the Nairobi special treatment clinic with a clinical diagnosis of chancroid were eligible for the study. A detailed history, physical examination, swabs for Haemophilus ducreyi culture
Efficacy of surgical and/or podophyllotoxin treatment against flat acetowhite penile human papillomavirus associated lesions.: Int J STD AIDS. 1998 Sep;9(9):537-42. Unique Identifier : AIDSLINE MED/98435967; Wikstrom A; von Krogh G; Department of Dermatovenereology, Karolinska Hospital, Stockholm,; Sweden.; In order to investigate the efficacy of treatment modalities favoured by us against flat acetowhite penile human papillomavirus (HPV)-induced lesions, we studied retrospectively standardized medical records of 81 men who had been treated for this condition. The patients were treated surgically with diathermy (n=32) or
Emergency unit care of sexually transmitted infections.: Int J STD AIDS. 1998 Sep;9(9):543-4. Unique Identifier : AIDSLINE MED/98435968; Jarvis RR; Jebakumar S; Bhattacharyya MN; Mackway-Jones K; Department of Genitourinary Medicine, Manchester Royal Infirmary,; UK. rani.jarvis@btinternet.com; The aim of the study was to assess provisions for management of sexually transmitted infections (STIs), emergency contraception and pregnancy test in UK emergency departments. Postal questionnaires were sent to all consultant-led emergency departments in the UK in January 1996. The response rate was 64%. Most departme
Cytomegalovirus pp65 antigenaemia as an indicator of end-organ disease in AIDS.: Int J STD AIDS. 1998 Sep;9(9):545-7. Unique Identifier : AIDSLINE MED/98435969; Fox EF; Smith NA; Rice P; Dunn H; Peters BS; Department of Genitourinary Medicine, Guy's and St Thomas'; Hospital, London, UK.; We aim to assess the usefulness of the cytomegalovirus ( CMV ) pp65 antigenaemia test, also called the CMV direct antigen test (DAT), in the management of patients with advanced human immunodeficiency virus (HIV) infection; we
HIV infection and asymptomatic sexually transmitted infections in a rural South African community.: Int J STD AIDS. 1998 Sep;9(9):548-50. Unique Identifier : AIDSLINE MED/98435970; Colvin M; Abdool Karim SS; Connolly C; Hoosen AA; Ntuli N; Centre for Epidemiological Research in South Africa, Medical; Research Council, Congella.; The objective was to determine the prevalence of HIV and other sexually transmitted infections (STIs) in a rural community. A population-based survey of adults in 110 homesteads was conducted in 1995. A questionnaire on demographics, sexual practices and history of STDs was administered. Neisseria gonorrhoeae and Chla
The availability and cost of antibiotics for treating PID in the Central Region of Ghana and implications for compliance with national treatment guidelines.: Int J STD AIDS. 1998 Sep;9(9):551-3. Unique Identifier : AIDSLINE MED/98435971; Bosu WK; Mabey D; Department of Infectious and Tropical Diseases, London School of; Hygiene and Tropical Medicine. wbosu@gha.healthnet.org; The availability and cost of antibiotics for treating pelvic inflammatory disease (PID) were assessed in 17 drug-dispensing outlets in 5 districts of the Central Region, Ghana . The outlets included the dispensaries of 2 regional and 4 district hospitals, 4 privately-owned pharmacies
Renal calculi developing de novo in a patient taking saquinavir [letter]: Int J STD AIDS. 1998 Sep;9(9):555. Unique Identifier : AIDSLINE MED/98435972; Green ST; McKendrick MW; Schmid ML; Mohsen AH; Prakasam SF
Redefining AIDS: case exemplified by Penicillium marneffei infection in HIV-infected people in Hong Kong [letter]: Int J STD AIDS. 1998 Sep;9(9):555-6. Unique Identifier : AIDSLINE MED/98435973; Wong KH; Lee SS; Chan KC; Choi T
Cervical smear: is screening of teenagers justified? [letter]: Int J STD AIDS. 1998 Sep;9(9):556-7. Unique Identifier : AIDSLINE MED/98435974; O'Mahony C
Study Site Coordinator/Research Nurse [letter]: Int J STD AIDS. 1998 Sep;9(9):557-8. Unique Identifier : AIDSLINE MED/98435975; McKernan S
[Ultrastructural aspects of lesions caused by Mycobacterium spp in AIDS]: Invest Clin. 1998 Sep;39(3):189-98. Unique Identifier : AIDSLINE MED/98453838; Parada D; Caleiras E; Estrada S; Tovar R; Garcia-Tamayo J; Unidad de Investigacion en Patologia Ultraestructural y; Biologia Molecular, Facultad de Medicina, Universidad Central de; Venezuela, Caracas.; Samples from necrotizing lesions in eight autopsy cases of AIDS were examined with transmission electron microscopy. They were selected among 35 autopsies of Mycobacterium spp infection and AIDS, and were part of a series of 230 autopsy cases of AIDS performed from 1984 to 1995 in the Anatomopathologic Institute at Ce
Influence of cell surface glycoprotein gC produced by pseudorabies virus on cytopathic effect.: J Vet Med Sci. 1998 Aug;60(8):905-9. Unique Identifier : AIDSLINE MED/98436893; Katayama S; Okada N; Ohgitani T; Kokubu T; Shimizu Y; Division of Veterinary Microbiology, Kyoto Biken Laboratories,; Japan.; The wild-type pseudorabies virus (WT-PRV) produced a round-type cytopathic effect (CPE) in PK-15 cell line of porcine kidney origin, while PRVgCs lacking in gC-transmembrane-anchor region and PRVgC-defecting in gC gene produced a syncytium-type CPE. The mouse embryo cell line (BALB/3T3 clone A31) were transfected with
Seroprevalence of Bartonella henselae and Toxoplasma gondii infections among pet cats in Kanagawa and Saitama Prefectures.: J Vet Med Sci. 1998 Sep;60(9):997-1000. Unique Identifier : AIDSLINE MED/99011991; Maruyama S; Hiraga S; Yokoyama E; Naoi M; Tsuruoka Y; Ogura Y; Tamura K; Namba S; Kameyama Y; Nakamura S; Katsube Y; Department of Veterinary Medicine, College of Bioresource; Sciences, Nihon University, Kanagawa, Japan.; Seroprevalence of Bartonella henselae and Toxoplasma gondii was investigated among 471 pet cats obtained from seven private animal hospitals in Kanagawa and Saitama Prefectures during the period from May 1994 to June 1995. Furthermore, 67 randomly selected from the 471 serum samples were examined for the feline immun
A combinatorial phage display library for the generation of specific Fab fragments recognizing human spermatozoa and inhibiting fertilizing capacity in vitro.: Biol Reprod. 1998 Nov;59(5):1180-6. Unique Identifier : AIDSLINE MED/98455447; Clayton R; Cooke ID; Partridge LJ; Moore HD; Department of Molecular Biology and Biotechnology, University of; Sheffield, Sheffield, United Kingdom.; To select a source of lymphocytes for the generation of an anti-sperm-biased combinatorial phage display library, venous blood was obtained from 34 vasovasostomy (vasectomy reversal) patients approximately 3 mo after surgery. Using a variety of immunoassays, serum was analyzed for antibodies against human spermatozoa,
Primary cutaneous aspergillosis--an emerging infection among immunocompromised patients [editorial; comment]: Clin Infect Dis. 1998 Sep;27(3):453-7. Unique Identifier : AIDSLINE MED/98442275; Walsh TJ
Entamoeba gingivalis in human immunodeficiency virus type 1-infected patients with periodontal disease.: Clin Infect Dis. 1998 Sep;27(3):471-3. Unique Identifier : AIDSLINE MED/98442278; Lucht E; Eveng~ard B; Skott J; Pehrson P; Nord CE; Department of Immunology, Microbiology, Pathology, and Infectious; Diseases, Karolinska Institute, Huddinge University Hospital,; Stockholm, Sweden.; Necrotic periodontal disease is a progressive painful oral lesion in human immunodeficiency virus type 1 (HIV-1)-infected patients, and the etiology is unknown. Earlier studies of HIV-1-infected patients have shown significant changes in the viral and fungal oral microflora. The aim of this study was to relate the occ
Diarrhea and Clostridium difficile infection in Latin American patients with AIDS. Working Group on AIDS in Peru.: Clin Infect Dis. 1998 Sep;27(3):487-93. Unique Identifier : AIDSLINE MED/98442281; Willingham FF; Ticona Chavez E; Taylor DN; Bowen AB; Crane AR; Gottlieb AL; Gayles MK; Grahn KF; Chavez Perez VM; Salas Apolinario I; Gilman RH; Department of International Health, Johns Hopkins University; School of Hygiene and Public Health, Baltimore, Maryland 21205,; USA.; Diarrhea and wasting are among the most debilitating and deadly manifestations of AIDS, yet only limited information is available regarding the etiology, clinical consequences, and immunologic effects of infection with diarrheal agents. Peruvian AIDS patients presenting with and without diarrhea were followed prospect
Microglial nodular encephalitis and ventriculoencephalitis due to cytomegalovirus infection in patients with AIDS: two distinct clinical patterns.: Clin Infect Dis. 1998 Sep;27(3):504-8. Unique Identifier : AIDSLINE MED/98442284; Grassi MP; Clerici F; Perin C; D'Arminio Monforte A; Vago L; Borella M; Boldorini R; Mangoni A; I Clinica Neurologica, Clinica di Malattie Infettive, Anatomia; Patologica-Istituto di Scienze Biomediche, Milano, Italy.; In patients with AIDS, cerebral infection due to cytomegalovirus ( CMV ) results in two distinct neuropathological patterns: microglial nodular encephalitis (MGNE) and ventriculoencephalitis (VE). In order to identify clinical
Herpes zoster and lymphopenia associated with sodium stibogluconate therapy for cutaneous leishmaniasis.: Clin Infect Dis. 1998 Sep;27(3):509-12. Unique Identifier : AIDSLINE MED/98442285; Wortmann GW; Aronson NE; Byrd JC; Grever MR; Oster CN; Infectious Disease Service, Walter Reed Army Medical Center,; Washington, D.C. 20307-5001, USA.; A review of 84 patients with cutaneous leishmaniasis treated with sodium stibogluconate (Pentostam) at our institution revealed that three had developed herpes zoster during or shortly after receiving therapy. Because zoster has been associated with depressed cellular immunity, we prospectively followed serial lymphoc
Clindamycin with primaquine vs. Trimethoprim-sulfamethoxazole therapy for mild and moderately severe Pneumocystis carinii pneumonia in patients with AIDS: a multicenter, double-blind, randomized trial (CTN 004). CTN-PCP Study Group.: Clin Infect Dis. 1998 Sep;27(3):524-30. Unique Identifier : AIDSLINE MED/98442288; Toma E; Thorne A; Singer J; Raboud J; Lemieux C; Trottier S; Bergeron MG; Tsoukas C; Falutz J; Lalonde R; Gaudreau C; Therrien R; Department of Microbiology and Infectious Diseases, Centre; Hospitalier de l'Universite de Montreal, Quebec, Canada.; This double-blind, randomized, multicenter trial compared clindamycin/primaquine (Cm/Prq) with trimethoprim-sulfamethoxazole (TMP-SMZ) as therapy for AIDS-related Pneumocystis carinii pneumonia (PCP). Forty-five patients received clindamycin (450 mg four times daily [q.i.d.]) and primaquine (15 mg of base/d); 42 recei
Cryptosporidiosis in patients with AIDS: correlates of disease and survival.: Clin Infect Dis. 1998 Sep;27(3):536-42. Unique Identifier : AIDSLINE MED/98442290; Manabe YC; Clark DP; Moore RD; Lumadue JA; Dahlman HR; Belitsos PC; Chaisson RE; Sears CL; Department of Pathology, Johns Hopkins University School of; Medicine, Baltimore, Maryland, USA.; Although 10%-15% of patients with AIDS in the United States may acquire cryptosporidium infection, little data exist on clinical or histological characteristics that differentiate clinical outcomes. A case-control study of 83 HIV-positive adult patients with cryptosporidiosis was condu
Predictive value of cytomegalovirus (CMV) antigenemia and digene hybrid capture DNA assays for CMV disease in human immunodeficiency virus-infected patients.: Clin Infect Dis. 1998 Sep;27(3):573-81. Unique Identifier : AIDSLINE MED/98442295; Walmsley S; O'Rourke K; Mortimer C; Rachlis A; Fong I; Mazzulli T; Department of Medicine, University of Toronto, Ontario, Canada.; Oral ganciclovir prophylaxis decreases the incidence of cytomegalovirus ( CMV ) disease among persons infected with the human immunodeficiency virus (HIV), but universal prophylaxis is not cost-effective. We evaluated urine and
Primary cutaneous aspergillosis in human immunodeficiency virus-infected patients: two cases and review [see comments]: Clin Infect Dis. 1998 Sep;27(3):641-3. Unique Identifier : AIDSLINE MED/98442304; Arikan S; Uzun O; Cetinkaya Y; Kocagoz S; Akova M; Unal S; Department of Microbiology and Clinical Microbiology, Hacettepe; University School of Medicine, Ankara, Turkey.
Itraconazole therapy for primary cutaneous aspergillosis in patients with AIDS [see comments]: Clin Infect Dis. 1998 Sep;27(3):643-4. Unique Identifier : AIDSLINE MED/98442305; van Burik JA; Colven R; Spach DH; Department of Medicine, University of Washington School of; Medicine, Seattle, USA.
Hepatitis A in human immunodeficiency virus-infected patients.: Clin Infect Dis. 1998 Sep;27(3):651-3. Unique Identifier : AIDSLINE MED/98442311; Wallace MR; Hill HE; Tasker SA; Miller LK; Department of Internal Medicine, Naval Medical Center, San Diego,; California, USA.
Bloody diarrhea caused by Plesiomonas shigelloides proctitis in a human immunodeficiency virus-infected patient.: Clin Infect Dis. 1998 Sep;27(3):657. Unique Identifier : AIDSLINE MED/98442315; Ahmad M; Aggarwal M; Ahmed A; Department of Medicine, Stanford University School of Medicine,; California, USA.
Clarithromycin therapy for bacillary peliosis did not prevent bacillary angiomatosis.: Clin Infect Dis. 1998 Sep;27(3):658. Unique Identifier : AIDSLINE MED/98442316; Mukunda BN; West BC; Shekar R; Department of Medicine, Meridia Huron Hospital, Cleveland, Ohio,; USA.
[Fungemia in patients with HIV infection]: An Med Interna. 1998 Oct;15(10):523-7. Unique Identifier : AIDSLINE MED/99060216; Santos J; Palacios R; Esteve A; Garcia V; Rivero A; Marquez M; Unidad de Infecciosos, Hospital Virgen de la Victoria, Malaga.; OBJECTIVE: To make an analysis of fungemia in HIV-infected patients in our hospital. PATIENTS AND METHODS: We retrospectively (1989-1997) studied all HIV-infected patients with positive blood cultures for Candida sp., Cryptococcus neoformans or any other fungal infection. RESULTS: C. neoformans was isolated in 11 pati
[Hospital detoxification unit: 4-year experience. Treatment and infections]: An Med Interna. 1998 Oct;15(10):528-30. Unique Identifier : AIDSLINE MED/99060217; Gutierrez del Rio C; Casanueva Gutierrez M; de la Fuente Garcia B; Gallo Alvaro C; Garcia-Alcalde Fernandez ML; Moris de la Tassa J; Servicio de Medicina Interna, Hospital de Cabuenes, Gijon,; Asturias.; BACKGROUND: Analysis of the main infections complications in drug-dependents and their relation between the way of consumption and sexual activity; the detoxification treatments used are taken into consideration. MATERIAL AND METHODS: We studied the patients admitted to the HDU (Hospital Detoxification Unit) between 1
Induction of antitumor cytotoxic activity using CD34+ cord blood cell-derived and irradiated tumor cell-primed dendritic cells.: Int J Hematol. 1998 Aug;68(2):169-82. Unique Identifier : AIDSLINE MED/99020516; Fujii S; Fujimoto K; Osato M; Matsui K; Takatsuki K; Kawakita M; Second Department of Internal Medicine, Kumamoto University; School of Medicine, Japan.; Dendritic cells (DCs) are the most powerful antigen-presenting cells in the immune system. They can activate immunologically naive T cells and improve the efficacy of immunotherapy against tumors. In the present study we investigated whether CD34+ cord blood cell-derived DCs are capable of inducing antitumor cytotoxic
[Study of the inhibiting effect of the molecular complex yeast RNA-tilorone on HIV-1 reproduction in vitro]: Biull Eksp Biol Med. 1998 Oct;126(10):433-5. Unique Identifier : AIDSLINE MED/99042585; Karpov AV; Antonenko SV; Barbasheva EV; Spivak NIa
Gene delivery to human B-precursor acute lymphoblastic leukemia cells.: Blood. 1998 Nov 15;92(10):3537-45. Unique Identifier : AIDSLINE MED/99025925; Mascarenhas L; Stripecke R; Case SS; Xu D; Weinberg KI; Kohn DB; Divisions of Research Immunology/Bone Marrow Transplantation and; Hematology/ Oncology, Department of Pediatrics, University of; Southern California School of Medicine, Childrens Hospital Los; Angeles, Los Angeles, CA, USA.; Autologous leukemia cells engineered to express immune-stimulating molecules may be used to elicit antileukemia immune responses. Gene delivery to human B-precursor acute lymphoblastic leukemia (ALL) cells was investigated using the enhanced green fluorescent protein (EGFP) as a reporter gene, measured by flow cytomet
Risk factors for adult T-cell leukemia among carriers of human T-lymphotropic virus type I.: Blood. 1998 Nov 15;92(10):3557-61. Unique Identifier : AIDSLINE MED/99025927; Hisada M; Okayama A; Shioiri S; Spiegelman DL; Stuver SO; Mueller NE; Departments of Epidemiology and Biostatistics, Harvard School of; Public Health, Boston, MA, USA. mh280i@nih.gov; The presence of circulating flower cells and a low prevalence of antibody to Tax regulatory protein of human T-lymphotropic virus type I (HTLV-I) are characteristics of adult T-cell leukemia (ATL). To examine the predictability of levels of HTLV-I antibodies and of flower cell-like abnormal lymphocytes (Ably) for th
Possible role of interleukin-10 (IL-10) and CD40 ligand expression in the pathogenesis of hypergammaglobulinemia in human immunodeficiency virus infection: modulation of IL-10 and Ig production after intravenous Ig infusion.: Blood. 1998 Nov 15;92(10):3721-9. Unique Identifier : AIDSLINE MED/99025946; Muller F; Aukrust P; Nordoy I; Froland SS; Section of Clinical Immunology and Infectious Diseases, Medical; Department A and Research Institute for Internal Medicine,; University of Oslo, The National Hospital, Rikshospitalet, Oslo,; Norway.; The mechanisms leading to polyclonal hypergammaglobulinemia in patients with human immunodeficiency virus (HIV) infection are not well understood. In light of the important role of interleukin-10 (IL-10) and the interaction between CD40 and CD40 ligand in the normal regulation of B-lymphocyte function and Ig productio
Immunostimulatory CpG oligodeoxynucleotides enhance the immune response to vaccine strategies involving granulocyte-macrophage colony-stimulating factor.: Blood. 1998 Nov 15;92(10):3730-6. Unique Identifier : AIDSLINE MED/99025947; Liu HM; Newbrough SE; Bhatia SK; Dahle CE; Krieg AM; Weiner GJ; University of Iowa Interdisciplinary Graduate Program in; Immunology, University of Iowa Department of Internal Medicine,; University of Iowa Cancer Center, USA.; Immunostimulatory oligodeoxynucleotides containing the CpG motif (CpG ODN) can activate various immune cell subsets and induce production of a number of cytokines. Prior studies have demonstrated that both CpG ODN and granulocyte-macrophage colony-stimulating factor (GM-CSF) can serve as potent vaccine adjuvants. We u
Semiquantitative Epstein-Barr virus polymerase chain reaction analysis of peripheral blood from organ transplant patients and risk for the development of lymphoproliferative disease.: Blood. 1998 Nov 15;92(10):3977-8. Unique Identifier : AIDSLINE MED/99076956; Lucas KG; Filo F; Heilman DK; Lee CH; Emanuel DJ
Virological and immunological features of long-term human immunodeficiency virus-infected individuals who have remained asymptomatic compared with those who have progressed to acquired immunodeficiency syndrome.: Blood. 1998 Nov 1;92(9):3105-14. Unique Identifier : AIDSLINE MED/99005336; Barker E; Mackewicz CE; Reyes-Teran G; Sato A; Stranford SA; Fujimura SH; Christopherson C; Chang SY; Levy JA; Department of Medicine, University of California, San Francisco,; USA.; Infection with the human immunodeficiency virus (HIV) leads to a decrease in CD4(+) T cells and disease progression within a decade of seroconversion. However, a small group of infected people, despite being infected by HIV for 10 or more years, remain clinically asymptomatic and have stable CD4(+) cell counts without
Expansion of Philadelphia chromosome-negative CD3(+)CD56(+) cytotoxic cells from chronic myeloid leukemia patients: in vitro and in vivo efficacy in severe combined immunodeficiency disease mice.: s/IMMUNOLOGY Transplantation, Homologous/IMMUNOLOGY Tumor Cells, Cultured Tumor Necrosis Factor/BIOSYNTHESIS Tumor Stem Cell Assay Tumor Stem Cells/DRUG EFFECTS Blood. 1998 Nov 1;92(9):3318-27. Unique Identifier : AIDSLINE MED/99005360; Hoyle C; Bangs CD; Chang P; Kamel O; Mehta B; Negrin RS; Division of Bone Marrow Transplantation, Department of Medicine;; the Department of Pathology, Stanford University Medical School,; Stanford, CA, USA.
OX40 costimulation enhances interleukin-4 (IL-4) expression at priming and promotes the differentiation of naive human CD4(+) T cells into high IL-4-producing effectors.: Blood. 1998 Nov 1;92(9):3338-45. Unique Identifier : AIDSLINE MED/99005362; Ohshima Y; Yang LP; Uchiyama T; Tanaka Y; Baum P; Sergerie M; Hermann P; Delespesse G; University of Montreal, Centre de Recherche Louis-Charles Simard,; Notre-Dame Hospital, and the Department of Obstetrics and; Gynecology, Montreal, Quebec, Canada.; Th2 c