1999

Effect of CpG methylation on isotype and magnitude of antibody responses to influenza hemagglutinin-expressing plasmid.: DNA Cell Biol. 1999 Sep;18(9):663-70. Unique Identifier : AIDSLINE MED/99420146; Feltquate DM; Robinson HL; Department of Pathology, University of Massachusetts Medical; School, Worcester, USA.; We previously showed that intramuscular saline DNA immunizations favor the development of an IgG2a-dominant Th1 immune response, whereas gene gun DNA immunizations stimulate the production of an IgG1-dominant Th2 immune response. Several studies have implicated immunostimulatory CpG sequences as the causative factor i
Dual activity of pyrrolidine dithiocarbamate on kappa B-dependent gene expression in U937 cells: I. Regulation by the phorbol ester TPA.: Cell Signal. 1999 Jul;11(7):479-89. Unique Identifier : AIDSLINE MED/99334230; Watanabe K; Kazakova I; Furniss M; Miller SC; Signal Transduction Laboratory, SRI International, Menlo Park, CA; 94025, USA.; Pyrrolidine dithiocarbamate (PDTC) has been widely used as an inhibitor of the nuclear factor-kappa B, (NF-kappa B) signalling pathway. Here, we show that kappa B-dependent reporter gene expression induced by low concentrations of 12-O-tetradecanoylphorbol-13-acetate (TPA) is potentiated by PDTC in the human pro-monoc
Basic fibroblast growth factor in HIV-associated hemolytic uremic syndrome.: Pediatr Nephrol. 1999 Sep;13(7):586-93. Unique Identifier : AIDSLINE MED/99389603; Ray PE; Liu XH; Xu L; Rakusan T; Center IV, Room R-211, Children's Research Institute, Children's; National Medical Center, 111 Michigan Avenue N.W., Washington, DC; 20010, USA, Pray@cnmc.org; Endothelial injury is the primary pathogenic event leading to the renal thrombotic microangiopathic lesions typical of the hemolytic uremic syndrome (HUS). Basic fibroblast growth factor (bFGF) is an angiogenic growth factor released by injured endothelial cells. In a previous study we have found a significant accumul
The distinct role of CD4+ and CD8+ T-cells during the anti-tumour effects of targeted superantigens.: Br J Cancer. 1999 Sep;81(2):359-66. Unique Identifier : AIDSLINE MED/99424685; Litton MJ; Dohlsten M; Rosendahl A; Ohlsson L; Sogaard M; Andersson J; Andersson U; Department of Immunology, Wenner-Gren's Institute, Stockholm; University, Sweden.; To target T-cells to the tumour area we created a recombinant protein of the bacterial superantigen (SAg) Staphylococcal enterotoxin A (SEA) and the Fab-fragment of a tumour-reactive antibody. This antibody-targeted SAg immunotherapy therapy has been shown to be highly efficient, eliminating > 95% of the pulmonary met
Holistic care.: Nurs Stand. 1999 May 26-Jun 1;13(36):20. Unique Identifier : AIDSLINE MED/99427190; Snee T
The National HIV Nurses' Association.: Nurs Stand. 1999 Jun 9-15;13(38):31. Unique Identifier : AIDSLINE MED/99427119; Shaw T; Welsh L; Foundation of Nursing Studies, London. theresa.shaw@fons.org
T-cell subsets in schizophrenia: a comparison between drug-naive first episode patients and chronic schizophrenic patients.: Schizophr Res. 1999 Jul 27;38(1):61-70. Unique Identifier : AIDSLINE MED/99356618; Sperner-Unterweger B; Whitworth A; Kemmler G; Hilbe W; Thaler J; Weiss G; Fleischhacker WW; Department of Biological Psychiatry, Innsbruck University; Clinics, Austria.; T-cell subsets (CD3+, CD4+, CD8+, NK-cells) and the CD4+/CD8+ ratio were measured in 56 schizophrenic patients admitted to hospital with an acute psychosis. Thirty-five patients with chronic schizophrenia and 21 drug-naive first episode schizophrenic patients were compared with 16 healthy controls. T-cell subsets were
An alternate pathway for type 1 T cell differentiation.: Int Immunol. 1999 Aug;11(8):1185-94. Unique Identifier : AIDSLINE MED/99352249; Feng C; Watanabe S; Maruyama S; Suzuki G; Sato M; Furuta T; Kojima S; Taki S; Asano Y; Department of Microbiology and Immunology, Ehime University; School of Medicine, Shigenobu, Ehime 791-0295, Japan.; IFN-regulatory factor-1 (IRF-1) gene-disrupted mice are defective in IL-12 and IL-18 gene expression at the transcriptional and post-translational level respectively. The mutant mouse mounts a type 2 T cell response upon bacterial infection because of the impaired induction of the IL-12 p40 gene and IFN-gamma-producin
A dominant-negative mutant of c-Jun inhibits cell cycle progression during the transition of CD4(-)CD8(-) to CD4(+)CD8(+) thymocytes.: Int Immunol. 1999 Aug;11(8):1203-16. Unique Identifier : AIDSLINE MED/99352251; King LB; Tolosa E; Lenczowski JM; Lu F; Lind EF; Hunziker R; Petrie HT; Ashwell JD; Laboratory of Immune Cell Biology, National Cancer Institute,; National Institutes of Health, Bethesda MD 20892, USA.; While Jun/Fos-containing transcription factors are known to be necessary for many TCR-mediated events in mature T cells, relatively little is known about their roles in thymocyte development. We have generated transgenic mice that express a trans-dominant-negative mutant of c-Jun (TAM-67) specifically in thymocytes. E
Death by neglect as a deletional mechanism of peripheral tolerance.: Int Immunol. 1999 Aug;11(8):1225-38. Unique Identifier : AIDSLINE MED/99352253; Bertolino P; Trescol-Biemont MC; Thomas J; de St Groth BF; Pihlgren M; Marvel J; Rabourdin-Combe C; Ecole Normale Superieure de Lyon, INSERM U98, 46 Allee; d'Italie, 69364 Lyon Cedex 07, France.; In contrast to most organs, the anatomy of the liver may allow naive CD8(+) T cells to make direct contact with liver parenchymal cells. We have previously shown, using a combination of TCR transgenic T cells specific for H-2 K(b) and hepatocytes expressing a transgenic H-2 K(b) molecule, that hepatocytes can induce a
Autoimmunity to a pathogenic retinal antigen begins as a balanced cytokine response that polarizes towards type 1 in a disease-susceptible and towards type 2 in a disease-resistant genotype.: Int Immunol. 1999 Aug;11(8):1307-12. Unique Identifier : AIDSLINE MED/99352261; Sun B; Sun SH; Chan CC; Wiggert B; Caspi RR; Laboratory of Immunology, and Laboratory of Retinal Cell and; Molecular Biology, National Eye Institute, NIH, Bethesda, MD; 20892, USA.; Susceptible, but not resistant, strains of rodents immunized for induction of experimental autoimmune uveitis (EAU) with the uveitogenic protein interphotoreceptor retinoid-binding protein (IRBP) exhibit a type 1 response at the time of disease expression. Here we investigate the evolution of this response using the p
Peripheral human CD8(+)CD28(+)T lymphocytes give rise to CD28(-)progeny, but IL-4 prevents loss of CD28 expression.: Int Immunol. 1999 Aug;11(8):1327-36. Unique Identifier : AIDSLINE MED/99352263; Labalette M; Leteurtre E; Thumerelle C; Grutzmacher C; Tourvieille B; Dessaint JP; Service d'Immunologie, EA 2686, Centre Hospitalier et; Universitaire de Lille, 59045 Lille, France.; At birth, virtually all peripheral CD8(+) T cells express the CD28 co-stimulatory molecule, but healthy human adults accumulate CD28(-)CD8(+) T cells that often express the CD57 marker. While these CD28(-) subpopulations are known to exert effector-type functions, the generation, maintenance and regulation of CD28(-)
Astrocytoma infiltrating lymphocytes include major T cell clonal expansions confined to the CD8 subset.: Unique Identifier : AIDSLINE MED/99352264; Perrin G; Schnuriger V; Quiquerez AL; Saas P; Pannetier C; de Tribolet N; Tiercy JM; Aubry JP; Dietrich PY; Walker PR; Laboratory of Tumor Immunology, Division of Oncology, University; Hospital, 1211 Geneva 14, Switzerland.; Anaplastic astrocytoma and glioblastoma are frequent and malignant brain tumors that are infiltrated by T lymphocytes. Whether these cells result from non-specific inflammation following blood-brain barrier disruption or an antigen-driven specific immune response is unknown. In this study, an in-depth characterization
HLA-G-mediated inhibition of antigen-specific cytotoxic T lymphocytes.: Int Immunol. 1999 Aug;11(8):1351-6. Unique Identifier : AIDSLINE MED/99352265; Le Gal FA; Riteau B; Sedlik C; Khalil-Daher I; Menier C; Dausset J; Guillet JG; Carosella ED; Rouas-Freiss N; Laboratoire d'Immunologie des Pathologies Infectieuses et; Tumorales, INSERM U445, Institut Cochin de Genetique; Moleculaire, 27, rue du Faubourg St Jacques, Universite Rene; Descartes, 75014 Paris, France.; In the present study, we demonstrate that the non-classical MHC class I molecule HLA-G impairs specific cytolytic T cell functions in addition to its well-established inhibition of NK lysis. The antigen-specific cytotoxic T lymphocyte (CTL) response analyzed was mediated by CD8(+) T cells specific for the influenza vi
Effect of nonpolar substitutions of the conserved Phe11 in the fusion peptide of HIV-1 gp41 on its function, structure, and organization in membranes.: Biochemistry. 1999 Aug 31;38(35):11359-71. Unique Identifier : AIDSLINE MED/99400476; Pritsker M; Rucker J; Hoffman TL; Doms RW; Shai Y; Department of Biological Chemistry, Weizmann Institute of; Science, Rehovot, Israel.; The fusion domain of the HIV-1 envelope glycoprotein (gp120-gp41) is a conserved hydrophobic region located at the N-terminus of the transmembrane subunit (gp41). A prominent feature of this domain is a conserved five-residue FLGFL sequence at positions 8-12. Mutation of the highly conserved Phe(11) to Val (F11V), p
Isothiazolone derivatives selectively inhibit telomerase from human and rat cancer cells in vitro.: Biochemistry. 1999 Aug 31;38(35):11501-7. Unique Identifier : AIDSLINE MED/99400492; Hayakawa N; Nozawa K; Ogawa A; Kato N; Yoshida K; Akamatsu Ki; Tsuchiya M; Nagasaka A; Yoshida S; Department of Internal Medicine, Fujita Health University School; of Medicine, Toyoake, Aichi, Japan.; The telomere hypothesis postulates stabilization of telomere length and telomerase activation as key events in cellular immortalization and carcinogeneses. Accordingly, telomerase has been suggested as a novel and highly selective target for design of antitumor drugs. Screening of a chemical library including 16 000 s
Lung allograft dysfunction correlates with gamma-interferon gene expression in bronchoalveolar lavage.: J Heart Lung Transplant. 1999 Jul;18(7):627-36. Unique Identifier : AIDSLINE MED/99379407; Ross DJ; Moudgil A; Bagga A; Toyoda M; Marchevsky AM; Kass RM; Jordan SC; Division of Pulmonary and Critical Care Medicine, Cedars-Sinai; Medical Center Lung and Heart-Lung Transplant Program, Los; Angeles, California, USA. ROSS-D@CSMC.EDU; BACKGROUND: Preceding episodes of acute cellular rejection (ACR) may predispose lung allografts to the subsequent development of irreversible dysfunction or bronchiolitis obliterans syndrome (BOS). Other histologic patterns such as bronchiolitis obliterans with organizing pneumonia (BOOP), organizing pneumonia, lympho
Changing attitudes towards antiretroviral treatment of HIV infection: a prospective study in a sample of Dutch general practitioners.: AIDS Care. 1999 Apr;11(2):141-5. Unique Identifier : AIDSLINE MED/99403865; Reedijk M; Bindels PJ; Mohrs J; Wigersma L; Department of General Practice, Academic Medical Centre,; University of Amsterdam, The Netherlands.; This study investigated the attitude towards antiretroviral therapy (ART) for HIV infection over time, in a sample of Dutch general practitioners (GPs). Twenty-one GPs, of which 16 were practising in Amsterdam, completed multiple questionnaires on HIV-related topics between April 1995 and March 1997. In 1995, only 10%
Use of protease inhibitors among persons with AIDS in Los Angeles County.: AIDS Care. 1999 Apr;11(2):147-55. Unique Identifier : AIDSLINE MED/99403866; Sorvillo F; Kerndt P; Odem S; Castillon M; Carruth A; Contreras R; Los Angeles County Department of Health Services, HIV; Epidemiology Program, California 90005, USA.; sorv100w@wonder.em.cdc.gov; We evaluated the access to, and the factors associated with, protease inhibitor use among persons with AIDS in Los Angeles County. A population-based sample of adult persons with AIDS is routinely interviewed in Los Angeles County and includes a 30% random sample of men who have sex with men and all other persons repo
AIDS diagnosis and depression in the Multicenter AIDS Cohort Study: the ameliorating impact of pet ownership.: AIDS Care. 1999 Apr;11(2):157-70. Unique Identifier : AIDSLINE MED/99403867; Siegel JM; Angulo FJ; Detels R; Wesch J; Mullen A; University of California, Los Angeles, USA. jmsiegel@ucla.edu; The impact of pet ownership on depression was tested among a sample of gay and bisexual men (n = 1,872). Multivariate analyses, controlling for demographics and baseline depressive symptomatology, showed that neither pet ownership nor the presence of HIV infection was associated with depression. Depression was influen
Measuring the stress associated with caring for clients with HIV/AIDS.: AIDS Care. 1999 Apr;11(2):171-80. Unique Identifier : AIDSLINE MED/99403868; Niven CA; Knussen C; Department of Nursing and Midwifery, University of Stirling, UK.; The AIDS-stress scale (Pleck et al., 1988) provides measures of the sources of stress faced by health care workers caring for people with AIDS. The aim of the study was to consider the utility of the scale as a means of identifying groups of health care workers who would benefit from intervention. Data were collected
Heterosexual couples confronting the challenges of HIV infection.: AIDS Care. 1999 Apr;11(2):181-93. Unique Identifier : AIDSLINE MED/99403869; VanDevanter N; Thacker AS; Bass G; Arnold M; Columbia University School of Public Health, Division of; Sociomedical Sciences, New York, NY 10032, USA. nlvl@columbia.edu; Couples confronted with HIV infection face significant challenges. Little is known about the impact of HIV on heterosexual couples who account for the vast majority of cases worldwide and an increasing proportion of cases in the USA, especially among women. In this study, analysis of data collected on HIV-discordant c
Women who are HIV infected: the role of religious activity in psychosocial adjustment.: AIDS Care. 1999 Apr;11(2):195-9. Unique Identifier : AIDSLINE MED/99403870; Biggar H; Forehand R; Devine D; Brody G; Armistead L; Morse E; Simon P; Institute for Behavioral Research, University of Georgia, Athens; 30602, USA.; The role of religious activity in the psychosocial adjustment of 205 inner-city African-American women, one-half of whom are HIV infected, was examined. Those who were HIV infected reported praying more but viewed prayer as less effective in coping with a chronic illness. Frequency of prayer predicted optimism about t
'In an important way, I did die': uncertainty and revival in persons living with HIV or AIDS.: AIDS Care. 1999 Apr;11(2):201-19. Unique Identifier : AIDSLINE MED/99403871; Brashers DE; Neidig JL; Cardillo LW; Dobbs LK; Russell JA; Haas SM; Department of Speech Communication, University of Illinois,; Urbana 61801-3631, USA. dbrasher@uiuc.edu; This study reports the revival experiences of persons who once were reconciled to their death from HIV/AIDS but who, as a result of dramatic treatment responses, now believe they may survive (popularly known as the Lazarus Syndrome). A purposive sample of men and women living with HIV infection or AIDS were interviewe
Parallel accounts? Discrepancies between self-report (diary) and recall (questionnaire) measures of the same sexual behaviour.: AIDS Care. 1999 Apr;11(2):221-34. Unique Identifier : AIDSLINE MED/99403872; Coxon AP; University of Essex, Colchester, UK. apmc@essex.ac.uk; Questionnaires and diaries have complementary biases and advantages for obtaining information on sexual behaviour but self-completed sexual diaries have the advantage of reducing retrospective bias. In a validation study of homosexual behaviour, sexual diary counts and subsequent questionnaire estimates (together with
Nature and consequences of stressful life events in homosexual HIV-positive men: a review.: Unique Identifier : AIDSLINE MED/99403873; Nott KH; Vedhara K; Department of Psychology, University Newcastle upon Tyne, UK.; A great deal of research has been conducted into the stressful experiences that befall HIV-infected individuals. In this review we have focused on the work that has been conducted with HIV-positive homosexual males and have examined issues concerning the measurement, nature and consequences of stressful life events. I
UNAIDS/WHO global AIDS statistics.: AIDS Care. 1999 Apr;11(2):253-64. Unique Identifier : AIDSLINE MED/99403874
HIV risk behaviours of current sex workers attending syringe exchange: the experiences of women in five US cities.: AIDS Care. 1999 Jun;11(3):269-80. Unique Identifier : AIDSLINE MED/99403875; Paone D; Cooper H; Alperen J; Shi Q; Des Jarlais DC; Beth Israel Medical Center, Chemical Dependency Institute, New; York, NY 10003, USA.; Existing research indicates that sex workers who inject drugs are vulnerable to HIV infection through both risky sexual and drug use practices. This study is the first attempt to learn whether this increased risk persists among current sex workers who participate in syringe exchange programmes (SEPs). With data from i
Factors associated with gay men's sexual behaviours and risk on holiday.: AIDS Care. 1999 Jun;11(3):281-95. Unique Identifier : AIDSLINE MED/99403876; Clift SM; Forrest SP; Centre for Health Education and Research, Canterbury Christ; Church University College, UK. s.m.clift@cant.ac.uk; Findings are presented from a questionnaire survey of 562 gay men resident in southern England on their sexual behaviour in the context of holidays. Data were gathered during summer 1996 by means of a self-completion questionnaire; 395 men reported at least one holiday undertaken in 1996 and the analysis focuses on th
HIV risk behaviours among male-to-female transgenders in comparison with homosexual or bisexual males and heterosexual females.: Unique Identifier : AIDSLINE MED/99403877; Nemoto T; Luke D
Social support and unsupportive social interactions: their association with depression among people living with HIV.: AIDS Care. 1999 Jun;11(3):313-29. Unique Identifier : AIDSLINE MED/99403878; Ingram KM; Jones DA; Fass RJ; Neidig JL; Song YS; Department of Psychology, Virginia Commonwealth University,; Richmond 23284-2018, USA. kingram@saturn.vcu.edu; Although numerous studies of people living with HIV have focused on positive social support, researchers have directed surprisingly little attention to the nature and effects of negative social interactions in this population. Based on data from a diverse sample of people with HIV (N = 271), we conducted a factor anal
Patient satisfaction with HIV service provision in NPMS hospitals: the development of a standard satisfaction questionnaire. NPMS Steering Group.: AIDS Care. 1999 Jun;11(3):331-43. Unique Identifier : AIDSLINE MED/99403879; Beck EJ; Griffith R; Fitzpatrick R; Mandalia S; Carrier J; Conlon C; Mandel B; Ong E; Pozniak A; Tang A; Tomlinson D; Williams I; Department of Epidemiology and Public Health, Imperial College; School of Medicine, (Chelsea and Westminster Hospital), London,; UK. e.beck@ic.ac.uk; A self-completion satisfaction questionnaire evaluating the standard of care of HIV outpatient services was developed as part of the National Prospective Monitoring System on the Use, Cost and Outcome of HIV Service Provision in English Hospitals (NPMS). The questionnaire was designed in conjunction with service users
Use of chart reminders for physicians to promote discussion of advance directives in patients with AIDS.: AIDS Care. 1999 Jun;11(3):345-53. Unique Identifier : AIDSLINE MED/99403880; Walker NM; Mandell KL; Tsevat J; Department of Internal Medicine, University of Cincinnati Medical; Center, Ohio 45267-0535, USA.; To determine if use of a physician chart reminder improves the rate of physician-initiated discussion and subsequent completion of advance directives (ADs) in patients with AIDS, a controlled study was conducted with 74 patients with AIDS and ten physicians providing primary care at a university-based hospital clinic.
Reluctance amongst nurses and doctors to care for and treat patients with HIV/AIDS.: AIDS Care. 1999 Jun;11(3):355-9. Unique Identifier : AIDSLINE MED/99403881; McCann TV; Faculty of Nursing, University of Newcastle, Callaghan, New South; Wales, Australia. vntm@cc.newcastle.edu.au; A survey was carried out, using a questionnaire and semi-structured interviews, to examine why nurses and doctors might be reluctant to care for patients with HIV/AIDS. The findings provided four main themes: perceptions about sexual promiscuity; blaming certain patients with HIV/AIDS; belief in the right to refuse to
Predictors of outpatient medical appointment attendance among persons with HIV.: AIDS Care. 1999 Jun;11(3):361-73. Unique Identifier : AIDSLINE MED/99403882; Catz SL; McClure JB; Jones GN; Brantley PJ; Center for AIDS Intervention Research (CAIR), Medical College of; Wisconsin, Milwaukee 53202, USA.; Non-adherence to medical regimens is a critical threat to the health of HIV-infected individuals. Patients who do not adhere to routine medical care cannot fully benefit from the increasingly efficacious treatments available to them. Consistent attendance at medical appointments plays a central role in both prolonging
Young people and HIV in Cambodia: meanings, contexts and sexual cultures.: Unique Identifier : AIDSLINE MED/99403883; Tarr CM; Aggleton P; University of Phnom Penh, Cambodia. Choumeng@camnet.com.kh; Like many other countries in South East Asia, Cambodia is experiencing a rapidly developing AIDS epidemic. Groups reported as being particularly seriously affected include sex workers and their clients. Young people too may be at heightened risk: some young women find sex work a
Application of oligo-(14-amino-3,6,9,12-tetraoxatetradecanoic acid) lipid conjugates as steric barrier molecules in liposomal formulations.: Bioconjug Chem. 1999 Jul-Aug;10(4):653-66. Unique Identifier : AIDSLINE MED/99339826; Ansell SM; Kojic LD; Hankins JS; Sekirov L; Boey A; Lee DK; Bennett AR; Klimuk SK; Harasym TO; Santos ND; Semple SC; Inex Pharmaceuticals Corp., 100-8900 Glenlyon Parkway, Burnaby,; B.C., V5J 5J8, Canada. sansell@inexpharm.com; Lipid conjugates of oligo-(14-amino-3,6,9,12-tetraoxatetradecanoic acid) (ATTAn) were synthesized as monodisperse analogues of poly(ethylene glycol) (PEG) derivatives used in liposomal drug delivery systems. The new lipids were shown to be at least equivalent to MePEGA-2000-DSPE in assays designed to evaluate the effe
Overexpression of Fas/CD95 and Fas-induced apoptosis in a patient with idiopathic CD4+ T lymphocytopenia.: Unique Identifier : AIDSLINE MED/99379696; Roger PM; Bernard-Pomier G; Counillon E; Breittmayer JP; Bernard A
Evolution of vaginal Candida species recovered from human immunodeficiency virus-infected women receiving fluconazole prophylaxis: the emergence of Candida glabrata? Terry Beirn Community Programs for Clinical Research in AIDS (CPCRA).: Clin Infect Dis. 1999 May;28(5):1025-31. Unique Identifier : AIDSLINE MED/99379698; Vazquez JA; Sobel JD; Peng G; Steele-Moore L; Schuman P; Holloway W; Neaton JD; Division of Infectious Diseases, Wayne State University School of; Medicine, Detroit, Michigan, USA. jvazquez@oncgate.roc.wayne.edu; The effect of fluconazole prophylaxis on the vaginal flora of 323 human immunodeficiency virus-infected women was evaluated in a multicenter, randomized, double-blind, placebo-controlled trial. Women with CD4 cell counts of
Chronic active hepatitis B exacerbations in human immunodeficiency virus-infected patients following development of resistance to or withdrawal of lamivudine.: Clin Infect Dis. 1999 May;28(5):1032-5. Unique Identifier : AIDSLINE MED/99379699; Bessesen M; Ives D; Condreay L; Lawrence S; Sherman KE; Department of Medicine, University of Colorado Health Sciences; Center, Denver, USA. mary.bessesen@med.va.gov; Lamivudine is a nucleoside analog with activity against human immunodeficiency virus (HIV) and hepatitis B virus (HBV). Patients coinfected with HIV and HBV may have hepatitis flares when lamivudine therapy is discontinued or when resistance of HBV to
Interferon gamma (IFN-gamma) deficiency in generalized Epstein-Barr virus infection with interstitial lymphoid and granulomatous pneumonia, focal cerebral lesions, and genital ulcers: remission following IFN-gamma substitution therapy.: Clin Infect Dis. 1999 May;28(5):1036-42. Unique Identifier : AIDSLINE MED/99379700; Andersson J; Isberg B; Christensson B; Veress B; Linde A; Bratel T; Department of Infectious Diseases, Karolinska Institutet,; Huddinge University Hospital, Stockholm, Sweden.; jan.andersson@infect.hs.sll.se; A 26-year-old previously healthy woman developed granulomatous pneumonitis, encephalitis, and genital ulceration during primary Epstein-Barr virus (EBV) infection. EBV DNA was demonstrated by polymerase chain reaction analysis of serum, lung tissue, and genital ulcer specimens. Serology verified primary EBV infection.
Itraconazole prophylaxis for fungal infections in patients with advanced human immunodeficiency virus infection: randomized, placebo-controlled, double-blind study. National Institute of Allergy and Infectious Diseases Mycoses Study Group.: Unique Identifier : AIDSLINE MED/99379702; McKinsey DS; Wheat LJ; Cloud GA; Pierce M; Black JR; Bamberger DM; Goldman M
A randomized, placebo-controlled study of rifabutin added to a regimen of clarithromycin and ethambutol for treatment of disseminated infection with Mycobacterium avium complex.: Clin Infect Dis. 1999 May;28(5):1080-5. Unique Identifier : AIDSLINE MED/99379707; Gordin FM; Sullam PM; Shafran SD; Cohn DL; Wynne B; Paxton L; Perry K; Horsburgh CR Jr; Veterans Affairs Medical Center and Georgetown University,; Washington, DC, USA.; Current guidelines suggest that disseminated Mycobacterium avium complex (MAC) infection be treated with a macrolide plus ethambutol or rifabutin or both. From 1993 to 1996, 198 AIDS patients with MAC bacteremia participated in a prospective, placebo-controlled trial of clarithromycin (500 mg b.i.d.) plus ethambutol (
Genital ulcers: etiology, clinical diagnosis, and associated human immunodeficiency virus infection in Kingston, Jamaica.: Clin Infect Dis. 1999 May;28(5):1086-90. Unique Identifier : AIDSLINE MED/99379708; Behets FM; Brathwaite AR; Hylton-Kong T; Chen CY; Hoffman I; Weiss JB; Morse SA; Dallabetta G; Cohen MS; Figueroa JP; Department of Medicine, University of North Carolina at Chapel; Hill, USA. BehetsF@aol.com; Individuals presenting consecutively with genital ulcers in Kingston, Jamaica , underwent serological testing for human immunodeficiency virus (HIV) infection, chlamydial infection, and syphilis. Ulcer material was analyzed by multiplex polymerase chain reaction (M-PCR) analysis. D
Bordetella bronchiseptica infection in human immunodeficiency virus-infected patients.: Clin Infect Dis. 1999 May;28(5):1095-9. Unique Identifier : AIDSLINE MED/99379710; Dworkin MS; Sullivan PS; Buskin SE; Harrington RD; Olliffe J; MacArthur RD; Lopez CE; Centers for Disease Control and Prevention, National Center for; HIV, STD and TB Prevention, Division of HIV/AIDS; Prevention-Surveillance and Epidemiology, Atlanta, Georgia 30333,; USA. mdd3@cdc.gov; Bordetella bronchiseptica is a pleomorphic gram-negative coccobacillus that commonly causes respiratory tract infections in dogs. We identified nine human immunodeficiency virus (HIV)-infected persons with culture-confirmed B. bronchiseptica infections (eight respiratory tract and one disseminated infection). The resp
Treatment of human immunodeficiency virus 1-infected infants and children with the protease inhibitor nelfinavir mesylate.: Clin Infect Dis. 1999 May;28(5):1109-18. Unique Identifier : AIDSLINE MED/99379713; Krogstad P; Wiznia A; Luzuriaga K; Dankner W; Nielsen K; Gersten M; Kerr B; Hendricks A; Boczany B; Rosenberg M; Jung D; Spector SA; Bryson Y; Department of Pediatrics, UCLA, Los Angeles, California,; 90095-3075, USA. pkrogsta@pediatrics.medsch.ucla.edu; An open-label study was conducted of nelfinavir mesylate, given with reverse transcriptase inhibitors to human immunodeficiency virus 1 (HIV-1)-infected infants and children 3 months to 13 years of age. Doses of nelfinavir mesylate of 20-30 mg/kg yielded drug exposures comparable to those seen in adults. The drug was
Progressive multifocal leukoencephalopathy in patients with AIDS receiving highly active antiretroviral therapy.: Clin Infect Dis. 1999 May;28(5):1152-4. Unique Identifier : AIDSLINE MED/99379720; Tantisiriwat W; Tebas P; Clifford DB; Powderly WG; Fichtenbaum CJ; Department of Medicine, Washington University School of Medicine,; St. Louis, Missouri 63108, USA.; Recent reports suggest that human immunodeficiency virus (HIV)-associated progressive multifocal leukoencephalopathy (PML) may improve with highly active antiretroviral therapy (HAART). We observed three patients who developed PML while receiving HAART. All patients received HAART for 4-11 months and had low plasma le
Pneumocystis carinii pneumonia mimicking Wegener's granulomatosis.: Clin Infect Dis. 1999 May;28(5):1163-4. Unique Identifier : AIDSLINE MED/99379725; Evans RH; Gelder CM; Smith AP; Freedman AR; Department of Medicine and Infectious Diseases, University; Hospital of Wales, Cardiff.
Two episodes of acute renal failure, rhabdomyolysis, and severe hepatitis in an AIDS patient successively treated with ritonavir and indinavir.: Clin Infect Dis. 1999 May;28(5):1180-1. Unique Identifier : AIDSLINE MED/99379737; Benveniste O; Longuet P; Duval X; Le Moing V; Leport C; Vilde JL; Service des Maladies Infectieuses et Tropicales, Hopital; Bichat-Claude Bernard, Paris, France.; olivier.benveniste@psl.ap-hop-paris.fr
Prospective follow-up of 67 indinavir-experienced human immunodeficiency virus-infected and AIDS patients treated with the ritonavir/saquinavir combination.: Clin Infect Dis. 1999 May;28(5):1184-5. Unique Identifier : AIDSLINE MED/99379741; Lallemand F; Adda N; Schneider V; Jacomet C; Salhi Y; Rozenbaum W; Department of Infectious Diseases, Hospital Rothschild, Paris,; France.
Tropical infectious diseases in human immunodeficiency virus-infected patients.: Clin Infect Dis. 1999 May;28(5):947-63; quiz 964-5. Unique Identifier : AIDSLINE MED/99379688; Karp CL; Neva FA; Department of Medicine, Johns Hopkins University Schools of; Medicine, and Hygiene and Public Health, Baltimore, Maryland; 21205, USA. ckarp@welchlink.welch.jhu.edu
Acetylator phenotype prevalence in HIV-infected patients without previous trimethoprim-sulfamethoxazole hypersensitivity [letter]: Biomed Pharmacother. 1999 Jun;53(5-6):286-7. Unique Identifier : AIDSLINE MED/99353097; Quirino T; Bonfanti P; Arcidiacono M; Pusterla L; Cagni A; Scaglione F; Milazzo F; This trial was conducted to study the frequency of the slow acetylator phenotype in asymptomatic HIV patients having no previous reaction to sulfa-drugs, and to compare this frequency with the frequency found in healthy controls. Results show that HIV alone is not capable of modifying the acetylator phenotype; the pre
Lineage-specific expression of human immunodeficiency virus (HIV) receptor/coreceptors in differentiating hematopoietic precursors: correlation with susceptibility to T- and M-tropic HIV and chemokine-mediated HIV resistance.: Blood. 1999 Sep 1;94(5):1590-600. Unique Identifier : AIDSLINE MED/99409031; Chelucci C; Casella I; Federico M; Testa U; Macioce G; Pelosi E; Guerriero R; Mariani G; Giampaolo A; Hassan HJ; Peschle C; Departments of Hematology-Oncology and Virology, Istituto; Superiore di Sanita, Rome, Italy; and Kimmel Cancer Center,; Thomas Jefferson University, Philadelphia, PA 19107-5541, USA.; Human immunodeficiency virus (HIV) entry is mediated not only by the CD4 receptor, but also by interaction with closely related molecules that act as membrane coreceptors. We have analyzed mRNA expression and/or cell membrane exposition of the coreceptors most widely used by diverse HIV-1 strains (CXCR4, CCR5, and CCR
Human immunodeficiency virus-1 (HIV-1)-Tat protein promotes migration of acquired immunodeficiency syndrome-related lymphoma cells and enhances their adhesion to endothelial cells.: Blood. 1999 Sep 1;94(5):1747-54. Unique Identifier : AIDSLINE MED/99409047; Chirivi RG; Taraboletti G; Bani MR; Barra L; Piccinini G; Giacca M; Bussolino F; Giavazzi R; Laboratory of the Biology and Treatment of Metastasis, Mario; Negri Institute for Pharmacological Research, Bergamo, Italy.; Human immunodeficiency virus-1 (HIV-1)-Tat, the transactivating gene product of HIV-1, has been shown to interact with different cell types, inducing gene expression, altering their growth and migratory behavior. In this study we examined whether Tat might affect functions of acquired immunodeficiency syndrome (AIDS)-
Sensitivity of CD4+ peripheral blood T cells toward spontaneous and CD95 (APO-1/Fas)-induced apoptosis in pediatric human immunodeficiency virus infection [letter]: Blood. 1999 Sep 1;94(5):1829-33. Unique Identifier : AIDSLINE MED/99433224; Bohler T; Debatin KM; Linde R
[Cytogenic characteristics and virogenic status of lymphoid cells from malignant baboon lymphomas]: Vestn Ross Akad Med Nauk. 1999;(7):49-53. Unique Identifier : AIDSLINE MED/99397217; Agrba VZ; Medvedeva NM; Iakovleva LA; Chikobava MG; Araviashvili DE; Timanovskaia VV; Lapin BA; Four lymphoid cell cultures obtained from Papio hamadryads with malignant lymphomas were studied. The cultured cells produced two lymphotropic EBV-like herpes virus of Papio (HVP) and T-lymphotropic monkey retrovirus STLV-1 (HTLV-1 family) or HVP alone. More than 100 subcultured cell lines were shown to remain mixed B
Southern Africa's 'Holocaust': is HIV infection uncontrollable?: Natl Med J India. 1999 May-Jun;12(3):132-3. Unique Identifier : AIDSLINE MED/99422260; Walker AR
Increasing seroprevalence of HIV among high-risk hospitalized patients in Mumbai [letter]: Natl Med J India. 1999 May-Jun;12(3):139-40. Unique Identifier : AIDSLINE MED/99422264; Kamat HA; Koppikar GV; Banker DD
Persistent infection with human T lymphotropic virus type 1 after allogeneic bone marrow transplantation from a seronegative donor [letter]: Bone Marrow Transplant. 1999 Aug;24(3):349. Unique Identifier : AIDSLINE MED/99394753; Kanda Y; Taketazu F; Chiba S; Yazaki Y; Hirai H
Estradiol prevents and testosterone promotes Fas-dependent apoptosis in CD4+ Th2 cells by altering Bcl 2 expression.: Lupus. 1999;8(5):384-7. Unique Identifier : AIDSLINE MED/99394769; Huber SA; Kupperman J; Newell MK; Department of Pathology, University of Vermont, Burlington 05405,; USA.; Coxsackievirus B3 (CVB3) induces myocarditis in male BALB/c mice. Female mice are resistant to viral myocarditis, except in the third trimester of pregnancy and postpartum. Cardiac damage is mediated by T lymphocytes activated during virus infection. Th1 (interferon-gamma+) cell responses promote cardiac injury, while
[Tracing infants born to HIV positive mothers (letter)]: Arch Pediatr. 1999 Aug;6(8):902-3. Unique Identifier : AIDSLINE MED/99401628; Herve F; Chaux MC; Smail A; Dollfus C; Courpotin C
An autopsy case of primary nodal plasmacytoma associated with Sjogren's syndrome [letter]: Pathol Int. 1999 Jun;49(6):577-9. Unique Identifier : AIDSLINE MED/99398193; Watanabe K; Yatabe Y; Narita M; Ogawa T; Mori N; An 81-year-old man with a 1 year history of Sjogren s syndrome and hypergammaglobulinemic purpura was admitted because of high fever and lymphadenopathy. Primary nodal plasmacytoma was suggested from the microscopic and immunohistochemical findings of an inguinal lymph node biopsy specimen. Although chemotherapy achie
Exacerbation of viral and autoimmune animal models for multiple sclerosis by bacterial DNA.: Brain Pathol. 1999 Jul;9(3):481-93. Unique Identifier : AIDSLINE MED/99343431; Tsunoda I; Tolley ND; Theil DJ; Whitton JL; Kobayashi H; Fujinami RS; Department of Neurology, University of Utah School of Medicine,; Salt Lake City 84132, USA.; Theiler s murine encephalomyelitis virus (TMEV) infection and relapsing-remitting experimental allergic encephalomyelitis (R-EAE) have been used to investigate the viral and autoimmune etiology of multiple sclerosis (MS), a possible Th1-type mediated disease. DNA immunization is a novel vaccination strategy in which f
Case of the month: March 1999--A 26 year old HIV positive male with dura based masses.: Brain Pathol. 1999 Jul;9(3):609-10. Unique Identifier : AIDSLINE MED/99343440; Karpinski NC; Yaghmai R; Barba D; Hansen LA; Department of Pathology (Neuropathology), UCSD Medical Center,; San Diego, CA, USA.; A 26-year-old male with AIDS presented with a chief complaint of headaches and neck pain. An MRI revealed two enhancing extra-axial dura based masses, one in the area of the left sphenoid wing and one at the level of C2-3. In both cases, microscopic sections showed actin positive spindle cell neoplasms with long slend
Diagnosis of esophageal ulcers in acquired immunodeficiency syndrome.: Semin Gastrointest Dis. 1999 Jul;10(3):85-92. Unique Identifier : AIDSLINE MED/99362048; Monkemuller KE; Wilcox CM; Department of Medicine, University of Alabama at Birmingham,; 35294-0007, USA.; The esophagus is one of the most common sites of gastrointestinal involvement in human immunodeficiency virus (HIV)-infected patients, with at least 30% of the patients having esophageal symptoms at some point during the course of HIV infection. Esophageal ulcers are commonly caused by infections such as
The quest for novel bioactive peptides utilizing orphan seven-transmembrane-domain receptors.: J Mol Med. 1999 Jun;77(6):495-504. Unique Identifier : AIDSLINE MED/99402049; Hinuma S; Onda H; Fujino M; Discovery Research Division, Takeda Chemical Industries, Ltd.,; Tsukuba, Ibaraki, Japan. Hinuma_Shuji@takeda.co.jp; Various sorts of bioactive molecules including hormones, neurotransmitters, and chemokines transmit signals into cells by binding to so-called seven-transmembrane-domain receptors (7TMRs). The recent progress in cDNA and genome DNA analyses has brought the discovery of numerous genes encoding ligand-unknown orphan 7
Chemokine gene expression in human oral mucosa.: Eur J Oral Sci. 1999 Aug;107(4):231-5. Unique Identifier : AIDSLINE MED/99396013; Zehnder M; Greenspan JS; Greenspan D; Bickel M; Department of Removable Prosthodontics, School of Dental; Medicine, University of Bern, Switzerland.; In order to gain further understanding of the role of chemokines in healthy oral mucosa, we analyzed mRNA expression of the alpha (CXC)-family chemokines IL-8 and GROgamma as well as of the beta (CC)-family chemokines MIP-1alpha, MIP-1beta and MCP-1 in twenty young and healthy subjects with good oral hygiene. Twenty b
Control of cytomegalovirus retinitis after combination antiretroviral therapy.: Acta Ophthalmol Scand. 1999 Aug;77(4):471-3. Unique Identifier : AIDSLINE MED/99391067; Ruhswurm I; Ries E; Krepler K; Derbolav A; Rieger A; Armbruster C; Wedrich A; Department of Ophthalmology, University of Vienna, Medical; School, Austria.; PURPOSE: To report on AIDS patients having combination antiretroviral therapy whose cytomegalovirus ( CMV ) retinitis remained inactive after discontinuation of anti-CMV maintenance therapy. METHODS: We describe the course of C
Emergency department characteristics of male sexual assault.: Acad Emerg Med. 1999 Aug;6(8):792-8. Unique Identifier : AIDSLINE MED/99391191; Pesola GR; Westfal RE; Kuffner CA; Department of Emergency Medicine, Saint Vincent's Hospital, New; York, NY 10011, USA.; OBJECTIVE: To characterize the nature, frequency, and treatment of male sexual assault encountered by physicians in an ED. A minor objective compared the lengths of time the victim knew the assailant between males and females to determine whether there were differences between male and female victims. METHODS: Retrosp
Allo-immunization elicits CD8+ T cell-derived chemokines, HIV suppressor factors and resistance to HIV infection in women.: Nat Med. 1999 Sep;5(9):1004-9. Unique Identifier : AIDSLINE MED/99401079; Wang Y; Tao L; Mitchell E; Bravery C; Berlingieri P; Armstrong P; Vaughan R; Underwood J; Lehner T; Department of Immunobiology, Guy's, King's and St. Thomas'; Medical and Dental Schools at Guy's Hospital, Medical School; Building, 3rd Floor, London SE1 9RT, UK.; We assessed the potential for an allogeneic-based vaccine against HIV infection in women who were allo-immunized with their partners mononuclear leucocytes to prevent spontaneous recurrent abortion. Within 1 month of allo-immunization, there was significant upregulation in the concentrations of CD8 cell-derived suppr
Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library [see comments]: Nat Med. 1999 Sep;5(9):1026-31. Unique Identifier : AIDSLINE MED/99401082; Wong FS; Karttunen J; Dumont C; Wen L; Visintin I; Pilip IM; Shastri N; Pamer EG; Janeway CA Jr; Section of Immunobiology, Yale School of Medicine, 310 Cedar; Street, New Haven, Connecticut 06520-8011, USA.; susan.wong@yale.edu; Type 1 diabetes is an autoimmune disease in which the insulin-producing pancreatic beta cells are destroyed at an early age by an immune process that involves both CD4 and CD8 T lymphocytes. The identification of autoantigens in diabetes is very important for the design of antigen-specific immunotherapy. By screening
Cytomegalovirus US2 destroys two components of the MHC class II pathway, preventing recognition by CD4+ T cells.: Nat Med. 1999 Sep;5(9):1039-43. Unique Identifier : AIDSLINE MED/99401084; Tomazin R; Boname J; Hegde NR; Lewinsohn DM; Altschuler Y; Jones TR; Cresswell P; Nelson JA; Riddell SR; Johnson DC; Department of Molecular Microbiology & Immunology, Oregon Health; Sciences University, Portland, Oregon 97201, USA.; Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus that causes life-threatening disease in patients who are immunosuppressed for bone marrow or tissue transplantation or who have AIDS (ref. 1). HCMV establishes lifelong latent infections and, after periodic reactivation from
MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs.: Nat Med. 1999 Sep;5(9):1048-51. Unique Identifier : AIDSLINE MED/99401086; Schuetz JD; Connelly MC; Sun D; Paibir SG; Flynn PM; Srinivas RV; Kumar A; Fridland A; Department of Pharmaceutical Sciences, St. Jude Children's; Research Hospital, Memphis, Tennessee 38105, USA.; john.schuetz@stjude.org; Dideoxynucleosides, which are potent inhibitors of HIV reverse transcriptase and other viral DNA polymerases, are a common component of highly active anti-retroviral therapy (HAART) (ref. 1). Six reverse transcriptase inhibitors have been approved for human use: azidothymidine; 2 3 -dideoxycytidine; 2 3 -dideoxyinosin
Equivalent amplification of intrinsically variable nucleic acid sequences by multiple-primer-induced overlapping amplification assay: applications for universal detection and quantitation.: Nat Med. 1999 Sep;5(9):1081-5. Unique Identifier : AIDSLINE MED/99401093; Lu W; Cao L; Ty L; Arlie M; Andrieu JM; Laboratoire d'Oncologie et Virologie Moleculaires, Hopital; Laennec, Faculte de Medecine Necker, Universite Rene; Descartes-Paris V, 75007 Paris, France.
Uganda gives lessons in stemming the AIDS epidemic [editorial]: Nat Med. 1999 Sep;5(9):963. Unique Identifier : AIDSLINE MED/99401044
HIV-1 Nef protein: An invitation to a kill [news; comment]: Nat Med. 1999 Sep;5(9):985-6. Unique Identifier : AIDSLINE MED/99401070; Cullen BR
Spotting a killer's target in autoimmune diabetes [news; comment]: Nat Med. 1999 Sep;5(9):992-3. Unique Identifier : AIDSLINE MED/99401075; Benoist C; Mathis D
HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages [see comments]: Nat Med. 1999 Sep;5(9):997-103. Unique Identifier : AIDSLINE MED/99401078; Swingler S; Mann A; Jacque J; Brichacek B; Sasseville VG; Williams K; Lackner AA; Janoff EN; Wang R; Fisher D; Stevenson M; University of Massachusetts Medical Center, Program in Molecular; Medicine, 373 Plantation Street, Worcester, Massachusetts 01605,; USA.; Infection of macrophage lineage cells is a feature of primate lentivirus replication, and several properties of primate lentiviruses seem to have evolved to promote the infection of macrophages. Here we demonstrate that the accessory gene product Nef induces the production of two CC-chemokines, macrophage inflammatory
A new look at hypersensitivity pneumonitis.: Curr Opin Pulm Med. 1999 Sep;5(5):299-304. Unique Identifier : AIDSLINE MED/99390635; Ando M; Suga M; Kohrogi H; First Department of Internal Medicine, Kumamoto University School; of Medicine, Japan.; Hypersensitivity pneumonitis is an immunologically induced lung disease. Although both immune complex-mediated immune response and T cell-mediated immune response are involved in the pathogenesis of the disease, recent studies show the latter mechanism to be more important. As for T cell-mediated immune response, Th1/
On down-regulation of the immune response to metastatic malignant melanoma.: Unique Identifier : AIDSLINE MED/99405747; H~akansson A; Gustafsson B; Krysander L; Hjelmqvist B; Rettrup B; H~akansson L; Department of Oncology, University Hospital, Linkoping, Sweden.; annika.hakansson@lio.se; Treatment of metastatic malignant melanoma with interferon alpha (IFNalpha) results in objective remission in approximately 15% of patients. In a previous investigation, we found that about 50% of the patients achieved at least minor or short-lived remissions. In some tumours extensive areas of regressive tumour chang
Immunoregulation in pancreatic cancer patients.: Cancer Immunol Immunother. 1999 Aug;48(5):270-9. Unique Identifier : AIDSLINE MED/99405749; Plate JM; Shott S; Harris JE; Section of Medical Oncology, Department of Medicine,; Rush-Presbyterian St. Luke's Medical Center, Chicago, IL 60612,; USA. jplate@sispro.sis.rpslmc.edu; Metastatic pancreatic cancer is one of the most aggressive cancer known in man yet specific antitumor immunity has been demonstrated in lymph nodes draining the sites of pancreatic tumors. Despite this immunity, pancreatic cancer patients suffer a quick demise. To further define tumor immunity in patients with metasta
Punctate outer retinal toxoplasmosis in an HIV-positive child.: Ocul Immunol Inflamm. 1999 Jun;7(2):93-5. Unique Identifier : AIDSLINE MED/99350660; Moraes HV Jr; Federal University of Rio de Janeiro, University Hospital,; Department of Ophthalmology, Brazil Rio de Janeiro.; haroldjr@alternex.com.br; PURPOSE: To discover whether the outer layer of the retina can be the site for toxoplasmosis in AIDS patients. METHODS: An HIV-positive child, who previously had a normal ocular examination, was reexamined three months later. This examination showed outer retinal lesions compatible with toxoplasmosis and positive IgM
Cluster formation by protein kinase Ctheta during murine T cell activation: effect of age.: Cell Immunol. 1999 Jul 10;195(1):28-36. Unique Identifier : AIDSLINE MED/99365230; Yang D; Miller RA; Department of Pathology, University of Michigan, Ann Arbor,; Michigan, 48109-0940, USA.; Protein kinase Ctheta; (PKCtheta;) is thought to play an important role in T cell activation, in that exposure of cloned T cells to antigen-presenting cells bearing agonist peptides, but not antagonist peptides, leads to clustering of PKCtheta; molecules in the section of the T cell plasma membrane that is in contact
Bovine insulin and porcine or human insulin prime distinct CD4(+) T cell subsets in C57BL/6 mice.: Cell Immunol. 1999 Jul 10;195(1):66-74. Unique Identifier : AIDSLINE MED/99365234; Long SA; Zimecki M; Kapp JA; Department of Ophthalmology, Emory University, Atlanta, Georgia,; 30322, USA.; H-2(b) mice produce insulin-specific antibody when injected with bovine but not porcine or human insulin. Nevertheless, CD4(+) T cells have been cloned from C57BL/6 mice primed with porcine, human, and bovine insulin. Here we tested the hypothesis that CD4(+) T cells from C57BL/6 mice primed with porcine or human insu
Prevalence of sinonasal symptoms in patients with HIV infection.: Am J Rhinol. 1999 May-Jun;13(3):203-8. Unique Identifier : AIDSLINE MED/99320536; Porter JP; Patel AA; Dewey CM; Stewart MG; Bobby R. Alford Department of Otorhinolaryngology and; Communicative Sciences, Baylor College of Medicine, Houston,; Texas 77030, USA.; Infection with the human immunodeficiency virus (HIV) is increasing in prevalence, and disease patterns are changing as patient survival lengthens. The purpose of this cross-sectional epidemiological study was to assess the prevalence and severity of self-reported symptoms of otolaryngologic disease in a group of pati
Structural and functional characterization of an epitope in the conserved C-terminal region of HIV-1 gp120.: J Pept Res. 1999 Jul;54(1):32-42. Unique Identifier : AIDSLINE MED/99376198; Ferrer M; Sullivan BJ; Godbout KL; Burke E; Stump HS; Godoy J; Golden A; Profy AT; van Schravendijk MR; Department of Molecular and Cellular Biology, Harvard University,; Cambridge, MA 02138, USA.; Through an integrated study of the reactivity of a monoclonal antibody, 803-15.6, with synthetic peptides and native recombinant HIV-1 envelope glycoprotein gp120, we have obtained structure-functional information on a region of rgp120 not yet elucidated by X-ray crystallography. mAb 803-15.6 binds with high affinity
Graft-vs.-host and graft-vs.-leukemia reactions after delayed infusions of donor T-subsets.: Biol Blood Marrow Transplant. 1999;5(3):123-32. Unique Identifier : AIDSLINE MED/99320129; Johnson BD; Becker EE; Truitt RL; Department of Pediatrics, Medical College of Wisconsin, Milwaukee; 53226, USA. bjohnson@mcw.edu; Infusions of donor leukocytes have been given to allogeneic bone marrow recipients after transplant to treat leukemia relapse. Treatment with these delayed infusions of donor cells has been called delayed or donor leukocyte infusion (DLI). While graft-vs.-host disease (GVHD) has typically been less severe than expecte
Depletion of CD34+ CD4+ cells in bone marrow from HIV-1-infected individuals.: Biol Blood Marrow Transplant. 1999;5(3):162-72. Unique Identifier : AIDSLINE MED/99320133; Banda NK; Simon GR; Sipple JD; Terrell KL; Archer P; Shpall EJ; Akkina RK; Myers AM; Harrison GS; Department of Medicine, University of Colorado Health Sciences; Center, Denver 80262, USA. nirmal.banda@uchsc.edu; Pancytopenia as a consequence of bone marrow abnormalities is commonly seen in HIV-infected individuals. To examine the effect that HIV-1 has on hematopoietic cells, we compared hematopoietic properties of bone marrow samples from HTV+ patients at various stages of disease with bone marrow samples from uninfected dono
Generation of anti-p53 cytotoxic T lymphocytes from human peripheral blood using autologous dendritic cells.: Clin Cancer Res. 1999 Jun;5(6):1281-8. Unique Identifier : AIDSLINE MED/99316772; Chikamatsu K; Nakano K; Storkus WJ; Appella E; Lotze MT; Whiteside TL; DeLeo AB; University of Pittsburgh Cancer Institute, Pennsylvania 15213,; USA.; CTLs recognizing the HLA-A2.1-restricted, wild-type sequence p53 epitopes p53(149-157) and p53(264-272) were generated from CD8-enriched populations of nonadherent peripheral blood lymphocytes (PBLs) obtained from healthy donors. The PBLs were restimulated in vitro with peptide-pulsed granulocyte macrophage colony-sti
Antiviral activity of magnesium and magnesium/poly r(A-U) combinations against two RNA viruses.: Nucleosides Nucleotides. 1999 Jun-Jul;18(6-7):1221-2. Unique Identifier : AIDSLINE MED/99403425; Jamison J; Gilloteaux J; Nassiri MR; Tsai CC; Summers J; Department of Urology, Summa Health System/N.E. Ohio Universities; College of Medicine, Rootstown 44272, USA.; Magnesium (Mg2+) potentiated the anti-vesicular stomatitis virus (VSV) activity of poly r(A-U) or poly r(G-C) and the anti-HIV-1 activity of poly r(A-U). Mg2+ did not affect the anti-VSV activity of poly (rI).poly (rC), poly (dA-dT).poly (dA-dT) or poly (dG-dC).poly (dG-dC). Modulation of one or more nuclear (nucleola
Synthesis and biological activity of 2',5'-oligoadenylate trimers containing 5'-terminal 5'-amino-5'-deoxy- and 5'-amino-3',5'-dideoxyadenosine derivatives.: Nucleosides Nucleotides. 1999 Jun-Jul;18(6-7):1483-4. Unique Identifier : AIDSLINE MED/99403436; Kvasyuk EI; Mikhailopulo IA; Suhadolnik RJ; Henderson EE; Muto NF; Iacono KT; Homon J; Pfleiderer W; Institute of Bioorganic Chemistry, Byelorussian Academy of; Sciences, Minsk, Belarus.; Some new 2 ,5 -oligonucleotide trimers containing 5 -terminal 5 -amino-5 -deoxy- and 5 -amino-3 ,5 -dideoxyadenosine derivatives have been synthesized. Some of the trimers showed biological inhibitions of HIV-1 reverse transcriptase (RT), HIV-1 induced syncytia formation and PCR amplification.
Synthesis of oligonucleotide-intercalator conjugates capable to inhibit HIV-1 DNA integration.: Nucleosides Nucleotides. 1999 Jun-Jul;18(6-7):1645-6. Unique Identifier : AIDSLINE MED/99403447; Gottikh MB; Volkov EM; Romanova EA; Oretskaya TS; Shabarova ZA; A.N. Belozersky Institute of Physical Chemical Biology, Lomonosov; Moscow State University, Russia.; This investigation is devoted to design of short switch oligonucleotides mono- or bi-functionnalized with intercalating agents capable to form a stable triplex with HIV integrase-cognate sequences and inhibit selectively HIV integration. Methods of intercalator incorporation at 5 - and/or 3 -terminal positions or on
Binding of chemically-modified oligonucleotides to the double-stranded stem of an RNA hairpin.: Nucleosides Nucleotides. 1999 Jun-Jul;18(6-7):1647-50. Unique Identifier : AIDSLINE MED/99403448; Aupeix K; Toulme JJ; INSERM U 386, IFR Pathologies Infectieuses, Universite Victor; Segalen, Bordeaux, France.; We monitored the binding of triplex-forming oligopyrimidines to the double-stranded stem of the RNA hairpin responsible for the gag-pol frameshift in HIV-1. Whereas the substitution of 5, propynyl-C for C had a limited effect, the use of a Peptide Nucleic Acid 12mer led to a drastic reduction in the stability of the o
Antisense oligodeoxynucleotide complementary to CXCR4 mRNA block replication of HIV-1 in COS cells.: Nucleosides Nucleotides. 1999 Jun-Jul;18(6-7):1705-8. Unique Identifier : AIDSLINE MED/99403459; Kusunoki A; Wada A; Kurosaki N; Kimura T; Takai K; Yamamoto N; Takaku H; Department of Industrial Chemistry, Chiba Institute of; Technology, Japan.; CXCR4 is both a chemokine receptor and an entry co-receptor for the T-cell line-adapted human immunodeficiency virus type 1 (HIV-1). To find a more efficacious therapeutic treatment of acquired immunodeficiency syndrome, we examined the effects of antisense oligonucleotides on CXCR4 production. COS cells, stably expre
Inhibition of HIV-1 integration by mono- & bi-functionalized triple helix forming oligonucleotides.: Nucleosides Nucleotides. 1999 Jun-Jul;18(6-7):1717-8. Unique Identifier : AIDSLINE MED/99403462; Brodin P; Gottikh M; Auclair C; Mouscadet JF; CNRS-UMR 1772, Institut Gustave Roussy, Villejuif, France.; HIV-1 DNA integration is carried out by integrase, a viral protein which binds to specific sequences located on both extremities of the HIV-1 DNA LTR. Inhibition of integration was observed with submicromolar concentrations of mono- or bifunctionalized 11-mer oligonucleotide-intercalators, which were designed to form
Solid state studies of drug-cyclodextrin inclusion complexes in PEG 6000 prepared by a new method.: Eur J Pharm Sci. 1999 Aug;8(4):269-81. Unique Identifier : AIDSLINE MED/99356107; Wulff M; Alden M; Department of Pharmaceutical Chemistry, Physical and Inorganic; Chemistry, Box 574, Biomedical Center, Uppsala University, S-751; 23, Uppsala, Sweden.; The melting method was investigated as a possible method for producing drug-cyclodextrin (CD) inclusion compounds in a carrier. Various solid dispersions of alpha-, beta- and gamma-CD in polyethylene glycol (PEG) 6000 with and without the addition of 5% w/w indomethacin or griseofulvin were prepared using the original
Manipulation of powder characteristics by interactions at the solid-liquid interface: 1-sulphadiazine.: Eur J Pharm Sci. 1999 Aug;8(4):283-90. Unique Identifier : AIDSLINE MED/99356108; Hammouda YE; El-Khordagui LK; Darwish IA; El-Kamel AH; Department of Pharmaceutics, University of Alexandria,; Alexandria, Egypt.; A solvent-treatment technique aiming at manipulating the properties of powdered materials is reported. Potentials of the technique were assessed using sulphadiazine (SD). A suspension of the drug in a preselected solvent (5% aqueous ammonia solution) was stirred under controlled conditions. The solvent was subsequentl
Correlation of anti-HIV activity with structure: use of electrostatic potential and conformational analysis.: Bioorg Med Chem Lett. 1999 Jul 19;9(14):1963-8. Unique Identifier : AIDSLINE MED/99378172; Mickle T; Nair V; Department of Chemistry, The University of Iowa, Iowa City 52242,; USA.; Electrostatic potential distribution, 3-D electron density shapes, and conformational analysis were used to correlate anti-HIV activity or inactivity of AZT , (-) carbovir, oxetanocin A, and 16 isomeric dideoxynucleosides of different families. The str
4-hydroxy-5,6-dihydro-2H-pyran-2-ones.3. Bicyclic and hetero-aromatic ring systems as 3-position scaffolds to bind to S1' and S2' of the HIV-1 protease enzyme.: Bioorg Med Chem Lett. 1999 Jul 19;9(14):2019-24. Unique Identifier : AIDSLINE MED/99378182; Ellsworth EL; Domagala J; Prasad JV; Hagen S; Ferguson D; Holler T; Hupe D; Graham N; Nouhan C; Tummino PJ; Zeikus G; Lunney EA; Department of Chemistry, Parke-Davis Pharmaceutical Research; Division of the Warner-Lambert Company, Ann Arbor, MI 48105, USA.; 5,6-Dihydro-2H-pyran-2-ones are potent inhibitors of HIV-1 protease, which bind to the S1, S2, S1 , and S2 pockets and have a unique binding mode with the catalytic aspartyl groups and the flap region of the enzyme. Efforts to explore 3-position heterocyclic scaffolds that bind to the S1 and S2 pockets have provide
Topical DMSO treatment for pegylated liposomal doxorubicin-induced palmar-plantar erythrodysesthesia.: Cancer Chemother Pharmacol. 1999;44(4):303-6. Unique Identifier : AIDSLINE MED/99376759; Lopez AM; Wallace L; Dorr RT; Koff M; Hersh EM; Alberts DS; Department of Medicine, College of Medicine, University of; Arizona, Tucson, AZ 85724, USA.; PURPOSE: Chemotherapeutic regimens that utilize fluorouracil, cytarabine, and doxorubicin have been shown to cause a dermatologic syndrome known as hand-foot syndrome, or palmar-plantar erythrodysesthesia syndrome (PPES). Pegylated liposomal doxorubicin has proven effective in the treatment of AIDS-related Kaposi s sa
[Long-term effect of lamivudine treatment in chronic hepatitis B virus infection]: Unique Identifier : AIDSLINE MED/99418037; Yao G; Wang B
[Recent advance in neuroimmunology]: Rinsho Shinkeigaku. 1998 Dec;38(12):993-6. Unique Identifier : AIDSLINE MED/99278953; Arimura K; Osame M; 3rd Department of Interna Medicine, Faculty of Medicine,; Kagoshima University.; Many important reports have been published during these several years in Japan in the field of neuroimmunology. Serum vascular endothelial factor (VEGF) levels in Crow-Fukase (POEMS) syndrome were about 15 to 30 times than those in the control subjects and other neurological disorde
[A case of limbic encephalitis associated with breast cancer developed in an HTLV-1 carrier]: Rinsho Shinkeigaku. 1999 May;39(5):555-9. Unique Identifier : AIDSLINE MED/99352948; Kikuchi A; Chida K; Misu T; Okita N; Takase S; Nagata T; Sakai K; Itoyama Y; Department of Neurology, Kohnan Hospital.; We here present a case of 44-year-old woman, a carrier of human T-lymphotrophic virus type-1 (HTLV-1), who suffered from limbic encephalitis and breast cancer. In December 1997, the patient s behavior became abnormal. Three weeks later, she became markedly forgetful. At that time neurological examinations revealed tha
Mediastinal lymphadenitis due to cryptococcal infection in HIV-positive patients on highly active antiretroviral therapy [letter]: Chest. 1999 Sep;116(3):848-9. Unique Identifier : AIDSLINE MED/99420058; Lanzafame M; Trevenzoli M; Carretta G; Lazzarini L; Vento S; Concia E
Prospective study of healing time after hemorrhoidectomy: influence of HIV infection, acquired immunodeficiency syndrome, and anal wound infection.: Dis Colon Rectum. 1999 Sep;42(9):1140-4. Unique Identifier : AIDSLINE MED/99424872; Morandi E; Merlini D; Salvaggio A; Foschi D; Trabucchi E; I Department of Surgery, Institute of Biomedical Science L.; Sacco, University of Milan, Italy.; PURPOSE: Hemorrhoids and rectal diseases are very frequent in HIV-positive patients, especially in those with homosexual habits. This study was designed to compare posthemorrhoidectomy healing time in such patients, and evaluate the role of various factors related to their HIV-positive status. METHODS: The study invol
Changing epidemiology of anorectal melanoma.: Dis Colon Rectum. 1999 Sep;42(9):1203-8. Unique Identifier : AIDSLINE MED/99424882; Cagir B; Whiteford MH; Topham A; Rakinic J; Fry RD; Department of Surgery, Jefferson Medical College, Thomas; Jefferson University Hospital, Philadelphia, Pennsylvania 19107,; USA.; PURPOSE: We reviewed 117 cases of anorectal melanoma to better define epidemiologic and survival characteristics of this rare neoplasm. METHODS: The National Cancer Institute Surveillance, Epidemiology, and End Results database covering the period 1973 through 1992 was used. This represents 9.5 percent of the
Nutritional status of adult inpatients in Bujumbura, Burundi (impact of HIV infection).: Eur J Clin Nutr. 1999 Jul;53(7):579-82. Unique Identifier : AIDSLINE MED/99379482; Niyongabo T; Henzel D; Ndayishimyie JM; Melchior JC; Ndayiragije A; Ndihokubwayo JB; Nikoyagize E; Rwasa T; Aubry P; Larouze B; Departement de Medecine Interne, CHU de Bujumbura, Burundi.; OBJECTIVE: To determine the prevalence and analyse the characteristics and causes of malnutrition among inpatients in an HIV highly endemic area. DESIGN: Prospective cross-sectional study. SETTING: Department of Internal Medicine, University Hospital, Bujumbura, Burundi . SUBJECTS:
Rare AIDS-defining diseases in the Swiss HIV Cohort Study.: Eur J Clin Microbiol Infect Dis. 1999 Jun;18(6):399-402. Unique Identifier : AIDSLINE MED/99369020; Burckhardt B; Sendi P; Pfluger D; Zimmerli W; Nuesch R; Bucher HC; Drewe J; Gyr N; Battegay M; Outpatient Department of Internal Medicine, University of Basel,; Switzerland.; The objective of this study was to investigate the spectrum and frequency of rare AIDS-defining diseases in the Swiss HIV Cohort Study. AIDS-defining diseases contributing less than 1% to the absolute number of all recorded AIDS-defining diseases in at least one of five periods (1988-1990, 1991-1992, 1993-1994, 1995-1
Usefulness of genotypic analysis of resistance to nucleoside analogues in the clinical setting.: Eur J Clin Microbiol Infect Dis. 1999 Jun;18(6):448-9. Unique Identifier : AIDSLINE MED/99369030; Perez-Olmeda M; Rodriguez-Rosado R; Gomez-Cano M; Briones C; Soriano V; Service of Infectious Diseases, Hospital Carlos III, Instituto de; Salud Carlos III, Madrid, Spain.; The introduction of drug resistance testing during clinical care of patients infected with the human immunodeficiency virus (HIV) is still a matter for discussion. Thirty-seven HIV-infected subjects who had positive plasma viraemia despite undergoing antiretroviral therapy were tested for the presence of genotypic mut
Functional expression of the fractalkine (CX3C) receptor and its regulation by lipopolysaccharide in rat microglia.: Eur J Pharmacol. 1999 Jun 18;374(2):309-13. Unique Identifier : AIDSLINE MED/99349635; Boddeke EW; Meigel I; Frentzel S; Biber K; Renn LQ; Gebicke-Harter P; Department of Medical Physiology, University of Groningen,; Netherlands. h.w.g.m.boddeke@med.rug.nl; Functional expression of CX3CR1, a recently discovered receptor for the chemokine fractalkine, was investigated in cultured rat microglia. Reverse transcriptase polymerase chain reaction (PCR) experiments show abundant expression of fractalkine receptor mRNA in microglia. mRNA expression of fractalkine was undetectabl
Simulation studies of phase III clinical trials to test the efficacy of a candidate HIV-1 vaccine.: Epidemiol Infect. 1999 Aug;123(1):65-88. Unique Identifier : AIDSLINE MED/99415584; Desai KN; Boily MC; Masse BR; Alary M; Anderson RM; CHA-Pavillon St-Sacrement, Groupe de recherche en; epidemiologie, Quebec, Quebec, Canada.; One question of particular importance in phase III HIV vaccine trials is the choice of efficacy measure (EM) to validly and precisely estimate the true vaccinal efficacy. Traditional EMs, based on hazard rate ratio (HRR) or cumulative incidence ratio (CIR) are time-sensitive to mode of vaccine action and population he
Risk factors for monoinfections and coinfections with HIV, hepatitis B and hepatitis C viruses in northern Spanish prisoners.: Epidemiol Infect. 1999 Aug;123(1):95-102. Unique Identifier : AIDSLINE MED/99415586; Pallas J; Farinas-Alvarez C; Prieto D; Llorca J; Delgado-Rodriguez M; Provincial Prison, Santander, Spain.; A cross-sectional study was conducted in prisons of Cantabria (northern Spain ) from June 1992 to December 1994. Inmates were asked to participate in a survey on prevalence and risk factors for monoinfections and coinfections with HIV, HBV and HCV. Crude and multiple odds ratios of r
Parentification and its impact on adolescent children of parents with AIDS.: Fam Process. 1999 Summer;38(2):193-208. Unique Identifier : AIDSLINE MED/99336058; Stein JA; Riedel M; Rotheram-Borus MJ; Department of Psychology, University of California, Los Angeles; 90095-1563, USA. jastein@ucla.edu; Parentification refers to children or adolescents assuming adult roles before they are emotionally or developmentally ready to manage those roles successfully. We assess predictors and outcomes of parentification among adolescent children of Parents with AIDS (PWAs) in two phases. In Phase 1, relationships among paren
Seroprevalence of syphilis, human immunodeficiency virus type-1, and hepatitis B virus infections among pregnant women in Turkey.: Int J Gynaecol Obstet. 1999 Aug;66(2):171-2. Unique Identifier : AIDSLINE MED/99396418; Nas T; Taner MZ; Yildiz A; Gazi University Hospital, Besevler, Ankara, Turkey.
Human immunodeficiency virus infection in pregnant women in Nigeria.: Int J Gynaecol Obstet. 1999 Aug;66(2):183-4. Unique Identifier : AIDSLINE MED/99396423; Sagay AS; Imade GE; Nwokedi EE; Department of Obstetrics and Gynaecology, Jos University Teaching; Hospital, Nigeria. sagays@unijos.edu.ng
Onset of type 1 diabetes: a dynamical instability.: Diabetes. 1999 Sep;48(9):1677-85. Unique Identifier : AIDSLINE MED/99408471; Freiesleben De Blasio B; Bak P; Pociot F; Karlsen AE; Nerup J; Niels Bohr Institute, Copenhagen, Denmark.; Type 1 diabetes is a disease characterized by progressive loss of beta-cell function due to an autoimmune reaction affecting the islets of Langerhans. It is now generally accepted that cytokines are implicated in the pathogenesis of autoimmune diseases. Animal studies have shown that interleukin-1beta, tumor necrosis
Neonatal porcine islet cells induce human CD4+, but not CD8+, lymphocyte proliferation and resist cell-mediated cytolytic injury in vitro.: Diabetes. 1999 Sep;48(9):1713-9. Unique Identifier : AIDSLINE MED/99408476; Murray AG; Nelson RC; Rayat GR; Elliott JF; Korbutt GS; Department of Medicine, University of Alberta, Edmonton, Canada.; amurray@mercury.uah.ualberta.ca; Xenotransplantation of porcine tissue to human recipients promises to alleviate the organ shortage. Human antibody-mediated and cell-mediated immune responses against porcine grafts, however, represent barriers to successful xenotransplantation. We compared neonatal porcine islet cells (NPICs) and neonatal porcine spl
Protection against HIV infection for medical trainees outside the United States.: Fam Med. 1999 Jul-Aug;31(7):495-500. Unique Identifier : AIDSLINE MED/99354263; Markle WH; Department of Family Medicine and Clinical Epidemiology,; University of Pittsburgh, USA. whm@mars.upmc.edu; BACKGROUND AND OBJECTIVES: The increase in HIV infection rates around the world has created concern among medical educators for the safety of students and residents taking overseas electives. In some areas, the HIV adult positivity rate is 15%-20% or higher. Medical schools and residency programs need to make policies
Clinical application of adoptive immunotherapy and IL-2 for the treatment of advanced digestive tract cancer.: Hepatogastroenterology. 1999 May;46 Suppl 1:1274-9. Unique Identifier : AIDSLINE MED/99357043; Ueda Y; Yamagishi H; Tanioka Y; Fujiwara H; Fuji N; Itoh T; Fujiki H; Yoshimura T; Oka T; Second Department of Surgery, Kyoto Prefectural University of; Medicine, Japan.; BACKGROUND/AIMS: We investigated the clinical efficacy of systemic and locoregional adoptive immunotherapy (AIT) with or without interleukin-2 ( IL-2 ) against solid metastatic lesions from digestive tract cancer, which are refractory to conventional chemotherapy or radi
Enteric pathogens in southern Indian HIV-infected patients with & without diarrhoea.: Indian J Med Res. 1999 Mar;109:85-9. Unique Identifier : AIDSLINE MED/99419587; Mukhopadhya A; Ramakrishna BS; Kang G; Pulimood AB; Mathan MM; Zachariah A; Mathai DC; Wellcome Trust Research Laboratory, Department of; Gastrointestinal Sciences, Christian Medical College Hospital,; Vellore.; This study was undertaken to determine the carriage rate of various enteric pathogens in southern Indian patients with HIV infection, both with and without diarrhoea. Stool from 111 consecutive HIV-positive patients (50 without and 61 with diarrhoea) was examined by microscopy and culture. Jejunal biopsy and fluid exa
Repetition of the mother-infant dyad and the process of dying in the psychotherapy of an HIV-positive man.: J Am Acad Psychoanal. 1999 Summer;27(2):191-203. Unique Identifier : AIDSLINE MED/99390719; Des Rosiers P; McGill University, Department of Psychiatry.
A new potent HIV-1 reverse transcriptase inhibitor. A synthetic peptide derived from the interface subunit domains.: J Biol Chem. 1999 Aug 27;274(35):24941-6. Unique Identifier : AIDSLINE MED/99386978; Morris MC; Robert-Hebmann V; Chaloin L; Mery J; Heitz F; Devaux C; Goody RS; Divita G; Biophysics Department, Centre de Recherches de Biochimie; Macromoleculaire, CNRS, 1919 Route de Mende, 34283 Montpellier,; Cedex 5, France.; The biologically relevant and active forms of human immunodeficiency viruses type 1 and 2 reverse transcriptase found in infectious virions are heterodimers produced in a two-step dimerization process. Dimerization involves first the rapid association of the two subunits, followed by a slow conformational change yield
Self-association of Puralpha is mediated by RNA.: J Cell Biochem. 1999 Sep 1;74(3):334-48. Unique Identifier : AIDSLINE MED/99341941; Gallia GL; Darbinian N; Johnson EM; Khalili K; Center for NeuroVirology and NeuroOncology, MCP Hahnemann; University, Philadelphia, Pennsylvania 19102, USA.; The 322 amino acid cellular protein, Puralpha, is a sequence-specific single-stranded DNA-binding protein implicated in control of transcription and replication. Previous studies have demonstrated that the interaction between Puralpha and its target DNA sequence results in the formation of multimeric complexes. In thi
Detection of dendritic cells in the non-obese diabetic (NOD) mouse islet pancreas infiltrate is correlated with Th2-cytokine production.: J Cell Biochem. 1999 Sep 1;74(3):447-57. Unique Identifier : AIDSLINE MED/99341950; Papaccio G; De Luca A; De Luca B; Pisanti FA; Zarrilli S; Institute of Histology and Embryology, School of Medicine, Second; University of Naples, 80138 Naples, Italy. gpapacc@tin.it; We investigate the role played by dendritic cells (DCs) in the non-obese diabetic (NOD) mouse pancreas. The early peri-islet, nondestructive infiltration phase, and intra-islet, destructive infiltration phase, which immediately precedes overt diabetes, are studied. Results show that infiltrating cells are Ia-b, ICAM-1
American Academy of Dermatology 1999 Awards for Young Investigators in Dermatology. Active transcription of human herpesvirus 8 cellular homologue genes and HIV-1 tat in various forms of Kaposi's sarcoma.: J Am Acad Dermatol. 1999 Sep;41(3 Pt 1):458-9. Unique Identifier : AIDSLINE MED/99430845; Moore AY; The University of Texas Medical Branch at Galveston, USA.
Striae formation in two HIV-positive persons receiving protease inhibitors.: J Am Acad Dermatol. 1999 Sep;41(3 Pt 1):467-9. Unique Identifier : AIDSLINE MED/99389770; Darvay A; Acland K; Lynn W; Russell-Jones R; Department of Dermatology, Ealing Hospital, London, United; Kingdom.; Steroidal side effects such as buffalo hump and visceral abdominal fat accumulation have been reported in association with protease inhibitors . We report two cases of severe disfiguring striae formation in patients with HIV who recently started
Oral candidiasis in children with immune suppression: clinical appearance and therapeutic considerations.: ASDC J Dent Child. 1999 May-Jun;66(3):161-6, 154. Unique Identifier : AIDSLINE MED/99405268; Flaitz CM; Hicks MJ; Department of Stomatology, University of Texas-Houston Health; Science Center, USA.; Children and adolescents with immune compromise and suppression are particularly susceptible to the development of oral candidiasis. In fact, oral candidiasis is the most common oral manifestation in HIV-infected children. Oral candidiasis has been linked to a depressed immune system, more rapid progression to AIDS, m
The detection of viral genomes by polymerase chain reaction in the myocardium of pediatric patients with advanced HIV disease.: J Am Coll Cardiol. 1999 Sep;34(3):857-65. Unique Identifier : AIDSLINE MED/99411771; Bowles NE; Kearney DL; Ni J; Perez-Atayde AR; Kline MW; Bricker JT; Ayres NA; Lipshultz SE; Shearer WT; Towbin JA; Department of Pediatrics, Baylor College of Medicine, Houston,; Texas 77030, USA.; OBJECTIVES: The aim of this study was to investigate the frequency of viral nucleic acid detection in the myocardium of human immunodeficiency virus (HIV)-infected children to determine whether an association exists with the development of heart disease. BACKGROUND: As improved medical interventions increase the life
Nevirapine-induced cutaneous hypersensitivity reactions and successful tolerance induction.: J Allergy Clin Immunol. 1999 Aug;104(2 Pt 1):504-5. Unique Identifier : AIDSLINE MED/99382355; Demoly P; Messaad D; Fabre J; Reynes J; Bousquet J; Department of Maladies Respiratoires, Institut National de la; Sante et de la Recherche Medicale U454-IFR3, Hopital Arnaud de; Villeneuve, and Centre Hospitalier Universitaire, Montpellier,; France.
Measurement of body composition in people with HIV/AIDS: a comparison of bioelectrical impedance and skinfold anthropometry with dual-energy x-ray absorptiometry.: J Am Diet Assoc. 1999 Sep;99(9):1109-11. Unique Identifier : AIDSLINE MED/99420513; Batterham MJ; Garsia R; Greenop P; Department of Nutrition and Dietetics, Royal Prince Alfred; Hospital, Camperdown, NSW, Australia.
[Orbital lymphoma and AIDS. Apropos of a case]: J Fr Ophtalmol. 1999 May;22(5):594-8. Unique Identifier : AIDSLINE MED/99346478; Than-Trong T; Morel X; D'Hermies F; Dighiero P; Le Tourneau A; Audouin J; Diebold J; Delmer A; Zittoun R; Renard G; Service d'ophtalmologie du Pr. Renard, Hotel Dieu, Paris.; We report the case of a 33-year-old HIV-seropositive male who had a large cell Epstein-Barr virus-associated non-Hodgkin s orbital lymphoma. A thorough medical examination enabled us to find on thoracic CT-scan a mediastinal lymph node involvement as large as 18 cm in diameter. The regression of the tumor was dramatic
The effects of HIV viral load on the phagocytic activity of monocytes activated with lipopolysaccharide from oral microorganisms.: Immunopharmacol Immunotoxicol. 1999 Aug;21(3):421-38. Unique Identifier : AIDSLINE MED/99395566; Baqui AA; Meiller TF; Zhang M; Falkler WA Jr; Department of Oral Medicine, Dental School, University of; Maryland, Baltimore 21201, USA.; A study was undertaken to determine whether viral load status in HIV+ patients has any potential effect on monocyte phagocytic function both before and after challenge of the monocytes with lipopolysaccharide (LPS) isolated from oral microorganisms. LPS of two putative periodontal pathogens Porphyromonas gingivalis (P
[The disinfection of non-autoclavable hysteroscopes in gynecology. Proposition of a protocol and organization of its management]: J Gynecol Obstet Biol Reprod (Paris). 1999 Jul;28(4):381-3. Unique Identifier : AIDSLINE MED/99409439; Cravello L; Cailleux J; Roger V; Bretelle F; Blanc B; Service de Gynecologie-Obstetrique B, Hopital de la; Conception, Marseille.; Iatrogenic infections may result from diagnostic hysteroscopy in case of non autoclavable equipment (such as fibrohysteroscopes) and because of new infectious agents (such as HIV, hepatitis, ...). The equipment should be completely and thoroughly disinfected according to the manufacturer s instructions to prevent infe
The role of HBV DNA quantitative PCR in monitoring the response to interferon treatment in chronic hepatitis B virus infection.: J Hepatol. 1999 Jun;30(6):965-9. Unique Identifier : AIDSLINE MED/99332804; Nagata I; Colucci G; Gregorio GV; Cheeseman P; Williams R; Mieli-Vergani G; Vergani D; Institute of Hepatology, University College London Medical School; and Hospital, Denmark Hill, UK.; BACKGROUND/AIMS: To investigate whether the measurement of HBV DNA by quantitative polymerase chain reaction (PCR) is helpful in monitoring response to interferon treatment in chronic hepatitis B virus infection, we have determined sequentially serum levels of HBV DNA during and up to 18 months after treatment, in 10
Treatment of T lymphocytes with 8-methoxypsoralen plus ultraviolet A induces transient but biologically active Th1-skewing cytokine production.: J Invest Dermatol. 1999 Aug;113(2):202-8. Unique Identifier : AIDSLINE MED/99399290; Tokura Y; Seo N; Yagi H; Wakita H; Moriwaki S; Furukawa F; Takigawa M; Department of Dermatology, Hamamatsu University School of; Medicine, Japan.; 8-Methoxypsoralen plus ultraviolet A light is suggested to shift T lymphocytes from Th2 to Th1 cells. To clarify this issue, we examined the effects of 8-methoxypsoralen/ultraviolet A on the expression/production of cytokines in peripheral blood mononuclear cells from normal subjects and a Sezary syndrome patient. 8-M
[Evaluation of a new screening assay kit for the combined detection of HIV p24 antigen and antibody--comparison of the performance of the new kit and HIV antibody assay kits]: Kansenshogaku Zasshi. 1999 Jul;73(7):681-8. Unique Identifier : AIDSLINE MED/99411018; Hayashi T; Watanabe S; Kondo M; Saito T; Imai M; Department of Virology, Kanagawa Prefectural Public Health; Laboratory.; DUO is an automated HIV infection screening test kit based on the combined detection of p24 Ag and anti-HIV-1 and anti-HIV-2 IgG in human sera or plasma using the ELFA technique (Enzyme-Linked Fluorescent Assay). The performance of DUO was compared with that of HIV-1/HIV-2 3rd generation EIA plus and particle agglutin
[Granular lymphocyte-proliferative disorder following initiation of protease inhibitor therapy in a patient with acquired immunodeficiency syndrome]: Kansenshogaku Zasshi. 1999 Jul;73(7):702-6. Unique Identifier : AIDSLINE MED/99411021; Tanaka K; Honda J; Shiraishi K; Jojima H; Tanaka M; Okubo Y; Fukahori S; Fujimatsu Y; Oizumi K; First Department of Internal Medicine, Kurume University School; of Medicine.; The authors experienced granular lymphocyte-proliferative disorder (GLPD) with increased lymphocyte and CD4 cell counts after HIV treatment with a protease inhibitor indinavir in a 51-year-old male AIDS patient. GLPD proved to be the chronic type, but
Co-expression of a trans-dominant negative mutant of the human immunodeficiency virus type 1 (HIV-1) Rev protein affects the Rev-dependent splicing pattern and expression of HIV-1 RNAs.: J Gen Virol. 1999 Aug;80 ( Pt 8):1965-74. Unique Identifier : AIDSLINE MED/99394668; Szilvay AM; Boe SO; Kalland KH; Department of Molecular Biology, The Gade Institute, University; of Bergen, Norway. Anne.Szilvay@mbi.uib.no; Trans-dominant negative mutants of the human immunodeficiency virus type 1 (HIV-1) regulatory protein Rev inhibit the function of wild-type Rev in a dose-dependent manner. This was previously shown to be caused by nuclear retention of the wild-type protein. In the present work, further analysis of the trans-dominant n
Mutations in the env gene of human immunodeficiency virus type 1 NDK isolates and the use of African green monkey CXCR4 as a co-receptor in COS-7 cells.: J Gen Virol. 1999 Aug;80 ( Pt 8):1975-82. Unique Identifier : AIDSLINE MED/99394669; Dumonceaux J; Chanel C; Valente S; Quivet L; Briand P; Hazan U; INSERM Unite 380 Laboratoire de Genetique et Pathologie; Experimentales, Institut Cochin de Genetique Moleculaire,; Paris, France.; A previous report from this laboratory described the isolation of the first CD4-independent human immunodeficiency virus type 1 isolate, m7NDK. This independence of CD4 is due to seven mutations located in the C2, V3 and C3 regions of the gp120 protein. The present report describes the entry features of the m5NDK viru
Manganese cations increase the mutation rate of human immunodeficiency virus type 1 ex vivo.: J Gen Virol. 1999 Aug;80 ( Pt 8):1983-6. Unique Identifier : AIDSLINE MED/99394670; Vartanian JP; Sala M; Henry M; Wain-Hobson S; Meyerhans A; Institut Pasteur, Unite de Retrovirologie Moleculaire, Paris,; France. jpvart@pasteur.fr; Human immunodeficiency virus (HIV) reverse transcription is an error-prone process with an overall mutation rate of approximately 3.4 x 10(-5) per base per replication cycle. This rate can be modulated by changes in different components of the retrotranscription reaction. In particular, in vitro substitution of magnes
Human neutralizing human immunodeficiency virus type 2-specific Fab molecules generated by phage display.: J Gen Virol. 1999 Aug;80 ( Pt 8):1987-93. Unique Identifier : AIDSLINE MED/99394671; Bjorling E; von Garrelts E; Morner A; Ehnlund M; Persson MA; Microbiology and Tumorbiology Center, Karolinska Institute,; Stockholm, Sweden. ewa.bjorling@mtc.ki.se; A panel of human immunodeficiency virus type 2 (HIV-2)-neutralizing, recombinant Fab fragments was generated by using the phage display technique. The combinatorial library was derived from an asymptomatic, HIV-2-seropositive individual and constructed on the surface of filamentous phage by using the pComb3 phagemid v
Identification and phylogenetic characterization of a human T-cell leukaemia virus type I isolate from a native inhabitant (Rapa Nui) of Easter Island.: J Gen Virol. 1999 Aug;80 ( Pt 8):1995-2001. Unique Identifier : AIDSLINE GENBANK/AF132300; Ohkura S; Yamashita M; Cartier L; Tanabe DG; Hayami M; Sonoda S; Tajima K; Laboratory of Viral Pathogenesis, Research Center for AIDS,; Institute for Virus Research, Kyoto University, Japan.; Human T-cell leukaemia virus type I (HTLV-I) is endemic in Melanesia, one of the three ethnogeographic regions of the Pacific; in the other two regions, Polynesia and Micronesia , the incidence of the virus is relatively low. In an e
Herpes simplex virus type 1 infection has two separate modes of spread in three-dimensional keratinocyte culture.: J Gen Virol. 1999 Aug;80 ( Pt 8):2149-55. Unique Identifier : AIDSLINE MED/99394690; Hukkanen V; Mikola H; Nykanen M; Syrjanen S; Department of Virology, University of Turku, Finland.; This study describes the outcome of herpes simplex virus type 1 (HSV-1) infection in an organotypic raft culture of spontaneously immortalized HaCat keratinocytes and human fibroblasts, as related to the virus load and epithelial stratification and differentiation. In this model, a confluent monolayer of HaCat keratin
Transcriptional activation by the human herpesvirus-8-encoded interferon regulatory factor.: J Gen Virol. 1999 Aug;80 ( Pt 8):2205-9. Unique Identifier : AIDSLINE MED/99394696; Roan F; Zimring JC; Goodbourn S; Offermann MK; Winship Cancer Center, Emory University, Atlanta, GA 30322, USA.; Human herpesvirus-8 (HHV-8), a gammaherpesvirus that is thought to be the viral aetiologic agent of Kaposi s sarcoma and primary effusion lymphoma, encodes a homologue to cellular interferon regulatory factors (IRFs). The HHV-8 IRF homologue (vIRF; ORF K9) has previously been shown to inhibit gene induction by interfe
A comparison of HIV/AIDS knowledge among high school freshmen and senior students.: J Community Health Nurs. 1999;16(3):151-63. Unique Identifier : AIDSLINE MED/99407947; Hancock T; Mikhail BI; Santos A; Nguyen A; Nguyen H; Bright D; Kern Medical Center, Bakersfield, California, USA.; Statistical data show that heterosexual transmission of AIDS among teenagers is a significant problem. The purpose of this study was to assess and compare the level of knowledge concerning HIV/AIDS among high school freshmen- and senior-level students and to determine the association between certain demographic variab
Influence of antimicrobial treatment on mortality in septicemia.: J Chemother. 1999 Jun;11(3):179-86. Unique Identifier : AIDSLINE MED/99362031; Behrendt G; Schneider S; Brodt HR; Just-Nubling G; Shah PM; Department of Medicine, Universitatsklinikum, Frankfurt am Main,; Germany.; OBJECTIVE: To determine the influence of antimicrobial therapy and of predisposing illness on the septicemia mortality rate. METHOD: All blood-culture-positive episodes of septicemia in the Department of Medicine at the University Hospital in Frankfurt between 1989 and 1993 were entered on a database. Underlying illne
Cytomegalovirus antigenemia surveillance in the treatment of cytomegalovirus disease in AIDS patients.: J Chemother. 1999 Jun;11(3):195-202. Unique Identifier : AIDSLINE MED/99362034; Carton JA; Rodriguez-Guardado A; Melon S; Maradona JA; De Ona M; Asensi V; Infectious Diseases Department, Hospital Central de Asturias,; Universidad de Oviedo, Spain.; OBJECTIVE: Surveillance of quantitative cytomegalovirus ( CMV ) antigenemia among AIDS patients with CMV treated complications in order to determine its value in assessing the response to treatment and survival. METHODS: A long
Successful treatment of cytomegalovirus colitis with ganciclovir in a patient with adult T cell leukemia lymphoma: case report.: J Chemother. 1999 Jun;11(3):215-9. Unique Identifier : AIDSLINE MED/99362038; Oshima Y; Nishida K; Kawazoye S; Noda T; Arima F; Miyahara M; Higashijima M; Yanaga T; Department of Hematology, Takagi Hospital, Ohkawa-city, Fukuoka,; Japan. oshima@i.kyushu-u.ac.jp; An 84-year-old patient with adult T cell leukemia lymphoma (ATLL) developed diarrhea on day 5 of chemotherapy and was diagnosed with cytomegalovirus ( CMV ) colitis. Sigmoidoscopy revealed multiple superficial erosions surround
Gastric and gingival localization of mucosa-associated lymphoid tissue (MALT) lymphoma. An immunohistochemical, virological and clinical case report.: J Periodontol. 1999 Aug;70(8):914-8. Unique Identifier : AIDSLINE MED/99404551; Margiotta V; Franco V; Rizzo A; Porter S; Scully C; Di Alberti L; Department of Oral Medicine, University of Palermo, Italy.; vamargio@tin.it; Non-Hodgkin s lymphomas (NHL) of the mucosa-associated lymphoid tissue (MALT) are characterized by their mucosal and glandular tissue localization. The case described here falls into the European-American classification of a low-grade B-cell lymphoma of the MALT type, with a gingival lesion 2 years after a gastric les
Telomere dynamics in monkeys: increased cell turnover in macaques infected with chimeric simian-human immunodeficiency viruses.: J Med Primatol. 1999 Feb;28(1):1-10. Unique Identifier : AIDSLINE MED/99299750; Shibata R; Feng YR; Gee D; Norwood D; Xiao X; Zeichner SL; Martin MA; Dimitrov DS; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.; To address the question of how cell turnover is affected by retroviral infections, we used the telomeric terminal restriction fragments (TRFs) as markers of cell replicative history and measured their length in macaques infected with chimeric simian-human immunodeficiency viruses (SHIVs). The TRF lengths of mononuclea
Solution structure of the capsid protein from the human T-cell leukemia virus type-I.: J Mol Biol. 1999 Aug 13;291(2):491-505. Unique Identifier : AIDSLINE PDB/1QRJ; Khorasanizadeh S; Campos-Olivas R; Summers MF; Howard Hughes Medical Institute and Department of Chemistry and; Biochemistry, University of Maryland Baltimore County, Baltimore,; MD, 21250, USA.; The solution structure of the capsid protein (CA) from the human T-cell leukemia virus type one (HTLV-I), a retrovirus that causes T-cell leukemia and HTLV-I-associated myelopathy in humans, has been determined by NMR methods. The protein consists of independent N and C-terminal domains connected by a flexible linker.
Potential use of a caspase against HIV.: JAMA. 1999 Sep 15;282(11):1021-2. Unique Identifier : AIDSLINE MED/99420931; Finkel TH; Division of Basic Sciences, National Jewish Medical and Research; Center, Denver, Colo, USA. finkelt@email.chop.edu
Admission trends in a rural South African hospital during the early years of the HIV epidemic.: JAMA. 1999 Sep 15;282(11):1087-91. Unique Identifier : AIDSLINE MED/99420953; Floyd K; Reid RA; Wilkinson D; Gilks CF; Division of Tropical Medicine, Liverpool School of Tropical; Medicine, England. kfloyd@liverpool.ac.uk; CONTEXT: Few studies have attempted to quantify the effect of the epidemic of human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) on demand for health care in developing countries. More data are required to improve understanding of its impact and to guide development of appropriate response st
[Current strategies for treatment of CMV retinitis in patients with AIDS]: Klin Monatsbl Augenheilkd. 1999 Jul;215(1):4-9. Unique Identifier : AIDSLINE MED/99377753; Luke C; Bartz-Schmidt KU; Walter P; Heimann K; Abteilung fur Netzhaut- und Glaskorperchirurgie der; Universitat Koln.; BACKGROUND: CMV retinitis is the most common manifestation of active CMV infection in patients with AIDS. Before ganciclovir became available, the prognosis of CMV retinitis was very poor. Meanwhile a number of strategies for the management of CMV retinitis have
Absence of Kaposi's sarcoma-associated herpesvirus (KSHV) in bone marrow cells from Japanese myeloma patients [letter]: Leukemia. 1999 Sep;13(9):1465-6. Unique Identifier : AIDSLINE MED/99418726; Harada N; Hata H; Matsuno F; Sonoki T; Kuribayashi N; Matsuzaki H; Mitsuya H
[Dynamics of immunoglobulin production in non infected children born from HIV-1 infected mothers: effect of zidovudine]: Med Clin (Barc). 1999 May 1;112(15):568-71. Unique Identifier : AIDSLINE MED/99293716; Resino S; Gurbindo MD; Bellon JM; Jimenez JL; Leon JA; Navarro J; Munoz-Fernandez MA; Division de Inmunologia, Hospital General Universitario; Gregorio Maranon, Madrid.; BACKGROUND: To evaluate the possible effect of zidovudine (ZDV) on inmunoglobins production in infants born to HIV-1 infected women. SUBJECTS AND METHODS: We have studied the immunoglobulins serum levels in 57 non-infected children born to HIV-infected mothers. The children were divided into two groups: group A, 28 ch
[Anorectal Hodgkin disease in an HIV-infected patient (letter)]: Med Clin (Barc). 1999 May 1;112(15):598-9. Unique Identifier : AIDSLINE MED/99293727; Marquez-Moreno AJ; Rubio-Garrido J; Rueda-Dominguez A; Blanes Berenguel A
[Serious accusations against HIV-positive persons (letter)]: Lakartidningen. 1999 Sep 8;96(36):3759-60. Unique Identifier : AIDSLINE MED/99430178; Backekihl U
Court order for HIV-1 test for baby.: Lancet. 1999 Sep 11;354(9182):884. Unique Identifier : AIDSLINE MED/99418477; Brahams D; Old Square Chambers, Gray's Inn, London, UK.
Efficacy of azithromycin in prevention of Pneumocystis carinii pneumonia: a randomised trial. California Collaborative Treatment Group.: Lancet. 1999 Sep 11;354(9182):891-5. Unique Identifier : AIDSLINE MED/99418479; Dunne MW; Bozzette S; McCutchan JA; Dube MP; Sattler FR; Forthal D; Kemper CA; Havlir D; Pfizer Central Research, Groton, CT 06340, USA. dunnem@pfizer.com; BACKGROUND: Azithromycin in combination with sulphonamides is active against Pneumocystis carinii pneumonia (PCP) in animals. We assessed the clinical efficacy of azithromycin for PCP prophylaxis in human beings. METHODS: We identified HIV-1-infected patients with PCP during a prospective randomised trial comparing az
A neonate with haemorrhagic ascites.: Lancet. 1999 Sep 11;354(9182):914. Unique Identifier : AIDSLINE MED/99418484; Pillay T; Jeena PM; Department of Paediatrics and Child Health, University of Natal,; Medical School, Durban, South Africa. pillayti@med.und.ac.za
UNAIDS to publish HIV-vaccine-trial ethics guidance [news]: Lancet. 1999 Sep 11;354(9182):923. Unique Identifier : AIDSLINE MED/99418493; Ramsay S
Immunisation with gp160 in HIV-1 infection [letter]: Lancet. 1999 Sep 11;354(9182):948; discussion 949. Unique Identifier : AIDSLINE MED/99418508; Fiala C; Stewart GT
Immunisation with gp160 in HIV-1 infection [letter]: Lancet. 1999 Sep 11;354(9182):948-9. Unique Identifier : AIDSLINE MED/99418509; Pontesilli O; Aiuti F
Relationship of hepatitis C viremia to HIV state and to infection by specific hepatitis C genotypes.: Liver. 1999 Aug;19(4):288-93. Unique Identifier : AIDSLINE MED/99387382; Perez-Gracia T; Galan F; Fernandez-Gutierrez C; Giron JA; Rodriguez-Iglesias M; Microbiology Service, Hospital Universitario Puerto Real, Spain.; AIMS/BACKGROUND: This study was undertaken to examine the relationship of hepatitis C (HCV) viremia to human immunodeficiency virus (HIV) infection and to investigate the evidence of infection by specific hepatitis C genotypes. PATIENTS AND METHODS: The analysis of HCV viremia was performed by reverse transcription-po
HBeAg immunostaining of liver tissue in various stages of chronic hepatitis B.: Liver. 1999 Aug;19(4):294-8. Unique Identifier : AIDSLINE MED/99387383; Lindh M; Savage K; Rees J; Garwood L; Horal P; Norkrans G; Dhillon AP; Department of Clinical Virology, Goteborg University, Sweden.; AIMS: We studied the tissue expression of hepatitis B e antigen (HBeAg) in 29 liver biopsies from 27 HBV carriers. METHODS: HBeAg expression was assessed in relation to HBeAg in serum, precore mutations, HBV DNA levels and liver damage as measured by histology activity index. RESULTS: HBeAg in liver tissue was detecte
Screening blood donations for hepatitis C in Central Africa: analysis of a risk- and cost-based decision tree.: Med Decis Making. 1999 Jul-Sep;19(3):296-306. Unique Identifier : AIDSLINE MED/99352122; Cancre N; Bois F; Gresenguet G; Fretz C; Fournel JJ; Belec L; B3E-INSERM U444, Faculte de Medecine St. Antoine, Paris,; France.; Four screening strategies (no testing, HC Abbott, HC Pasteur, and a combined test) for the detection of hepatitis C virus (HCV) antibody in donated blood were considered in a formal decision tree. Decision criteria included residual risk of infection and overall monetary cost. Tree parameters were determined using dat
Cardiopulmonary and CD4 cell changes in response to exercise training in early symptomatic HIV infection.: Med Sci Sports Exerc. 1999 Jul;31(7):973-9. Unique Identifier : AIDSLINE MED/99342947; Perna FM; LaPerriere A; Klimas N; Ironson G; Perry A; Pavone J; Goldstein A; Majors P; Makemson D; Talutto C; Schneiderman N; Fletcher MA; Meijer OG; Koppes L; School of Physical Education, Sport Psychology Program, West; Virginia University, Morgantown 26506-6116, USA.; PURPOSE: The purposes of the present study were to assess the effects of a 12-wk laboratory based aerobic exercise program on cardiopulmonary function, CD4 cell count, and physician-assessed health status among symptomatic pre-AIDS HIV-infected individuals (N = 28) and to assess the degree to which ill health was asso
1999 USPHS/IDSA guidelines for the prevention of opportunistic infections in persons infected with human immunodeficiency virus. U.S. Public Health Service (USPHS) and Infectious Diseases Society of America (IDSA).: MMWR Morb Mortal Wkly Rep. 1999 Aug 20;48(RR-10):1-59, 61-6. Unique Identifier : AIDSLINE MED/99428016
The AIDS epidemic--considerations for the 21st century.: N Engl J Med. 1999 Sep 30;341(14):1046-50. Unique Identifier : AIDSLINE MED/99417083; Fauci AS; National Institute of Allergy and Infectious Diseases, National; Institutes of Health, Bethesda, MD 20892, USA.; afauci@niaid.nih.gov
Call for governments to back development of AIDS vaccine [news]: Nature. 1999 Sep 2;401(6748):4. Unique Identifier : AIDSLINE MED/99413700; Dickson D
Rapid on/off cycling of cytokine production by virus-specific CD8+ T cells.: Nature. 1999 Sep 2;401(6748):76-9. Unique Identifier : AIDSLINE MED/99413718; Slifka MK; Rodriguez F; Whitton JL; Department of Neuropharmacology, The Scripps Research Institute,; La Jolla, California 92037, USA. mslifka@scripps.edu; CD8-positive T cells protect the body against viral pathogens by two important mechanisms: production of antiviral cytokines and lysis of infected cells. Cytokine production can have both local and systemic consequences, whereas cytolytic activity is limited to infected cells that are in direct contact with T cells. H
Microbiological and radioactive contamination from radioaerosol ventilation scanning: is there a problem?: Nucl Med Commun. 1999 Aug;20(8):755-60. Unique Identifier : AIDSLINE MED/99381191; Brown A; Carter NJ; O'Doherty MJ; Department of Nuclear Medicine, Kent and Canterbury Hospital, UK.; Radioaerosol lung imaging may result in (a) microbiological contamination of nebulizer circuits (a potential hazard to patients if the circuit is re-used), and (b) radioaerosol contamination of the atmosphere (a hazard to staff, particularly if inhaled, ingested or both). Altogether, 138 circuits were assessed for bac
The absence of correlation between immunoregulatory T cells and induced lymphoproliferative response in treated B-chronic lymphocytic leukemia patients.: Panminerva Med. 1999 Jun;41(2):93-7. Unique Identifier : AIDSLINE MED/99409175; Milosevic D; Marinkovic M; Colovic M; Jelic S; Institute for Oncology and Radiology of Serbia, Belgrade,; Yugoslavia.; BACKGROUND: Many data suggest T cell functional impairment in B-cell chronic lymphocytic leukemia (B-CLL). The mechanism responsible for this phenomenon is still unresolved. METHODS: In 88 B-CLL patients (RAI II-IV) the relationship between immunoregulatory T cells and PHA induced lymphoproliferative response (LPR) wa
Serotype distribution and secretory acid proteinase activity of Candida albicans isolated from the oral mucosa of patients with denture stomatitis.: Oral Microbiol Immunol. 1999 Jun;14(3):183-9. Unique Identifier : AIDSLINE MED/99425720; McMullan-Vogel CG; Jude HD; Ollert MW; Vogel CW; Department of Prosthodontics, University Hospital Eppendorf,; Germany.; Denture stomatitis is the most common form of oral Candida infection in humans. In the current study, the distribution of Candida albicans serotype A and B as well as the activity of the secreted acid proteinase were determined in clinical isolates from patients with denture stomatitis. It was found that 70% of indivi
Immunizations for the immunocompromised child.: Pediatr Ann. 1999 Aug;28(8):487-96. Unique Identifier : AIDSLINE MED/99413092; McFarland E; Children's Hospital Immunodeficiency Program, University of; Colorado Health Sciences Center, Denver 80262, USA.; Although immunocompromised children are unlikely to have optimal immune responses to vaccines, some will benefit from immunization. They should receive inactivated vaccines that are routinely recommended for immunocompetent children plus pneumococcal and influenza immunizations. Live viral and bacterial vaccines are c
HIV infection and seizures.: Postgrad Med J. 1999 Jul;75(885):387-90. Unique Identifier : AIDSLINE MED/99403968; Garg RK; Department of Neurology, Banaras Hindu University, Varanasi,; India.; New-onset seizures are frequent manifestations of central nervous system disorders in patients infected with human immunodeficiency virus (HIV). Seizures are more common in advanced stages of the disease, although they may occur early in the course of illness. In the majority of patients, seizures are of the generalis
Inhibition of intestinal metabolism of the antiviral ester prodrug bis(POC)-PMPA by nature-identical fruit extracts as a strategy to enhance its oral absorption: an in vitro study.: Pharm Res. 1999 Jul;16(7):1035-40. Unique Identifier : AIDSLINE MED/99378136; Van Gelder J; Annaert P; Naesens L; De Clercq E; Van den Mooter G; Kinget R; Augustijns P; Laboratorium voor Farmacotechnologie en Biofarmacie, O&N,; KULeuven, Belgium.; PURPOSE: To explore the usefulness of fruit extracts as enhancers of the oral absorption of esterase-sensitive prodrugs. METHODS: Inhibition of esterase-mediated degradation by nature-identical fruit extracts was evaluated using 1) p-nitrophenylacetate (model substrate for esterase-activity) in rat intestinal homogena
An epidemiological review of tuberculosis in the Puerto Rican population.: P R Health Sci J. 1999 Jun;18(2):117-22. Unique Identifier : AIDSLINE MED/99390418; Perez-Perdomo R; Perez-Cardona CM; University of Puerto Rico, Graduate School of Public Health,; Department of Biostatistics and Epidemiology, San Juan; 00936-5067. ros_perez@rcmaca.upr.clu.edu; Past and recent developments related with tuberculosis (TB) epidemiology in the island were reviewed. Characteristics of the disease such as surveillance, incidence, mortality and the relation of TB with HIV infection were included. TB remains an important public health problem in
[The efficacy of sequential treatment with amphotericin B-fluorocytosine and fluconazole in cryptococcal meningitis not associated with AIDS (letter)]: Rev Clin Esp. 1999 Jul;199(7):480. Unique Identifier : AIDSLINE MED/99411185; Pintado Garcia V; Martin Davila P; Munoz Labian V; Quereda Rodriguez-Navarro C
[A very, very short of breath HIV-infected patient]: Rev Med Interne. 1999;20 Suppl 2:256s-259s. Unique Identifier : AIDSLINE MED/99351061; Megarbane B; Fromont C; Nion I; Chary I; Axler O; Slama A; Brivet M; Rustin P; Munnich A; Brivet F; Service des urgences medicales et de reanimation medicale,; hopital Antoine-Beclere, Clamart.
[Why to look for vermin?]: Rev Med Interne. 1999;20 Suppl 2:277s-278s. Unique Identifier : AIDSLINE MED/99351068; Ribier G; Schroder S; Ramialison C; Service de medecine interne, CHU de la meynard, Fort de France.
Visit-driven endpoints in randomized HIV/AIDS clinical trials: impact of missing data on treatment difference measured on summary statistics.: Stat Med. 1999 Jul 30;18(14):1803-17; discussion 1819. Unique Identifier : AIDSLINE MED/99337845; Le Corfec E; Chevret S; Costagliola D; INSERM U444, Faculte de Medecine St-Antoine, 27 rue Chaligny,; 75571 Paris Cedex 12, France.; In randomized HIV/AIDS clinical trials, CD4 lymphocyte counts and plasma HIV-1 RNA measurements are often used as endpoints. The comparison between treatment groups is mainly based on a summary measure of outcome, so-called summary statistic. Such analyses are often complicated by missing data occurring as drop-outs.
Estimation of the treatment effect in a clinical trial when recurrent events define the endpoint.: Stat Med. 1999 Jul 30;18(14):1821-9; discussion 1831. Unique Identifier : AIDSLINE MED/99337847; Mahe C; Chevret S; Departement de Biostatistique et Informatique Medicale,; Hopital St-Louis, INSERM U444, 1 avenue Claude Vellefaux, 75475; Paris cedex 10, France.; Recurrent events are frequently encountered in clinical trials when individuals may experience an event more than once. Examples are common in medical research, including infectious episodes, myocardial infarctions and hospital admissions. However, when only the first event is considered, there is a loss of informatio
[Management of professional exposures to blood and other biological liquids contaminated with hepatitis B and C and HIV]: Rev Med Suisse Romande. 1999 Jul;119(7):587-92. Unique Identifier : AIDSLINE MED/99397184; Dubey BR; Telenti A; Francioli P
[Palliative care in non-cancerous diseases]: Rev Prat. 1999 May 15;49(10):1069-72. Unique Identifier : AIDSLINE MED/99414846; Blanchet V; Equipe mobile de soins palliatifs, Hopital Saint-Louis, Paris.; Palliative treatment is instituted at a particular point in the course of a potentially fatal disease. This palliative phase is often less well-defined than in cancer. Treatment mainly aims at slowing the course of the disease and maintaining the best quality of life possible for the patient. Palliative management of
Collaboration between developing and developed countries and between developing countries in occupational health research and surveillance.: Scand J Work Environ Health. 1999 Jun;25(3):296-300. Unique Identifier : AIDSLINE MED/99377992; Partanen TJ; Hogstedt C; Ahasan R; Aragon A; Arroyave ME; Jeyaratnam J; Kurppa K; Loewenson R; Lundberg I; Ngowi AV; Mbakaya CF; Stayner L; Steenland K; Weiderpass E; Wesseling C; Department of Epidemiology and Biostatistics, Finnish Institute; of Occupational Health, Helsinki. timo.partanen@occuphealth.fi; Collaborative occupational health and safety studies between counterparts in developing and developed countries and between developing countries have demonstrated their potential for improving occupational health and safety. Such collaboration in occupational health and safety is encouraged in the development of infra
Race on for local AIDS vaccine [news]: S Afr Med J. 1999 Jun;89(6):582. Unique Identifier : AIDSLINE MED/99372145; Jones JS
All about AIDS [news]: S Afr Med J. 1999 Jun;89(6):583. Unique Identifier : AIDSLINE MED/99372146; Jones JS
AIDS to become notifiable disease? [news]: S Afr Med J. 1999 Jun;89(6):583. Unique Identifier : AIDSLINE MED/99372147; van der Linde I
SAMA Committee wants free AZT for rape survivors [news]: S Afr Med J. 1999 Jun;89(6):584. Unique Identifier : AIDSLINE MED/99372148; van der Linde I
UNAIDS and BMS to combat AIDS [news]: S Afr Med J. 1999 Jun;89(6):585. Unique Identifier : AIDSLINE MED/99372149; van der Linde I
Making AIDS a notifiable disease--is it an appropriate policy for South Africa?: S Afr Med J. 1999 Jun;89(6):609-11. Unique Identifier : AIDSLINE MED/99372152; Abdool Karim SS; Center for Epidemiological Research in South Africa, Medical; Research Council, Durban.
Denying effective antiretroviral drugs to HIV-positive pregnant women--the national government's flawed decision [editorial]: S Afr Med J. 1999 Jun;89(6):621-3. Unique Identifier : AIDSLINE MED/99372155; Lurie M; Lurie P; IJsselmuiden C; Gray G
Mortality in a cohort of children born to HIV-1 infected women from Durban, South Africa.: S Afr Med J. 1999 Jun;89(6):646-8. Unique Identifier : AIDSLINE MED/99372163; Bobat R; Coovadia H; Moodley D; Coutsoudis A; Department of Paediatrics and Child Health, University of Natal.; OBJECTIVES: To describe mortality in a cohort of infants with vertically transmitted HIV-1 infection. PATIENTS AND METHODS: Children of HIV-1 infected women were followed up from birth and a record was made at each visit of growth, development and all illnesses. Details surrounding death were obtained from hospital re
Use of antiviral agents in pregnant women with HIV infection [letter]: S Afr Med J. 1999 Jul;89(7):704. Unique Identifier : AIDSLINE MED/99399310; Nash E; Benatar S; Abratt R; van Zyl Smit R; van Niekerk JP; Meyerson D; Ress S; Kyriacos U; Sanders HR; Stewart C; Peter E
["Safe sex" among HIV-positive heterosexual couples]: Ugeskr Laeger. 1999 Jun 14;161(24):3666-9. Unique Identifier : AIDSLINE MED/99414882; Weis NM; Skinnes L; Vesterdal B; Aabech P; Mathiesen LR; H:S Hvidovre Hospital, infektionsmedicinsk afdeling.; To investigate the use of condoms ( safe sex ) as prevention of transmission with human immuno deficiency virus (hiv) among heterosexual couples, 57 hiv-positive heterosexual patients and their partners if there was one interviewed. Forty-three of the 57 patients were heterosexually infected. Five out of 30 patients i
[Treatment for infertility in HIV positive couples--psychosomatic and ethical considerations]: Zentralbl Gynakol. 1999;121 Suppl 1:50-2. Unique Identifier : AIDSLINE MED/99397010; Siedentopf F; Kentenich H; DRK Frauen- und Kinderklinik, Berlin.
Absence of thallium-201 brain uptake in progressive multifocal leukoencephalopathy in AIDS patients.: Acta Neurol Scand. 1999 Aug;100(2):102-5. Unique Identifier : AIDSLINE MED/99369055; Iranzo A; Marti-Fabregas J; Domingo P; Catafau A; Molet J; Moreno A; Pujol J; Matias-Guiu X; Cadafalch J; Department of Neurology, Santa Creu i Sant Pau Hospital,; Autonomous University of Barcelona, Spain.; OBJECTIVE: To evaluate the presence of thallium-201 brain uptake determined by thallium-201 brain SPECT (Tl-201 SPECT) in patients with progressive multifocal leukoencephalopathy (PML) and AIDS. MATERIAL AND METHODS: Six AIDS patients with stereotactic biopsy diagnosis of PML were prospectively evaluated with Tl-201 S
[The treatment of cytomegalovirus retinitis in human immunodeficiency virus infection]: Acta Med Port. 1999 Apr-Jun;12(4-6):203-7. Unique Identifier : AIDSLINE MED/99410937; Rabadao E; Duque V; Melico-Silvestre A; Departamento de Doencas Infecciosas, Hospitais da Universidade; de Coimbra.; Most of the patients with immunodeficiency virus infection (75%-85%) are coinfected with cytomegalovirus . It is estimated that cytomegalovirus disease develops in 45% of them, mainly those presenting low CD4 cell counts (
[Kaposi's sarcoma: a sexually transmitted cancer?]: Actas Urol Esp. 1999 Feb;23(2):89-94. Unique Identifier : AIDSLINE MED/99259655; Sousa Escandon MA; Picallo Sanchez JA; Arguelles Pintos M; Alonso Alonso P; Alvarez Asensio E; Mateos Colino A; Servicio de Urologia, Hospital Comarcal de Monforte, Lugo.; Kaposi s sarcoma is a lymphoproliferative opportunistic tumor associated with acquired immunodeficiency syndrome whose frequency is going down due to the use of combined therapies including proteases and others antivirals. During the last years, it has been postulated that it s origin is in the oncogenic potential of
[Painful erections related to sleeping]: Actas Urol Esp. 1999 Jun;23(6):539-41. Unique Identifier : AIDSLINE MED/99394231; Menendez Lopez V; Mora Rufete A; Prieto Chaparro L; Galan Llopis JA; Fernandez Puentes C; Garcia Lopez F; Servicio de Urologia, Hospital General Universitario de Elche,; Universidad Miguel Hernandez, Alicante.; Case report of sleep-related painful erections in a 34 year-old male with grade C3 HIV infection. Due to severe impairment of the patient s general condition, no proper diagnostic studies were performed to gain deeper knowledge of the symptom s pathological etiology. Empirical therapy was started based on evidence fro
Dose-effect relationship between overdose mortality and prescribed methadone dosage in low-threshold maintenance programs.: Addict Behav. 1999 Jul-Aug;24(4):559-63. Unique Identifier : AIDSLINE MED/99394727; van Ameijden EJ; Langendam MW; Coutinho RA; Municipal Health Service, Division of Public Health and; Environment, Amsterdam, The Netherlands.; evameijden@GGGD.amsterdam.nl; The present study evaluates the effectiveness of low-threshold methadone maintenance in reducing overdose mortality. In a prospective cohort study conducted in Amsterdam, 498 Dutch injecting drug users (IDU) provided 1,969 person years of follow-up (1989-1995). Forty-four IDU died in this period, 15 due to illicit dru
Reducing HIV risk-associated sexual behavior among African American