1997

Molecular epidemiology of Encephalitozoon cuniculi and first detection of Enterocytozoon bieneusi in faecal samples of pigs.: J Eukaryot Microbiol. 1996 Sep-Oct;43(5):93S. Unique Identifier : AIDSLINE GENBANK/U61180; Deplazes P; Mathis A; Muller C; Weber R; Institute of Parasitology, Univ. of Zurich, Switzerland.
Retesting of sera for antibodies to HIV-1/HIV-2.: Commun Dis Rep CDR Wkly. 1996 May 3;6(18):153. Unique Identifier : AIDSLINE MED/97089510
HIV infection and AIDS in the United States.: Commun Dis Rep CDR Wkly. 1996 May 3;6(18):153, 156. Unique Identifier : AIDSLINE MED/97089511
AIDS and HIV-1 infection in the United Kingdom: monthly report.: Commun Dis Rep CDR Wkly. 1996 Oct 18;6(42):371-4. Unique Identifier : AIDSLINE MED/97091053
Romanian adoption. The Manitoba experience.: Arch Pediatr Adolesc Med. 1996 Dec;150(12):1278-82. Unique Identifier : AIDSLINE MED/97112311; Benoit TC; Jocelyn LJ; Moddemann DM; Embree JE; Department of Pediatrics and Child Health, Children's Hospital,; Health Sciences Centre, Winnipeg, Manitoba.; OBJECTIVE: To study the developmental, behavioral, and medical features in a cohort of Romanian children adopted by Manitoba families. DESIGN: A prospective longitudinal study. SETTING: The Child Development Clinic, Children s Hospital, Winnipeg, Manitoba, from September 1990 to June 1992. PATIENTS: Developmental, beh
Evolving ethical issues in selection of subjects for clinical research.: Camb Q Healthc Ethics. 1996 Summer;5(3):334-45. Unique Identifier : AIDSLINE MED/97016184; Weijer C; Clinical Trials Research Group, McGill University, Montreal,; Canada.
For her own good: protecting (and neglecting) women in research.: Camb Q Healthc Ethics. 1996 Summer;5(3):346-61. Unique Identifier : AIDSLINE MED/97016185; Shuster E; Department of Psychiatry, University of Pennsylvania,; Philadelphia, USA.
Patient access to experimental drugs and AIDS clinical trial designs: ethical issues.: Camb Q Healthc Ethics. 1996 Summer;5(3):400-9. Unique Identifier : AIDSLINE MED/97016189; Schuklenk U; Hogan C; Monash University Centre for Human Bioethics, Australia.
HIV-related parotid lymphoepithelial cysts. Immunohistochemistry and 3-D reconstruction of surgical and autopsy material with special reference to formal pathogenesis.: Virchows Arch. 1996 Oct;429(2-3):139-47. Unique Identifier : AIDSLINE MED/97075324; Ihrler S; Zietz C; Riederer A; Diebold J; Lohrs U; Institute of Pathology, Ludwig Maximilians University, Munchen,; Germany.; Whether lymphoepithelial cysts in the parotid glands in HIV-infected patients develop from pre-existing salivary gland inclusions in intraparotid lymph nodes or from a lymphoepithelial lesion of salivary parenchyma is unclear. To examine their pathogenesis we performed a histological and immunohistochemical study of s
Chronic rejection of concordant aortic xenografts in the hamster-to-rat model.: Transpl Immunol. 1996 Sep;4(3):192-7. Unique Identifier : AIDSLINE MED/97048617; Scheringa M; Buchner B; de Bruin RW; Geerling RA; Melief MJ; Mulder AH; Schraa EO; Ijzermans JN; Marquet RL; Department of Surgery, Leiden University Hospital, The; Netherlands.; Several groups have demonstrated that it is possible to obtain long-term graft survival of concordant xenografts. One of the important questions that remains is whether xenografts are susceptible to chronic rejection. To answer this question we used the aorta transplantation model. One centimetre of hamster aorta was
Xenogeneic iso-skin graft and mixed lymphocyte reaction studies using HLA-DP transgenic mice.: Transpl Immunol. 1996 Sep;4(3):220-6. Unique Identifier : AIDSLINE MED/97048622; Hagihara M; Shimura T; Takebe K; Munkhbat B; Sato T; Tsuchida F; Sato K; Tsuji K; Department of Transplantation Immunology, Tokai University School; of Medicine, Kanagawa, Japan.; To elucidate the cellular responses against xeno-MHC antigens, in vitro mixed lymphocyte culture (MLC) and in vivo skin grafting (SG) studies were conducted using HLA-DP transgenic mice (B6-DP mice). Xenogenic iso-(B6-DP to B6 mice) MLC showed positive but much lower responses compared to allo-MLC responses. Neverthel
[Expanded serologic infection testing of autologous blood donors: a report of experiences]: Beitr Infusionsther Transfusionsmed. 1996;33:196-200. Unique Identifier : AIDSLINE MED/97019457; Zimmermann R; Weisbach V; Wittmann G; Zingsem J; Neidhardt B; Eckstein R; Abteilung fur Transfusionsmedizin und Hamostaseologie,; Friedrich-Alexander-Universitat Erlangen-Nurnberg, Deutschland.; PURPOSE: The transmission of hepatitis B virus (HBV), hepatitis C virus (HCV), or human immunodeficiency virus (HIV-1/2) may cause serious disease in the recipient in cases of inadvertant homologous transfusion of autologous blood. Therefore data on the incidence of these infections in autologous blood donors are nece
[Nanofiltration in production of Beriplex P/N: increasing the capacity of virus elimination while maintaining product quality]: Beitr Infusionsther Transfusionsmed. 1996;33:220-4. Unique Identifier : AIDSLINE MED/97019462; Romisch J; Groner A; Bernhardt D; Diehl KH; Hein B; List W; Muller HG; Nowak T; Ronneberger H; Schuler E; Weimer T; Hilfenhaus J; Centeon Pharma GmbH, Marburg/Lahn, Deutschland.; For the manufacture of the PCC Beriplex P/N, nanofiltration was introduced into the production process of Beriplex HS providing an additional means to heat treatment for the clearance/inactivation of viruses. By nanofiltration, large enveloped viruses (HSV-1, HIV-1) were completely eliminated by a factor of more than
[Donor exclusions, discarded blood and transfusion unsuited blood conserves of 2,13 million potential blood donors 1991 to 1994]: Beitr Infusionsther Transfusionsmed. 1996;33:81-92. Unique Identifier : AIDSLINE MED/97019436; Diekamp U; Wehrend W; Marklof E; Kamutzky K; DRK-Blutspendedienst NSOB, Springe, Deutschland.; German authorities plan to legislate transfusion safety. We report on the efficacy of donor selection, unit pre-release testing, quality assurance and look-back efforts (LBE): Among 2,127,102 visits by 503,971 donors are 8.7% first-time donors. 96% of repeaters present our donor ID-card. We defer 5.6% repeat and 18.2%
High frequencies of human T-lymphotropic virus type I (HTLV-I) infection and presence of HTLV-II proviral DNA in blood donors with anti-thyroid antibodies.: J Mol Med. 1996 Aug;74(8):471-7. Unique Identifier : AIDSLINE MED/97026683; Mine H; Kawai H; Yokoi K; Akaike M; Saito S; First Department of Internal Medicine, School of Medicine,; University of Tokushima, Japan.; To investigate the relationship between human T-lymphotropic virus (HTLV) types I and II and the pathogenesis of autoimmune thyroid diseases, we examined serum anti-thyroid antibodies in 1019 blood donors with or without serum anti-HTLV-I antibody as well as proviral DNA for HTLV-II in leukocyte DNA by the polymerase
Interesting resources from the Web.: NP News. 1996 Jul-Aug;4(4):2, 5. Unique Identifier : AIDSLINE MED/97086737; Smithing RT; Wiley MD
Rhegmatogenous retinal detachments in HIV-positive patients with ocular syphilis.: Ophthalmic Surg Lasers. 1996 Aug;27(8):699-705. Unique Identifier : AIDSLINE MED/97011626; Williams JK; Kirsch LS; Russack V; Freeman WR; Department of Ophthalmology, University of California at San; Diego, La Jolla 92093-0946, USA.; The purpose of this study is to report retinal manifestations of lues in human immunodeficiency virus (HIV)-positive patients and to suggest a method for treatment of rhegmatogenous retinal detachments in these patients. Two HIV-positive patients with bilateral retinitis were examined and treated at the authors insti
TH2 cells in allergic inflammation: a target of immunotherapy.: Clin Exp Allergy. 1996 Jul;26(7):756-65. Unique Identifier : AIDSLINE MED/96440237; Lord CJ; Lamb JR; Department of Biology, Imperial College of Science, Technology; and Medicine, London, UK.
Experimental graft versus host disease in the (BN x LEW) F1 rat hybrid: an immunohistochemical study of early disease in oral mucosa.: Oral Dis. 1996 Mar;2(1):2-10. Unique Identifier : AIDSLINE MED/97116847; Peszkowski MJ; Fujiwara K; Warfvinge G; Larsson A; Department of Oral Pathology, Lund University, Malmo, Sweden.; OBJECTIVE: To study the initial cellular events in oral mucosa (tongue) of experimental hyperplastic GVHD, in order to increase our understanding of the possible pathogenic mechanisms that may be shared with eg mercury (and other drug)-induced immunological reactions. MATERIALS AND METHODS: GVHD was induced by one i.v
Knowledge of and attitudes about blood-borne viruses and infection control in Brazilian dental practice.: Oral Dis. 1996 Mar;2(1):41-4. Unique Identifier : AIDSLINE MED/97116851; Jorge J; Jorge R; Almeida OP; Scully C; Department of Oral Pathology, Faculty of Odontology, Piracicaba; SP, Brazil.; OBJECTIVE: To determine whether there were any recent changes in hepatitis B immunisation of dental staff, infection control or understanding of viral infections in Brazilian dentists. DESIGN: A randomised survey was conducted on 740 dentists attending the National Dental Congress in Sao Paulo, Brazil in 1994. SUBJECT
The periodontal health of homosexual men with HIV infection: a controlled study.: Oral Dis. 1996 Mar;2(1):45-52. Unique Identifier : AIDSLINE MED/97116852; Robinson PG; Sheiham A; Challacombe SJ; Zakrzewska JM; Department of Epidemiology and Public Health, University College,; London, UK.; OBJECTIVE: Identify types, prevalence and severity of periodontal changes associated with HIV infection. DESIGN: Cross-sectional controlled blinded study. SETTING: Open access genito-urinary medicine clinic. PARTICIPANTS: Convenience sample of 794 homosexual men aged 18-65. OUTCOME MEASURES: Prevalence, extent and sev
Cellular immunity and hypersensitivity as components of periodontal destruction.: Oral Dis. 1996 Mar;2(1):96-101. Unique Identifier : AIDSLINE MED/97116858; Seymour GJ; Gemmell E; Kjeldsen M; Yamazaki K; Nakajima T; Hara K; Department of Dentistry, University of Queensland, Brisbane,; Australia.; BACKGROUND: Cellular immunity has been implicated in periodontal destruction for over 25 years. Studies in the 1970s used lymphocyte transformation and lymphokine assays to establish a role for cell-mediated mechanisms in periodontal disease. Immunohistological studies subsequently showed that the formation of gingivi
Expression of inflammatory cytokines and inducible nitric oxide synthase in brains of SIV-infected rhesus monkeys: applications to HIV-induced central nervous system disease.: Mol Med. 1996 Jan;2(1):27-37. Unique Identifier : AIDSLINE MED/97056192; Lane TE; Buchmeier MJ; Watry DD; Fox HS; Department of Neuropharmacology, Scripps Research Institute, La; Jolla, California 92037, USA.; BACKGROUND: Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system (CNS) can lead to severe impairments in cognition, behavior, and motor skills. The mechanism(s) by which HIV-1 induces CNS disease are not well understood. Recent evidence suggests that expression of inducible nitric oxide
Role of IgE immune complexes in the regulation of HIV-1 replication and increased cell death of infected U1 monocytes: involvement of CD23/Fc epsilon RII-mediated nitric oxide and cyclic AMP pathways.: Mol Med. 1996 Jan;2(1):38-49. Unique Identifier : AIDSLINE MED/97056193; Ouaaz F; Ruscetti FW; Dugas B; Mikovits J; Agut H; Debre P; Mossalayi MD; Molecular Immuno-hematology Group, CNRS URA625,; Pitie-Salpetriere Hospital, Paris, France.; BACKGROUND: IgE/anti-IgE immune complexes (IgE-IC) induce the release of multiple mediators from monocytes/macrophages and the monocytic cell line U937 following the ligation of the low-affinity Fc epsilon receptors (Fc epsilon RII/CD23). These effects are mediated through an accumulation of cAMP and the generation of
Neurovirulent simian immunodeficiency virus infection induces neuronal, endothelial, and glial apoptosis.: Mol Med. 1996 Jul;2(4):417-28. Unique Identifier : AIDSLINE MED/96425269; Adamson DC; Dawson TM; Zink MC; Clements JE; Dawson VL; Department of Neuroscience, Johns Hopkins University School of; Medicine, Baltimore, Maryland 21287, USA.; BACKGROUND: Studies of human immunodeficiency virus type 1 (HIV-1) associated dementia have shown neuronal loss in discrete areas. The presence and mechanism of neuronal death, however, has remained quite elusive. One mechanism of cell death, apoptosis, has been clearly demonstrate
Overexpression of select T cell receptor V beta gene families within CD4+ and CD8+ T cell subsets of myasthenia gravis patients: a role for superantigen(s)?: Mol Med. 1996 Jul;2(4):452-9. Unique Identifier : AIDSLINE MED/96425272; Gigliotti D; Lefvert AK; Jeddi-Tehrani M; Esin S; Hodara V; Pirskanen R; Wigzell H; Andersson R; Microbiology and Tumorbiology Center (MTC), Karolinska Institute,; Stockholm, Sweden.; BACKGROUND: The principal symptoms of myasthenia gravis (MG), muscle weakness and fatigue due to impaired neuromuscular transmission, are caused by autoantibodies to the muscle nicotinic acetylcholine receptor (AChR). The mechanisms underlying the autoimmune response, however, appear to be initiated by activation of s
A critical role of nitric oxide in human immunodeficiency virus type 1-induced hyperresponsiveness of cultured monocytes.: Mol Med. 1996 Jul;2(4):460-8. Unique Identifier : AIDSLINE MED/96425273; Bukrinsky M; Schmidtmayerova H; Zybarth G; Dubrovsky L; Sherry B; Enikolopov G; Picower Institute for Medical Research, Manhasset, New York.; BACKGROUND: Human immunodeficiency virus type 1 (HIV-1) infection leads to a general exhaustion of the immune system. Prior to this widespread decline of immune functions, however, there is an evident hyperactivation of the monocyte/macrophage arm. Increased levels of cytokines and other biologically active molecules
[Apoptosis in the nervous system]: Rev Neurol. 1996 Nov;24(135):1356-60. Unique Identifier : AIDSLINE MED/97090712; Macaya A; Seccion de Neurologia Infantil, Centro de Investigaciones en; Bioquimica y Biologia Molecular, Vall d'Hebron Hospitals,; Barcelona.; Apoptosis (programmed cell death) is a distinct form of controlled cell degeneration, different from necrosis. It serves multiple physiological functions, such as the control of cell numbers during development, the maintenance of tissue homeostasis and the deletion of abnormal cells. Apoptosis has unique morphological
[Changes in the immunocompetent cell system of the peripheral blood in HIV carriage]: Lik Sprava. 1995 Mar-Apr;(3-4):112-5. Unique Identifier : AIDSLINE MED/96417148; Karabanov VR; Markov IS; Marchenko NE; HIV-carriage is characterized by hematological signs such as normocytosis of the general leucocyte count and deviations within normal range of values for myeloid series cells (neutrophiles, eosinophiles, basophiles). A peculiar hematological sign seen in HIV-infection is a finding of a raised content of cellular eleme
[A case of Kaposi's sarcoma of the eye in an AIDS patient]: Lik Sprava. 1995 Mar-Apr;(3-4):172-4. Unique Identifier : AIDSLINE MED/96417168; Barshtein IuA; Vovk AD; Antoniak SM; Shcherbyns'ka AM
Infectious disease challenges in the 1990's.: Med Health R I. 1996 Mar;79(3):100-9. Unique Identifier : AIDSLINE MED/97056951; Opal SM; Infectious Disease Fellowship Program, Brown University School of; Medicine, USA.
Physicians should support needle exchange in Rhode Island [editorial]: Med Health R I. 1996 Jun;79(6):206. Unique Identifier : AIDSLINE MED/96390291; Lewis DC; Rich JD; Brown University Center for Alcohol and Addiction Studies, USA.
AIDS and minorities.: Med Health R I. 1996 Jul;79(7):264-5. Unique Identifier : AIDSLINE MED/96390306; Fisher AE; Emgushov RT; Brown University School of Medicine, Providence, RI, USA.
Antisense oligonucleotides inhibit in vitro cDNA synthesis by HIV-1 reverse transcriptase.: Antisense Nucleic Acid Drug Dev. 1996 Summer;6(2):103-9. Unique Identifier : AIDSLINE MED/97000182; Boiziau C; Tarrago-Litvak L; Sinha ND; Moreau S; Litvak S; Toulme JJ; INSERM U386, Universite Bordeaux II, France.; The inhibition of reverse transcription by various chemically modified antisense oligonucleotides was studied in a cell-free system, composed of an RNA template, a primer oligodeoxynucleotide, and the HIV-1 reverse transcriptase (RT). Different mechanisms of inhibition were observed depending on the chemical structure
Correlation of activity with stability of chemically modified ribozymes in nuclei suspension.: Antisense Nucleic Acid Drug Dev. 1996 Summer;6(2):111-8. Unique Identifier : AIDSLINE MED/97000183; Heidenreich O; Xu X; Swiderski P; Rossi JJ; Nerenberg M; Scripps Research Institute, Department of Molecular and; Experimental Medicine, La Jolla, CA 92037, USA.; To examine hammerhead ribozyme activity in the nuclear environment, we have used nuclei isolated from HTLV-I tax transformed fibroblasts to evaluate ribozymes targeted against HTLV-I tax RNA. The ribozyme activity in nuclei suspension was strongly dependent on the resistance of the particular ribozyme to endogenous nu
A hammerhead ribozyme cleaves its target RNA during RNA preparation.: Antisense Nucleic Acid Drug Dev. 1996 Summer;6(2):141-4. Unique Identifier : AIDSLINE MED/97000187; Heidenreich O; Xu X; Nerenberg M; Department of Molecular and Experimental Medicine, Scripps; Research Institute, La Jolla, CA 92037, USA.; A chemically modified hammerhead ribozyme was designed to cleave the tax RNA of human T cell leukemia virus type I. This ribozyme was exogenously delivered to tax-transformed fibroblasts by DOTAP-mediated transfection. The analysis of RNA from ribozyme-transfected cells by RNase protection detected ribozyme cleavage p
4-(Arylamino)phenyl alpha-D-glucopyranosides as potential anti-HIV agents.: Carbohydr Res. 1996 Mar 18;282(2):293-8. Unique Identifier : AIDSLINE MED/97056753; Briggs JC; Haines AH; School of Chemical Sciences, University of East Anglia, Norwich,; United Kingdom.
Structure of the O-deacetylated glucuronoxylomannan from Cryptococcus neoformans Cap70 as determined by 2D NMR spectroscopy.: Carbohydr Res. 1996 Mar 22;283:95-110. Unique Identifier : AIDSLINE MED/97056926; Bacon BE; Cherniak R; Kwon-Chung KJ; Jacobson ES; Department of Chemistry, Georgia State University, Atlanta 30303,; USA.; Cryptococcus neoformans, an opportunistic pathogen, is the fourth leading cause of death among AIDS patients. The yeast s capsule is a major virulence factor, and serotype is related to the chemical structure of glucuronoxylomannan (GXM), its capsular polysaccharide. The GXM from Cap70, a hypocapsular mutant of seroty
Immune response against medullary thyroid carcinoma (MTC) induced by parental and/or interleukin-2-secreting MTC cells in a rat model of human familial medullary thyroid carcinoma.: Cancer Immunol Immunother. 1996 Oct;43(2):116-23. Unique Identifier : AIDSLINE MED/97112466; Lausson S; Fournes B; Borrel C; Milhaud G; Treilhou-Lahille F; Laboratoire d'Endocrinologie Cellulaire et Evolution, U. R. A.; 1116 CNRS, Universite Paris-Sud, Centre d'Orsay, France.; The existence of inherited aggressive forms of medullary thyroid carcinoma (MTC), and their resistance to all classical therapies, make it a prime candidate for adoptive immunotherapy. As a prelude to a vaccine for the protection of family members at risk of developing the disease, we investigated the immunological an
CD4-independent infection by HIV-2 is mediated by fusin/CXCR4.: Cell. 1996 Nov 15;87(4):745-56. Unique Identifier : AIDSLINE MED/97083584; Endres MJ; Clapham PR; Marsh M; Ahuja M; Turner JD; McKnight A; Thomas JF; Stoebenau-Haggarty B; Choe S; Vance PJ; Wells TN; Power CA; Sutterwala SS; Doms RW; Landau NR; Hoxie JA; Hematology-Oncology Division, University of Pennsylvania,; Philadelphia 19104, USA.; Several members of the chemokine receptor family have been shown to function in association with CD4 to permit HIV-1 entry and infection. However, the mechanism by which these molecules serve as CD4-associated cofactors is unclear. In the present report, we show that one member of this family, termed Fusin/ CXCR4, is
The use of SCID mice in biotechnology and as a model for human disease.: Crit Rev Biotechnol. 1996;16(1):95-118. Unique Identifier : AIDSLINE MED/97090002; Sandhu JS; Boynton E; Gorczynski R; Hozumi N; Department of Surgery, University of Toronto, Ontario, Canada.; The use of SCID (severe combined immunodeficient) mice in medical research and biotechnology has increased tremendously in recent years. This review outlines the major characteristics of these animals and the impediments that they pose to the engraftment of human cells and tissues. The development of our SCID mice pre
New hydrolyzable tannins, shephagenins A and B, from Shepherdia argentea as HIV-1 reverse transcriptase inhibitors.: Chem Pharm Bull (Tokyo). 1996 Aug;44(8):1436-9. Unique Identifier : AIDSLINE MED/96387794; Yoshida T; Ito H; Hatano T; Kurata M; Nakanishi T; Inada A; Murata H; Inatomi Y; Matsuura N; Ono K; Nakane H; Noda M; Lang FA; Murata J; Faculty of Pharmaceutical Sciences, Okayama University, Japan.; Two new hydrolyzable tannins, shephagenins A and B, were isolated along with hippophaenin A and strictinin from the leaf extract of Shepherdia argentea, which showed a remarkable inhibitory activity against human immunodeficiency virus (HIV)-1 reverse transcriptase. Their structures, having a gluconic acid core, have
Association of HTLV-I with autoimmune thyroiditis in patients with adult T-cell leukaemia (ATL) and in HTLV-I carriers.: Clin Endocrinol (Oxf). 1996 Oct;45(4):461-6. Unique Identifier : AIDSLINE MED/97118203; Akamine H; Takasu N; Komiya I; Ishikawa K; Shinjyo T; Nakachi K; Masuda M; Second Department of Internal Medicine, Faculty of Medicine,; University of the Ryukyus, Okinawa, Japan.; OBJECTIVE: Human T-lymphotrophic virus type I (HTLV-I) is a retrovirus that causes adult T-cell leukaemia (ATL). This virus is associated with a variety of autoimmune disorders. The possible association between HTLV-I Infection and autoimmune thyroiditis has not been fully studied. We therefore evaluated anti-thyroid
The association of hepatitis C viral infection with porphyria cutanea tarda in the Lothian region of Scotland.: Clin Exp Dermatol. 1996 Jul;21(4):283-5. Unique Identifier : AIDSLINE MED/97119077; Hussain I; Hepburn NC; Jones A; O'Rourke K; Hayes PC; Centre for Liver and Digestive Disorders, Royal Infirmary of; Edinburgh, Scotland.; Porphyria cutanea tarda (PCT) is believed to be associated with reduced hepatic uroporphyrinogen decarboxylase activity and risk factors such as alcohol abuse and medication with oral contraceptives and certain other drugs. Recently it has been suggested that hepatitis C virus (HCV) infection may also be associated wi
Inhibition of classical complement activation by sera from HIV-1-positive patients.: Clin Immunol Immunopathol. 1996 Nov;81(2):114-21. Unique Identifier : AIDSLINE MED/97064122; Burek V; Gerencer M; Department of Clinical Immunology, University Hospital of; Infectious Diseases Dr Fran Mihaljevic, University of Zagreb,; Croatia.; It was shown that gp120/160-coupled CD4+ T cells could be lysed by complement activation, but the target cell lysis was strongly inhibited by the majority of HIV-1-positive sera. Significantly more sera from HIV-1-infected patients with CD4+ T cell count higher than 500 microl (N = 38) as well as from patients with 20
Lymphocyte muscarinic cholinergic activity and PGE2 involvement in experimental Trypanosoma cruzi infection.: Clin Immunol Immunopathol. 1996 Nov;81(2):122-8. Unique Identifier : AIDSLINE MED/97064123; Sterin-Borda L; Gorelik G; Goren N; Cappa SG; Celentano AM; Borda E; CEFYBO-CONICET, Catedras de Microbiologia y Farmacologia,; Facultad de Medicina y de Odontologia, Universidad de Buenos; Aires, Argentina.; In this paper, we demonstrated that the production of PGE2 by CD8+ T lymphocytes through muscarinic cholinergic receptor (mAChR) activation of lymphocytes from mice acutely infected with nonlethal Trypanosoma cruzi CA-1 strain could enhance resistance to infection. Treatment in vivo with either atropine or cyclooxygen
Decreased alpha/beta heterodimer among CD8 molecules of peripheral blood T cells in Wiskott-Aldrich syndrome.: Clin Immunol Immunopathol. 1996 Nov;81(2):129-35. Unique Identifier : AIDSLINE MED/97064124; Kawabata K; Nagasawa M; Morio T; Okawa H; Yata J; Department of Pediatrics, School of Medicine, Tokyo Medical and; Dental University, Japan.; Cell surface CD8 molecules exist as either alpha/alpha homodimers or alpha/beta heterodimers, and most CD8+ T cells that undergo differentiation in the thymus express alpha/beta heterodimers. CD8 molecules on peripheral blood lymphocytes of patients with Wiskott-Aldrich syndrome (WAS), an X-linked immunodeficiency dis
Serum and secretory IgA from HIV-infected individuals mediate antibody-dependent cellular cytotoxicity.: Clin Immunol Immunopathol. 1996 Nov;81(2):182-90. Unique Identifier : AIDSLINE MED/97064131; Black KP; Cummins JE Jr; Jackson S; Department of Microbiology, University of Alabama at Birmingham,; 35294-2170, USA.; The potential function of IgA anti-HIV antibodies in mediation of antibody-dependent cellular cytotoxicity (ADCC) was investigated in this study. Serum IgA isolated from HIV-seropositive subjects in stage B3 or C3 and from healthy seronegative individuals was compared to IgG and whole serum for the ability to mediate
HIV disease in children is associated with a selective decrease in CD23+ and CD62L+ B cells.: Clin Immunol Immunopathol. 1996 Nov;81(2):191-9. Unique Identifier : AIDSLINE MED/97064132; Rodriguez C; Thomas JK; O'Rourke S; Stiehm ER; Plaeger S; Department of Pediatrics, UCLA School of Medicine, Los Angeles,; California 90095, USA.; We characterized the surface phenotype of B cells from HIV+ children in order to better understand the biology of B cell dysregulation. Twenty-nine HIV-infected, twenty-one exposed, and nineteen age-matched control children were studied for expression of CD5, CD10, CD21, CD23, CD25, CD62L, CD71, and CD69. We conclude
Comparison of the Vbeta repertoire in peripheral blood and in lymph nodes of HIV-infected subjects reveals skewed usage predominantly in CD8+ T cells.: Clin Immunol Immunopathol. 1996 Nov;81(2):200-9. Unique Identifier : AIDSLINE MED/97064133; Carbonari M; Cibati M; Pesce AM; Dell'Anna L; D'Offizi G; Angelici A; Uccini S; Fiorilli M; Department of Clinical Medicine, University of Rome La Sapienza,; Italy.; Perturbations of the repertoire of variable-beta (Vbeta) regions of the T cell receptor have been observed in patients infected by HIV and have been attributed to stimulation by viral antigens or superantigens. We further sought for traces of HIV-induced perturbations by comparing Vbeta repertoire in peripheral blood
Abnormalities of CD45 isoform expression in HIV infection.: Clin Immunol Immunopathol. 1996 Nov;81(2):210-4. Unique Identifier : AIDSLINE MED/97064134; Mahalingam M; Pozniak A; McManus TJ; Senaldi G; Vergani D; Peakman M; Department of Immunology, King's College Hospital, London, United; Kingdom.; Using monoclonal antibodies against CD45, CD45RA, CD45RB, and CD45RO, the surface density of expression and proportions of different CD45 isoforms were analyzed on CD4+ and CD8+ T lymphocyte subsets in HIV+ patients and controls. Analysis of the relative specific fluorescence (RSF) of CD45 isoforms showed a significan
Volumetric capillary cytometry: a new method for absolute cell enumeration.: Cytometry. 1996 Mar 1;23(3):177-86. Unique Identifier : AIDSLINE MED/97077010; Dietz LJ; Dubrow RS; Manian BS; Sizto NL; Biometric Imaging, Mountain View, California 94043, USA.; This article describes a novel cytometry system that is capable of imaging, identifying, and counting populations of fluorescently labeled cells within a precisely known volume of unlysed whole blood contained in a precision capillary. The whole blood is reacted with dye-labeled antibodies directed at cell surface ant
Improved four-color flow cytometry method using fluo-3 and triple immunofluorescence for analysis of intracellular calcium ion ([Ca2+]i) fluxes among mouse lymph node B- and T-lymphocyte subsets.: Cytometry. 1996 Mar 1;23(3):205-17. Unique Identifier : AIDSLINE MED/97077013; Greimers R; Trebak M; Moutschen M; Jacobs N; Boniver J; Laboratory of Pathological and Cytological Anatomy, University; Hospital of Liege, Belgium.; A visible-light, dual-laser, flow cytometric method was developed for the simultaneous analysis of intracellular ionized calcium concentration ([Ca2+]i) and three cell-surface markers (CD4, CD8, and Thy-1.2 antigens) by using the calcium probe fluo-3 and using R-phycoerythrin (PE), peridinin chlorophyll-alpha protein
[AIDS patients for pain therapy often have to rely on an opiate (news)]: Dtsch Med Wochenschr. 1996 Nov 15;121(46):A45. Unique Identifier : AIDSLINE MED/97128153
Tissue-specific self-peptides bound by major histocompatibility complex class I molecules of a human pancreatic beta-cell line.: Diabetes. 1996 Dec;45(12):1761-5. Unique Identifier : AIDSLINE MED/97081081; Papadopoulos KP; Colovai AI; Maffei A; Jaraquemada D; Suciu-Foca N; Harris PE; Department of Medicine, College of Physicians and Surgeons,; Columbia University, New York, New York 10032, USA.; The process of beta-cell destruction in IDDM is mediated, in part, by CD8+ T-cells. Structural characterization of HLA-I-bound self-peptides presented by the human beta-cell line HP-62 was performed to identify possible tissue-specific autoantigens in the context of CD8+ T-cell/HLA-I interactions. The sequences of the
American Gastroenterological Association medical position statement: guidelines for the management of malnutrition and cachexia, chronic diarrhea, and hepatobiliary disease in patients with human immunodeficiency virus infection.: Gastroenterology. 1996 Dec;111(6):1722-3. Unique Identifier : AIDSLINE MED/97098214
AGA technical review: malnutrition and cachexia, chronic diarrhea, and hepatobiliary disease in patients with human immunodeficiency virus infection.: Gastroenterology. 1996 Dec;111(6):1724-52. Unique Identifier : AIDSLINE MED/97098215; Wilcox CM; Rabeneck L; Friedman S; Department of Medicine, University of Alabama at Birmingham, USA.
Characterization of a leucine-zipper-like domain in Vpr protein of human immunodeficiency virus type 1.: Gene. 1996 Oct 31;178(1-2):7-13. Unique Identifier : AIDSLINE MED/97080539; Wang L; Mukherjee S; Narayan O; Zhao LJ; Marion Merrell Dow Foundation, Department of Microbiology,; Molecular Genetics and Immunology, University of Kansas Medical; Center, Kansas City 66160-7424, USA.; Human immunodeficiency virus type 1 (HIV-1) replicates productively in vitro in CD4(+)-T cells and/or macrophages. In the host, however, HIV-1 replication may be restricted by the quiescence of susceptible cells. Vpr is a 15-kDa late viral gene product, which is assembled in the virion and suspected to enhance HIV-1 r
[AIDS as a social problem]: Gig Sanit. 1996 Sep-Oct;(5):40-2. Unique Identifier : AIDSLINE MED/97061985; Sidorenko GI; Vashkova VV; Mozhaev EA; Rotova EG
A cervical teratoma with invasive squamous cell carcinoma in an HIV-infected patient: a case report.: Gynecol Oncol. 1996 Mar;60(3):475-9. Unique Identifier : AIDSLINE MED/96370764; Bell MC; Schmidt-Grimminger DC; Connor MG; Alvarez RD; Department of Obstetrics and Gynecology, University of Alabama at; Birmingham 35233, USA.; HIV infection among women is increasing in the United States . Since January 1993, cervical cancer has been considered an AIDS-defining illness. We report a rare case of squamous cell carcinoma arising in a teratoma of the uterine cervix in an HIV-infected patient. This patient was trea
Invasive vulvar carcinoma in two women infected with human immunodeficiency virus.: Gynecol Oncol. 1996 Mar;60(3):500-3. Unique Identifier : AIDSLINE MED/96370771; Wright TC; Koulos JP; Liu P; Sun XW; Department of Pathology, College of Physicians and Surgeons,; Columbia University, New York, New York 10032, USA.; This report presents two HIV-infected women who developed invasive squamous cell carcinoma of the vulva. One patient was diagnosed with Stage II vulvar cancer 4 years after surgical excision of VIN. This patient underwent a hemivulvectomy and external-beam radiation therapy, but has subsequently developed recurrent vu
[Atypical mycoses--also a sequela of medical progress (interview by Dr. rer. nat. Anita Schweiger)]: Fortschr Med. 1996 Aug 20;114(22-23):14-5. Unique Identifier : AIDSLINE MED/96415331; Mayser P
Assessment of adult sibling grief: a review of measurement issues.: Hosp J. 1996;11(1):1-18. Unique Identifier : AIDSLINE MED/97077741; Robinson L; Pickett M; Over the past decade hospice care has been delivered to an increasing population of persons with Acquired Immunodeficiency Syndrome (PWAS) and their families. Adult siblings likely comprise a large number of these surviving family members. Investigations that examine sibling bereavement are scarce (Osterweis, Solomon
Quantifying phagocytosis of Mycobacterium avium complex by human monocytes in whole blood.: Immunol Cell Biol. 1996 Aug;74(4):306-12. Unique Identifier : AIDSLINE MED/97026000; Hewish MJ; Meikle AM; Hunter SD; Crowe SM; AIDS Pathogenesis Research Unit, Macfarlane Burnet Centre for; Medical Research, Fairfield, Victoria, Australia.; Studies of phagocytic efficiency in cells of the macrophage lineage have assumed additional importance since the discovery that HIV infection of these cells impairs their immune function. A rapid method has been developed for measuring phagocytosis of the opportunistic pathogen Mycobacterium avium complex by human mon
Anal and cervical abnormality in women--prediction by human papillomavirus tests.: Int J Cancer. 1996 Nov 27;68(5):559-64. Unique Identifier : AIDSLINE MED/97092714; Melbye M; Smith E; Wohlfahrt J; Osterlind A; Orholm M; Bergmann OJ; Mathiesen L; Darragh TM; Palefsky JM; Department of Epidemiology Research, Statens Serum Institut,; Copenhagen, Denmark. mmelbye@desc.ssi.dk; A total of 151 women at risk of human immunodeficiency virus infection were investigated, to study the strength of the association between cervix and anus regarding the presence of HPV and cytological abnormality. An equal percentage of women had abnormal cervical (12.2%) and anal (12.1%) Papanicolaou smears. HPV meas
Psychodynamic group therapy with adolescents: exploration of HIV-related risk taking.: Int J Group Psychother. 1996 Apr;46(2):229-53. Unique Identifier : AIDSLINE MED/97089856; Henry RM; Department of Psychology, University of Wollongong, Australia.; Recent research shows that adolescents are a high-risk group for HIV infection, and that educational campaigns designed to reduce risk taking concerning HIV/AIDS have been largely ineffective with this population. It is probable that irrational psychodynamic processes underlie this risky behavior. In order to explore
Focusing on living: attitudinal approaches of long-term survivors of AIDS.: Issues Ment Health Nurs. 1996 Sep-Oct;17(5):395-407. Unique Identifier : AIDSLINE MED/97077772; Barroso J; This naturalistic study reports the attitudinal approaches of long-term survivors of AIDS. Ethnographic interviewing techniques were employed to interview a purposive sample of 14 men and 6 women who had had AIDS for at least 3 years and who were living in the Tampa/St. Petersburg, FL, area. As part of a larger study
Teen perspectives on HIV and the relevance of Hawaii's health providers.: Hawaii Med J. 1996 Oct;55(10):205-11. Unique Identifier : AIDSLINE MED/97097500; Bidwell RJ; Mueller CW; Mann E; Mew S; Goo C; Dunbar H; McGrady G; Vera M; Liebow E; Lovely RH; Department of Pediatrics, John A. Burns School of Medicine,; University of Hawaii, Honolulu 96826, USA.; Based on focus group interviews with adolescents from an urban Honolulu community, the present article describes how these adolescents view HIV, HIV-prevention and the role of health care providers in addressing HIV-related needs. Although medical providers are known to be knowledgeable experts in a variety of health
Safe intravenous antibiotic therapy at home: experience of a UK based programme.: J Antimicrob Chemother. 1996 May;37(5):1023-9. Unique Identifier : AIDSLINE MED/96346916; Kayley J; Berendt AR; Snelling MJ; Moore H; Hamilton HC; Peto TE; Crook DW; Conlon CP; East Oxford Health Centre, UK.; Outpatient i.v. antibiotic therapy is well developed in the United States , largely because of pressures from third-party payers to reduce costs of medical care. We have developed an outpatient i.v. antibiotic programme in Oxford, that has evolved from a desire to provide high quality i
Fluconazole plus allopurinol in treatment of visceral leishmaniasis [letter]: J Antimicrob Chemother. 1996 May;37(5):1042-3. Unique Identifier : AIDSLINE MED/96346924; Torrus D; Boix V; Massa B; Portilla J; Perez-Mateo M
Current therapeutic approaches to cryptosporidiosis in immunocompromised patients.: J Antimicrob Chemother. 1996 May;37(5):871-80. Unique Identifier : AIDSLINE MED/96346899; Hoepelman AI; Department of Medicine, University Hospital, Utrecht, The; Netherlands.; Cryptosporidium parvum is a protozon which can cause a severe debilitating disease in immunocompromised patients. Animal models show that cellular immunity is the most important factor protecting against the development of the disease, but patients with a humoral immune deficiency are also at risk. In HIV-infected pat
Arkansas HIV/AIDS report 1983-1996.: J Ark Med Soc. 1996 May;92(12):636-7. Unique Identifier : AIDSLINE MED/97090117
Synthesis of full-length viral DNA in CD4-positive membrane vesicles exposed to HIV-1. A model for studies of early stages of the hiv-1 life cycle.: J Biol Chem. 1996 Nov 8;271(45):28266-70. Unique Identifier : AIDSLINE MED/97067043; Simm M; Pekarskaya O; Volsky DJ; Molecular Virology Laboratory, St. Luke's-Roosevelt Hospital; Center and College of Physicians & Surgeons, Columbia University,; New York, New York 10019, USA. djv@columbia.edu; CD4-positive membrane vesicles (MV) were isolated under isotonic conditions from human T lymphoblastoid cells MT-2 and CEM and tested for their ability to support reverse transcription of viral RNA upon exposure to human immunodeficiency virus, type 1 (HIV-1). MV contained cytoplasms as confirmed by the presence of mi
AIDS-related obsessive compulsive disorder: deconditioning based on fluoxetine-induced inhibition of anxiety.: J Behav Ther Exp Psychiatry. 1996 Mar;27(1):51-6. Unique Identifier : AIDSLINE MED/96409539; Kraus RP; Nicholson IR; Department of Psychiatry, University of Western Ontario, London,; Canada.; Abel s (1993) review of treatments for obsessive compulsive disorder (OCD) indicated that both behavioral treatment (exposure with response prevention, and biological treatment (specific serotonin reuptake inhibiting drugs) are effective. It was recognized that having both available for patients is preferable because
Unusual pattern of enhancement in cryptococcal meningitis: in vivo findings with postmortem correlation.: J Comput Assist Tomogr. 1996 Nov-Dec;20(6):1023-6. Unique Identifier : AIDSLINE MED/97087874; Arnder L; Castillo M; Heinz ER; Scatliff JH; Enterline D; Department of Radiology, University of North Carolina School of; Medicine, Chapel Hill, USA.; Leptomeningeal enhancement on CT and MR imaging studies secondary to cryptococcal meningitis is an uncommon finding. In immunocompromised patients, this meningitis incites only a mild inflammatory reaction and abnormalities are often absent on imaging studies. We recently encountered two patients with cryptococcal men
Comparison of in-phase and opposed-phase GRE and conventional SE MR pulse sequences in T1-weighted imaging of liver lesions.: J Comput Assist Tomogr. 1996 Nov-Dec;20(6):890-7. Unique Identifier : AIDSLINE MED/97087848; Martin J; Sentis M; Puig J; Rue M; Falco J; Donoso L; Zidan A; Unitat de Diagnostic per la Imatge D'Alta Tecnologia (UDIAT),; Consorci Hospitalari del Parc Tauli, Barcelona, Spain.; PURPOSE: Our goal was to compare in-phase (IP) and opposed-phase (OP) GRE and conventional SE sequences in T1-weighted (T1-W) imaging of the liver and to evaluate chemical shift GRE imaging in characterizing liver/lesions for fat content. METHOD: IP and OP T1-W GRE with fast low angle shot (FLASH) technique and T1-W S
Using factor analysis to explore nurses' fear of AIDS in the United States of America.: J Adv Nurs. 1996 Aug;24(2):287-95. Unique Identifier : AIDSLINE MED/97011422; Wang JF; Paterson J; Department of Health Systems, School of Nursing, West Virginia; University, Morgantown 26508-9610, USA.; The purpose of this study was to create a reliable research instrument to test the fear of AIDS (FOA) and to explore the dimension of FOA among nurses. We hypothesized that certain factors, such as physical closeness to AIDS patients or HIV-positive blood and nontolerance of homosexuals, increase fear of AIDS among nu
Effects of group discussion and guided patient care experience on nurses' attitudes towards care of patients with AIDS.: J Adv Nurs. 1996 Aug;24(2):296-302. Unique Identifier : AIDSLINE MED/97011423; Kemppainen JK; Dubbert PM; McWilliams P; University of California, San Francisco, USA.; Nurses with limited experience in caring for persons with AIDS (PWAs) were randomized into three groups receiving an educational session on universal precautions and (a) three group discussion sessions; (b) three sessions of caring for a PWA; or (c) assessment materials only. Both interventions were conducted by a nur
The regulation of the development of CD8 effector T cells.: J Immunol. 1996 Nov 15;157(10):4287-92. Unique Identifier : AIDSLINE MED/97064182; Dutton RW; Trudeau Institute, Saranac Lake, NY 12983, USA.
Impaired signaling in alloantigen-specific CD8+ T cells tolerized in vivo: employing a model of Ld-specific TCR transgenic mice transplanted with allogenic hearts under the cover of a short-term rapamycin treatment.: J Immunol. 1996 Nov 15;157(10):4297-308. Unique Identifier : AIDSLINE MED/97064184; Chen H; Luo H; Xu D; Loh DY; Daloze PM; Veillette A; Qi S; Wu J; Louis-Charles Simard Research Center, Notre-Dame Hospital,; University of Montreal, Canada.; Peripheral tolerance of T cells is necessary because thymic deletion is not complete, and tissue-specific Ags exist outside the thymus. We have reported that persistent Ag is required to maintain peripheral tolerance in vivo. We suspect that the TCR signaling pathway in in vivo tolerized cells is compromised due to co
Lack of IL-12 signaling in human allergen-specific Th2 cells.: J Immunol. 1996 Nov 15;157(10):4316-21. Unique Identifier : AIDSLINE MED/97064186; Hilkens CM; Messer G; Tesselaar K; van Rietschoten AG; Kapsenberg ML; Wierenga EA; Department of Cell Biology and Histology, Academic Medical; Center, University of Amsterdam, The Netherlands.; IL-12 is a powerful skewer of CD4+ T cell responses toward the Th1 phenotype by inducing IFN-gamma production in naive Th cells. In the present study we addressed the question of whether IL-12 can reverse established Th2 responses into Th1/Th0 responses by inducing IFN-gamma production in memory Th2 cells. To this aim
Reciprocal cytotoxic T lymphocyte cross-reactivity interactions between two major epitopes within HIV-1 gp160.: J Immunol. 1996 Nov 15;157(10):4399-411. Unique Identifier : AIDSLINE MED/97064196; Shirai M; Kurokohchi K; Pendleton CD; Arichi T; Boyd LF; Takahashi H; Margulies DH; Berzofsky JA; Molecular Immunogenetics and Vaccine Research Section, National; Cancer Institute, Bethesda, MD 20892, USA.; We have observed and analyzed an unexpected cross-reactivity of CD8+ CTL between two nonhomologous peptides of the HIV-1 IIIB gp160 envelope protein, P18 (residues 315-329) and HP53 (834-848, also called TH4.1), in the context of four different class I MHC molecules, Dd, Dp, Dq (or Lq), and H-2u. In strains expressing
Early production of IL-4 and induction of Th2 responses in the lymph node originate from an MHC class I-independent CD4+NK1.1- T cell population.: J Immunol. 1996 Nov 15;157(10):4421-7. Unique Identifier : AIDSLINE MED/97064198; von der Weid T; Beebe AM; Roopenian DC; Coffman RL; Department of Immunology, DNAX Research Institute of Molecular; and Cellular Biology, Palo Alto, CA 94304, USA.; Splenic CD4+NK1.1+ T cells have been shown to secrete large and transient amounts of IL-4 mRNA 90 min after i.v. injection of anti-CD3 Ab, suggesting that this novel subset of T cells may induce Th2 responses in the spleen by quickly providing IL-4 at the onset of an immune response. beta2-microglobulin-deficient (bet
Alloreactive CD8+ T cells can recognize unusual, rare, and unique processed peptide/MHC complexes.: J Immunol. 1996 Nov 15;157(10):4464-73. Unique Identifier : AIDSLINE MED/97064204; Malarkannan S; Gonzalez F; Nguyen V; Adair G; Shastri N; Department of Molecular and Cell Biology, University of; California, Berkeley 94720, USA.; The identity and abundance of self-peptide/MHC class I complexes that serve as ligands for alloreactive T cells remain largely unknown. Using the Kb-restricted, alloreactive T cells as a probe, the Ag precursor gene, adenosine phosphoribosyl transferase (APRT), was isolated by expression cloning. Its naturally process
The granulomatous response in murine Schistosomiasis mansoni does not switch to Th1 in IL-4-deficient C57BL/6 mice.: J Immunol. 1996 Nov 15;157(10):4546-53. Unique Identifier : AIDSLINE MED/97064214; Metwali A; Elliott D; Blum AM; Li J; Sandor M; Lynch R; Noben-Trauth N; Weinstock JV; Department of Internal Medicine, University of Iowa, Iowa City; 52242, USA.; IL-4 plays an important role in polarizing inflammation toward a Th2 response. It remains uncertain, however, whether IL-4 also serves to prevent expression of Th1 inflammation. Therefore, using a genetically pure C57BL/6 IL-4-deficient mouse, we studied the role of IL-4 in regulating the production of IFN-gamma and T
Role of monocyte chemoattractant protein-1 (MCP-1) in Th1 (mycobacterial) and Th2 (schistosomal) antigen-induced granuloma formation: relationship to local inflammation, Th cell expression, and IL-12 production.: J Immunol. 1996 Nov 15;157(10):4602-8. Unique Identifier : AIDSLINE MED/97064220; Chensue SW; Warmington KS; Ruth JH; Sanghi PS; Lincoln P; Kunkel SL; Department of Pathology, Veterans Affairs Medical Center, Ann; Arbor, MI 48105, USA.; The present study examined the contribution of monocyte chemotactic protein-1 (MCP-1) to granulomatous inflammation mediated by Th1- and Th2-related cytokines. Types 1 and 2 lung granulomas (GR) were respectively induced in presensitized CBA mice by embolization of beads coupled to purified protein derivative of Mycob
Selection of T cells reactive against autologous B lymphoblastoid cells during chronic rheumatoid arthritis.: J Immunol. 1996 Nov 15;157(10):4697-706. Unique Identifier : AIDSLINE MED/97064232; David-Ameline J; Lim A; Davodeau F; Peyrat MA; Berthelot JM; Semana G; Pannetier C; Gaschet J; Vie H; Even J; Bonneville M; INSERM Unit 211, Institute of Biology, Nantes, France.; The repertoire and Ag specificity of T cells infiltrating inflamed joints from a chronic rheumatoid arthritis (RA) patient were studied in detail. Repertoire analysis demonstrated a reduced clonality of joint-infiltrating lymphocytes (JIL) as compared with patient s PBL, which was presumably due to an intra-articular
IL-4 neutralization or TNF-alpha treatment ameliorate disease by an intracellular pathogen in IFN-gamma receptor-deficient mice.: J Immunol. 1996 Dec 1;157(11):4746-50. Unique Identifier : AIDSLINE MED/97098698; Szalay G; Ladel CH; Blum C; Kaufmann SH; Department of Immunology, University of Ulm, Germany.; Successful control of infectious disease depends on aquisition of an appropriate protective immune response. IFN-gamma, first produced by NK cells and then by Th1 cells, is central to acquired resistance against intracellular bacteria, including Listeria monocytogenes. In contrast, IL-4 is not generated to a measurabl
Deficient expression of p56(lck) in Th2 cells leads to partial TCR signaling and a dysregulation in lymphokine mRNA levels.: J Immunol. 1996 Dec 1;157(11):4751-61. Unique Identifier : AIDSLINE MED/97098699; al-Ramadi BK; Nakamura T; Leitenberg D; Bothwell AL; Section of Immunobiology, Yale University School of Medicine, New; Haven, CT 06520, USA.; Activation of T lymphocytes through their TCR is regulated by a delicate balance of phosphorylation and dephosphorylation of protein substrates by protein tyrosine kinases (PTKs) and phosphotyrosyl phosphatases, respectively. One of the earliest steps in the activation pathway is thought to involve the Src family PTKs
Recipient CD8+ cells are responsible for the rapid elimination of allogeneic donor lymphoid cells.: J Immunol. 1996 Dec 1;157(11):4805-10. Unique Identifier : AIDSLINE MED/97098705; Fast LD; Department of Medicine, Rhode Island Hospital and Brown; University School of Medicine, Providence 02903, USA.; Blood transfusion can result in a variety of immunologic responses, including alloimmunization, transfusion-associated graft-versus-host disease, and immunosuppression that results in increased postoperative infection rate, and can also result in increased survival of allografts. One of the many factors influencing th
Allospecific CD8+ Tc1 and Tc2 populations in graft-versus-leukemia effect and graft-versus-host disease.: J Immunol. 1996 Dec 1;157(11):4811-21. Unique Identifier : AIDSLINE MED/97098706; Fowler DH; Breglio J; Nagel G; Eckhaus MA; Gress RE; Transplantation Therapy Section, Medical Oncology Branch,; National Cancer Institute, National Institutes of Health,; Bethesda, MD 20892, USA.; Allogeneic CD8+ T cells mediate both a graft-vs-leukemia (GVL) effect and graft-vs-host disease (GVHD). To evaluate whether CD8 cells of defined cytokine phenotype differentially mediate these processes, alloreactive donor CD8+ T cells preferentially secreting type I or type II cytokines were generated by alloantigeni
Loss of either CD4+ or CD8+ T cells does not affect the magnitude of protective immunity to an intracellular pathogen, Francisella tularensis strain LVS.: J Immunol. 1996 Dec 1;157(11):5042-8. Unique Identifier : AIDSLINE MED/97098736; Yee D; Rhinehart-Jones TR; Elkins KL; Laboratory of Enteric and Sexually Transmitted Diseases, Division; of Bacterial Products, Center for Biologics Evaluation and; Research, Rockville, MD 20852, USA.; Normal mice readily survive a sublethal intradermal (i.d.) infection with Francisella tularensis live vaccine strain (LVS), a model intracellular bacterium, and are strongly protected against subsequent lethal challenge. However, athymic nu/nu mice, which lack mature alphabeta TCR+ T lymphocytes, succumb to i.d. infec
Extrathymic differentiation of resident T cells in the joints of mice with collagen-induced arthritis.: J Immunol. 1996 Dec 1;157(11):5170-7. Unique Identifier : AIDSLINE MED/97098752; Arai K; Yamamura S; Hanyu T; Takahashi HE; Umezu H; Watanabe H; Abo T; Department of Immunology, Niigata University School of Medicine,; Japan.; Murine collagen-induced arthritis (CIA) is known as a T cell-mediated autoimmune disease, although autoantibodies are also suspected to be associated with the onset of the disease. To determine the origin of such T cells in the joints of mice with CIA, their phenotypic properties as well as those of T cells in other i
Experience of human lymphotropic virus type I (HTLV-I) in an East London hospital.: J Infect. 1996 Jan;32(1):33-9. Unique Identifier : AIDSLINE MED/97005238; Hoque S; Kelsey S; van der Walt JD; Breuer J; Department of Medical Microbiology, Royal London Hospital, U.K.; We describe the experience of The Royal London Hospital with human T-cell lymphotropic virus type 1 (HTLV-1) related disease. Twelve patients presented from 1988-1993, nine of them in 1993. None were born in the U.K. and 11 were of West Indian origin. Ten had overt lymphomas, one tropical spastic paraparesis/HTLV-1 as
The epidemiology of HIV infection in Edinburgh related to the injecting of drugs: an historical perspective and new insight regarding the past incidence of HIV infection derived from retrospective HIV antibody testing of stored samples of serum.: J Infect. 1996 Jan;32(1):53-62. Unique Identifier : AIDSLINE MED/97005241; Burns SM; Brettle RP; Gore SM; Peutherer JF; Robertson JR; Regional Virus Laboratory, City Hospital, Edinburgh, U.K.; The pattern of sudden explosive outbreaks of HIV infection among drug users has been seen in several countries but is as yet incompletely understood. The epidemic of injecting drugs in Edinburgh was associated with at least four overlapping epidemics of blood-borne viruses (hepatitis B, C, D and HIV). Only hepatitis B
Toxoplasma pneumonia in Africa [letter]: J Infect. 1996 Jan;32(1):70. Unique Identifier : AIDSLINE MED/97005245; Doherty JF; Chiposi L; Gwanzura L; Mason PR; Beaman MH
Ocular melanoma and human immunodeficiency virus infection.: Insight. 1996 Sep;21(3):86-8. Unique Identifier : AIDSLINE MED/97112813; Abramson DH; Servodidio CA; The number of reports of malignant complications of human immunodeficiency virus infection is increasing. Cutaneous melanoma has been previously reported in five patients with human immunodeficiency virus infection, but no cases of ocular melanoma have been documented. We describe the first case of ocular melanoma rep
Interleukin (IL)-4-independent immunoglobulin class switch to immunoglobulin (Ig)E in the mouse.: J Exp Med. 1996 Nov 1;184(5):1651-61. Unique Identifier : AIDSLINE MED/97079123; Morawetz RA; Gabriele L; Rizzo LV; Noben-Trauth N; Kuhn R; Rajewsky K; Muller W; Doherty TM; Finkelman F; Coffman RL; Morse HC 3rd; Laboratory of Immunopathology, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda,; Maryland 20892, USA.; Immunoglobulin (Ig) class switching in B cells is regulated by stimuli transduced by cytokines and cell-cell contact. Among these stimuli, interleukin (IL)-4 has been considered an absolute prerequisite for class switching to IgE in the mouse. Here we report that IL-4-deficient (IL-4-/-) and wildtype mice had comparab
Domains of the TCR beta-chain required for early thymocyte development.: J Exp Med. 1996 Nov 1;184(5):1833-43. Unique Identifier : AIDSLINE MED/97079139; Jacobs H; Iacomini J; van de Ven M; Tonegawa S; Berns A; Division of Molecular Genetics, The Netherlands Cancer Institute,; Amsterdam, The Netherlands.; The T cell receptor beta (TCR beta) chain controls the developmental transition from CD4-CD8- to CD4+8+thymocytes. We show that the extracellular constant region and the transmembrane region, but not the variable domain or cytoplasmic tail of the TCR beta chain are required for this differentiation step. TCR beta muta
CD4+ but not CD8+ cells are essential for allorejection.: J Exp Med. 1996 Nov 1;184(5):2013-8. Unique Identifier : AIDSLINE MED/97079156; Krieger NR; Yin DP; Garrison Fathman C; Department of Medicine, Stanford University School of Medicine,; California 94305, USA.; The generation of knockout mice with targeted gene disruption has provided a valuable tool for studying the immune response. Here we describe the use of CD4 and CD8 knockout mice to examine the role of CD4+ and CD8+ cells in initiating allotransplantation rejection. Pretreatment with a brief course of depletive anti-C
Reconstitution of T cell receptor signaling in ZAP-70-deficient cells by retroviral transduction of the ZAP-70 gene.: J Exp Med. 1996 Nov 1;184(5):2031-6. Unique Identifier : AIDSLINE MED/97079159; Taylor N; Bacon KB; Smith S; Jahn T; Kadlecek TA; Uribe L; Kohn DB; Gelfand EW; Weiss A; Weinberg K; Division of Research Immunology and Bone Marrow Transplantation,; Children's Hospital, Los Angeles, California 90027, USA.; A variant of severe combined immunodeficiency syndrome (SCID) with a selective inability to produce CD8 single positive T cells and a signal transduction defect in peripheral CD4+ cells has recently been shown to be the result of mutations in the ZAP-70 gene. T cell receptor (TCR) signaling requires the association of
Is a case study approach effective in altering the attitudes of student nurses toward AIDS?: J N Y State Nurses Assoc. 1996 Jun;27(2):13-7. Unique Identifier : AIDSLINE MED/97056434; Scherer YK; Dickerson S; Grzankowski J; The effect of a case study approach on attitudes of sophomore nursing students toward caring for patients with AIDS was examined. Pre- and post-program attitudes of 36 students were measured using an AIDS questionnaire. No significant differences were found between pre- and post-program scores on the questionnaire. An
Children's perceptions of peers with AIDS: assessing the impact of contagion information, perceived similarity, and illness conceptualization.: J Pediatr Psychol. 1996 Jun;21(3):321-33. Unique Identifier : AIDSLINE MED/97089328; Maieron MJ; Roberts MC; Prentice-Dunn S; Minnesota Epilsepsy Group, P. A., USA.; Assessed factors that affected acceptance of a hypothetical peer with AIDS. Children in Grades 4-6 read vignettes containing one of four levels of contagion information and one of two levels of perceived similarity. Illness conceptualization was measured as a continuous variable. Results indicated that the type of AID
Impairment of expressive behavior in pediatric HIV-infected patients with evidence of CNS disease.: J Pediatr Psychol. 1996 Jun;21(3):379-400. Unique Identifier : AIDSLINE MED/97089332; Moss HA; Wolters PL; Brouwers P; Hendricks ML; Pizzo PA; Pediatric Branch, National Cancer Institute, Rockville Pike,; Bethesda, Maryland 20892, USA.; Rated observations of videotapes were made of 16 variables representing 5 behavioral domains (task orientation, positive social-emotional, motor skills, expressive speech, and activity) on a sample of 83 HIV-infected children. Comparisons were made on the rated behaviors between children classified as either encephalo
Effect of formulation and processing factors on the characteristics of biodegradable microcapsules of zidovudine.: J Microencapsul. 1996 Sep-Oct;13(5):545-57. Unique Identifier : AIDSLINE MED/97018376; Mandal TK; Shekleton M; Onyebueke E; Washington L; Penson T; College of Pharmacy, Xavier University of Louisiana, New Orleans; 70125, USA.; Biodegradable microcapsules of zidovudine ( AZT ) were prepared using poly-(lactide/glycolide) by the solvent evaporation technique. The objective of this project was to focus on the effect of several formulation and processing factors on the efficiency
Synthesis of alpha-glucosidase I inhibitors showing antiviral (HIV-1) and immunosuppressive activity.: J Pharm Pharmacol. 1996 Feb;48(2):172-8. Unique Identifier : AIDSLINE MED/97089258; van den Broek LA; Kat-Van Den Nieuwenhof MW; Butters TD; Van Boeckel CA; Department of Medicinal Chemistry, N.V. Organon, Netherlands.; The synthesis of a series of analogues of the monosaccharide alpha-glucosidase I inhibitor N-decyl-1-deoxynojirimycin (1) is described. With the incorporation of a single oxygen atom particularly at position seven in the N-decyl side chain, i.e. to give N-7-oxadecyl-dNM (4), the therapeutic ratio (alpha-glucosidase I
College students' judgements and perceptions of persons with AIDS from different risk groups.: J Psychol. 1996 Sep;130(5):527-36. Unique Identifier : AIDSLINE MED/97019010; Johnson ME; Baer AJ; Department of Psychology, University of Alaska Anchorage 99508,; USA.; In this analog study, 104 female and 75 male undergraduate students in the United States read 1 of 8 vignettes that described a person who had just received positive HIV antigen results. The vignettes were identical except for the sex of the person described and his or her risk-group m
Risk behaviors, self-efficacy, and AIDS prevention among adolescents.: J Psychol. 1996 Sep;130(5):537-46. Unique Identifier : AIDSLINE MED/97019011; Goh DS; Primavera C; Bartalini G; Graduate Program in School Psychology, City University of New; York-Queens College, Flushing 11367, USA.; This study was conducted to investigate risk behaviors and AIDS-preventive variables in high school adolescents. One hundred fifty-two students in Grades 10 through 12 were administered an AIDS-related behavior questionnaire and the Attitudes Toward AIDS Scale-High School Version (ATAS-HS; Goh, 1992). The results indi
Expression of membrane form of the pregnancy associated protein TJ6 on decidual lymphocytes in the first trimester of pregnancy.: J Reprod Immunol. 1996 Feb;30(1):17-27. Unique Identifier : AIDSLINE MED/97077598; Rubesa G; Beaman KD; Beer AE; Haller H; Rukavina D; Department of Physiology and Immunology, University of Rijeka,; Croatia.; TJ6, a newly described protein produced locally in the uterine decidua during pregnancy, may be involved in maintaining a unique immunological environment at the maternal-fetal interface. The aim of this study was to determine whether TJ6 is expressed as membrane form on decidual lymphocytes (DL), to define the phenot
HTLV-1 21 bp repeat sequences facilitate stable association between Tax and CREB to increase CREB binding affinity.: J Mol Biol. 1996 Nov 22;264(1):20-31. Unique Identifier : AIDSLINE MED/97107524; Yin MJ; Gaynor RB; Department of Internal Medicine, University of Texas Southwestern; Medical Center Dallas 75235-8594, USA.; The human T-cell leukemia virus type I (HTLV-I) transactivator protein Tax is critical for the activation of viral gene expression and the transformation of T-lymphocytes. Tax activation of HTLV-I gene expression is mediated by three highly homologous regulatory elements known as 21 bp repeats which bind the transcrip
HIV-1 reverse transcriptase discriminates against non-self tRNA primers.: J Mol Biol. 1996 Nov 29;264(2):243-54. Unique Identifier : AIDSLINE MED/97109094; Oude Essink BB; Das AT; Berkhout B; Department of Human Retrovirology, Academic Medical Center,; University of Amsterdam, The Netherlands.; The interactions between the Reverse Transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) and the natural tRNA(Lys3) primer for initiation of viral DNA synthesis were examined. We constructed a set of HIV-1 RNA templates in which the wild-type primer binding site (PBS(Lys3)) is replaced by sequences compl
Oligonucleotide inhibitors of Taq DNA polymerase facilitate detection of low copy number targets by PCR.: J Mol Biol. 1996 Nov 29;264(2):268-78. Unique Identifier : AIDSLINE MED/97109096; Dang C; Jayasena SD; NeXstar Pharmaceuticals Inc., Boulder, CO 80301, USA.; A random sequence library of single stranded DNA was screened to isolate sequences with high affinity for Thermus aquaticus DNA polymerase (Taq pol), a thermostable enzyme commonly used in the polymerase chain reaction (PCR). Selected oligonucleotide sequences bound Taq pol with dissociation constants in the low picom
alpha-Interferon-2b treatment for chronic hepatitis-B infection in children with cancer.: J Trop Pediatr. 1996 Oct;42(5):262-6. Unique Identifier : AIDSLINE MED/97091220; Cetingul N; Kavakli K; Vergin C; Oztop S; Nisli G; Aydogdu S; Ozacar T; Bilgic A; Yuce G; Yagci R; Department of Pediatric Hematology-Oncology, Ege University,; Faculty of Medicine, Bornova, Izmir, Turkey.; We have evaluated the efficacy of treatment with recombinant Interferon-2b (IFN-2b) in 12 children with cancer who developed chronic hepatitis-B infection. Seven of them had lymphoblastic leukaemia and others had solid tumours. Seven cases were male. Mean age was 10.5 years with a range of 5-16 years. Chronic Hepatiti
Vitamin A deficiency and T-cell subpopulations in children with meningococcal disease.: J Trop Pediatr. 1996 Oct;42(5):287-90. Unique Identifier : AIDSLINE MED/97091225; Semba RD; Bulterys M; Munyeshuli V; Gatsinzi T; Saah A; Chao A; Dushimimana A; Department of Ophthalmology, School of Medicine, Johns Hopkins; University, Baltimore, MD, USA.; Although group A meningococcal disease is a major cause of child morbidity and mortality in sub-Saharan Africa, little is known about vitamin A status and T-cell subpopulations in affected children. A prospective study of vitamin A levels and T-cell subpopulations was conducted in 41 children hospitalized for meningoc
A source of glycosylated human T-cell lymphotropic virus type 1 envelope protein: expression of gp46 by the vaccinia virus/T7 polymerase system.: J Virol. 1996 Nov;70(11):7349-59. Unique Identifier : AIDSLINE MED/97048012; Arp J; LeVatte M; Rowe J; Perkins S; King E; Leystra-Lantz C; Foung SK; Dekaban GA; Gene Therapy and Molecular Virology Group, John P. Robarts; Research Institute, London, Ontario, Canada.; Heterologous expression of the human T-cell lymphotropic virus type 1 (HTLV-1) envelope surface glycoprotein (gp46) in a vaccinia virus/T7 polymerase system resulted in the production of authentic recombinant gp46. Five differentially glycosylated forms of the surface envelope protein were produced by this mammalian s
Tumor necrosis factor alpha inhibits entry of human immunodeficiency virus type 1 into primary human macrophages: a selective role for the 75-kilodalton receptor.: J Virol. 1996 Nov;70(11):7388-97. Unique Identifier : AIDSLINE MED/97048016; Herbein G; Montaner LJ; Gordon S; Sir William Dunn School of Pathology, University of Oxford,; United Kingdom.; The proinflammatory cytokine tumor necrosis factor alpha (TNFalpha) is readily detected after human immunodeficiency virus type 1 (HIV-1) infection of primary macrophages in vitro and is present in plasma and tissues of patients with AIDS. Previous studies have shown that human recombinant TNFalpha (hrTNFalpha) enhanc
Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface.: J Virol. 1996 Nov;70(11):7462-70. Unique Identifier : AIDSLINE MED/97048023; Hu H; Shioda T; Moriya C; Xin X; Hasan MK; Miyake K; Shimada T; Nagai Y; Department of Viral Infection, Institute of Medical Science,; University of Tokyo, Minato-ku, Japan.; The envelope protein, gp120, of human immunodeficiency virus type 1 (HIV-1) is heavily glycosylated and sialylated. The heavy sialylation greatly affects the physical properties of the protein, as it resolves into a wide acidic pH range despite the basic pI value predicted for its polypeptide backbone (B. S. Stein and
The oncoprotein Tax of the human T-cell leukemia virus type 1 activates transcription via interaction with cellular ATF-1/CREB factors in Saccharomyces cerevisiae.: J Virol. 1996 Nov;70(11):7478-84. Unique Identifier : AIDSLINE MED/97048025; Shnyreva M; Munder T; Department of Cell and Molecular Biology, Hans-Knoll-Institut; fur Naturstoff-Forschung e.V., Jena, Germany.; The transcription factor Tax of the oncogenic human T-cell leukemia virus type 1 is likely to be responsible for viral replication in the host organism and for the induction of proliferation in infected cells. To investigate Tax-mediated transcription in vivo, we expressed Tax as well as CREB in Saccharomyces cerevisi
Anergic TH1 clones specific for hepatitis B virus (HBV) core peptides are inhibitory to other HBV core-specific CD4+ T cells in vitro.: J Virol. 1996 Nov;70(11):7540-8. Unique Identifier : AIDSLINE MED/97048032; Diepolder HM; Jung MC; Wierenga E; Hoffmann RM; Zachoval R; Gerlach TJ; Scholz S; Heavner G; Riethmuller G; Pape GR; Institute for Immunology, University of Munich, Germany.; A strong and transient hepatitis B virus core (HBc)-specific CD4+ T-cell response has been shown to be associated with viral elimination in acute self-limited hepatitis B but to be absent in chronic hepatitis B. So far, little is known about immunological mechanisms involved in the regulation of the HBc-specific CD4+
Feline immunodeficiency virus vaccination: characterization of the immune correlates of protection.: J Virol. 1996 Nov;70(11):7561-8. Unique Identifier : AIDSLINE MED/97048034; Hosie MJ; Flynn JN; MRC Retrovirus Research Laboratory, Department of Veterinary; Pathology, University of Glasgow, Bearsden, United Kingdom.; m.hosie@vet.gla.ac.uk.; Whole inactivated virus (WIV) vaccines derived from the FL4 cell line protect cats against challenge with feline immunodeficiency virus (FIV). To investigate the correlates of protective immunity induced by WIV, we established an immunization regimen which protected a proportion of the vaccinates against challenge. A
Progression to persistent lymphocytosis and tumor development in bovine leukemia virus (BLV)-infected cattle correlates with impaired proliferation of CD4+ T cells in response to gag- and env-encoded BLV proteins.: J Virol. 1996 Nov;70(11):7584-93. Unique Identifier : AIDSLINE MED/97048037; Orlik O; Splitter GA; Department of Animal Health and Biomedical Sciences, University; of Wisconsin--Madison, 53706, USA.; The mechanism of leukemogenesis and persistent lymphocytosis (PL; benign expansion of B lymphocytes) in cattle infected with bovine leukemia virus (BLV; a retrovirus closely related to human T-cell leukemia virus type 1) is unknown; however, the immune system likely plays an important role in controlling the outcome o
Dynamics and modulation of human immunodeficiency virus type 1 transcripts in vitro and in vivo.: J Virol. 1996 Nov;70(11):7603-13. Unique Identifier : AIDSLINE MED/97048039; Bagnarelli P; Valenza A; Menzo S; Sampaolesi R; Varaldo PE; Butini L; Montroni M; Perno CF; Aquaro S; Mathez D; Leibowitch J; Balotta C; Clementi M; Istituto di Microbiologia, Universita di Ancona, Italy.; The dynamics of human immunodeficiency virus type 1 (HIV-1) transcription was analyzed in vitro and in vivo by using a specific molecular approach which allows accurate quantitation of the different classes of viral mRNAs. Unspliced (US) and multiply spliced (MS) HIV-1 transcripts were assayed by competitive reverse t
Infection of primary human microglia and monocyte-derived macrophages with human immunodeficiency virus type 1 isolates: evidence of differential tropism.: J Virol. 1996 Nov;70(11):7654-62. Unique Identifier : AIDSLINE MED/97048044; Strizki JM; Albright AV; Sheng H; O'Connor M; Perrin L; Gonzalez-Scarano F; Department of Neurology, University of Pennsylvania School of; Medicine, Philadelphia 19104-6146, USA.; To ascertain whether viruses present at the time of primary viremia can infect the central nervous system and to determine if microglial tropism is distinct from tropism for monocyte-derived macrophages (MDM), 27 human immunodeficiency virus type 1 (HIV-1) isolates obtained from acutely infected individuals, as well a
In vivo transcriptional regulation of the human immunodeficiency virus in the central nervous system in transgenic mice.: J Virol. 1996 Nov;70(11):7686-94. Unique Identifier : AIDSLINE MED/97048048; Kurth J; Buzy JM; Lindstrom L; Clements JE; Division of Comparative Medicine, Johns Hopkins University School; of Medicine, Baltimore, Maryland 21205, USA.; Human immunodeficiency virus type 1 (HIV-1) causes infections of the central nervous system (CNS) and has been implicated as the causative agent of AIDS-associated encephalopathy and the AIDS dementia complex. The development of in vivo models of HIV-1-mediated gene expression has
Human recombinant antibody fragments neutralizing human immunodeficiency virus type 1 reverse transcriptase provide an experimental basis for the structural classification of the DNA polymerase family.: J Virol. 1996 Nov;70(11):7706-12. Unique Identifier : AIDSLINE MED/97048050; Gargano N; Biocca S; Bradbury A; Cattaneo A; International School for Advanced Studies, Trieste, Italy.; We describe in this paper the binding and biochemical properties of two human antibody fragments directed against the human immunodeficiency virus type 1 reverse transcriptase (RT). These fragments were isolated from a synthetic combinatorial library of human Fab antibody fragments displayed on the surface of filament
Cytotoxic T-lymphocyte responses to cytomegalovirus in normal and simian immunodeficiency virus-infected rhesus macaques.: J Virol. 1996 Nov;70(11):7725-33. Unique Identifier : AIDSLINE MED/97048052; Kaur A; Daniel MD; Hempel D; Lee-Parritz D; Hirsch MS; Johnson RP; Division of Immunology, New England Regional Primate Center,; Southborough, Massachusetts 01772, USA.; Disseminated cytomegalovirus ( CMV ) infection is a frequent occurrence in human immunodeficiency virus-infected humans and in simian immunodeficiency virus (SIV)-infected rhesus macaques. Rhesus macaques are a suitable animal
Cytoskeletal proteins inside human immunodeficiency virus type 1 virions.: J Virol. 1996 Nov;70(11):7734-43. Unique Identifier : AIDSLINE MED/97048053; Ott DE; Coren LV; Kane BP; Busch LK; Johnson DG; Sowder RC 2nd; Chertova EN; Arthur LO; Henderson LE; AIDS Vaccine Program, National Cancer Institute, Frederick Cancer; Research and Development Center, Maryland 21702-1201, USA.; ott@avpvx1.ncifcrf.gov.; We have identified three types of cytoskeletal proteins inside human immunodeficiency virus type 1 (HIV-1) virions by analyzing subtilisin-digested particles. HIV-1 virions were digested with protease, and the treated particles were isolated by sucrose density centrifugation. This method removes both exterior viral pr
High frequency of defective nef alleles in a long-term survivor with nonprogressive human immunodeficiency virus type 1 infection.: J Virol. 1996 Nov;70(11):7752-64. Unique Identifier : AIDSLINE MED/97048055; Mariani R; Kirchhoff F; Greenough TC; Sullivan JL; Desrosiers RC; Skowronski J; Cold Spring Harbor Laboratory, New York 11724, USA.; A large number of nef alleles were obtained from peripheral blood mononuclear cells (PBMC) of four long-term nonprogressing survivors of human immunodeficiency virus type 1 (HIV-1) infection and from five individuals with progressive HIV-1 infection. These primary nef alleles were characterized by DNA sequence analysi
Intracellular expression of human immunodeficiency virus type 1 (HIV-1) protease variants inhibits replication of wild-type and protease inhibitor-resistant HIV-1 strains in human T-cell lines.: J Virol. 1996 Nov;70(11):7765-72. Unique Identifier : AIDSLINE MED/97048056; Junker U; Escaich S; Plavec I; Baker J; McPhee F; Rose JR; Craik CS; Bohnlein E; Progenesys Program at Systemix, Palo Alto, California 94304, USA.; The enzymatic activity of the human immunodeficiency type 1 (HIV-1) protease (PR) is crucial to render HIV-1 virions mature and infectious. Hence, genetic intervention strategies based on trans-dominant (td) variants of the HIV-1 PR might be an alternative to current pharmacological and gene therapy regimens for AIDS.
Identification of a gag-encoded cytotoxic T-lymphocyte epitope from FBL-3 leukemia shared by Friend, Moloney, and Rauscher murine leukemia virus-induced tumors.: J Virol. 1996 Nov;70(11):7773-82. Unique Identifier : AIDSLINE MED/97048057; Chen W; Qin H; Chesebro B; Cheever MA; Division of Oncology, Department of Medicine, University of; Washington, Seattle 98195, USA. wchen@cesmtp.ccf.org.; FBL-3 is a highly immunogenic murine leukemia of C57BL/6 origin induced by Friend murine leukemia virus (MuLV). Immunization of C57BL/6 mice with FBL-3 readily elicits CD8+ cytotoxic T lymphocytes (CTL) capable of lysing FBL-3 as well as syngeneic leukemias induced by Moloney and Rauscher MuLV. The aim of this current
Generation of atypical pulmonary inflammatory responses in BALB/c mice after immunization with the native attachment (G) glycoprotein of respiratory syncytial virus.: J Virol. 1996 Nov;70(11):7783-91. Unique Identifier : AIDSLINE MED/97048058; Hancock GE; Speelman DJ; Heers K; Bortell E; Smith J; Cosco C; Department of Immunology, Lederle-Praxis Biologicals, Inc., West; Henrietta, New York 14586-9728, USA.; The feasibility of using the highly purified native attachment (G) protein in a subunit vaccine against respiratory syncytial virus (RSV) was examined in a murine model with or without the fusion (F) protein of RSV and the adjuvant QS-21. The studies established that QS-21 was more potent than AIOH as an adjuvant for
Twin studies demonstrate a host cell genetic effect on productive human immunodeficiency virus infection of human monocytes and macrophages in vitro.: J Virol. 1996 Nov;70(11):7792-803. Unique Identifier : AIDSLINE MED/97048059; Chang J; Naif HM; Li S; Sullivan JS; Randle CM; Cunningham AL; Virology Department, ICPMR, Westmead Hospital, University of; Sydney, National Centre in HIV Research, New South Wales,; Australia.; Biological and genetic variability is a prominent feature of human immunodeficiency virus (HIV) strains, especially in tropism, syncytium formation, and replicative capacity. To determine whether there were variable host cell effects on HIV replication in monocytes, three different strains of low-passage-number monocy
Neutralization serotypes of human immunodeficiency virus type 1 field isolates are not predicted by genetic subtype. The WHO Network for HIV Isolation and Characterization.: J Virol. 1996 Nov;70(11):7827-32. Unique Identifier : AIDSLINE MED/97048063; Weber J; Fenyo EM; Beddows S; Kaleebu P; Bjorndal A; Department of Communicable Diseases, Imperial College School of; Medicine at St. Mary's, London, United Kingdom.; Human immunodeficiency virus type 1 (HIV-1) primary isolates from four geographical locations in Thailand , Brazil , Rwanda , and Uganda , representing genetic subtypes A, B
Nevirapine-resistant human immunodeficiency virus: kinetics of replication and estimated prevalence in untreated patients.: J Virol. 1996 Nov;70(11):7894-9. Unique Identifier : AIDSLINE MED/97048071; Havlir DV; Eastman S; Gamst A; Richman DD; Department of Medicine, University of California, San Diego; 92103, USA. dhavlir@ucsd.edu.; The nonnucleoside reverse transcriptase inhibitor nevirapine rapidly selects for mutant human immunodeficiency virus (HIV) in vivo. The most common mutation occurs at amino acid residue 181 in patients receiving monotherapy. After the initiation of ne
T-cell dysfunctions in hu-PBL-SCID mice infected with human immunodeficiency virus (HIV) shortly after reconstitution: in vivo effects of HIV on highly activated human immune cells.: J Virol. 1996 Nov;70(11):7958-64. Unique Identifier : AIDSLINE MED/97048078; Rizza P; Santini SM; Logozzi MA; Lapenta C; Sestili P; Gherardi G; Lande R; Spada M; Parlato S; Belardelli F; Fais S; Laboratory of Virology, Istituto Superiore di Sanita, Rome,; Italy.; The state of activation of the immune system may be an important factor which renders a host more receptive to human immunodeficiency virus (HIV) and more vulnerable to its effects. To explore this issue with a practical in vivo model, we developed a modified protocol of HIV infection in hu-PBL-SCID mice. First, we as
A mechanism of restricted human immunodeficiency virus type 1 expression in human glial cells.: J Virol. 1996 Nov;70(11):7992-8002. Unique Identifier : AIDSLINE MED/97048082; Shahabuddin M; Bentsman G; Volsky B; Rodriguez I; Volsky DJ; Molecular Virology Laboratory, St. Luke's-Roosevelt Hospital; Center, New York, New York 10019, USA.; We characterized in detail the life cycle of human immunodeficiency virus type 1 (HIV-1) in human glioma H4/CD4 cells which stably express transfected CD4 DNA (B. Volsky, K. Sakai, M. Reddy, and D. J. Volsky, Virology 186:303-308, 1992). Infection of cloned H4/CD4 cells with the N1T strain of cell-free HIV-1 (HIV-1/N1
An in vivo mutation from leucine to tryptophan at position 210 in human immunodeficiency virus type 1 reverse transcriptase contributes to high-level resistance to 3'-azido-3'-deoxythymidine.: J Virol. 1996 Nov;70(11):8010-8. Unique Identifier : AIDSLINE GENBANK/Z31355; Hooker DJ; Tachedjian G; Solomon AE; Gurusinghe AD; Land S; Birch C; Anderson JL; Roy BM; Arnold E; Deacon NJ; AIDS Molecular Biology Laboratory, Macfarlane Burnet Center for; Medical Research, Fairfield, Australia.; Sequencing of the reverse transcriptase (RT) region of 26 human immunodeficiency virus type 1 (HIV-1) isolates from eight patients treated with 3 -azido-3 -deoxythymidine ( AZT ) revealed a mutation at codon 210 from TTG (leucine) to TGG (tryptophan) ex
Postbinding events mediated by human immunodeficiency virus type 1 are sensitive to modifications in the D4-transmembrane linker region of CD4.: J Virol. 1996 Nov;70(11):8019-28. Unique Identifier : AIDSLINE MED/97048085; Moir S; Perreault J; Poulin L; Centre de Recherche en Infectiologie du Centre Hospitalier; Universitaire de Quebec, Canada.; Evidence from both structural and functional studies of the CD4 molecule suggests that several domains, including the transmembrane (TM) domain and the adjoining extracellular region (D4-TM linker), contribute to the post-gp12O-binding events leading to human immunodeficiency virus-mediated membrane fusion. To investi
Inhibition of human immunodeficiency virus type 1 and type 2 Tat function by transdominant Tat protein localized to both the nucleus and cytoplasm.: J Virol. 1996 Nov;70(11):8055-63. Unique Identifier : AIDSLINE MED/97048089; Orsini MJ; Debouck CM; Department of Molecular Genetics, SmithKline Beecham; Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA.; We introduced various mutations into the activation and RNA binding domains of human immunodeficiency virus type 1 (HIV-1) Tat in order to develop a novel and potent transdominant Tat protein and to characterize its mechanism of action. The different mutant Tat proteins were characterized for their abilities to activa
Transforming activity of retroviral genomes encoding Gag-Axl fusion proteins.: J Virol. 1996 Nov;70(11):8089-97. Unique Identifier : AIDSLINE MED/97048093; Zhang QK; Boast S; de los Santos K; Begemann M; Goff SP; Department of Microbiology, College of Physicians and Surgeons,; Columbia University, New York, New York 10032, USA.; Retroviral genomes encoding a portion of the Moloney murine leukemia virus Gag protein fused to portions of the murine axl cDNA were constructed so as to mimic naturally occurring transforming viruses. Virus MA1 retained 5 amino acids of the extracellular domain and the complete transmembrane and intracellular domains
Endogenous Mtv-encoded superantigens are not required for development of murine AIDS.: J Virol. 1996 Nov;70(11):8148-50. Unique Identifier : AIDSLINE MED/97048102; McCarty TC; Chattopadhyay SK; Scherer MT; Fredrickson TN; Hartley JW; Morse HC 3rd; Laboratory of Immunopathology, National Institute of Allergy and; Infectious Diseases, Bethesda, Maryland 20892, USA.; Immune activation in murine AIDS (MAIDS) has been suggested to involve a superantigen (SAG). The possibility that SAGs encoded by mammary tumor virus (MTV) might be the source of stimulation was studied by using Mtv mice. Mtv- mice developed typical MAIDS, excluding a requirement for Mtv-encoded SAGs in the pathogenes
The size and conformation of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) DNA in infected cells and virions.: J Virol. 1996 Nov;70(11):8151-4. Unique Identifier : AIDSLINE MED/97048103; Renne R; Lagunoff M; Zhong W; Ganem D; Howard Hughes Medical Institute and Department of Microbiology,; University of California, San Francisco 94143, USA.; The genome of a novel human herpesvirus has been detected in specimens of Kaposi s sarcoma (KS) and in several AIDS-related lymphoproliferative disorders. Here we examine the size and genomic conformation of the DNA of this virus (known as KS-associated herpesvirus or human herpesvirus 8) in latently and lytically inf
Human immunodeficiency virus type 1 capsid formation in reticulocyte lysates.: J Virol. 1996 Nov;70(11):8187-94. Unique Identifier : AIDSLINE MED/97048110; Spearman P; Ratner L; Department of Pediatrics, Vanderbilt University, Nashville,; Tennessee 37232-2581, USA.; The Gag polyprotein of human immunodeficiency virus (HIV) (Pr55Gag) contains sufficient information to direct particle assembly events when expressed within tissue culture cells. HIV Gag proteins normally form particles at a plasma membrane assembly site, in a manner analogous to that of the type C avian and mammalian
Human immunodeficiency virus type 1 subtypes defined by env show high frequency of recombinant gag genes. The UNAIDS Network for HIV Isolation and Characterization.: J Virol. 1996 Nov;70(11):8209-12. Unique Identifier : AIDSLINE MED/97048114; Cornelissen M; Kampinga G; Zorgdrager F; Goudsmit J; Department of Human Retrovirology, Academic Medical Centre,; Amsterdam, The Netherlands.; Genetic subtypes of human immunodeficiency virus type 1 can be distinguished on the basis of phylogenetic analysis of their envelope (env) gene. A significant proportion of human immunodeficiency virus type 1 strains was retrospectively shown to result from recombination events between viruses belonging genetically to
HIV infection : primary care update. [videorecording]: [Oakland, Calif.] : Kaiser Foundation Health Plan, c1996 1 videocassette (50 min.) : sd., col. ; 1/2 in. + 1 guide (15 p.) Medicine in the nineties) Unique Identifier : AIDSLINE MED/9617388; Hammer H
SPID i opportunisticheskie virusnye neiroinfektsii.: Ekaterinburg : Izd-vo Ural'skogo universiteta, 1993 225 p. : ill Unique Identifier : AIDSLINE MED/9513735; Glinskikh NP
Aids e sexualidade : o ponto de vista da ciencias humanas.: Rio de Janeiro : Relume Dumara, c1994 246 p. : ill Unique Identifier : AIDSLINE MED/9600350; Loyola MA
AIDS : amores, transtornos e desgracas.: Sao Paulo : Livraria Pioneira Editora, c1994 xii, 123 p. : Colecao Novos umbrais) Unique Identifier : AIDSLINE MED/9517522; Amato Neto V
Epidemiologiia i profilaktika VICh-infektsii v voiskakh : uchebnoe posobie.: Sankt-Peterburg : Voenno-med. akademiia, 1994 61 p Unique Identifier : AIDSLINE MED/9610714; Zolochevskii MA
Seminario a epidemiologia social da aids : anais.: Rio de Janeiro : IMS, 1994 61 p. : ill Unique Identifier : AIDSLINE MED/9601706; Parker RG
El SIDA y la infeccion VIH en Republica Dominicana : documento de divulgacion.: Santo Domingo, D.N. : Secretaria de Estado de Salud Publica y Asistencia Social (SESPAS), Programa Control de Enfermedades de Transmision Sexual y SIDA (PROCETS), [1994] 25 p. : ill Unique Identifier : AIDSLINE MED/9614051; Baez C
Argentina, pais HIV : primera encuesta nacional sobre sexualidad y prevencion del SIDA.: Buenos Aires : Editorial Galerna, c1995 176, xiii p Unique Identifier : AIDSLINE MED/9614126; Frontera LA
Zur wissenschaftlichen Konstruktion von Krankheit am Beispiel AIDS.: Klagenfurt : Institut fur interdisziplinare Forschung und Fortbildung der Universitaten Innsbruck, Klagenfurt und Wien, [1995?] 155 leaves : ill (Klagenfurter Beitrage zur Technikdiskussion ; Heft 68) Unique Identifier : AIDSLINE MED/9609985; Zellacher L
Delivering HIV care in a managed care environment : issues and strategies : a meeting sponsored by the Kaiser Family Foundation in collaboration with the Health Resources and Services Administration : meeting summary.: Washington, DC (1450 G St., NW, Suite 250, Washington 20005) : Health Systems Research, [1996] 1 v. (various pagings) Unique Identifier : AIDSLINE MED/9617797; Bartlett L
HIV infection : primary care update. [videorecording]: [Oakland, Calif.] : Kaiser Foundation Health Plan, c1996 1 videocassette (50 min.) : sd., col. ; 1/2 in. + 1 guide (15 p.) (Medicine in the nineties) Unique Identifier : AIDSLINE AV/9617388; Hammer H
SPID i opportunisticheskie virusnye neiroinfektsii.: Ekaterinburg : Izd-vo Ural'skogo universiteta, 1993 225 p. : ill Unique Identifier : AIDSLINE CAT/9513735; Glinskikh NP
Aids e sexualidade : o ponto de vista da ciencias humanas.: Rio de Janeiro : Relume Dumara, c1994 246 p. : ill Unique Identifier : AIDSLINE CAT/9600350; Loyola MA
AIDS : amores, transtornos e desgracas.: Sao Paulo : Livraria Pioneira Editora, c1994 xii, 123 p. : (Colecao Novos umbrais) Unique Identifier : AIDSLINE CAT/9517522; Amato Neto V
Epidemiologiia i profilaktika VICh-infektsii v voiskakh : uchebnoe posobie.: Sankt-Peterburg : Voenno-med. akademiia, 1994 61 p Unique Identifier : AIDSLINE CAT/9610714; Zolochevskii MA
Seminario a epidemiologia social da aids : anais.: Rio de Janeiro : IMS, 1994 61 p. : ill Unique Identifier : AIDSLINE CAT/9601706; Parker RG
El SIDA y la infeccion VIH en Republica Dominicana : documento de divulgacion.: Santo Domingo, D.N. : Secretaria de Estado de Salud Publica y Asistencia Social (SESPAS), Programa Control de Enfermedades de Transmision Sexual y SIDA (PROCETS), [1994] 25 p. : ill Unique Identifier : AIDSLINE CAT/9614051; Baez C
Argentina, pais HIV : primera encuesta nacional sobre sexualidad y prevencion del SIDA.: Buenos Aires : Editorial Galerna, c1995 176, xiii p Unique Identifier : AIDSLINE CAT/9614126; Frontera LA
Zur wissenschaftlichen Konstruktion von Krankheit am Beispiel AIDS.: Klagenfurt : Institut fur interdisziplinare Forschung und Fortbildung der Universitaten Innsbruck, Klagenfurt und Wien, [1995?] 155 leaves : ill (Klagenfurter Beitrage zur Technikdiskussion ; Heft 68) Unique Identifier : AIDSLINE CAT/9609985; Zellacher L
Delivering HIV care in a managed care environment : issues and strategies : a meeting sponsored by the Kaiser Family Foundation in collaboration with the Health Resources and Services Administration : meeting summary.: Washington, DC (1450 G St., NW, Suite 250, Washington 20005) : Health Systems Research, [1996] 1 v. (various pagings) Unique Identifier : AIDSLINE CAT/9617797; Bartlett L
HIV-Ausbreitung und Pravention : epidemiologische Trends und praventive Strategien.: Weinheim : Juventa Verlag, 1996 206 p. : ill (Gesundheitsforschung) Unique Identifier : AIDSLINE CAT/9611876; Kramer A
HIV-Prophylaxe in einem computersimulierten Realitatsbereich.: Hamburg : Verlag Dr. Kovac, c1996 128 p. : ill Unique Identifier : AIDSLINE CAT/9610615; Bronner E
Choosing unsafe sex : AIDS-risk denial among disadvantaged women.: Philadelphia : University of Pennsylvania Press, c1995 ix, 232 p Unique Identifier : AIDSLINE CAT/9613934; Sobo EJ
Recent HIV seroprevalence levels by country : July 1995.: [Washington, D.C.] : Health Studies Branch, International Programs Center, Population Division, U.S. Bureau of the Census, [1995] v, 48 p. : ill (Research note ; no. 17) Unique Identifier : AIDSLINE CAT/9614239; Corbin J
The nature of the HIV/AIDS epidemic in sub-Saharan Africa.: [Canberra] : Australian National University, [1995] 22 p. : ill (Health Transition working paper ; no. 22) Unique Identifier : AIDSLINE CAT/9617680; Caldwell JC
Le sida et les fragilites francaises : nos reactions face a l'epidemie.: Paris : Albin Michel, c1995 376 p Unique Identifier : AIDSLINE CAT/9615537; Savigny Jd
Interventions to prevent HIV risk : January 1991 through November 1996.: Bethesda, Md. (8600 Rockville Pike) : U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, National Library of Medicine, Reference Section ; Pittsburgh, PA. : Sold by the Supt. of Docs., U.S. G.P.O., 1996 (Current bibliographies in medicine ; 96-7) Unique Identifier : AIDSLINE CAT/9701253; Tillman PS; Pequegnat W; Interventions to Prevent HIV Risk Behaviors
Peregrinos del SIDA. 1. ed.: Santa Fe de Bogota, D.C., Colombia : Temas'de hoy, c1995 408 p (Coleccion Colombia hoy ; 2) Unique Identifier : AIDSLINE CAT/9616079; Canon M. L
Processo de desenvolvimento de vacinas anti-HIV/AIDS : problemas e beneficios : anais do seminario 1994 = Proces de developpement de vaccins anti-VIH/SIDA : problemes et beneficies : annales du seminaire 1994.: (Brazil) [Brasilia] : Ministerio da Saude, Secretaria de Assistencia a Saude, Programa Nacional de DST/AIDS. c1995 185 p Unique Identifier : AIDSLINE CAT/9601704
HIV-1 tat protein enhanced zidovudine-induced bone marrow toxicity (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 37:A1958 1996. Unique Identifier : AIDSLINE ICDB/97631958; Chitnis S; Schmidt J; Mondal D; Biswas MK; Prakash O; Agrawal KC; Dept. of Pharmacology, Tulane Univ. Sch. of Medicine, New; Orleans, LA, 70112; The trans-activator protein (Tat) of HIV-1 has been shown in our laboratory to significantly inhibit butyric acid-induced differentiation in a hematopoietic progenitor cell line, K562, upon coculturing with HL-tat cells or transfection with an affinity purified GST-Tat fusion protein. We have investigated the role of
Azidothymidine enhances in vitro cisplatin and cisplatin plus 5-fluorouracil cytotoxicity against the human colorectal cancer cell line COLO-320DM (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 37:A1985 1996. Unique Identifier : AIDSLINE ICDB/97631985; Andreuccetti M; Allegrini G; Antonuzzo A; Danesi R; Malvaldi G; Conte PF; Del Tacca M; Falcone A; Dept. Biomedicina, Sez. Patologia Generale, Via Roma 55 co Scuola; Medica, Pisa, Italy; Cisplatin (CDDP) and 5-Fluorouracil (5-FU) have demonstrated synergism which seems to be related to the inhibition of CDDP-DNA adducts repair by 5-FU. The toxic thymidine analogue azidothymidine ( AZT ) might also interfere with CDDP-DNA adducts repair
AZT is capable of modulating 5-FU resistance in human colon tumor cells (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 37:A1993 1996. Unique Identifier : AIDSLINE ICDB/97631993; Szekeres T; Findenig G; Fritzer-Szekeres M; Mader R; Gobl R; Inst. of Medical Chemistry, Univ. of Vienna, Wahringerstrabe 10,; A-1090 Vienna, Austria; 5-Fluorouracil (5-FU) is an inhibitor of thymidylate synthase and clinically used in the treatment of several solid tumors, including colorectal, head and neck, gastric and pancreatic cancers. The drug effectively inhibits dNTP de novo synthesis, however this inhibition can be circumvented by increased thymidine kinas
Interleukin-12 (IL-12) induces lymphokine activated killer (LAK) activity in peripheral blood lymphocytes from recipients of autologous and allogeneic stem cell transplants (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A722 1996. Unique Identifier : AIDSLINE ICDB/97635722; Lindgren C; Robinson N; Keeler T; Thompson JA; Fefer A; Div. of Medical Oncology, Univ. of Washington, Seattle, WA; Interleukin-12 (IL-12) is a heterodimeric cytokine which has been reported to enhance the tumor cytotoxicity of NK and T cells, to induce low levels of LAK activity in normal human lymphocytes, and to be synergistic with IL-2 via independent pathways. In murine models,
Long-term use of DOX-SL (Stealth liposomal doxorubicin HCl) in the treatment of moderate to severe AIDS-related Kaposi's sarcoma (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A842 1996. Unique Identifier : AIDSLINE ICDB/97635842; Jablonowski H; Boden D; Haussinger D; Department of Gastroenterology and Infectious Disease, University; of Dusseldorf, Germany; Advances in the design of liposomes as carriers of cytotoxic drugs have resulted in a new formulation of doxorubicin with improved pharmacokinetics and tumor localization. This new generation of liposomes, referred to as Stealth is characterized by a long circulation time with stable retention of drug, reduced hepatos
Reduced cardiotoxicity of DOXIL (pegylated liposomal doxorubicin) in AIDS Kaposi's sarcoma patients compared to a matched control group of cancer patients given doxorubicin (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A843 1996. Unique Identifier : AIDSLINE ICDB/97635843; Berry G; Billingham M; Alderman E; Torti F; Lum B; DuMond C; Martin F; Stanford Medical Center, Stanford, CA 94305; Doxorubicin (DOX)-induced cardiotoxicity can limit the duration of therapy with this agent and may be exacerbated by combination with newer agents such as taxanes. DOXIL , a pegylated liposome formulation of doxorubicin, is less cardiotoxic than DOX in rats, dogs and ra
Validation of the AIDS clinical trials group (ACTG) staging classification for AIDS-associated Kaposi's sarcoma (AIDS/KS) (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A844 1996. Unique Identifier : AIDSLINE ICDB/97635844; Krown SE; Testa M; Huang J; Memorial Sloan-Kettering Cancer Center, New York, NY 10021; In 1989, the ACTG Oncology Committee published a proposal for staging of AIDS/KS (J Clin Oncol; 7:1201 1989) that classified patients into good-risk (subscript 0) and poor-risk (subscript 1) categories according to the extent of tumor (T), severity (CD4 greater than or equal to or less than 200/mm3) of immunosuppr
HIV-related cervical cancer (CA) in Italy; a report of 54 cases from the Italian Cooperative Group on AIDS and tumors (GICAT) (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A845 1996. Unique Identifier : AIDSLINE ICDB/97635845; Spina M; Vaccher E; Sopracordevole F; Santarossa S; Torresin A; Rizzardini G; Conti M; Mangioni C; Scarabelli C; Tirelli U; Italian Cooperative Group on AIDS and Tumors, C.R.O., Aviano,; Italy; The incidence of cervical intraepithelial neoplasias has increased in HlV-infected women, and invasive cervical ca is currently considered an AIDS defining condition. However the natural history of HIV-related cervical ca is still unknown. To better characterize cervical ca in HIV-infected women we evaluated 54 cases,
Epirubicin, bleomycin, vinblastine and prednisone (EBVP) chemotherapy (CT) in combination with antiretroviral therapy and primary use of G-CSF for patients (pts) with Hodgkin's disease and HIV infection (HD-HIV) (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A847 1996. Unique Identifier : AIDSLINE ICDB/97635846; Tirelli U; Errante D; Gisselbrecht C; Marolleau JP; Kerneis Y; Ridolfo A; Mazzetti M; Levis A; Veneri D; Rossi G; Spina M; Vaccher E; Division of Medical Oncology and AIDS, C.R.O. National Cancer; Institute, 33081 Aviano, Italy; The optimal therapeutic approach for pts with HD-HIV is unknown. In an attempt to improve the results that we obtained in a previous prospective study with EBV without G-CSF (Cancer 73:437-44, 1994), in January 1993 we started a second trial consisting of CT, concomitant antiretroviral therapy (
Age and LDH are independent prognostic factors also in HIV-related non-Hodgkin's lymphoma (HIV-NHL): a monoinstitutional study of 96 patients (pts) (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A848 1996. Unique Identifier : AIDSLINE ICDB/97635848; Vaccher E; Spina M; Errante D; Tavio M; Nasti G; Simonelli C; Talamini R; Tirelli U; Division of Medical Oncology and AIDS, C.R.O. National Cancer; Institute, 33081 Aviano, Italy; In patients with HIV-NHL several prognostic factors have already been identified to correlate with survival: low CD4 count, prior history of AIDS and poor performance status (PS). The role of other prognostic factors, such as age, LDH, stage and multiple extranodal sites, that have been identified in intermediate-high
Low dose radiation in the treatment of HIV related benign lymphoepithelial lesions of the parotid gland (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A850 1996. Unique Identifier : AIDSLINE ICDB/97635850; Teng M; Tchelebi A; Moscatello A; Moorthy CR; Kaufmann T; Ahmed T; Department of Radiation, Westchester County Medical Center, New; York Medical College, Valhalla, NY 10595; At NYMC 17 patients with HIV related benign lymphoepithelial lesions of the parotid gland were treated with external beam radiation therapy from 1991 to 1995. Patients age ranged from 31 to 58 year old with a median age of 38 years; 10 patients were males and 5 were females. The median duration of symptoms was 1.5 yea
Mitoguazone dihydrochloride (MGBG) in combination with radiation therapy in the treatment of AIDS related primary CNS lymphoma (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A853 1996. Unique Identifier : AIDSLINE ICDB/97635853; Tulpule A; Espina BM; Montgomery T; VonHoff DD; Tessman D; Levine AM; University of Southern California, Los Angeles, CA; Prognosis for patients with AIDS-related primary central nervous system (CNS) lymphoma is very poor, with median survivals of 2-3 months, even with radiation therapy. Mitoguazone dihydrochloride (MGBG) at a dose of 600 mg/m2 given intravenously on day 1, 8 and then every 2 weeks has shown activity in patients with rel
Paclitaxel (Taxol) in the treatment of relapsed or refractory advanced AIDS-related Kaposi's sarcoma (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A854 1996. Unique Identifier : AIDSLINE ICDB/97635854; Gill PS; Tulpule A; Reynolds T; Hadjenberg J; Mocharnuk R; Espina BM; Bresnahan J; Cabriales S; Ilaw M; Shea K; Scadden DT; University of Southern California School of Medicine, Los; Angeles, CA; Taxol is a potent cytotoxic agent with preliminary evidence of antitumor efficacy in patients with AIDS-related Kaposi s sarcoma (AIDS-KS). We studied AIDS-KS patients who relapsed or were refractory to at least one prior cytotoxic chemotherapy regimen. Low dose Taxol was given at a dose of 100 mg/m2 iv over 3 hours e
Long-term, disease free survival in AIDS-related lymphoma (AIDS-NHL) (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A855 1996. Unique Identifier : AIDSLINE ICDB/97635855; Mocharnuk RS; Ghadialy A; Tulpule A; Espina B; Levine AM; USC School of Med., Los Angeles, CA 90033; Although lymphoma comprises approximately 3% of all initial AIDS defining illnesses, it is the cause of death in approximately 16% of AIDS patients. Lymphoma is thus felt to represent a late manifestation of HIV disease, with increasing numbers of patients expected as survival with HIV is prolonged. While advances in
Increase in CD4 cell number in AIDS patients with CD4 count below 200/mm3 by neuroimmunotherapy with subcutaneous low-dose IL-2 and the pineal hormone melatonin (MLT) (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A857 1996. Unique Identifier : AIDSLINE ICDB/97635857; Lissoni P; Vigano MG; Giani L; Brivio F; Barni S; Ardizzoia A; Tancini G; Div. of Radiotherapy, S. Gerardo Hospital, Monza, Italy; IL-2 deficiency is the main AIDS-related immune disorder. Low levels of IL-2 are associated with a poor prognosis. At the other side, IL-2 injection has appeared to increase CD4 cell number in patients (pts) with CD4 count greater than 200/mm3, whereas no benefit was s
Low dose weekly paclitaxel for HIV associated Kaposi's sarcoma (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A859 1996. Unique Identifier : AIDSLINE ICDB/97635859; Mega A; Akhtar MS; Safran H; Rich J; Sikov W; Flanigan T; Brown University Oncology Group, The Miriam Hospital, Providence,; RI; Paclitaxel is among the most active agents for Kaposi s sarcoma (KS) but its use in patients with HIV is limited by myelosupression. The Brown University Oncology Group has demonstrated that weekly paclitaxel may be more active and less myelosuppressive than a standard 21-day schedule. Therefore, we investigated a reg
Survival times of patients with AIDS-related Kaposi's sarcoma with pulmonary involvement using liposomal doxorubicin (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A860 1996. Unique Identifier : AIDSLINE ICDB/97635860; Goebel FD; Gruenaug M; Bogner JR; Med. Poliklinik, University of Munich, 80336 Munich, Germany; Pulmonary KS in HIV-infected pts carries a grave prognosis with a mean survival time between 2.1 and 6 months (JAIDS; 1:23 1988, Amer J Med; 87:57 1989). In a phase II study liposomal doxorubicin (SL-Dox) has been shown to be effective in advanced AIDS-related KS. In a single participating center 18 pts with endoscopi
Sanctuary growth of human immunodeficiency virus in the presence of AZT: implications for antiviral and antineoplastic therapy in patients with HIV infection (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A861 1996. Unique Identifier : AIDSLINE ICDB/97635861; Medina D; Tung PP; Strair RK; Cancer Institute of New Jersey, Robert Wood Johnson Medical; School, Piscataway, NJ; The current hypothesis for the failure of antiretroviral agents to completely inhibit HIV is the emergence of drug-resistant virus. This theory may explain the failure of the non-nucleoside reverse transcriptase inhibitors but it does not explain why AZT
Treatment of advanced epidemic Kaposi's sarcoma (EKS) with bleomycin or a combination of doxorubicin, bleomycin and vincristine (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A862 1996. Unique Identifier : AIDSLINE ICDB/97635862; Hernandez DE; Perez JR; Vargas Medical School, Universidad Central de Venezuela, 1070-A; Caracas, Venezuela; EKS remains the most common neoplastic complication of AIDS,affecting up to 20% of patients (pts). Twenty-four homosexual or bisexual male pts, between 21 and 49 years old (median age, 35) were included. Pts were clinically staged according to AIDS Clinical Trial Group (ACTG) criteria. Pts in both groups had more than
Systemic treatment with human chorionic gonadotropin (HCG) in patients (pts) with HIV-related Kaposi's sarcoma (KS) (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A864 1996. Unique Identifier : AIDSLINE ICDB/97635864; Tavio M; Nasti G; Vaccher E; Errante D; Spina M; Simonelli C; Tirelli U; Div. of Medical Oncology and AIDS, C.R.O. National Cancer; Institute, 33081 Aviano, Italy; The beta-chain of human chorionic gonadotropin (HCG) is able to block tumorigenesis and metastasis of neoplastic KS cell line in immune deficient mice (Lunardi-Iskandar et al, Nature; 375:64-8 1995). Based on this data we began a clinical trial with escalating doses of HCG in 5 pts with HIV-KS, according to the follow
The interferon (INF) system in neoplastic and retroviral diseases (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A865 1996. Unique Identifier : AIDSLINE ICDB/97635865; Ambrus JL; Chadha K; Stadler S; Koreshi A; Department of Medicine, State University of NY at Buffalo,; Buffalo, NY; In patients with advanced AIDS and related lymphoma, acid labile alpha-INF and INF-inhibitory activity was found in the circulation. It prevented virus-induced INF production and antiviral and antineoplastic effect of human INF alpha, beta, and pi, but not INFS of other species. Similar inhibitory activity was found i
Phase I study - photodynamic therapy (PDT) for treatment of AIDS-associated Kaposi's sarcoma (AIDS/KS) (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A866 1996. Unique Identifier : AIDSLINE ICDB/97635866; Bernstein ZP; Wilson D; Foulke L; Brooks J; Oseroff A; Bellnier D; Sumlin A; Mang TS; Dougherty T; Division of Medicine, Roswell Park Cancer Institute, Buffalo, NY; 14263; We have conducted a Phase I study utilizing PDT for palliative therapy of AIDS/KS without compromise of pts immune status. This therapy utilizes the activation by light of a photosensitizing drug (Photofrin) which preferentially accumulates in tumor tissues such as KS. All 26 entrants received 1.0 mg/kg of Photofrin
Immune recovery after cessation of chemotherapy (CT) in children with cancer (Ca) (Meeting abstract).: Proc Annu Meet Am Soc Clin Oncol; 15:A1776 1996. Unique Identifier : AIDSLINE ICDB/97636776; Mustafa MM; Buchanan GR; Winick NJ; Lipscomb M; Tkaczewski I; Ansari Q; Department of Pediatrics, University of Texas Southwestern; Medical Center, Dallas, TX 75235; We evaluated the humoral and cellular immunity of 43 children with Ca at completion of CT and every 3 mo thereafter for one yr. There were 17 pts with ALL, 17 with solid tumors and 9 with Hodgkin s disease. Their median age was 12 yr and they received CT for a median of 15 mo. Significant results are shown in a table.
A descriptive-exploratory study of outcome and some biopsychosocial characteristics of drug dependent veterans in Puerto Rico.: Bol Asoc Med P R. 1996 Jan-Mar;88(1-3):3-7. Unique Identifier : AIDSLINE MED/97039934; Santos EF; Diaz D; Martinez A; Gomez E; Visbal GN; I. OBJECTIVE: The authors attempted to correlate outcomes with various significant biopsychosocial variables in drug dependent veterans receiving outpatient treatment at San Juan V.A.M.C. II. METHODS: The clinical charts of 120 inactive patients were examined using a 50 item questionnaire. The data was processed and a
Opportunistic oral infections in the immunosuppressed patient: oral hairy leukoplakia and oral candidiasis.: Adv Dent Res. 1996 Apr;10(1):69-72. Unique Identifier : AIDSLINE MED/97089021; Sciubba JJ; Department of Dental Medicine, Long Island Jewish Medical Center,; New Hyde Park, New York, USA.; Several opportunistic infections associated with immunosuppression are noted to occur secondary to an altered relationship between host and organism. In relation to diminished host immunologic defenses, associated commensal organisms may evolve to a pathogen state. Candidiasis, a common oral marker disease reflective
Quantitation of HIV-1 p24 antibody expressed as relative binding capacity p24 antigen (p24 RBC) in infants born to HIV-1 seropositive mothers: correlation of this serological marker with the HIV-1 maternal antibody course and p24 antigenemia detection.: Viral Immunol. 1995;8(2):93-9. Unique Identifier : AIDSLINE MED/96422677; Portolani M; Meacci M; Pecorari M; Pietrosemoli P; Cermelli C; Cellini M; Tampieri A; Tartoni P; Stella F; Centre for Diagnosis of Viral Diseases, University of Modena,; Italy.; The antibody content to HIV-1 p24 Ag expressed as relative binding capacity to the target antigen (p24 RBC) was retrospectively quantified in serum samples from 20 HIV-1-uninfected infants born to HIV-1 seropositive mothers. p24 RBC values quantified at birth were included either in a low (0-20%) or high (80-100%) ran
Anti-idiotypic antibody to the V3 domain of gp120 binds to vimentin: a possible role of intermediate filaments in the early steps of HIV-1 infection cycle.: Viral Immunol. 1996;9(2):73-87. Unique Identifier : AIDSLINE MED/96419925; Thomas EK; Connelly RJ; Pennathur S; Dubrovsky L; Haffar OK; Bukrinsky MI; Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle,; Washington 98121, USA.; Although the CD4 molecule is the major cellular receptor for human immunodeficiency virus (HIV), several lines of evidence suggest participation of additional molecules that are engaged after the binding of HIV to the CD4 receptor and that may facilitate viral entry into the target cell. Some of the post-CD4 binding,
The theatre: an effective tool for health promotion.: World Health Forum. 1996;17(1):64-9. Unique Identifier : AIDSLINE MED/96417355; Seguin A; Rancourt C; In Africa and in North America, in both rural and urban settings, theatre can be an effective means of health promotion. Projects on women s health, care for patients with mental disorders, and AIDS prevention show the usefulness of this medium for community action programmes.
Multisectoral strategy for AIDS prevention at community level.: World Health Forum. 1996;17(1):70-4. Unique Identifier : AIDSLINE MED/96417356; Elkins DB; Kuyyakanond T; Maticka-Tyndale E; Rujkorakarn D; Haswell-Elkins M; Northeast Centre for AIDS Prevention and Care, Khon Kaen; University, Thailand.; In north-east Thailand a five-act drama is broadcast on the village sound system to catalyse involvement in planning and carrying out AIDS prevention activities. Each community s own suggestions for an effective strategy are presented to the relevant government and nongovernmenta
Does AIDS emerge from a disequilibrium between two complementary groups of molecules that mimic MHC?: Immunol Today. 1996 Mar;17(3):114-9. Unique Identifier : AIDSLINE MED/96417477; Susal C; Daniel V; Opelz G; Department of Transplantation Immunology, Institute of; Immunology, University of Heidelberg, Germany.; caner.suesal@krzmail.krz.uni-heidelberg.de; There is increasing evidence that a disturbance of self-nonself-recognition plays an important role in the immunopathogenesis of AIDS. Here, Caner Susal, Volker Daniel and Gerhard Opelz speculate that the immune system is balanced between two groups of molecules that mimic major histocompatibility complex (MHC) protei
The role of host immune responses in determining the outcome of HIV infection.: Immunol Today. 1996 Mar;17(3):120-6. Unique Identifier : AIDSLINE MED/96417478; Westby M; Manca F; Dalgleish AG; Division of Oncology, Cellular and Molecular Sciences, St; George's Hospital Medical School, Tooting, UK.; dalgleis@sghms.ac.uk; The progression of disease following infection with human immunodeficiency virus (HIV) correlates with an activated immune system and would appear to depend to some degree on the immunogenetics of the host. Here, Michael Westby, Fabrizio Manca and Angus Dalgleish discuss the evidence for HLA determination of clinical
The expanding universe of T-cell subsets: Th1, Th2 and more.: Immunol Today. 1996 Mar;17(3):138-46. Unique Identifier : AIDSLINE MED/96417481; Mosmann TR; Sad S; Department of Medical Microbiology and Immunology, University of; Alberta, Edmonton, Canada. tim.mosmann@ualberta.ca; Since their discovery nearly ten years ago, T helper 1 (Th1) and Th2 subsets have been implicated in the regulation of many immune responses. In this article, Tim Mosmann and Subash Sad discuss the increasing number of T-cell subsets defined by cytokine patterns; the differentiation pathways of CD4+ and CD8+ T cells;
Can you exercise to make your immune system fitter?: Immunol Today. 1996 Jun;17(6):252-4. Unique Identifier : AIDSLINE MED/96402035; Brines R; Hoffman-Goetz L; Pedersen BK; Immunology Today.
HIV-I infection and cellular metabolism.: Immunol Today. 1996 Jun;17(6):256-8. Unique Identifier : AIDSLINE MED/96402037; De Simone C; Famularo G; Cifone G; Mitsuya H; Dept of Experimental Medicine, University of L'Aquila, Italy.
Inhibition of cyclophilin function in HIV-I infection by cyclosporin A.: Immunol Today. 1996 Jun;17(6):259-60. Unique Identifier : AIDSLINE MED/96402038; Huss R; Institute of Pathology, University of Munich, Germany.; u7912ab@sunmail.Irz-muenchen.de
Mechanisms that contribute to the development of lymphoid malignancies: roles for genetic alterations and cytokine production.: Crit Rev Immunol. 1996;16(1):31-57. Unique Identifier : AIDSLINE MED/96405332; Levy LS; Bost KL; Department of Microbiology and Immunology, Tulane University; Medical Center, New Orleans, Louisiana 70112, USA.; Recent studies have defined genetic alterations commonly associated with transformed lymphocytes. This review suggests roles for these alterations in the development of lymphoid neoplasms. Damage to the genes encoding proteins that function in intracellular signaling, transcription, or regulation of the cell cycle has
Role of cytokines in development of Th1 and Th2 cells.: Chem Immunol. 1996;63:1-13. Unique Identifier : AIDSLINE MED/97088920; O'Garra A; Murphy K; DNAX Research Institute, Palo Alto, Calif., USA.
Th1 and Th2 cells in HIV infection.: Chem Immunol. 1996;63:138-57. Unique Identifier : AIDSLINE MED/97088927; Manetti R; Annunziato F; Gianno V; Tomasevic L; Beloni L; Mavilia C; Maggi E; Institute of Internal Medicine and Immunoallergology, University; of Florence, Italy.
Th1 and Th2 cells in autoimmunity.: Chem Immunol. 1996;63:138-70. Unique Identifier : AIDSLINE MED/97088928; Druet P; Sheela R; Pelletier L; INSERM U28, Hopital de Purpan, Toulouse, France.
Role of interleukin-12 in human Th1 response.: Chem Immunol. 1996;63:14-29. Unique Identifier : AIDSLINE MED/97088921; Trinchieri G; Wistar Institute of Anatomy and Biology, Philadelphia, Pa., USA.
Role of Th1 and Th2 cells in neurologic disorders.: Chem Immunol. 1996;63:171-86. Unique Identifier : AIDSLINE MED/97088929; Windhagen A; Nicholson LB; Weiner HL; Kuchroo VK; Hafler DA; Center for Neurologic Diseases, Brigham and Women's Hospital and; Harvard Medical School, Boston, Mass., USA.
Role of Th1 and Th2 cells in human allergic disorders.: Chem Immunol. 1996;63:187-203. Unique Identifier : AIDSLINE MED/97088930; Robinson DS; Kay AB; Department of Allergy and Clinical Immunology, National Heart and; Lung Institute, London, UK.
Markers of Th1 and Th2 cells.: Chem Immunol. 1996;63:30-50. Unique Identifier : AIDSLINE MED/97088922; Almerigogna F; D'Elios MM; De Carli M; Del Prete G; Institute of Internal Medicine and Immunoallergology, University; of Florence, Italy.
Role of Th1 and Th2 cells in bacterial infections.: Chem Immunol. 1996;63:66-97. Unique Identifier : AIDSLINE MED/97088924; Daugelat S; Kaufmann SH; Department of Immunology, University of Ulm, Germany.
5-HT agonist-induced changes in peripheral immune cells in healthy volunteers: the impact of personality.: Behav Brain Res. 1996;73(1-2):359-63. Unique Identifier : AIDSLINE MED/96380519; Hennig J; Becker H; Netter P; Department of Psychology, University of Giessen, FRG.; juergen.hennig@psychol.uni-giessen.de; The present study was conducted to investigate the relationship between the serotonergic neurotransmitter system and migration patterns of peripheral lymphocytes. Altogether 40 healthy male volunteers were given either a single dosage of the 5-HT1a-receptor agonist ipsapirone (10 mg) or a placebo (n = 20 each) in a do
Conformational characteristics of high affinity Sp1 binding enhancer elements of HIV-LTR by high resolution 2D-NMR.: J Biomol Struct Dyn. 1995 Dec;13(3):553-64. Unique Identifier : AIDSLINE MED/96423135; Singh MP; Pon RT; Lown JW; Department of Chemistry, University of Alberta, Edmonton, Canada.; The understanding of early events in the expression of genes has vastly improved in recent years with the identification of a variety of gene- and sequence-specific DNA binding transcription factors. One such protein, Sp1, has been implicated in activating transcription of various cellular and viral genes including th
V3 seroreactivity and sequence variation: tracking the emergence of V3 genotypic variation in HIV-1-infected patients.: AIDS. 1996 Feb;10(2):121-9. Unique Identifier : AIDSLINE MED/96435813; Michael NL; Davis KE; Loomis-Price LD; VanCott TC; Burke DS; Redfield RR; Birx DL; Division of Retrovirology, Walter Reed Army Institute of; Research, Washington, DC, USA.; OBJECTIVE: To investigate the relationship between V3-specific immune responses and viral quasispecies evolution in 10 HIV-1-seropositive patients enrolled in a phase I trial of recombinant gp160. METHODS: Serologic responses to the HIVLAI V3 loop and autologous V3 loop DNA sequences were sequentially determined over
Overexpression of Fas antigen on T cells in advanced HIV-1 infection: differential ligation constantly induces apoptosis.: AIDS. 1996 Feb;10(2):131-41. Unique Identifier : AIDSLINE MED/96435814; Silvestris F; Cafforio P; Frassanito MA; Tucci M; Romito A; Nagata S; Dammacco F; Department of Biomedical Sciences and Human Oncology, University; of Bari, Italy.; OBJECTIVES: To investigate Fas in peripheral lymphocytes from HIV-1-positive patients at different disease stages with respect to the extent of apoptosis. DESIGN: The study included analysis of Fas involvement in T-cell apoptosis observed during HIV-1 infection. Because ligation of Fas can result in costimulation of p
Defective killing activity against gp120/41-expressing human erythroleukaemic K562 cell line by monocytes and natural killer cells from HIV-infected individuals.: AIDS. 1996 Feb;10(2):143-9. Unique Identifier : AIDSLINE MED/96435815; Ahmad A; Menezes J; Department of Microbiology and Immunology, University of; Montreal/Ste-Justine Hospital, Quebec, Canada.; OBJECTIVE: To determine the role of natural cellular cytotoxicity of peripheral blood mononuclear cells (PBMC) in killing of HIV-1 envelope protein-expressing, natural killer (NK)-sensitive human target cells, and to investigate this effector function in HIV-infected individuals. DESIGN AND METHODS: An HIV-1 env gene-
Localization of quinolinic acid in the murine AIDS model of retrovirus-induced immunodeficiency: implications for neurotoxicity and dendritic cell immunopathogenesis.: AIDS. 1996 Feb;10(2):151-8. Unique Identifier : AIDSLINE MED/96435816; Espey MG; Tang Y; Morse HC 3rd; Moffett JR; Namboodiri MA; Department of Biology, Georgetown University, Washington, DC USA.; OBJECTIVE AND DESIGN: Using murine AIDS (MAIDS) as a model of retrovirus-induced immunodeficiency, the aims of this study were (1) to determine the cellular source(s) of quinolinic acid (Quin) with regard to its significance as a potential neuroexcitotoxin in AIDS dementia complex,
The prognostic significance of serum viral load, codon 215 reverse transcriptase mutation and CD4+ T cells on progression of HIV disease in a double-blind study of thymopentin.: AIDS. 1996 Feb;10(2):159-65. Unique Identifier : AIDSLINE MED/96435817; Merigan TC; Hirsch RL; Fisher AC; Meyerson LA; Goldstein G; Winters MA; Center for AIDS Research, Stanford University Medical Center,; California 94305, USA.; OBJECTIVE: To determine in asymptomatic HIV-infected subjects the prognostic value of virion reverse transcriptase (RT) codon 215 mutation, serum HIV RNA level, CD4+ T-cell count and immune complex dissociated (ICD) p24 level. The retrospective evaluation of thymopentin treatment effect on subjects in high risk groups
Longitudinal serum HIV RNA quantification: correlation to viral phenotype at seroconversion and clinical outcome.: AIDS. 1996 Feb;10(2):167-73. Unique Identifier : AIDSLINE MED/96435818; Katzenstein TL; Pedersen C; Nielsen C; Lundgren JD; Jakobsen PH; Gerstoft J; Department of Infectious Diseases, Rigshospitalet, Copenhagen,; Denmark.; OBJECTIVE: To investigate the longitudinal changes in serum HIV RNA, and to clarify whether the viral load early in infection has a predictive value for the clinical outcome; also, to correlate viral phenotype at seroconversion and changes in CD4 cell counts with viral burden. DESIGN: Twenty seroconverters with HIV is
Kaposi's sarcoma-associated herpesvirus infection prior to onset of Kaposi's sarcoma.: AIDS. 1996 Feb;10(2):175-80. Unique Identifier : AIDSLINE MED/96435819; Moore PS; Kingsley LA; Holmberg SD; Spira T; Gupta P; Hoover DR; Parry JP; Conley LJ; Jaffe HW; Chang Y; Division of Epidemiology, Columbia University School of Public; Health, New York, New York, 10032 USA.; OBJECTIVES: Kaposi s sarcoma-associated herpesvirus (KSHV), a newly discovered human gammaherpesvirus, is found in the majority of KS lesions from patients with and without AIDS. Peripheral blood mononuclear cells (PBMC) were examined for KSHV DNA to determine whether viral infection precedes onset of this neoplasm. D
High frequency of non-Hodgkin's lymphoma in patients with HIV-associated Kaposi's sarcoma.: AIDS. 1996 Feb;10(2):181-5. Unique Identifier : AIDSLINE MED/96435820; Ridolfo AL; Santambrogio S; Mainini F; Vago L; Gervasoni C; Gori A; Parravicini C; Monforte A; Galli M; Clinic of Infectious Diseases, University of Milan, Italy.; OBJECTIVE: To evaluate, with the support of autopsy findings, the frequency of non-Hodgkin s lymphoma (NHL) among patients with AIDS-associated Kaposi s sarcoma (KS) in comparison with that of AIDS patients with other AIDS-defining diseases. METHODS: The study involved 363 consecut
Trends in HIV seroprevalence in men who have sex with men: New York City Department of Health sexually transmitted disease clinics, 1988-1993.: AIDS. 1996 Feb;10(2):187-92. Unique Identifier : AIDSLINE MED/96435821; Torian LV; Weisfuse IB; Makki HA; Benson DA; DiCamillo LM; Patel PR; Toribio FE; Office of AIDS Research and HIV Serosurveys, New York City; Department of Health, NY 10013, USA.; OBJECTIVE: To measure HIV seroprevalence trends in a primarily non-white sample (n = 1618) of men who have sex with men (MSM). The MSM were sampled at New York City Department of Health (NYC-DOH) sexually transmitted disease (STD) clinics during 1988-1993. DESIGN: Unlinked HIV-1 serosurvey using remnant serum original
Geographic variation in sexual behaviour in Britain: implications for sexually transmitted disease epidemiology and sexual health promotion.: AIDS. 1996 Feb;10(2):193-9. Unique Identifier : AIDSLINE MED/96435822; Wadsworth J; Hickman M; Johnson AM; Wellings K; Field J; Department of Epidemiology and Public Health, St Mary's Hospital; Medical School, London, UK.; OBJECTIVES: To explore geographical variation in sexual behaviour in Great Britain with reference to the prevalence of HIV infection. DESIGN: The National Survey of Sexual Attitudes and Lifestyles comprises a randomly selected, representative sample of almost 19,000 men and women aged 16-59 years living in Great Brita
Sexual behaviors and risk factors for HIV infection among men who have sex with men in the Dominican Republic.: AIDS. 1996 Feb;10(2):201-6. Unique Identifier : AIDSLINE MED/96435823; Tabet SR; de Moya EA; Holmes KK; Krone MR; de Quinones MR; de Lister MB; Garris I; Thorman M; Castellanos C; Swenson PD; Dallabeta GA; Ryan CA; Department of Medicine, University of Washington, Seattle, 98122; USA.; OBJECTIVE: To describe self-reported types of sexual identity of men who have sex with men (MSM) in the Dominican Republic , assess sociodemographics and behavioral characteristics, and measure the prevalence of HIV-1 and syphilis. D
Reported condom use is not associated with incidence of sexually transmitted diseases in Malawi.: AIDS. 1996 Feb;10(2):207-12. Unique Identifier : AIDSLINE MED/96435824; Taha TE; Canner JK; Chiphangwi JD; Dallabetta GA; Yang LP; Mtimavalye LA; Miotti PG; Johns Hopkins School of Hygiene and Public Health, Baltimore,; Maryland 21205, USA.; OBJECTIVES: To establish frequency of reported condom use and validate reliability of self-reporting among urban women in Malawi . DESIGN: Cross-sectional survey in antenatal women in 1989 and 1993. Prospective study in cohort first surveyed in 1989. METHODS: A total of 6561 women i
Behavioral interventions for reduction of sexually transmitted disease/HIV transmission among female commercial sex workers and clients in Bali, Indonesia.: AIDS. 1996 Feb;10(2):213-22. Unique Identifier : AIDSLINE MED/96435825; Ford K; Wirawan DN; Fajans P; Meliawan P; MacDonald K; Thorpe L; School of Public Health, University of Michigan, Ann Arbor; 48109-2029, USA.; OBJECTIVE: To describe and evaluate a behavioral intervention targeted to low-price female commercial sex workers (CSW) in large brothel complexes, their pimps, and their male clients. DESIGN AND METHODS: Fieldwork was conducted during 1994 in Bali, Indonesia . Intervention activ
Factors associated with tuberculosis at AIDS diagnosis in France.: AIDS. 1996 Feb;10(2):223-8. Unique Identifier : AIDSLINE MED/96435826; Triol I; Schwoebel V; Delmas MC; Pinget R; Laporte A; Brunet JB; National Public Health Centre, France.; OBJECTIVE: To identify factors associated with tuberculosis (TB) at AIDS diagnosis in France . DESIGN: Analysis of surveillance data. METHODS: Among all adult AIDS cases diagnosed since January 1988 and reported by December 1993 in France, the proportion diagnosed with AIDS-defining
Evolution of the V1 and V2 domains of the HIV-2 env gene in healthy but persistently infected macaques [letter]: AIDS. 1996 Feb;10(2):229-30. Unique Identifier : AIDSLINE MED/96435827; Bayon-Auboyer MH; Boussin FD; Le Grand R; Dormont D
Evaluation of a capillary polymerase chain reaction procedure for the rapid detection of HIV-1 DNA in blood [letter]: AIDS. 1996 Feb;10(2):230-1. Unique Identifier : AIDSLINE MED/96435828; Booth MJ; Boriskin YS; Booth JC; Carrington D; Sharland M; Davies EG
First case of new infection with zidovudine-resistant HIV-1 among prospectively studied intravenous drug users and homosexual men in Amsterdam, The Netherlands [letter]: AIDS. 1996 Feb;10(2):231-2. Unique Identifier : AIDSLINE MED/96435829; de Ronde A; Schuurman R; Goudsmit J; van den Hoek A; Boucher C
Quantitative relationship between platelet count and plasma virion HIV RNA [letter]: AIDS. 1996 Feb;10(2):232-3. Unique Identifier : AIDSLINE MED/96435830; Holodniy M; Margolis D; Carroll R; Todd J; Mole L
The use of oral fluid to determine HIV-1 prevalence rates among men in Mexico City [letter]: AIDS. 1996 Feb;10(2):233-4. Unique Identifier : AIDSLINE MED/96435831; del Rio C; Guarner J; Izazola-Licea JA
Condom use among HIV-infected patients in South Bronx, New York [letter]: AIDS. 1996 Feb;10(2):235-6. Unique Identifier : AIDSLINE MED/96435832; Sobel E; Shine D; DiPietro D; Rabinowitz M
Gonorrhoea in homosexual men in London [letter]: AIDS. 1996 Feb;10(2):236-7. Unique Identifier : AIDSLINE MED/96435833; Sherrard J; Barlow D
JC virus: a source of confusion [letter]: AIDS. 1996 Feb;10(2):237. Unique Identifier : AIDSLINE MED/96435834; Farr RW
Pentamidine isethionate as secondary prophylaxis against visceral leishmaniasis in HIV-positive patients [letter]: AIDS. 1996 Feb;10(2):237-8. Unique Identifier : AIDSLINE MED/96435835; Perez-Molina JA; Lopez-Velez R; Montilla P; Guerrero A
Comparative impact assessment of AIDS: between doomsday and complacency [letter]: AIDS. 1996 Feb;10(2):238-40. Unique Identifier : AIDSLINE MED/96435836; Jager JC; Achterberg PW; Postma MJ; Houweling H
Studies of HIV-1 envelope glycoprotein-mediated fusion using a simple fluorescence assay.: AIDS. 1996 Mar;10(3):241-6. Unique Identifier : AIDSLINE MED/97037015; Weiss CD; Barnett SW; Cacalano N; Killeen N; Littman DR; White JM; Department of Pharmacology, University of California, San; Francisco, USA.; OBJECTIVE: To study HIV envelope glycoprotein (Env)-mediated entry using a sensitive fusion assay. DESIGN AND METHODS: CD4+ lymphocytes or T-cell lines were labelled with fluorescent cytoplasm or membrane markers. Fusion with Env-expressing adherent cells was monitored by observing dye transfer from CD4+ cells to Env
Cytotoxic T-lymphocytes from HIV-infected individuals recognize an activation-dependent, non-polymorphic molecule on uninfected CD4+ lymphocytes.: AIDS. 1996 Mar;10(3):247-54. Unique Identifier : AIDSLINE MED/97037016; Bienzle D; Smaill FM; Rosenthal KL; Department of Pathology, McMaster University, Hamilton, Ontario,; Canada.; OBJECTIVES: Correlation of lysis of autologous CD4+ target cells by cytotoxic lymphocytes from HIV-seropositive patients to target activation, viral replication, and major histocompatibility complex (MHC) restriction. DESIGN: Twenty-two HIV-infected patients were evaluated for lysis of activated CD4+ cells, concurrent
Predictive value of viral load measurements in asymptomatic untreated HIV-1 infection: a mathematical model.: AIDS. 1996 Mar;10(3):255-62. Unique Identifier : AIDSLINE MED/97037017; Ioannidis JP; Cappelleri JC; Lau J; Sacks HS; Skolnik PR; Department of Medicine, Tufts University School of Medicine and; Tupper Research Institute, Boston, Massachusetts, USA.; OBJECTIVE: To model the predictive value of viral load measurements in asymptomatic patients with HIV-1 infection, who have CD4 cell counts > 500 x 10(6)/l and no prior antiretroviral therapy, when the time of seroconversion and the prior levels of viremia are unknown. DESIGN: A mathematical model was constructed for
Oropharyngeal yeast flora and fluconazole resistance in HIV-infected patients receiving long-term continuous versus intermittent fluconazole therapy.: AIDS. 1996 Mar;10(3):263-8. Unique Identifier : AIDSLINE MED/97037018; Heald AE; Cox GM; Schell WA; Bartlett JA; Perfect JR; Department of Medicine, Duke University Medical Center, Durham,; NC 27710, USA.; OBJECTIVE: To examine the impact of continuous versus intermittent fluconazole therapy on fungal colonization and fluconazole resistance in the oropharynx of HIV-infected patients. DESIGN: Case-control study. SETTING: Duke University Adult Infectious Diseases Clinic, a tertiary referral center in North Carolina which
Predictors of survival in HIV-infected tuberculosis patients.: AIDS. 1996 Mar;10(3):269-72. Unique Identifier : AIDSLINE MED/97037019; Shafer RW; Bloch AB; Larkin C; Vasudavan V; Seligman S; Dehovitz JD; DiFerdinando G; Stoneburner R; Cauthen G; Division of Infectious Diseases, Stanford University Medical; Center, Stanford, CA 94305, USA.; OBJECTIVE: To ascertain predictors of survival in HIV-infected tuberculosis (TB) patients. DESIGN: Retrospective cohort study. SETTING: New York City public hospital. PATIENTS: Fifty-four consecutive HIV-seropositive patients with newly diagnosed TB and no other AIDS-defining illnesses. MAIN OUTCOME MEASURES: CD4+ T-l
Association of maternal drug use during pregnancy with maternal HIV culture positivity and perinatal HIV transmission.: AIDS. 1996 Mar;10(3):273-82. Unique Identifier : AIDSLINE MED/97037020; Rodriguez EM; Mofenson LM; Chang BH; Rich KC; Fowler MG; Smeriglio V; Landesman S; Fox HE; Diaz C; Green K; Hanson IC; Health Resources Services Administration, National Institute of; Child Health and Human Development, National Institutes of; Health, Rockville, MD 20857, USA.; OBJECTIVE: To evaluate the relationship of drug use with maternal HIV culture positivity at delivery and perinatal HIV transmission. DESIGN: Multicenter prospective cohort study. SETTING: Obstetric and pediatric clinics in five cities in the United States . PARTICIPANTS: Five hundred an
Production of plasminogen activator and plasminogen activator inhibitors by alveolar macrophages in control subjects and AIDS patients.: AIDS. 1996 Mar;10(3):283-90. Unique Identifier : AIDSLINE MED/97037021; Angelici E; Contini C; Romani R; Epifano O; Serra P; Canipari R; Department of Clinical Medicine, La Sapienza University, Rome,; Italy.; OBJECTIVE: To reveal a possible impairment of the plasminogen activator system in the pulmonary infections of AIDS patients. DESIGN: To test the plasminogen activator system functionality in alveolar macrophages and bronchoalveolar lavage fluid (BALF) in control subjects and AIDS patients. Procedures were designed to
Increasing the use of bleach and condoms among injecting drug users in Denver: outcomes of a targeted, community-level HIV prevention program.: AIDS. 1996 Mar;10(3):291-8. Unique Identifier : AIDSLINE MED/97037022; Rietmeijer CA; Kane MS; Simons PZ; Corby NH; Wolitski RJ; Higgins DL; Judson FN; Cohn DL; Department of Public Health, University of Colorado Health; Sciences Center, Denver, Colorado 80204-4507, USA.; OBJECTIVE: To evaluate the impact of an HIV risk-reduction program among injecting drug users (IDU) in Denver, Colorado. DESIGN: A targeted, community-level intervention study with multiple, time-phased, cross-sectional measurements assessing HIV high-risk behaviors among IDU in intervention and comparison sites. SETT
An epidemiological study of tuberculosis and HIV infection in Tanzania, 1991-1993.: AIDS. 1996 Mar;10(3):299-309. Unique Identifier : AIDSLINE MED/97037023; Chum HJ; O'Brien RJ; Chonde TM; Graf P; Rieder HL; Tanzania National Tuberculosis and Leprosy Programme, Dar es; Salaam.; OBJECTIVE: In Tanzania during the past 6 years reported tuberculosis (TB) cases have nearly doubled, with proportionately much greater increases in smear-negative and extrapulmonary cases compared with smear-positive cases. At the same time, HIV infection has become widespread th
Frontloading: a risk factor for HIV and hepatitis C virus infection among injecting drug users in Berlin.: AIDS. 1996 Mar;10(3):311-7. Unique Identifier : AIDSLINE MED/97037024; Stark K; Muller R; Bienzle U; Guggenmoos-Holzmann I; Institute of Tropical Medicine, Free University of Berlin,; Germany.; OBJECTIVE: To determine whether frontloading (i.e., syringe-mediated drug-sharing) is a risk factor for HIV, hepatitis B virus (HBV) and hepatitis C virus (HCV) infection among injecting drug users (IDU). DESIGN: Cross-sectional study. Data on sociodemographic and behavioural characteristics were obtained by a standar
Evaluation of an HIV risk reduction intervention among African-American homosexual and bisexual men.: AIDS. 1996 Mar;10(3):319-25. Unique Identifier : AIDSLINE MED/97037025; Peterson JL; Coates TJ; Catania J; Hauck WW; Acree M; Daigle D; Hillard B; Middleton L; Hearst N; Department of Psychology, Georgia State University, Atlanta; 30303, USA.; OBJECTIVE: To provide the first data which evaluates an HIV risk reduction intervention designed to reduce HIV high-risk sexual behavior in African-American homosexual and bisexual men. SUBJECTS: Participants (n = 318) were recruited from bars, bathhouses, and erotic bookstores, and through homosexual African-American
Knowledge, attitudes and perception of AIDS in rural Senegal: relationship to sexual behaviour and behaviour change.: AIDS. 1996 Mar;10(3):327-34. Unique Identifier : AIDSLINE MED/97037026; Lagarde E; Pison G; Enel C; Laboratory of Biological Anthropology, National Museum of Natural; History, Paris, France.; OBJECTIVES: To describe the determinants of at risk sexual behaviour and perception of AIDS-related prevention messages in rural Africa. SETTING: A rural area in Southern Senegal . DESIGN: Cross-sectional study using a standardized questionnaire administered by local interviewers
Relationship between fluconazole dosage regimens and the emergence of fluconazole-resistant Candida albicans.: AIDS. 1996 Mar;10(3):335-6. Unique Identifier : AIDSLINE MED/97037027; Goetz MB
Hope for evidence-based HIV/AIDS prevention?: AIDS. 1996 Mar;10(3):337-8. Unique Identifier : AIDSLINE MED/97037028; Hart GJ
Poststenotic cavitating pneumonia due to Rhodococcus equi in HIV infection.: AIDS. 1996 Mar;10(3):339-40. Unique Identifier : AIDSLINE MED/97037029; Sutor GC; Fibich C; Kirscher P; Kuske M; Schmidt RE; Schedel I; Deicher H
Symptomatic leiomyoma of the adrenal gland in a woman with AIDS.: AIDS. 1996 Mar;10(3):340-1. Unique Identifier : AIDSLINE MED/97037030; Parola P; Petit N; Azzedine A; Dhiver C; Gastaut JA
Cutaneous reactions to trimethoprim-sulphametrole in AIDS patients treated for Pneumocystis carinii pneumonia.: AIDS. 1996 Mar;10(3):341-2. Unique Identifier : AIDSLINE MED/97037031; van der Ven AJ; Riegr A; Branten A; Reiman R; Vree TB; Koopmans PP; van der Meer JW
Diagnostic HIV antibody testing in the United States: the role of private providers and public programs.: AIDS. 1996 Mar;10(3):342-3. Unique Identifier : AIDSLINE MED/97037032; Anderson JE; Brackbill R; Wilson RW
Presence of HIV-1 group O infection in West Africa.: AIDS. 1996 Mar;10(3):343-4. Unique Identifier : AIDSLINE MED/97037033; Peeters M; Gaye A; Mboup S; Badombena W; Bassabi K; Prince-David M; Develoux M; Liegeois F; van der Groen G; Saman E; Delaporte E
Lower prevalence and incidence of HIV-1 syncytium-inducing phenotype among injecting drug users relative to homosexual men.: AIDS. 1996 Mar;10(3):344-5. Unique Identifier : AIDSLINE MED/97037034; Mocroft A; Sabin CA; Phillips AN
Cytomegalovirus infection: a possible cause of recurrent transient neurological dysfunction in advanced HIV infection.: AIDS. 1996 Mar;10(3):345-6. Unique Identifier : AIDSLINE MED/97037035; Klein JL; Price DA; Fisher M; Coker RJ
Evaluating behavioral interventions for HIV prevention.: AIDS. 1996 Mar;10(3):346-8. Unique Identifier : AIDSLINE MED/97037036; Darrow WW
Identification of a novel HLA-A25-restricted epitope in a conserved region of p24 gag (positions 71-80).: AIDS. 1996 Mar;10(3):348-50. Unique Identifier : AIDSLINE MED/97037037; Klenerman P; Luzzi G; McIntyre K; Phillips R; McMichael A
Evaluation of oligonucleotide probes for the determination of the two major HIV-1 env subtypes in Thailand.: AIDS. 1996 Mar;10(3):350-1. Unique Identifier : AIDSLINE MED/97037038; Subbarao S; Luo CC; Limpakarnjanarat K; Bhumisa-wasdi J; Young NL; Mastro TD; Schochetman G; Kalish ML
Molecular biology and epidemiology of Pneumocystis carinii infection in AIDS [editorial]: AIDS. 1996 Jun;10(6):561-71. Unique Identifier : AIDSLINE MED/96374583; Stringer JR; Walzer PD; Department of Molecular Genetics, Biochemistry and Microbiology,; University of Cincinnati College of Medicine, Ohio 45267-0524,; USA.
Cellular reservoirs of HIV-1 in the central nervous system of infected individuals: identification by the combination of in situ polymerase chain reaction and immunohistochemistry.: AIDS. 1996 Jun;10(6):573-85. Unique Identifier : AIDSLINE MED/96374584; Bagasra O; Lavi E; Bobroski L; Khalili K; Pestaner JP; Tawadros R; Pomerantz RJ; Dorrance H. Hamilton Laboratories, Department of Medicine,; Jefferson Medical College, Thomas Jefferson University,; Philadelphia, PA 19107, USA.; OBJECTIVES: The majority of HIV-1-infected individuals manifest a plethora of central nervous system (CNS) diseases unrelated to opportunistic infections, including AIDS dementia complex, encephalitis, and various other disorders of the CNS. The present study sought to evaluate the
Restricted antigenic variability of the epitope recognized by the neutralizing gp41 antibody 2F5.: AIDS. 1996 Jun;10(6):587-93. Unique Identifier : AIDSLINE MED/96374585; Purtscher M; Trkola A; Grassauer A; Schulz PM; Klima A; Dopper S; Gruber G; Buchacher A; Muster T; Katinger H; Institute of Applied Microbiology, University of Agriculture,; Vienna, Austria.; OBJECTIVE: To investigate whether variations of the conserved gp41 amino-acid sequence ELDKWA affect its binding or neutralization by monoclonal antibody (MAb) 2F5. DESIGN AND METHODS: Neutralization assays were performed with primary isolates from different HIV-1 subtypes and the sequences corresponding to the 2F5 ep
Follicular dendritic cells in vitro are not susceptible to infection by HIV-1.: AIDS. 1996 Jun;10(6):595-602. Unique Identifier : AIDSLINE MED/96374586; Tsunoda R; Hashimoto K; Baba M; Shigeta S; Sugai N; Department of Histology and Microbiology, Fukushima Medical; College, Japan.; OBJECTIVES: To investigate whether follicular dendritic cells (FDC) are target cells for HIV-1 infection. DESIGN: Based on the principle that if FDC are true target cells, HIV-1 particles will bind to the surface of FDC and then invade their cytoplasm and nuclei. METHODS: Freshly isolated tonsilar FDC were exposed to
Antigen-stimulated apoptotic T-cell death in HIV infection is selective for CD4+ T cells, modulated by cytokines and effected by lymphotoxin.: AIDS. 1996 Jun;10(6):603-11. Unique Identifier : AIDSLINE MED/96374587; Clerici M; Sarin A; Berzofsky JA; Landay AL; Kessler HA; Hashemi F; Hendrix CW; Blatt SP; Rusnak J; Dolan MJ; Coffman RL; Henkart PA; Shearer GM; Cattedra di Immunologia, Universita degli Studi di Milano,; Italy.; OBJECTIVE: To characterize the mechanism of in vitro antigen-induced apoptotic T-cell death in the peripheral blood mononuclear cells (PBMC) of HIV-1-infected individuals. DESIGN AND METHODS: PBMC from HIV-1 infected and uninfected individuals were unstimulated or stimulated with HIV-1 envelope synthetic peptides (Env
Phagocytosis and growth inhibition of Cryptococcus neoformans by human alveolar macrophages: effects of HIV-1 infection.: AIDS. 1996 Jun;10(6):613-8. Unique Identifier : AIDSLINE MED/96374588; Reardon CC; Kim SJ; Wagner RP; Koziel H; Kornfeld H; Pulmonary Center, Boston University School of Medicine, MA 02118,; USA.; OBJECTIVE: The purpose of this study was to investigate the in vitro processing of Cryptococcus neoformans by human alveolar macrophages from HIV-seropositive individuals compared with HIV-seronegative individuals. DESIGN AND METHODS: Bronchalveolar lavage (BAL) was performed on smoking and nonsmoking HIV-seropositive
Atovaquone is effective treatment for the symptoms of gastrointestinal microsporidiosis in HIV-1-infected patients.: AIDS. 1996 Jun;10(6):619-23. Unique Identifier : AIDSLINE MED/96374589; Anwar-Bruni DM; Hogan SE; Schwartz DA; Wilcox CM; Bryan RT; Lennox JL; Infectious Disease Program, Grady Health System, Atlanta,; Georgia, USA.; OBJECTIVE: To report the clinical response to atovaquone in HIV-1-infected patients with symptomatic intestinal microsporidiosis . DESIGN: A retrospective review of a cohort of AIDS patients with symptomatic intestinal microsporidiosis who received atovaquone. SETTING:
Development of resistance of zidovudine (ZDV) and didanosine (ddI) in HIV from patients in ZDV, ddI and alternating ZDV/ddI therapy.: AIDS. 1996 Jun;10(6):625-33. Unique Identifier : AIDSLINE MED/96374590; Nielsen C; Bruun L; Mathiesen LR; Pedersen C; Gerstoft J; Department of Virology, Statens Seruminstitut, Copenhagen,; Denmark.; OBJECTIVE: To study development of phenotypic and genotypic resistance against zidovudine (ZDV) and didanosine (ddI) during 24 months of mono- and monthly alternating therapy. PATIENTS: Forty-six patients, not previously treated with antiretroviral drugs, were included in the study. METHODS: ZDV and ddI sensitivity we
A controlled trial of nevirapine plus zidovudine versus zidovudine alone in p24 antigenaemic HIV-infected patients. The Dutch-Italian-Australian Nevirapine Study Group.: AIDS. 1996 Jun;10(6):635-41. Unique Identifier : AIDSLINE MED/96374591; Carr A; Vella S; de Jong MD; Sorice F; Imrie A; Boucher CA; Cooper DA; HIV Medicine Unit, St. Vincent's Hospital, Sydney, Australia.; OBJECTIVES: Nevirapine is a non-nucleoside reverse transcriptase inhibitor of HIV-1 which exhibits synergy in vitro with zidovudine (ZDV) and also is active against ZDV-resistant HIV. We evaluated the activity and safety of nevirapine in combination w
Kaposi's sarcoma and non-Hodgkin's lymphomas in children and adolescents with AIDS.: AIDS. 1996 Jun;10(6):643-7. Unique Identifier : AIDSLINE MED/96374592; Serraino D; Franceschi S; Epidemiology Unit, Aviano Cancer Center, Pordenone, Italy.; OBJECTIVE: To assess the proportion of, and the characteristics associated with, Kaposi s sarcoma (KS) and non-Hodgkin s lymphomas (NHL) in children (0-12 years) and adolescents (13-19 years) at AIDS diagnosis, in Europe and in the United States (US). DESIGN: Comparison of the proporti
Use of immunological markers and continuous-time Markov models to estimate progression of HIV infection in homosexual men.: AIDS. 1996 Jun;10(6):649-56. Unique Identifier : AIDSLINE MED/96374593; Hendriks JC; Satten GA; Longini IM; van Druten HA; Schellekens PT; Coutinho RA; van Griensven GJ; Department of Public Health, Municipal Health Service, Amsterdam,; The Netherlands.; OBJECTIVES: We used continuous-time Markov models based on CD4 cell counts and anti-CD3 reactivity (i.e., measure for T-cell quality) to study the progression of HIV infection in a cohort study of homosexual men in Amsterdam. We also compared the effectiveness of anti-CD3 reactivity as a marker for disease progression
HIV-1 prevalence in community-wide samples of injecting drug users in London, 1990-1993.: AIDS. 1996 Jun;10(6):657-66. Unique Identifier : AIDSLINE MED/96374594; Stimson GV; Hunter GM; Donoghoe MC; Rhodes T; Parry JV; Chalmers CP; Department of Psychiatry, Charing Cross and Westminster Medical; School, University of London, UK.; OBJECTIVE: To provide time-trend estimates of HIV-1 prevalence among injecting drug users (IDU) in London. DESIGN: HIV-1 prevalence and HIV testing behaviour were measured in four serial point prevalence surveys of IDU recruited at multiple sites in community-based non-treatment and drug treatment settings between 199
Physical disability in a cohort of persons with AIDS: data from the AIDS Time-Oriented Health Outcome Study.: AIDS. 1996 Jun;10(6):667-73. Unique Identifier : AIDSLINE MED/96374595; O'Dell MW; Hubert HB; Lubeck DP; O'Driscoll P; Department of Physical Medicine and Rehabilitation, University of; Cincinnati College of Medicine, Ohio, USA.; OBJECTIVE: Physical disability is one of the more important determinants of health-related quality of life in person with AIDS, although little information is available on specific physical functional deficits. The purpose of this study was to document the types, frequency, severity, and correlates of physical disabil
Cell-associated ceramide in HIV-1-infected subjects [letter]: AIDS. 1996 Jun;10(6):675-6. Unique Identifier : AIDSLINE MED/96374596; De Simone C; Cifone MG; Alesse E; Steinberg SM; Di Marzio L; Moretti S; Famularo G; Boschini A; Testi R
An alternative to 51Cr release assay for measurement of natural killer activity in HIV-infected patients [letter]: AIDS. 1996 Jun;10(6):676-8. Unique Identifier : AIDSLINE MED/96374597; Rizzardi GP; Brown L; Souberbielle BE; Dalgleish AG
Acute thrombocytopenia secondary to the administration of the peptidomimetic HIV protease inhibitor MK-639(L735524): AIDS. 1996 Jun;10(6):678-80. Unique Identifier : AIDSLINE MED/96374598; Stein DS; Dunn H; Drusano GL
CD4 lymphocyte counts in HIV/AIDS patients with intercurrent illness [letter]: AIDS. 1996 Jun;10(6):680-1. Unique Identifier : AIDSLINE MED/96374599; Woolley I; Spelman D; Hale G; Fairley C; Fuller A; Spicer WJ
Control of initial viraemia coincides with neutralizing antibody response after SIVmac infection of rhesus macaques [letter]: AIDS. 1996 Jun;10(6):681-2. Unique Identifier : AIDSLINE MED/96374600; Beer B; Norley S; Cichutek K; Kurth R
Alveolar macrophages are not an important source of viral production in HIV-1 infected patients [letter]: AIDS. 1996 Jun;10(6):682-4. Unique Identifier : AIDSLINE MED/96374601; Moreno P; Rebollo MJ; Pulido F; Rubio R; Noriega AR; Delgado R
Pentamidine-induced free radical toxicity to isolated islet cells [letter]: AIDS. 1996 Jun;10(6):684-5. Unique Identifier : AIDSLINE MED/96374602; Johansson AM; Grankvist KG
Recurrent muscle abscesses in a patient with HIV infection: beware the Baron von Munchausen [letter]: AIDS. 1996 Jun;10(6):685-7. Unique Identifier : AIDSLINE MED/96374603; Wolf LE; Skolnik PR; Noble JT
Chronic rhinosinusitis in patients with AIDS: potential role of microsporidia [letter]: AIDS. 1996 Jun;10(6):687-8. Unique Identifier : AIDSLINE MED/96374604; Franzen C; Muller A; Salzberger B; Fatkenheuer G; Diehl V; Schrappe M
Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis.: AIDS. 1996 Jul;10(8):F17-22. Unique Identifier : AIDSLINE MED/96426441; Effros RB; Allsopp R; Chiu CP; Hausner MA; Hirji K; Wang L; Harley CB; Villeponteau B; West MD; Giorgi JV; Department of Pathology and Laboratory Medicine, University of; California Los Angeles (UCLA) School of Medicine 90095-1745, USA.; OBJECTIVE: To test the hypothesis that the expanded population of non-proliferative CD28-CD8+ T cells in HIV disease have shortened telomeres, thereby providing evidence that increased rounds of CD8+ cell division occur during HIV disease, possibly leading to replicative senescence and exhaustion of CD8+ T-cell respon
Polymerase chain reaction for microsporidian DNA in gastrointestinal biopsy specimens of HIV-infected patients.: AIDS. 1996 Jul;10(8):F23-7. Unique Identifier : AIDSLINE MED/96426442; Franzen C; Muller A; Hegener P; Hartmann P; Salzberger B; Franzen B; Diehl V; Fatkenheuer G; Department of Internal Medicine I, University of Cologne,; Germany.; OBJECTIVE: To study the accuracy of polymerase chain reaction (PCR) for microsporidian DNA in gastrointestinal biopsy specimens of HIV-infected patients for the diagnosis of intestinal microsporidiosis . SETTING: Infectious disease in- and outpatient clinic of a univers
Recommendations for the development of vaginal microbicides. International Working Group on Vaginal Microbicides.: AIDS. 1996 Jul;10(8):1-6. Unique Identifier : AIDSLINE MED/96426466; Vaginal microbicides are products for vaginal administration that can be used to prevent HIV infection and other sexually transmitted diseases (STD). We recognize two potential sources of vaginal microbicides: existing spermicides and new products (new products may or may not be spermicidal). This document is meant to
Bone-marrow-derived dendritic cells and the pathogenesis of AIDS [editorial]: AIDS. 1996 Jul;10(8):807-17. Unique Identifier : AIDSLINE MED/96426443; Knight SC
Activating protein-1 cooperates with phorbol ester activation signals to increase HIV-1 expression.: AIDS. 1996 Jul;10(8):819-26. Unique Identifier : AIDSLINE MED/96426444; Roebuck KA; Gu DS; Kagnoff MF; Department of Immunology and Microbiology, Rush Presbyterian-St; Luke's Medical Center, Chicago, Illinois 60612, USA.; OBJECTIVE: To determine whether Jun and Fos, components of the activating protein-1 (AP-1) transcription factor, transactivate HIV-1 proviral expression. DESIGN: The effects of phorbol myristate acetate (PMA) and Jun or Fos transcription factors on HIV-1 expression were investigated using a provirus clone and long ter
Increased numbers of primed activated CD8+CD38+CD45RO+ T cells predict the decline of CD4+ T cells in HIV-1-infected patients.: AIDS. 1996 Jul;10(8):827-34. Unique Identifier : AIDSLINE MED/96426445; Bofill M; Mocroft A; Lipman M; Medina E; Borthwick NJ; Sabin CA; Timms A; Winter M; Baptista L; Johnson MA; Lee CA; Phillips AN; Janossy G; Department of Clinical Immunology, Royal Free Hospital and School; of Medicine, London, UK.; OBJECTIVE: To look for surrogate markers in HIV-1 infection that can predict the decline of CD4+ T cells. METHODS: Multiparameter flow cytometric analyses of CD8+ lymphocytes were performed. These cells were investigated for their expression of the activation marker CD38+ within the naive (CD45RA+) and primed (CD45RO+
Interleukin-10-induced HIV-1 expression is mediated by induction of both membrane-bound tumour necrosis factor (TNF)-alpha and TNF receptor type 1 in a promonocytic cell line.: AIDS. 1996 Jul;10(8):835-42. Unique Identifier : AIDSLINE MED/96426446; Barcellini W; Rizzardi GP; Marriott JB; Fain C; Shattock RJ; Meroni PL; Poli G; Dalgleish AG; Institute of Internal Medicine, Infectious Diseases and; Immunopathology, University of Milan, Italy.; OBJECTIVE: To investigate whether the upregulatory effect of interleukin (IL)-10 on HIV expression in a model of latent HIV infection is mediated by induction of endogenous tumour necrosis factor (TNF)-alpha and TNF receptors (TNFR). DESIGN: The latently HIV-infected promonocytic cell line U1 was examined, because in
Expression of HIV regulatory and structural mRNA in the central nervous system.: AIDS. 1996 Jul;10(8):843-7. Unique Identifier : AIDSLINE MED/96426447; Wiley CA; Baldwin M; Achim CL; Neuropathology Division, Presbyterian University Hospital,; Pittsburgh, Pennsylvania 15213-2582, USA.; OBJECTIVE: HIV encephalitis is observed in approximately one-half of AIDS autopsies. Although most investigators would agree that central nervous system (CNS) macrophages are the predominant infected cell in HIV encephalitis, there remains some controversy regarding whether other CNS cells can be infected by HIV and t
Rapid plasma virus and CD4+ T-cell turnover in HIV-1 infection: evidence for an only transient interruption by treatment.: AIDS. 1996 Jul;10(8):849-57. Unique Identifier : AIDSLINE MED/96426448; Stellbrink HJ; Zoller B; Fenner T; Lichtenberg G; van Lunzen J; Albrecht H; Thiele HG; Greten H; Medizinische Kernklinik und Poliklinik, Eppendorf University; Hospital, Hamburg, Germany.; OBJECTIVES: To analyse the short-term kinetics of viral plasma RNA and CD4+ T cells numbers in patients with different initial CD4+ T-cell counts treated with different antiretroviral regimens. METHODS: In 10 HIV-1 positive patients, in vivo kinetics of plasma HIV RNA and CD4+ T cells were studied during antiretrovira
HIV-1 RNA levels and the development of clinical disease. North American Lamivudine HIV Working Group.: AIDS. 1996 Jul;10(8):859-65. Unique Identifier : AIDSLINE MED/96426449; Phillips AN; Eron JJ; Bartlett JA; Rubin M; Johnson J; Price S; Self P; Hill AM; Department of Primary Care and Population Sciences, Royal Free; Hospital School of Medicine, London, UK.; OBJECTIVE: To assess the prognostic value of HIV RNA levels for predicting clinical disease independently of the CD4 lymphocyte count in patients on antiretroviral therapy. DESIGN: Cohort of HIV-infected patients from two trials of lamivudine therapy. PATIENTS: For 620 patients randomized in the North American NUCA300
The Alpha trial: European/Australian randomized double-blind trial of two doses of didanosine in zidovudine-intolerant patients with symptomatic HIV disease. Alpha International Coordinating Committee.: AIDS. 1996 Jul;10(8):867-80. Unique Identifier : AIDSLINE MED/96426450; OBJECTIVES: To compare the efficacy and toxicity of two doses of didanosine (ddI) in patients with symptomatic HIV disease who are intolerant of zidovudine (ZDV). DESIGN: The Alpha trial is a randomized double-blind multicentre trial of two doses of ddI. ddI was given as one buffered sachet twice daily in doses adjust
Source of Pneumocystis carinii in recurrent episodes of pneumonia in AIDS patients.: AIDS. 1996 Jul;10(8):881-8. Unique Identifier : AIDSLINE MED/96426451; Keely SP; Baughman RP; Smulian AG; Dohn MN; Stringer JR; Department of Molecular Genetics, Biochemistry and Microbiology,; University of Cincinnati College of Medicine, Ohio 45267-0524,; USA.; OBJECTIVE: To investigate the hypothesis that P.carinii special form hominis (P.c. hominis) reinfections occur in AIDS patients. DESIGN: Polymerase chain reaction (PCR) was used to identify patients who had different P.c. hominis mitochondrial DNA (mtrRNA) genotypes in the two disease episodes (genotype switching). P.
HIV/AIDS mortality in Canada: evidence of gender, regional and local area differentials.: AIDS. 1996 Jul;10(8):889-94. Unique Identifier : AIDSLINE MED/96426452; Hogg RS; Heath KV; Strathdee SA; Montaner JS; O'Shaughnessy MV; Schechter MT; British Columbia Centre for Excellence in HIV/AIDS, St Paul's; Hospital, Vancouver, Canada.; OBJECTIVE: To assess the impact of HIV infection and AIDS on mortality patterns in Canada with specific reference to gender and regional differentials and to other leading causes of death. DESIGN: Descriptive, population-based study. SETTING: Canada. PATIENTS: All persons for whom
HIV seroincidence and correlates of seroconversion in a cohort of male factory workers in Harare, Zimbabwe.: AIDS. 1996 Jul;10(8):895-901. Unique Identifier : AIDSLINE MED/96426453; Mbizvo MT; Machekano R; McFarland W; Ray S; Bassett M; Latif A; Katzenstein D; Zimbabwe AIDS Prevention Project, Department of Community; Medicine, Harare, Zimbabwe.; OBJECTIVES: Given that health promotion messages on transmission of HIV and other sexually transmitted diseases (STD) have been widely publicized in Zimbabwe and elsewhere in the late 1980s, it is vital to analyse which risk events still expose individuals to infection. A cohort
Epidemiological and molecular characteristics of HIV infection in Gabon, 1986-1994.: AIDS. 1996 Jul;10(8):903-10. Unique Identifier : AIDSLINE GENBANK/X90926; Delaporte E; Janssens W; Peeters M; Buve A; Dibanga G; Perret JL; Ditsambou V; Mba JR; Courbot MC; Georges A; Bourgeois A; Samb B; Henzel D; Heyndrickx L; Fransen K; van der Groen G; Larouze B; AIDS Programme, Institut Francais de Recherche Scientifique pour; le Developpement (ORSTOM), Montpellier, France.; OBJECTIVE: To describe trends in the prevalence of HIV-1 infection in different populations in Gabon , and the molecular characteristics of circulating HIV strains. METHODS: Data were collected on HIV prevalence through sentinel surveillance surveys in different populations in Librev
Epidemiology of AIDS-related Kaposi's sarcoma in Europe over 10 years. AIDS in Europe Study Group.: AIDS. 1996 Jul;10(8):911-7. Unique Identifier : AIDSLINE MED/96426455; Hermans P; Lundgren J; Sommereijns B; Pedersen C; Vella S; Katlama C; Luthy R; Pinching AJ; Gerstoft J; Pehrson P; Clumeck N; Saint-Pierre University Hospital, Brussels, Belgium.; OBJECTIVES: To determine the incidence and risk factors associated with Kaposi s sarcoma (KS) occurrence as an AIDS-defining condition or after the diagnosis of AIDS. DESIGN: Multicentre retrospective cohort study of AIDS in Europe database from 52 clinical centres in 17 European countries. METHODS: Patients charts (
Inhibition of tumour necrosis factor-alpha explains inhibition of HIV replication by peptide T [letter]: AIDS. 1996 Jul;10(8):919-20. Unique Identifier : AIDSLINE MED/96426456; Phipps DJ; MacFadden DK
Disorders of somatotrophic axis in HIV-infected patients [letter]: AIDS. 1996 Jul;10(8):920-2. Unique Identifier : AIDSLINE MED/96426457; Rabaud C; Dousset B; Hussennet F; Amiel C; May T; Canton P
Hepatitis C viraemia in HIV-infected patients. Hepatitis-HIV Spanish Study Group [letter]: AIDS. 1996 Jul;10(8):922-3. Unique Identifier : AIDSLINE MED/96426458; Soriano V; Bravo R; Mas A; Garcia-Samaniego J
Fatal complications after Cesarian section in HIV-infected women [letter]: AIDS. 1996 Jul;10(8):923-4. Unique Identifier : AIDSLINE MED/96426459; Bulterys M; Chao A; Dushimimana A; Saah A
Estimating the rate of occurrence of new HIV infections using serial prevalence surveys: the epidemic in India [letter]: AIDS. 1996 Jul;10(8):924-5. Unique Identifier : AIDSLINE MED/96426460; Brookmeyer R; Mehendale SM; Pelz RK; Shepherd ME; Quinn T; Rodrigues JJ; Bollinger RC
HIV seroprevalence surveys in Pakistan. HIV Seroprevalence Study Group of Pakistan [letter]: AIDS. 1996 Jul;10(8):926-7. Unique Identifier : AIDSLINE MED/96426461
Co-trimoxazole desensitization syndrome: delayed hematologic toxicity complicating prophylactic therapy in AIDS patients [letter]: AIDS. 1996 Jul;10(8):927-9. Unique Identifier : AIDSLINE MED/96426462; Stricker RB; Gullett JH; Williams LE; Goldberg B
Recombinant erythropoietin for treatment of anaemia in HIV-infected children [letter]: AIDS. 1996 Jul;10(8):929-31. Unique Identifier : AIDSLINE MED/96426463; Caselli D; Maccabruni A; Zuccotti GV; Riva E; Fundaro C; Portelli V; Galli L; Zizzadoro P; Gabiano C; Forni GL
Beri-Beri and thiamine deficiency in HIV infection [letter]: AIDS. 1996 Jul;10(8):931-2. Unique Identifier : AIDSLINE MED/96426464; Mouly S; Khuong MA; Cabie A; Saimot AG; Coulad JP
Bioethics and AIDS research in Uganda [letter]: AIDS. 1996 Jul;10(8):932-3. Unique Identifier : AIDSLINE MED/96426465; Loue S; Okello D; Kawuma M
AIDS 1995. Virology: overview.: AIDS. 1995;9 Suppl A:S1-3. Unique Identifier : AIDSLINE MED/96416769; Fenyo EM; Rosen CA; Microbiology and Tumorbiology Center, Karolinska Institute,; Stockholm, Sweden.
Variations in HIV prevalence between urban areas in sub-Saharan Africa: do we understand them?: AIDS. 1995;9 Suppl A:S103-9. Unique Identifier : AIDSLINE MED/96416781; Buve A; Carael M; Hayes R; Robinson NJ; Institute of Tropical Medicine, Antwerp, Belgium.
AIDS 1995. Vaccines and immunology: overview.: AIDS. 1995;9 Suppl A:S111-2. Unique Identifier : AIDSLINE MED/96416782; Montelaro RC; Wigzell H; Department of Molecular Genetics and Biochemistry, School of; Medicine, University of Pittsburgh, PA 15261-2072, USA.
HIV-1-specific cytotoxic T-cell responses.: AIDS. 1995;9 Suppl A:S113-6. Unique Identifier : AIDSLINE MED/96416783; Schooley RT; Division of Infectious Diseases, University of Colorado Health; Science Center, Denver 80262, USA.
HIV-1 neutralization: the consequences of viral adaptation to growth on transformed T cells.: AIDS. 1995;9 Suppl A:S117-36. Unique Identifier : AIDSLINE MED/96416784; Moore JP; Ho DD; Aaron Diamond AIDS Research Center, New York University School of; Medicine, New York 10016, USA.
Non-human primate models for AIDS vaccines.: AIDS. 1995;9 Suppl A:S137-41. Unique Identifier : AIDSLINE MED/96416785; Desrosiers RC; New England Regional Primate Research Center, Harvard Medical; School, Southborough, Massachusetts 01772-9102, USA.
Novel approaches to peptide and engineered protein vaccines for HIV using defined epitopes: advances in 1994-1995.: AIDS. 1995;9 Suppl A:S143-57. Unique Identifier : AIDSLINE MED/96416786; Berzofsky JA; Berkower IJ; Molecular Immunogenetics and Vaccine Research Section, National; Cancer Institute, National Institutes of Health, Bethesda, MD; 20892, USA.
Nucleic acid-based immunization against HIV-I: induction of protective in vivo immune responses.: AIDS. 1995;9 Suppl A:S159-70. Unique Identifier : AIDSLINE MED/96416787; Wang B; Boyer JD; Ugen KE; Srikantan V; Ayyaroo V; Agadjanyan MG; Williams WV; Newman M; Coney L; Carrano R; et al; Department of Pathology and Laboratory Medicine, University of; Pennsylvania, Philadelphia 19104-6100, USA.
Human trials of experimental HIV vaccines.: AIDS. 1995;9 Suppl A:S171-80. Unique Identifier : AIDSLINE MED/96416788; Burke DS; Division of Retrovirology, Walter Reed Army Institute of; Research, Washington, DC 20850, USA.
AIDS 1995. Clinical treatment: overview.: AIDS. 1995;9 Suppl A:S181-2. Unique Identifier : AIDSLINE MED/96416789; Weber J; Merigan TC; Department of Genito-urinary Medicine and Communicable Diseases,; St Mary's Hospital Medical School, London, UK.
HIV protease inhibitors.: AIDS. 1995;9 Suppl A:S183-92. Unique Identifier : AIDSLINE MED/96416790; Winslow DL; Otto MJ; DuPont Merck Pharmaceutical Company, Glenolden Laboratory,; Pennsylvania 19805, USA.
Regulation of HIV gene expression.: AIDS. 1995;9 Suppl A:S19-32. Unique Identifier : AIDSLINE MED/96416771; Cullen BR; Howard Hughes Medical Institute, Duke University Medical Center,; Durham, NC 27710, USA.
HIV virology for clinical trials.: AIDS. 1995;9 Suppl A:S193-202. Unique Identifier : AIDSLINE MED/96416791; Shafer RW; Merigan TC; Center for AIDS Research, Stanford University Medical Center,; California 94305, USA.
Gene therapy for HIV: from myth to reality?: AIDS. 1995;9 Suppl A:S203-12. Unique Identifier : AIDSLINE MED/96416792; Boyer O; Lemoine FM; Klatzmann D; Laboratory for Biology and Therapy for Immune Pathology, National; Centre for Scientific Research, Paris, France.
Management of diarrhoea in HIV infection.: AIDS. 1995;9 Suppl A:S213-9. Unique Identifier : AIDSLINE MED/96416793; Gazzard BG; Sharpstone D; Chelsea and Westminster Hospital, London, UK.
Management of AIDS dementia complex and HIV-1 infection of the nervous system.: AIDS. 1995;9 Suppl A:S221-36. Unique Identifier : AIDSLINE MED/96416794; Price RW; Department of Neurology, University of Minnesota Health Science; Center, Minneapolis 55455-0323, USA.
AIDS 1995. Social, cultural and political aspects: overview.: AIDS. 1995;9 Suppl A:S237-8. Unique Identifier : AIDSLINE MED/96416795; Aggleton P; Coates TJ; Department of Policy Studies, University of London, UK.
Change, co-option and the community sector.: AIDS. 1995;9 Suppl A:S239-43. Unique Identifier : AIDSLINE MED/96416796; Altman D; Department of Politics, LaTrobe University, Bundoora, Australia.
Social and behavioral issues in phase III HIV preventive vaccine trials.: AIDS. 1995;9 Suppl A:S245-50. Unique Identifier : AIDSLINE MED/96416797; Grinstead OA; Center for AIDS Prevention Studies (CAPS), University of; California, San Francisco 94105, USA.
Reducing HIV incidence in developing countries with structural and environmental interventions.: AIDS. 1995;9 Suppl A:S251-7. Unique Identifier : AIDSLINE MED/96416798; Sweat MD; Denison JA; AIDS Control and Prevention Project, Family Health International,; Arlington, Virginia, USA.
Global estimates and epidemiology of HIV-1 infections and AIDS: further heterogeneity in spread and impact.: AIDS. 1995;9 Suppl A:S259-72. Unique Identifier : AIDSLINE MED/96416799; Mertens TE; Belsey E; Stoneburner RL; Beer DL; Sato P; Burton A; Merson MH; Global Programme on AIDS, World Health Organization, Geneva,; Switzerland.
An Occam's razor approach to the immunopathogenesis of HIV infection.: AIDS. 1995;9 Suppl A:S33-40. Unique Identifier : AIDSLINE MED/96416772; Clerici M; Shearer GM; Cattedra di Immunologia, Universita degli Studi di Milano,; Italy.
Tissue lesions in AIDS patients involve both the lymphoid and the nervous system.: AIDS. 1995;9 Suppl A:S41-8. Unique Identifier : AIDSLINE MED/96416773; Chiodi F; Microbiology and Tumorbiology Center, Karolinska Institute,; Stockholm, Sweden.
Drug resistance in relation to pathogenesis.: AIDS. 1995;9 Suppl A:S49-53. Unique Identifier : AIDSLINE MED/96416774; Richman DD; San Diego Veterans Affairs Medical Center, La Jolla, California,; USA.
Heterogeneity of HIV-1 and HIV-2.: AIDS. 1995;9 Suppl A:S5-18. Unique Identifier : AIDSLINE MED/96416770; Korber BT; Allen EE; Farmer AD; Myers GL; Theoretical Biology and Biophysics, Theory Division, Los Alamos; National Laboratory, NM 87545, USA.
AIDS 1995. Epidemiology: overview.: AIDS. 1995;9 Suppl A:S55-7. Unique Identifier : AIDSLINE MED/96416775; Schechter MT; Laga M; Department of Health Care and Epidemiology, Faculty of Medicine,; University of British Columbia, Vancouver, Canada.
Interventions to reduce mother to child transmission of HIV.: AIDS. 1995;9 Suppl A:S59-66. Unique Identifier : AIDSLINE MED/96416776; Van de Perre P; Meda N; Ministry of Cooperation in Development, Brussels, Belgium.
Methodology of intervention trials to reduce mother to child transmission of HIV with special reference to developing countries. International Working Group on Mother to Child Transmission of HIV.: AIDS. 1995;9 Suppl A:S67-74. Unique Identifier : AIDSLINE MED/96416777; Dabis F; Msellati P; Newell ML; Halsey N; Van de Perre P; Peckham C; Lepage P; Unite INSERM 330, Universite de Bordeaux II, France.
Interventions among injecting drug users: do they work?: AIDS. 1995;9 Suppl A:S75-84. Unique Identifier : AIDSLINE MED/96416778; van Ameijden EJ; Watters JK; van den Hoek JA; Coutinho RA; Municipal Health Service, Amsterdam, The Netherlands.
The effectiveness of barrier methods of contraception in preventing the spread of HIV.: AIDS. 1995;9 Suppl A:S85-93. Unique Identifier : AIDSLINE MED/96416779; Feldblum PJ; Morrison CS; Roddy RE; Cates W Jr; Family Health International, Research Triangle Park, North; Carolina 27709, USA.; Because barrier methods provide protection against bacterial sexually transmitted diseases, these methods are valuable public health adjuncts irrespective of their effect on HIV. Male latex condoms offer substantial protection against HIV infection. Women at risk of sexual acquisition of HIV infection need one or more
Role of HIV counseling and testing in changing risk behavior in developing countries.: AIDS. 1995;9 Suppl A:S95-101. Unique Identifier : AIDSLINE MED/96416780; De Zoysa I; Phillips KA; Kamenga MC; O'Reilly KR; Sweat MD; White RA; Grinstead OA; Coates TJ; AIDS Control and Prevention (AIDSCAP) project, Family Health; International, Arlington, Virginia, USA.
Pharmacokinetics of zidovudine in HIV-infected patients with end-stage renal disease.: Blood Purif. 1995 Nov-Dec;13(6):340-6. Unique Identifier : AIDSLINE MED/96418413; Kimmel PL; Lew SQ; Umana WO; Li PP; Gordon AM; Straw J; Department of Medicine, George Washington University Medical; Center, Washington, D.C., 20037, USA.; We determined the pharmacokinetics of zidovudine ( AZT ) and its metabolite (GAZT) in HIV-infected patients with end-stage renal disease (ESRD), between dialysis sessions, and compared these to HIV-infected patients with normal renal function. Clearance
Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo.: Annu Rev Immunol. 1996;14:207-32. Unique Identifier : AIDSLINE MED/96292427; Kagi D; Ledermann B; Burki K; Zinkernagel RM; Hengartner H; Department of Pathology, University of Zurich, Switzerland.; Studies with perforin-deficient mice have demonstrated that two independent mechanisms account for T cell-mediated cytotoxicity: A main pathway is mediated by the secretion of the pore-forming protein perforin by the cytotoxic T cell, whereas an alternative nonsecretory pathway relies on the interaction of the Fas lig
Osteoblastic cell lines are not susceptible to HIV-1 infection.: Boll Soc Ital Biol Sper. 1995 Sep-Oct;71(9-10):275-9. Unique Identifier : AIDSLINE MED/96402754; Toneguzzi S; Lisignoli G; Monaco MC; Pozzi C; Bertollini V; Belvedere O; Degrassi A; Facchini A; Laboratorio di Immunologia e Genetica, I.O.R., Bologna.; Osteoblastic cells are in direct or indirect contact with lymphocytes and bone marrow cells that are the main targets of HIV-1. Therefore we analysed whether HIV-1 could infect these cells using three bone cell lines (HOS, MG-63, U2 OS) as a model. These cells were infected with HIV-1 (strain NL4-3) and the supernatan
The effect of 1,25-vitamin D3 on maturation of monocytes from HIV-infected patients varies with degree of immunodeficiency.: APMIS. 1996 Jul-Aug;104(7-8):539-48. Unique Identifier : AIDSLINE MED/97079075; Haug CJ; Muller F; Rollag H; Aukrust P; Degre M; Froland SS; Kaptein W. Wilhelmsen og Frues Institute of Bacteriology, Oslo,; Norway.; The active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (1,25D), has been shown to induce monocyte-to-macrophage maturation in vitro as well as monocytic differentiation of bone marrow precursors and monocytic leukaemic cell lines. In this study we assessed whether 1,25D could improve the maturation defect we hav
Preserved neutrophil response to Candida albicans stimulation in AIDS patients with candida esophagitis.: APMIS. 1996 Jul-Aug;104(7-8):591-7. Unique Identifier : AIDSLINE MED/97079082; Jensen T; Obel N; Department of Infectious Diseases, Rigshospitalet, Copenhagen,; Denmark.; Polymorphonuclear neutrophils (PMNs) and their interaction with immunoglobulins constitute a major line of defence against invading Candida albicans. The function of neutrophils, assessed by superoxide production, and the opsonizing efficacy of sera from 15 AIDS patients with esophageal candidiasis and 15 healthy cont
White matter disease and dementia.: Brain Cogn. 1996 Jul;31(2):250-68. Unique Identifier : AIDSLINE MED/96424898; Rao SM; Department of Neurology, Medical College of Wisconsin, Milwaukee; 53226, USA.; Dementia is a common occurrence in patients with disorders affecting cerebral hemispheric white matter. Relatively little is known, however, about the specific pattern of neurobehavioral changes associated with abnormal white matter function. This review examines in detail the neurobehavioral features of a common whit
Automated docking of flexible ligands: applications of AutoDock.: J Mol Recognit. 1996 Jan-Feb;9(1):1-5. Unique Identifier : AIDSLINE MED/96301829; Goodsell DS; Morris GM; Olson AJ; Department of Molecular Biology, Scripps Research Institute, La; Jolla, CA 92037, USA.; AutoDock is a suite of C programs used to predict the bound conformations of a small, flexible ligand to a macromolecular target of known structure. The technique combines simulated annealing for conformation searching with a rapid grid-based method of energy evaluation. This paper reviews recent applications of the t
[Sudden hearing loss and HIV infection]: Acta Otorrinolaringol Esp. 1996 Jul-Aug;47(4):311-3. Unique Identifier : AIDSLINE MED/97070066; Solanellas Soler J; Soldado Patino L; Lozano De Leon F; Servicio de ORL, Hospital Unviersitario de Valme, Sevilla.; A case is reported of left sudden hearing loss in a 29-year-old male with HIV infection and a history right sudden hearing loss 2 years earlier. The low frequency of sudden hearing loss in HIV+ patients is discussed. Neurosyphilis and cryptococcus infection were ruled out. The
Hospice at home--a new service for patients with advanced HIV/AIDS: a pilot evaluation of referrals and outcomes.: Br J Gen Pract. 1996 Sep;46(410):539-40. Unique Identifier : AIDSLINE MED/97075484; Koffman J; Higginson I; Naysmith A; Department of Public Health, Kensington & Chelsea and Westminster; Health Authority.; Between 50 and 70% of patients with a terminal illness indicate a preference to remain at home for as long as possible until their death. Nevertheless, a much smaller percentage actually die at home in England and Wales. A new hospice-at-home service in North London for patients with HIV/AIDS is described in this repo
War zone paediatrics in Rwanda.: J Paediatr Child Health. 1996 Aug;32(4):290-5. Unique Identifier : AIDSLINE MED/97001539; Pearn J; Office of the Director-General of Army Health Services,; Department of Defence, Canberra, ACT, Australia.; Children are particularly vulnerable to injury and death in two types of 20th century conflicts; terrorist attack and civil war. This account describes some first-hand experiences of the aftermath of the Rwandan Civil War of 1994. Events leading to the conflict are described, eye witness accounts of child trauma durin
Early phases of HIV type 1 infection.: AIDS Res Hum Retroviruses. 1996 Jan 1;12(1):1-9. Unique Identifier : AIDSLINE MED/96423011; D'Souza MP; Mathieson BJ; Pathogenesis and Basic Research Branch, Division of AIDS, NIAID,; Bethesda, Maryland 20892, USA.; A workshop entitled Early Phases of HIV-1 Infection was held to review current research on the immunological and virological aspects of early phases of HIV infection in humans and in animal models, to identify studies for future research, and to foster collaborations among investigators in the biomedical community.
Comparison of HIV type 1 RNA plasma viremia, p24 antigenemia, and unintegrated DNA as viral load markers in pediatric patients.: AIDS Res Hum Retroviruses. 1996 Jan 1;12(1):11-5. Unique Identifier : AIDSLINE MED/96423012; Bush CE; Donovan RM; Manzor O; Baxa D; Moore E; Cohen F; Saravolatz LD; Infectious Disease Research Laboratory, Henry Ford Hospital,; Detroit, Michigan 48202, USA.; Better surrogate markers need to be developed to evaluate therapy in HIV-infected children. This study evaluated plasma RNA, immune complex-dissociated p24 antigenemia, and unintegrated DNA (uDNA) in HIV-infected pediatric patients. Ten children were followed from initiation of nucleoside antiretroviral therapy at int
Correlation of CD8 lymphocyte activation with cellular viremia and plasma HIV RNA levels in asymptomatic patients infected by human immunodeficiency virus type 1.: AIDS Res Hum Retroviruses. 1996 Jan 1;12(1):17-24. Unique Identifier : AIDSLINE MED/96423013; Bouscarat F; Levacher-Clergeot M; Dazza MC; Strauss KW; Girard PM; Ruggeri C; Sinet M; INSERM U13, Paris, France.; The relationship between CD8 lymphocyte phenotypic alterations and virological parameters was studied in 47 asymptomatic subjects with human immunodeficiency virus type 1 (HIV-1) infection and CD4 T cell counts above 400/microliters. CD8 subsets were examined by means of three-color flow cytometry, using an extensive
Virucidal effect of stimulated eosinophils on human immunodeficiency virus type 1.: AIDS Res Hum Retroviruses. 1996 Jan 1;12(1):25-9. Unique Identifier : AIDSLINE MED/96423014; Klebanoff SJ; Coombs RW; Department of Medicine, University of Washington, Seattle 98195,; USA.; Eosinophils, when stimulated, release a variety of agents that can be toxic to ingested or extracellular targets. Among these systems is one that consists of eosinophil peroxidase (EPO), H2O2, and a halide. We report here that phorbol myristate acetate (PMA)-stimulated human eosinophils are virucidal to HIV-1 in a chl
Allostimulated lymphocytes inhibit replication of HIV type 1.: AIDS Res Hum Retroviruses. 1996 Jan 1;12(1):31-7. Unique Identifier : AIDSLINE MED/96423015; Bruhl P; Kerschbaum A; Zimmermann K; Eibl MM; Mannhalter JW; Department of Immunological Research, Immuno AG, Vienna, Austria.; Previous reports demonstrated that alloantigen- or xenoantigen-specific antibodies displayed neutralizing activity toward human or simian immunodeficiency viruses. In the present article we have addressed the question of alloantigen-induced cell-mediated anti-HIV activity. We show that allostimulation resulted in a ly
Inhibition of HIV activation in latently infected cells by flavonoid compounds.: AIDS Res Hum Retroviruses. 1996 Jan 1;12(1):39-46. Unique Identifier : AIDSLINE MED/96423016; Critchfield JW; Butera ST; Folks TM; Retrovirus Diseases Branch, National Center for Infectious; Diseases, Centers for Disease Control and Prevention, Atlanta,; Georgia 30333, USA.; Acute HIV-1 infection of H9 and C8166 cultures has been shown to be suppressed by certain flavonoids, and evidence for inhibition of HIV-1 protease, integrase, and reverse transcriptase by flavonoids also exists. The present aim was to determine whether flavonoids inhibit HIV-1 activation in models of latent infection
Inhibition of human immunodeficiency virus infection of CD4+ cells by CD4-free glycopeptides from monocytic U937 cells.: AIDS Res Hum Retroviruses. 1996 Jan 1;12(1):47-53. Unique Identifier : AIDSLINE MED/96423017; Mbemba E; Carre V; Atemezem A; Saffar L; Gluckman JC; Gattegno L; Faculte de Medecine Leonard de Vinci, Universite Paris-Nord,; Bobigny, France.; We have previously demonstrated that human immunodeficiency virus (HIV) envelope glycoproteins have specific carbohydrate-binding properties for mannosyl/N-acetylglucosaminyl residues presented at high density on a carrier in vitro. Here, we investigated whether HIV envelope glycoprotein gp120 was able to interact wit
Design, synthesis, and resistance patterns of MP-134 and MP-167, two novel inhibitors of HIV type 1 protease.: AIDS Res Hum Retroviruses. 1996 Jan 1;12(1):55-61. Unique Identifier : AIDSLINE MED/96423018; Mo H; Markowitz M; Majer P; Burt SK; Gulnik SV; Suvorov LI; Erickson JW; Ho DD; Aaron Diamond AIDS Research Center, New York University School of; Medicine, New York 10016, USA.; Inhibitors of HIV-1 protease represent a new class of antiretroviral compounds. Here, we report the design and synthesis of two novel C2 symmetry-based inhibitors, MP-134 and MP-167, specifically targeted against HIV-1 variants with reduced sensitivity to another related protease inhibitor, A-77003. In addition, we de
Inhibition of human immunodeficiency virus infection by heparin derivatives.: AIDS Res Hum Retroviruses. 1996 Jan 1;12(1):63-9. Unique Identifier : AIDSLINE MED/96423019; Clayette P; Moczar E; Mabondzo A; Martin M; Toutain B; Marce D; Dormont D; Commissariat a l'Energie Atomique, Centre de Recherches du; Service de Sante des Armees, Fontenay-aux-Roses, France.; Heparin (Hep) and sulfated polysaccharides (SPs) have been reported to inhibit HIV infection in vitro. In vivo, anticoagulant activity and reduced bioavailability were found to limit the antiviral effects of Hep. In this investigation, three nonanticoagulant N-acylated Hep conjugates [OI1:3Hep, Pal1:5Hep, and Pal1:5He
n-Docosanol inhibits in vitro replication of HIV and other retroviruses.: AIDS Res Hum Retroviruses. 1996 Jan 1;12(1):71-4. Unique Identifier : AIDSLINE MED/96423020; Marcelletti JF; Lusso P; Katz DH; LIDAK Pharmaceuticals, La Jolla, California 92037, USA.
Genetic polymorphism of envelope V3 region of HIV type 1 subtypes A, C, and D from Nairobi, Kenya.: AIDS Res Hum Retroviruses. 1996 Jan 1;12(1):75-8. Unique Identifier : AIDSLINE MED/96423021; Zachar V; Goustin AS; Zacharova V; Hager H; Koppelhus U; Womble DD; Liu X; Bambra C; Nyongo A; Ebbesen P; Department for Virus and Cancer, Danish Cancer Society, Aarhus,; Denmark.
HIV type 1 subtypes in Argentina and genetic heterogeneity of the V3 region.: AIDS Res Hum Retroviruses. 1996 Jan 1;12(1):79-81. Unique Identifier : AIDSLINE MED/96423022; Campodonico M; Janssens W; Heyndrickx L; Fransen K; Leonaers A; Fay FF; Taborda M; Van der Groen G; Fay OH; Bios Rosario S.A., Argentina.
Constraints on the sequence diversity of the protease of human immunodeficiency virus type 1: a guide for drug design.: AIDS Res Hum Retroviruses. 1996 Jul 1;12(10):849-53. Unique Identifier : AIDSLINE MED/96392156; Kaplan AH; Department of Medicine, UCLA School of Medicine 90024, USA.
Lack of correlation between V3 amino acid sequence and syncytium-inducing capacity of some HIV type 1 isolates [letter]: AIDS Res Hum Retroviruses. 1996 Jul 1;12(10):855-8. Unique Identifier : AIDSLINE MED/96392157; Sabri F; Chiodi F; Fenyo EM
Conference summary: novel HIV therapies--from discovery to clinical proof of concept.: AIDS Res Hum Retroviruses. 1996 Jul 1;12(10):859-65. Unique Identifier : AIDSLINE MED/96392158; Miller RH; Turk SR; Black RJ; Bridges S; Sarver N; Division of AIDS, National Institute of Allergy and Infectious; Diseases, National Institutes of Health, Bethesda, Maryland; 20892, USA.; In this report we have highlighted only a few examples of the extensive efforts underway to better understand the process of HIV pathogenesis, to develop new therapeutic agents to inhibit virus replication, and to identify strategies to restore damage done to the immune system during HIV disease progression. It is exp
Human immunodeficiency virus type 1 entry into murine cell lines and lymphocytes from transgenic mice expressing a glycoprotein 120-binding mutant mouse CD4.: AIDS Res Hum Retroviruses. 1996 Jul 1;12(10):867-76. Unique Identifier : AIDSLINE MED/96392159; Wieder KJ; Chatis P; Boltax J; Wieder I; Nuovo G; Strom TB; Division of Immunology, Beth Israel Hospital and Harvard Medical; School, Boston, Massachusetts 02215, USA.; Human CD4, the receptor for the gp120 envelope glycoprotein of HIV-1, is the route for viral entry into CD4+ cells; other cellular factors may cooperate with CD4 to facilitate HIV-1 entry into human cells. Human CD4 expressed on murine cells does not readily mediate HIV-1 entry, which may reflect a functional incompat
Surface CD4 is critical to in vitro HIV infection of human alveolar macrophages.: AIDS Res Hum Retroviruses. 1996 Jul 1;12(10):877-83. Unique Identifier : AIDSLINE MED/96392160; Lewin SR; Sonza S; Irving LB; McDonald CF; Mills J; Crowe SM; AIDS Pathogenesis Research Unit, Macfarlane Burnet Centre for; Medical Research, Fairfield, Victoria, Australia.; The CD4 glycoprotein is the major cellular receptor for HIV. CD4 surface expression of monocytes decreases with time in culture while their susceptibility to HIV-1 increases. Our aim was to investigate whether this phenomenon occurs in macrophages that have differentiated in vivo by investigating CD4 expression and HI
Monocytes in HIV type 1-infected individuals lose expression of costimulatory B7 molecules and acquire cytotoxic activity.: AIDS Res Hum Retroviruses. 1996 Jul 1;12(10):885-92. Unique Identifier : AIDSLINE MED/96392161; Dudhane A; Conti B; Orlikowsky T; Wang ZQ; Mangla N; Gupta A; Wormser GP; Hoffmann MK; Department of Microbiology and Immunology, New York Medical; College, Valhalla 10595, USA.; Monocytes/macrophages control the function of lymphocytes through positive and negative regulation. They release immunostimulatory cytokines and initiate costimulatory signals in T cells through the expression of B7 molecules. Their negative regulatory functions include the capacity to destroy cells with which they fo
AIDS patient monocytes target CD4 T cells for cellular conjugate formation and deletion through the membrane expression of HIV-1 envelope molecules.: AIDS Res Hum Retroviruses. 1996 Jul 1;12(10):893-9. Unique Identifier : AIDSLINE MED/96392162; Dudhane A; Wang ZQ; Orlikowsky T; Gupta A; Wormser GP; Horowitz H; Kufer P; Hoffmann MK; Department of Microbiology and Immunology, New York Medical; College, Valhalla 10595, USA.; The human immunodeficiency virus (HIV) causes in humans the acquired immunodeficiency syndrome (AIDS). It replicates at a high rate in lymphoid organs even before it causes clinical symptoms. It binds to CD4 cell surface markers and destroys T lymphocytes that express the receptor. The immune system replenishes CD4 T
Humoral immune response to immunocomplexed HIV envelope glycoprotein 120.: AIDS Res Hum Retroviruses. 1996 Jul 1;12(10):901-9. Unique Identifier : AIDSLINE MED/96392163; Denisova G; Stern B; Raviv D; Zwickel J; Smorodinsky NI; Gershoni JM; Department of Cell Research and Immunology, George S. Wise; Faculty of Life Sciences, Tel Aviv University, Israel.; To further our understanding of the nature of HIV-1 immunogenicity, we injected mice with the virus envelope protein gp120 in different configurations: free, complexed with its receptor CD4, and as an immunocomplex with a monoclonal antibody directed against the V3 loop of the protein. Analyses of the polyclonal sera,
Human antibody responses to HIV type 1 glycoprotein 41 cloned in phage display libraries suggest three major epitopes are recognized and give evidence for conserved antibody motifs in antigen binding.: AIDS Res Hum Retroviruses. 1996 Jul 1;12(10):911-24. Unique Identifier : AIDSLINE MED/96392164; Binley JM; Ditzel HJ; Barbas CF 3rd; Sullivan N; Sodroski J; Parren PW; Burton DR; Department of Immunology, Scripps Research Institute, La Jolla,; California 92037, USA.; A large panel of human Fab fragments against the gp41 subunit of the HIV-1 envelope glycoprotein was isolated by panning six phage-displayed antibody libraries against recombinant gp41. The libraries were prepared from HIV-1-seropositive donors. Twenty-three Fabs recognizing conformation-dependent determinants on gp41
Examination of HIV type 1 variants in mother-child pairs.: AIDS Res Hum Retroviruses. 1996 Jul 1;12(10):925-30. Unique Identifier : AIDSLINE +; Roth WW; Zuberi JA; Stringer HG Jr; Davidson SK; Bond VC; Department of Biochemistry, Morehouse School of Medicine,; Atlanta, Georgia 30310-1495, USA.
Antibodies against retroviral proteins and nuclear antigens in a subset of idiopathic CD4+ T lymphocytopenia patients.: AIDS Res Hum Retroviruses. 1996 Jul 1;12(10):931-40. Unique Identifier : AIDSLINE MED/96392166; Garry RF; Fermin CD; Kohler PF; Markert ML; Luo H; Department of Microbiology and Immunology, Tulane University; School of Medicine, New Orleans, Louisiana 70112, USA.; Idiopathic CD4+ T lymphocytopenia (ICL) is an immunodeficiency syndrome characterized by severe depletion of CD4+ T lymphocytes, but in which human immunodeficiency virus cannot be detected. Peripheral blood mononuclear cells (BPMCs) from an ICL patient were cocultured with HUT78 T-lymphoblastoid cells, and an acute c
Immunogenicity of variable regions of the surface envelope glycoprotein of HTLV type I and identification of new major epitopes in the 239-261 region.: AIDS Res Hum Retroviruses. 1996 Jul 1;12(10):941-50. Unique Identifier : AIDSLINE MED/96392167; Londos-Gagliardi D; Dalibart R; Geoffre S; Dalbon P; Pouliquen JF; Georges-Courbot MC; Sainte-Foie S; Hajjar C; Georges AJ; Moreau JP; Guillemain B; INSERUM, U 328, Structures et Fonctions des Retrovirus Humains,; Institut Bergonie, Bordeaux, France.; The reactivity of sera of 96 individuals infected with human T-cell leukemia virus type I (HTLV-I) was tested against various synthetic peptides corresponding to the gp46 immunodominant antigenic domains: residues 86-107, 175-199, and 239-261. The frequency of reactive sera was higher for 175-199 (93%) than for 239-26
HIV type 1 subtypes in The Netherlands circulating among women originating from AIDS-endemic regions.: AIDS Res Hum Retroviruses. 1996 Jul 1;12(10):951-3. Unique Identifier : AIDSLINE +; Lukashov VV; Kuiken CL; Boer K; Goudsmit J; Department of Human Retroviruses, University of Amsterdam, The; Netherlands.
env gene diversity of HIV type 1 isolates from Spain.: AIDS Res Hum Retroviruses. 1996 Jul 1;12(10):955-7. Unique Identifier : AIDSLINE +; Quinones-Mateu ME; Holguin A; Soriano V; Domingo E
Distinct but related human immunodeficiency virus type 1 variant populations in genital secretions and blood.: AIDS Res Hum Retroviruses. 1996 Jan 20;12(2):107-15. Unique Identifier : AIDSLINE MED/96431378; Overbaugh J; Anderson RJ; Ndinya-Achola JO; Kreiss JK; Department of Microbiology, University of Washington, Seattle; 98195, USA.; For a HIV vaccine to be effective, it will be essential that it protect against the virus variants to which individuals are most frequently exposed. HIV-1 is predominantly a sexually acquired virus, thus, variants in genital secretions are a potentially important reservoir of viruses that are transmitted. Because ther
Quantitative dynamics of HIV type 1 expression.: AIDS Res Hum Retroviruses. 1996 Jan 20;12(2):117-126. Unique Identifier : AIDSLINE MED/96431379; Comar M; Marzio G; D'Agaro P; Giacca M; International Centre for Genetic Engineering and Biotechnology,; Trieste, Italy.; A competitive PCR and RT-PCR procedure was developed for the quantification of HIV-1 nucleic acids in infected biological samples, with particular reference to the study of the kinetics of production of differently processed viral transcripts. The procedure entails the utilization of a competitor plasmid DNA (on DNA s
Effect of HIV infection on the frequency of cytokine-secreting cells in human peripheral blood.: AIDS Res Hum Retroviruses. 1996 Jan 20;12(2):127-133. Unique Identifier : AIDSLINE MED/96431380; Hagiwara E; Sacks T; Leitman-Klinman SF; Klinman DM; Division of Viral Products, Food and Drug Administration,; Bethesda, Maryland 20892, USA.; A selective decrease in type 1 cytokine secretion by in vitro stimulated peripheral blood cells is reportedly associated with disease progression in HIV-infected individuals. To examine whether a similar change in cytokine secretion occurs under physiologic conditions in vivo, sensitive and specific ELIspot assays wer
Characterization of T cell subsets involved in the production of IFN-gamma in asymptomatic HIV-infected patients.: AIDS Res Hum Retroviruses. 1996 Jan 20;12(2):135-41. Unique Identifier : AIDSLINE MED/96431381; Caruso A; Licenziati S; Canaris AD; Cantalamessa A; Corulli M; Benzoni B; Peroni L; Balsari A; Turano A; Institute of Microbiology, University of Brescia, Italy.; Cells capable of interferon (IFN)-gamma synthesis following mitogenic stimulation can be detected and quantified by a recently developed immunofluorescence assay and flow cytometric analysis. The production of IFN-gamma was investigated in a cohort of 20 asymptomatic human immunodeficiency virus (HIV)-seropositive pat
Suppression of the human immunodeficiency virus long terminal repeat by CD8+ T cells is dependent on the NFAT-1 element.: AIDS Res Hum Retroviruses. 1996 Jan 20;12(2):143-8. Unique Identifier : AIDSLINE MED/96431382; Copeland KF; McKay PJ; Rosenthal KL; Department of Pathology, McMaster University Health Sciences; Centre, Hamilton, Ontario, Canada.; CD8+ T lymphocytes of HIV-1 infected individuals produce a soluble factor that efficiently suppresses HIV-1 replication at the transcriptional level. We show here that the response of the HIV-1 long terminal repeat (LTR) to mitogenic or Tat-mediated activation is sensitive to the suppressive action of a Herpesvirus sa
Elevated cerebrospinal fluid sulfatide concentrations as a sign of increased metabolic turnover of myelin in HIV type I infection.: AIDS Res Hum Retroviruses. 1996 Jan 20;12(2):149-55. Unique Identifier : AIDSLINE MED/96431383; Gisslen M; Fredman P; Norkrans G; Hagberg L; Department of Infectious Diseases, Goteborg University, Sweden.; Cerebrospinal fluid (CSF) sulfatide concentrations were analyzed in 18 patients with asymptomatic HIV-1 infection, in 16 patients with AIDS who were free from opportunistic infections in the central nervous system (CNS), in 12 HIV-1-infected patients with opportunistic CNS infections or lymphoma, and in 19 HIV-negativ
Human T-lymphotropic virus type I excretion and specific antibody response in paired saliva and cervicovaginal secretions.: AIDS Res Hum Retroviruses. 1996 Jan 20;12(2):157-167. Unique Identifier : AIDSLINE MED/96431384; Belec L; Jean Georges A; Hallouin MC; Si Mohamed A; Morand-Joubert L; Georges-Courbot MC; Laboratoire de Virologie, Hopital Broussais, Paris, France.; Paired sera, salivas, and cervicovaginal secretions from 17 HTLV-I-infected women (10-75 years) were evaluated for total IgA, IgG, IgM, for IgA and IgG to whole HTLV-I lysate, for albumin, and for tax-rex proviral HTLV-DNA. IgG to HTLV-I were constantly detected, with much higher titers in serum (mean titer: 97,800) t
Complex mosaic structure of the partial envelope sequence from a Gambian HIV type 1 isolate.: AIDS Res Hum Retroviruses. 1996 Jan 20;12(2):169-171. Unique Identifier : AIDSLINE MED/96431385; Bobkov A; Cheingsong-Popov R; Salminen M; McCutchan F; Louwagie J; Ariyoshi K; Whittle H; Weber J; Department of Genito-Urinary Medicine and Communicable Diseases,; Imperial College of Science, Technology and Medicine, London, UK.
Reduced sensitivity to strain-specific neutralization of laboratory-adapted feline immunodeficiency virus after one passage in vivo: association with amino acid substitutions in the V4 region of the surface glycoprotein.: AIDS Res Hum Retroviruses. 1996 Jan 20;12(2):173-175. Unique Identifier : AIDSLINE MED/96431386; Cammarota G; Matteucci D; Pistello M; Nicoletti E; Giannecchini S; Bendinelli M; Department of Biomedicine, University of Pisa, Italy.
Positioning of positively charged residues in the V3 loop correlates with HIV type 1 syncytium-inducing phenotype.: AIDS Res Hum Retroviruses. 1996 Jan 20;12(2):83-90. Unique Identifier : AIDSLINE MED/96431375; Bhattacharyya D; Brooks BR; Callahan L; Division of Computer Research and Technology, National Institutes; of Health, Bethesda, Maryland 20892-5626, USA.; Although the V3 loop of the envelope glycoprotein (gp120) plays a role in determining the phenotype, pathogenesis, and tropism of human immunodeficiency virus-1 (HIV-1), there has not been any consistent correlation between structure and phenotype. Theoretically determined structures of the V3 loop of gp120, from 20 d
Kernel density analysis of variable and conserved regions of the envelope proteins of human immunodeficiency virus type 1 and associated epitopes.: AIDS Res Hum Retroviruses. 1996 Jan 20;12(2):91-97. Unique Identifier : AIDSLINE MED/96431376; Lauder IJ; Lin HJ; Siwak EB; Hollinger FB; Department of Statistics, University of Hong Kong.; A new statistical approach to the study of conservation of amino acid and nucleotide sequences based on kernel density analysis is described that enables analysis of both conserved and highly variable HIV-1 protein sequences. The amino acid sequences of HIV-1 env proteins in 63 isolates were analysed to determine, fir
Compositional similarities between the human immunodeficiency virus and surface antigens of pathogens.: AIDS Res Hum Retroviruses. 1996 Jan 20;12(2):99-106. Unique Identifier : AIDSLINE MED/96431377; Fitzgerald DJ; Bronson EC; Anderson JN; Department of Biological Sciences, Purdue University, West; Lafayette, Indiana 47907, USA.; The genome of the human immunodeficiency virus (HIV) is rich in A but not U and deficient in C but not G. This asymmetric nucleotide bias is the major factor in determining the unusual composition of HIV proteins. In this report, we have identified the cellular genes in the GenBank database that are compositionally si
HIV type 1 Nef perturbs eye lens development in transgenic mice.: AIDS Res Hum Retroviruses. 1996 Feb 10;12(3):177-89. Unique Identifier : AIDSLINE MED/96432128; Dickie P; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, National Institutes of Health,; Bethesda, Maryland 20892-0460, USA.; HIV transgenic mice often display lens cataracts as a consequence of viral-specific expression of HIV gene products in the developing lens. Cataractous mouse lines encoding either HIV-1 proviral DNA, HIV delta Gag/Pol] proviral DNA, or the HIV-1 nef gene alone were examined to ascertain the effect of Nef on murine len
Construction and characterization of a stable full-length macrophage-tropic HIV type 1 molecular clone that directs the production of high titers of progeny virions.: AIDS Res Hum Retroviruses. 1996 Feb 10;12(3):191-4. Unique Identifier : AIDSLINE MED/96432129; Theodore TS; Englund G; Buckler-White A; Buckler CE; Martin MA; Peden KW; Laboratory of Molecular Microbiology, NIAID, NIH, Bethesda,; Maryland 20892-0460, USA.
Substance P modulates human immunodeficiency virus replication in human peripheral blood monocyte-derived macrophages.: AIDS Res Hum Retroviruses. 1996 Feb 10;12(3):195-8. Unique Identifier : AIDSLINE MED/96432130; Ho WZ; Cnaan A; Li YH; Zhao H; Lee HR; Song L; Douglas SD; Department of Pediatrics, University of Pennsylvania Medical; School, Philadelphia 19104, USA.; Substance P (SP), a member of the tachykinin family of neuropeptides, is an important immunomodulator of lymphocyte and monocyte/macrophage function. We have examined the effects of SP on human immunodeficiency virus type 1 (HIV-1) infection of peripheral blood monocyte-derived macrophages (MDMs) in vitro. Human monoc
Tumor necrosis factor receptor p55 mediates induction of HIV type 1 expression in chronically infected U1 cells.: AIDS Res Hum Retroviruses. 1996 Feb 10;12(3):199-204. Unique Identifier : AIDSLINE MED/96432131; Edfjall C; Jacobsen H; Lotscher H; Mous J; Pharmaceutical Research Gene Technologies, F. Hoffmann-La Roche; Ltd., Basel, Switzerland.; Tumor necrosis factor alpha (TNF-alpha) is a potent inducer of human immunodeficiency virus type 1 (HIV-1) expression in chronically infected cells. The aim of this study was to investigate the role played by the two known TNF-alpha receptors, TNFR-p55 and TNFR-p75, in the activation of HIV-1 expression. As a model sy
Intrathecal synthesis of anti-sulfatide IgG is associated with peripheral nerve disease in acquired immunodeficiency syndrome.: AIDS Res Hum Retroviruses. 1996 Feb 10;12(3):205-11. Unique Identifier : AIDSLINE MED/96432132; De Gasperi R; Angel M; Sosa G; Patarca R; Battistini S; Lamoreux MR; Raghavan S; Kowall NW; Smith KH; Fletcher MA; Kolodny EH; Department of Neurology, New York University School of Medicine,; New York 10016, USA.; Peripheral nervous system involvement in the acquired immunodeficiency syndrome (AIDS) can take the form of an acute or chronic inflammatory demyelinating polyneuropathy, polyradiculopathy, mononeuropathy multiplex, or autonomic neuropathy. There is no widely held consensus on the etiology of PNS or other neurological
A multicenter proton magnetic resonance spectroscopy study of neurological complications of AIDS.: AIDS Res Hum Retroviruses. 1996 Feb 10;12(3):213-22. Unique Identifier : AIDSLINE MED/96432133; Paley M; Cozzone PJ; Alonso J; Vion-Dury J; Confort-Gouny S; Wilkinson ID; Chong WK; Hall-Craggs MA; Harrison MJ; Gili J; Rovira A; Capellades J; Rio J; Ocana I; Nicoli F; Dhiver C; Gastaut JL; Gastaut JA; Wicklow K; Sauter R; Department of Imaging and Neurology, Middlesex Hospital and; University College London Medical School, England.; Human immunodeficiency virus (HIV) infection as seen in Europe and the United States has predominantly been contracted through male homosexual sex or intravenous drug abuse. In infected subjects, the brain is frequently affected both clinically and neuropathologically. The aim of this
Long-term exposure to zidovudine affects in vitro and in vivo the efficiency of phosphorylation of thymidine kinase.: AIDS Res Hum Retroviruses. 1996 Feb 10;12(3):223-8. Unique Identifier : AIDSLINE MED/96432134; Antonelli G; Turriziani O; Verri A; Narciso P; Ferri F; D'Offizi G; Dianzani F; Department of Biomedicine, University of Pisa, Italy.; The purpose of this study was to investigate the mechanism of acquired cellular resistance to AZT , a mechanism that has been described as a potential source of drug resistance in addition to viral mutations. To study this phenomenon the kinetics param
Comparative pharmacokinetics of zidovudine and its toxic catabolite 3'-amino-3'-deoxythymidine in HIV-infected patients.: AIDS Res Hum Retroviruses. 1996 Feb 10;12(3):229-33. Unique Identifier : AIDSLINE MED/96432135; Zhou XJ; Sommadossi JP; Department of Pharmacology and Toxicology, University of Alabama; at Birmingham 35294-0019, USA.; The plasma pharmacokinetics of zidovudine (ZDV, 3 -azido-3 -deoxythymidine) and its toxic catabolite 3 -amino-3 -deoxythymidine (AMT) was investigated in six HIV-infected patients receiving 100 or 500 mg of ZDV by oral administration. Zidovudine plasma pharmacokinetic parameters were in good agreement with previously
Activity of granzyme A, a serine protease in the killing granules of cytotoxic T lymphocytes, is reduced in cells from HIV-infected hemophiliacs.: AIDS Res Hum Retroviruses. 1996 Feb 10;12(3):235-9. Unique Identifier : AIDSLINE MED/96432136; Chiang CF; Tenenbaum SA; Verret CR; Leissinger CA; Garry RF; Department of Chemistry, Tulane University, New Orleans,; Louisiana 70118, USA.; Cytotoxic CD8+ lymphocytes (CTLs) kill virally infected target cells by releasing cytotoxic granules. The primary objective of this study was to determine whether the activity of granzyme A, a serine protease in the killing granules of CTLs is altered in HIV-infected hemophiliacs. A sensitive colorimetric assay that m
Interleukin 1 beta, interleukin 6, tumor necrosis factor alpha, and interleukin 10 responses in peripheral blood mononuclear cells of cynomolgus macaques during acute infection with SIVmac251.: AIDS Res Hum Retroviruses. 1996 Feb 10;12(3):241-50. Unique Identifier : AIDSLINE MED/96432137; Benveniste O; Vaslin B; Le Grand R; Fouchet P; Omessa V; Theodoro F; Fretier P; Clayette P; Boussin F; Dormont D; Commissariat a l'Energie Atomique, Institut Paris-Sud sur les; Cytokines, Fontenay aux Roses, France.; HIV infection ultimately leads to AIDS, despite the immune responses elicited soon after infection. In addition to the observed changes in lymphoid cell subsets, alteration of the cytokine network most likely accompanies and/or contributes to the lack of protective immune responses. In an attempt to delineate the earl
Glycoprotein 120 polymorphism in an HIV type 1 epidemic originating from a point source: nucleotide sequence analysis of variants with conserved V3 loop sequences.: AIDS Res Hum Retroviruses. 1996 Feb 10;12(3):251-3. Unique Identifier : AIDSLINE MED/96432138; Bobkov A; Cheingsong-Popov R; Garaev M; Weber J; D. I. Ivanovsky Institute of Virology, Moscow, Russia.
Phylogenetic characterization of simian T lymphotropic virus type I (STLV-I) from the Ethiopian sacred baboon (Papio hamadryas).: AIDS Res Hum Retroviruses. 1996 Feb 10;12(3):255-8. Unique Identifier : AIDSLINE MED/96432139; Voevodin A; Miura T; Samilchuk E; Schatzl H; Department of Microbiology, Kuwait University, Safat.
Comparative Approach to Retroviral Vaccines. Workshop proceedings. Les Pensieres, Veyrier-du-Lac, France, June 23-24, 1995.: AIDS Res Hum Retroviruses. 1996 Mar 20;12(5):355-467. Unique Identifier : AIDSLINE MED/97100888
Environmental pathogenesis of human retroviruses.: AIDS Res Hum Retroviruses. 1996 Mar 20;12(5):357-9. Unique Identifier : AIDSLINE MED/97036662; Montagnier L; Unite d'Oncologie Virale Institut Pasteur, Paris, France.
Retroviral vaccines: challenges for the developing world.: AIDS Res Hum Retroviruses. 1996 Mar 20;12(5):361-3. Unique Identifier : AIDSLINE MED/97036663; Essex M; Harvard AIDS Institute, Boston, Massachusetts 02115, USA.
Roundtable: can experience with veterinary retroviral vaccines be applied to the human situation?: AIDS Res Hum Retroviruses. 1996 Mar 20;12(5):365-73. Unique Identifier : AIDSLINE MED/97036664
Correlates of immune protection after vaccination with attenuated live murine leukemia virus.: AIDS Res Hum Retroviruses. 1996 Mar 20;12(5):375-7. Unique Identifier : AIDSLINE MED/97036665; Ruprecht RM; Hu Y; Liska V; Rasmussen R; Sharma P; Laboratory of Viral Pathogenesis, Harvard Medical School and; Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.
Efficacy of an inactivated feline leukemia virus vaccine.: AIDS Res Hum Retroviruses. 1996 Mar 20;12(5):379-83. Unique Identifier : AIDSLINE MED/97036666; Hoover EA; Mullins JI; Chu HJ; Wasmoen TL; Department of Pathology, Colorado State University, Fort Collins; 80523, USA.; An inactivated whole-virus FeLV vaccine, developed from a molecularly cloned FeLV isolate (FeLV-61E-A), was assessed for its ability to protect cats against homologous and heterologous virulent viral challenge. The fractions of cats that resisted the induction of persistent viremia after FeLV challenge were as follows
The relevance of feline retroviruses to the development of vaccines against HIV.: AIDS Res Hum Retroviruses. 1996 Mar 20;12(5):385-7. Unique Identifier : AIDSLINE MED/97036667; Jarrett O; Department of Veterinary Pathology, University of Glasgow, United; Kingdom.
Comparative approach to retroviral vaccines.: AIDS Res Hum Retroviruses. 1996 Mar 20;12(5):389-92. Unique Identifier : AIDSLINE MED/97036668; Burny A; Faculty of Agronomy, University of Brussels, Belgium.
T cell-mediated destruction of bovine leukemia virus-infected peripheral lymphocytes by bovine leukemia virus env-vaccinia recombinant vaccine.: AIDS Res Hum Retroviruses. 1996 Mar 20;12(5):393-8. Unique Identifier : AIDSLINE MED/97036669; Ohishi K; Ikawa Y; Laboratory of Molecular Oncology, Tsukuba Life Science Center; (RIKEN), Ibaraki, Japan.
Simian retrovirus vaccines: simian retrovirus and simian immunodeficiency lentivirus.: AIDS Res Hum Retroviruses. 1996 Mar 20;12(5):399-401. Unique Identifier : AIDSLINE MED/97036670; Gardner MB; Luciw PA; Sawai ET; Marthas ML; Miller CJ; McChesney MB; Lerche NW; Pedersen NC; Department of Medical Pathology, University of California at; Davis 95616, USA.
Vaccine against human T cell leukemia-lymphoma virus type I: progress and prospects.: AIDS Res Hum Retroviruses. 1996 Mar 20;12(5):403-5. Unique Identifier : AIDSLINE MED/97036671; Bomford R; Kazanji M; De The G; Unite d'Epidemiologie des Virus Oncogenes, Institut Pasteur,; Paris, France.
Attenuated poxvirus vectors as carriers in vaccines against human T cell leukemia-lymphoma virus type I.: AIDS Res Hum Retroviruses. 1996 Mar 20;12(5):407-8. Unique Identifier : AIDSLINE MED/97036672; Franchini G; Benson J; Gallo R; Paoletti E; Tartaglia J; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, Maryland 20892-4255, USA.
Replication in goats in vivo of caprine arthritis-encephalitis virus deleted in vif or tat genes: possible use of these deletion mutants as live vaccines.: AIDS Res Hum Retroviruses. 1996 Mar 20;12(5):409-11. Unique Identifier : AIDSLINE MED/97036673; Harmache A; Russo P; Vitu C; Guiguen F; Mornex JF; Pepin M; Vigne R; Suzan M; Institut National de la Sante et de la Recherche Medicale U372,; Marseille, France.
Characterization of protective and enhancing immune responses to equine infectious anemia virus resulting from experimental vaccines.: AIDS Res Hum Retroviruses. 1996 Mar 20;12(5):413-5. Unique Identifier : AIDSLINE MED/97036674; Montelaro RC; Grund C; Raabe M; Woodson B; Cook RF; Cook S; Issel CJ; Department of Molecular Genetics and Biochemistry, University of; Pittsburgh School of Medicine, Pennsylvania 15261, USA.
Lentivirus replication in lymphoid tissue: use of lymphatic cannulation to study the initial stages of infection and immunity.: AIDS Res Hum Retroviruses. 1996 Mar 20;12(5):417-20. Unique Identifier : AIDSLINE MED/97036675; McConnell I; Blacklaws BA; Bird P; Lee WC; Roy DJ; Sargan D; Department of Clinical Veterinary Medicine, University of; Cambridge, United Kingdom.
Molecular studies of visna virus gene expression: analysis of envelope gene expression in transgenic sheep.: AIDS Res Hum Retroviruses. 1996 Mar 20;12(5):421-3. Unique Identifier : AIDSLINE MED/97036676; Clements JE; Hu L; Lindstrom L; Powell A; Rexroad C; Zink MC; Johns Hopkins University School of Medicine, Baltimore, Maryland; 21205, USA.
Evaluation of vaccines for ovine lentivirus infection.: AIDS Res Hum Retroviruses. 1996 Mar 20;12(5):425-6. Unique Identifier : AIDSLINE MED/97036677; Perk K; Yaniv A; Gazit A; Demartini JC; Koret School of Veterinary Medicine, Hebrew University of; Jerusalem, Israel.
Molecular characterization of field isolates of lentiviruses of small ruminants.: AIDS Res Hum Retroviruses. 1996 Mar 20;12(5):427-9. Unique Identifier : AIDSLINE MED/97036678; Leroux C; Greenland T; Mornex JF; INSERM CJF 93-08, Service de Pneumologie, Hopital Louis Pradel; and Universite Claude Bernard, Marcy l'Etoile, France.
Vaccination of cats with recombinant envelope glycoprotein of feline immunodeficiency virus: decreased viral load after challenge infection.: AIDS Res Hum Retroviruses. 1996 Mar 20;12(5):431-3. Unique Identifier : AIDSLINE MED/97036679; Lutz H; Hofmann-Lehmann R; Leutenegger C; Allenspach K; Cuisinier AM; Cronier J; Duquesne V; Aubert A; Department of Internal Veterinary Medicine, University of Zurich,; Switzerland.
Efficacy of recombinant feline leukemia virus vaccines.: AIDS Res Hum Retroviruses. 1996 Mar 20;12(5):435-6. Unique Identifier : AIDSLINE MED/97036680; Jarrett O; Department of Veterinary Pathology, University of Glasgow, United; Kingdom.
Accelerated viremia in cats vaccinated with recombinant vaccinia virus expressing envelope glycoprotein of feline immunodeficiency virus.: AIDS Res Hum Retroviruses. 1996 Mar 20;12(5):437-41. Unique Identifier : AIDSLINE MED/97036681; Osterhaus AD; Tijhaar E; Huisman RC; Huisman W; Darby IH; Francis MJ; Rimmelzwaan GF; Siebelink KH; Institute of Virology, Erasmus University Rotterdam, Netherlands.
Protection against human immunodeficiency virus type 2 and simian immunodeficiency virus in macaques vaccinated against human immunodeficiency virus type 2.: AIDS Res Hum Retroviruses. 1996 Mar 20;12(5):443-6. Unique Identifier : AIDSLINE MED/97036682; Biberfeld G; Thorstensson R; Putkonen P; Karolinska Institute and Swedish Institute for Infectious Disease; Control, Stockholm, Sweden.
Simian immunodeficiency virus live and inactivated experimental vaccines.: AIDS Res Hum Retroviruses. 1996 Mar 20;12(5):447-9. Unique Identifier : AIDSLINE MED/97036683; Norley S; Beer B; Binninger-Schinzel D; Vogel T; Siegel F; Cosma C; Konig H; Megede JZ; Kurth R; Paul-Ehrlich-Institut, Langen, Germany.
Recombinant subunit vaccines against primate lentiviruses.: AIDS Res Hum Retroviruses. 1996 Mar 20;12(5):451-3. Unique Identifier : AIDSLINE MED/97036684; Hu SL; Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle,; Washington 98121, USA.
DNA vaccines.: AIDS Res Hum Retroviruses. 1996 Mar 20;12(5):455-7. Unique Identifier : AIDSLINE MED/97036685; Robinson HL; Lu S; Feltquate DM; Torres CT; Richmond J; Boyle CM; Morin MJ; Santoro JC; Webster RG; Montefiori D; Yasutomi Y; Letvin NL; Manson K; Wyand M; Haynes JR; Department of Pathology, University of Massachusetts Medical; Center, Worcester 01655.
"Attenuated" simian immunodeficiency virus in macaque neonates.: AIDS Res Hum Retroviruses. 1996 Mar 20;12(5):459-60. Unique Identifier : AIDSLINE MED/97036686; Ruprecht RM; Baba TW; Liska V; Bronson R; Penninck D; Greene MF; Laboratory of Viral Pathogenesis, Harvard Medical School and; Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.
An approach to vaccines against human immunodeficiency virus.: AIDS Res Hum Retroviruses. 1996 Mar 20;12(5):461-3. Unique Identifier : AIDSLINE MED/97036687; Girard M; Barre-Sinoussi F; Van Der Ryst E; Fultz P; Institut Pasteur, Paris, France.
Perspectives on retroviral pathogenesis and vaccines.: AIDS Res Hum Retroviruses. 1996 Mar 20;12(5):465-7. Unique Identifier : AIDSLINE MED/97036688; Weiss RA; Chester Beatty Laboratories, Institute of Cancer Research,; London, United Kingdom.
[Treatment with interferon alfa-2b in patients with chronic hepatitis caused by hepatitis C virus: predictive factors for the response, relapse and early development to cirrhosis after treatment]: Rev Esp Enferm Dig. 1996 Sep;88(9):609-15. Unique Identifier : AIDSLINE MED/97091492; Perez Roldan F; De Diego A; Casado M; Matilla A; Banares R; Garcia-Duran F; Salcedo M; Cos E; Clemente G; Servicio de Aparato Digestivo, Hospital General Universitario,; Gregorio Maranon, Madrid.; The treatment of chronic hepatitis C is interferon (IFN). Diverse predictive factors influence a complete response. The aim of this study was to determine the response to IFN-alpha therapy and factors that may predict a sustained response before and after the first month of treatment. Likewise, it evaluates the relaps
[Kaposi's sarcoma of the bile ducts with cutaneous involvement in a patient with AIDS]: Rev Esp Enferm Dig. 1996 Sep;88(9):637-9. Unique Identifier : AIDSLINE MED/97091498; Segarra P; Abril V; Gil M; Ortega E; Ballester JE; Traves V; Servicio de Medicina Interna. Hospital General Universitario de; Valencia.; A 30 year-old man with acquired immunodeficiency syndrome was admitted because of abdominal pain, jaundice and fever. A severe pancreatitis without gallstones was detected. Later, dilation of biliary tract and clinical worsening appeared. Cholangiography revealed sclerosing cholangitis and papillary stenosis. Kaposi s
A virus, the vice chancellors and principles of vaccination [see comments]: Br Dent J. 1996 Feb 24;180(4):124-6. Unique Identifier : AIDSLINE MED/97002941; Laszlo J; Sivarajasingam V; Ogden GR; University of Dundee.; The Committee of Vice Chancellors and Principles have stated that from 1996, all students entering medical or dental school must show evidence of non-infectivity and satisfactory completion of immunisation against hepatitis B. This is believed to be the first time that immunisation status has been part of a requiremen
Needlestick injuries [letter]: Br Dent J. 1996 Oct 19;181(8):284. Unique Identifier : AIDSLINE MED/97091005; Erridge PL
Balancing the cost-quality equation: one hospital's approach to managing tuberculosis.: Aspens Advis Nurse Exec. 1996 Sep;11(12):1-4. Unique Identifier : AIDSLINE MED/97003513; Taylor M
Oral application of cytokines.: Biotherapy. 1996;8(3-4):205-12. Unique Identifier : AIDSLINE MED/96408288; Georgiades JA; Fleischmann WR Jr; Department of Microbiology and Immunology, University of Texas; Medical Branch, Galveston 77555, USA.; A number of different laboratories reported on studies with orally administered interferons and cytokines. Their observations extend previous observations which showed that orally administered interferons and cytokines can exert both local and systemic effects. As difficult as it may be to understand how orally admini
Cytokines and the immune response.: Biotherapy. 1996;8(3-4):243-9. Unique Identifier : AIDSLINE MED/96408292; Van der Meide PH; Schellekens H; Biomedical Primate Research Centre (BPRC), Rijswijk, The; Netherlands.; Cytokines participate in many physiological processes including the regulation of immune and inflammatory responses. These effector molecules are produced transiently and locally controlling the amplitude and duration of the response. A variety of experiments has shown that excessive or insufficient production may sig
A pharmacokinetic interaction study of didanosine coadministered with trimethoprim and/or sulphamethoxazole in HIV seropositive asymptomatic male patients.: Br J Clin Pharmacol. 1996 Mar;41(3):207-15. Unique Identifier : AIDSLINE MED/97020542; Srinivas NR; Knupp CA; Batteiger B; Smith RA; Barbhaiya RH; Department of Metabolism and Pharmacokinetics, Bristol-Myers; Squibb Pharmaceutical Research Institute, Princeton, NJ 08543,; USA.; 1. The pharmacokinetics of didanosine, trimethoprim, and sulphamethoxazole were evaluated in ten HIV seropositive asymptomatic patients as single agents and upon coadministration of single doses. 2. Using a randomized, balanced incomplete block crossover study with at least a 1-week washout period between successive t
Interleukin-13: characterization and biologic properties.: Cancer Treat Res. 1995;80:367-78. Unique Identifier : AIDSLINE MED/96418801; McKenzie AN; Zurawski G; MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.
DaunoXome data presented at international cancer meeting [news]: Oncology (Huntingt). 1996 Jun;10(6):830. Unique Identifier : AIDSLINE MED/96421101
Anorexia/cachexia in patients with HIV: lessons for the oncologist.: Oncology (Huntingt). 1996 Jul;10(7):1049-56; discussion 1062-4, 1067-8. Unique Identifier : AIDSLINE MED/96434142; Von Roenn JH; Knopf K; Northwestern University Chicago, Illinois, USA.; Early intervention and attention to nutritional status are essential in patients with cachexia. Identification of reversible causes of decreased energy intake and/or weight loss is the first step in treatment. When such factors cannot be identified, pharmacologic interventions should be considered. To date, megestrol
AIDS activists issue safeguards for people with AIDS who sell their life insurance policies.: Oncology (Huntingt). 1996 Jul;10(7):984, 987. Unique Identifier : AIDSLINE MED/96434138
Focal segmental glomerulosclerosis.: Pediatr Nephrol. 1996 Jun;10(3):374-91. Unique Identifier : AIDSLINE MED/96384521; Ichikawa I; Fogo A; Division of Pediatric Nephrology, Vanderbilt University Medical; Center, Nashville, TN 37232, USA.; Over the last 2 decades, we have learnt that focal segmental glomerulosclerosis (FSGS) is a ubiquitous phenomenon underlying the progressive deterioration of many different types of renal diseases in both pediatric and adult populations. FSGS may also be the primary renal lesion, whether in new disease entities such a
Joint United Nations programme on HIV/AIDS (UNAIDS). HIV and infant feeding: an interim statement.: Wkly Epidemiol Rec. 1996 Sep 27;71(39):289-91. Unique Identifier : AIDSLINE MED/97040361
Epidemiology of Kaposi's sarcoma in the Nordic countries before the AIDS epidemic.: Br J Cancer. 1996 Nov;74(9):1499-502. Unique Identifier : AIDSLINE MED/97069569; Hjalgrim H; Melbye M; Pukkala E; Langmark F; Frisch M; Dictor M; Ekbom A; Danish Epidemiology Science Centre, Statens Seruminstitut,; Copenhagen S, Denmark.; Based on data from the Nordic cancer registries, time-related trends in incidence of Kaposi s sarcoma (KS) were analysed in four ethnically similar populations before the AIDS epidemic. Data were available for different time periods in
AIDS. HIV in prison: the importance of prevention.: Nurs Stand. 1996 Oct 16;11(4):51-2. Unique Identifier : AIDSLINE MED/97086068; Ward K; Although the prison service aims to give inmates the same quality and range of health care services as those received by the general public, the provision of condoms and materials for cleaning shared injecting equipment is not the norm. These relatively inexpensive measures could, however, save many lives.
AIDS. Providing respite care in a rural environment.: Nurs Stand. 1996 Oct 16;11(4):53-5. Unique Identifier : AIDSLINE MED/97086069; Bradley S; Specialists multidisciplinary teams are an appropriate response to caring for people with HIV/AIDS in urban areas. In rural settings the problems are rather different and alternative approaches must be considered.
AIDS. Expanded horizons.: Nurs Stand. 1996 Oct 16;11(4):56. Unique Identifier : AIDSLINE MED/97086070; Howe J
HIV drug may raise hopes [news]: Nurs Stand. 1996 Nov 6;11(7):28. Unique Identifier : AIDSLINE MED/97100760
In vivo depletion of CD8+ T cells restores hair growth in the DEBR model for alopecia areata.: Br J Dermatol. 1996 Aug;135(2):211-7. Unique Identifier : AIDSLINE MED/97036014; McElwee KJ; Spiers EM; Oliver RF; Department of Biological Sciences, University of Dundee,; Scotland, U.K.; Alopecia areata (AA) is a putative autoimmune disease in which anagen hair follicles are the target of immune cell attack. While both CD4+ and CD8+ T lymphocytes are prominent in the infiltrate, their respective roles in the pathogenesis of AA remain unknown. Here we directly investigated the activity of CD8+ cells in
Mycobacterium kansasii infection limited to the skin in a patient with AIDS.: Br J Dermatol. 1996 Aug;135(2):324-6. Unique Identifier : AIDSLINE MED/97036038; Curco N; Pagerols X; Gomez L; Vives P; Department of Dermatology, Hospital Mutua de Terrassa,; Barcelona, Spain.; We describe a case of cutaneous Mycobacterium kansasii infection in a 56-year-old man with acquired immunodeficiency syndrome, who received treatment with trimethoprim-sulphamethoxazole for Pneumocystis carinii pneumonia. Resolution of the cutaneous lesion was observed without specific treatment.
EBV-positive non-Hodgkin's lymphoma developing after phenytoin therapy.: Br J Haematol. 1996 Nov;95(2):376-9. Unique Identifier : AIDSLINE MED/97060850; Garcia-Suarez J; Dominguez-Franjo P; Del Campo F; Herrero B; Munoz MA; Piris MA; Pardo A; Department of Haematology, Principe de Asturias University; Hospital, Alcala de Henares, Madrid, Spain.; We report the first case of Epstein Barr virus (EBV) positive non-Hodgkin s lymphoma occurring 20 years after continuous phenytoin therapy for idiopathic epilepsy. This malignant lymphoproliferative disease was preceded by an phenytoin-associated benign reactive lymphadenopathy. Se
Pathogenesis of Kaposi's sarcoma.: Clin Oncol (R Coll Radiol). 1996;8(3):189-94. Unique Identifier : AIDSLINE MED/96409394; Cooke FJ; Balliol College, Oxford, UK.
Changes in antigen densities on leukocyte subsets correlate with progression of HIV disease.: Int Immunol. 1996 Jan;8(1):1-11. Unique Identifier : AIDSLINE MED/96324740; Roederer M; Herzenberg LA; Herzenberg LA; Department of Genetics, Stanford University, Stanford, CA 94305,; USA.; In a cross-sectional study of 154 HIV-infected and 33 uninfected healthy adults, we show that characteristic changes in the levels of expression of leukocyte surface antigens occur in the HIV-infected individuals. These changes, which collectively occur on virtually every leukocyte subset, are specific: a particular a
Trypanosoma cruzi infection in MHC-deficient mice: further evidence for the role of both class I- and class II-restricted T cells in immune resistance and disease.: Int Immunol. 1996 Jan;8(1):13-22. Unique Identifier : AIDSLINE MED/96324741; Tarleton RL; Grusby MJ; Postan M; Glimcher LH; Department of Cellular Biology, University of Georgia, Athens, GA; 30602, USA.; The role of T cell population in immune control of Trypanosoma cruzi infection and subsequent development of disease has been examined using gene knockout mice deficient in the expression of either or both class I and Class II MHC. Mice deficient in either class I- or class II-restricted T cell populations show a stri
A monoclonal natural autoantibody that promotes remyelination suppresses central nervous system inflammation and increases virus expression after Theiler's virus-induced demyelination.: Int Immunol. 1996 Jan;8(1):131-41. Unique Identifier : AIDSLINE MED/96324753; Miller DJ; Njenga MK; Murray PD; Leibowitz J; Rodriguez M; Department of Immunology, Mayo Clinic and Foundation, Rochester,; MN 55905, USA.; We have used an established experimental model of multiple sclerosis to investigate the potential beneficial relationship between natural autoimmunity and remyelination after central nervous system (CNS) demyelination. Intracerebral infection of SJL/J mice with Theiler s murine encephalomyelitis virus (TMEV) produces
IgM natural antibody against an asialo-oligosaccharide, gangliotetraose (Gg4), sensitizes HIV-I infected cells for cytolysis by homologous complement.: Int Immunol. 1996 Jan;8(1):153-8. Unique Identifier : AIDSLINE MED/96324755; Wu X; Okada N; Iwamori M; Okada H; Department of Molecular Biology, Nagoya City University School of; Medicine, Mizuho-cho, Nagoya 467, Japan.; Although cells are usually resistant to homologous complement, the IgM antibody against gangliotetraose (Gg4), an asialo-oligosaccharide of GM1, was found to cause cytolysis of HIV-1 infected cells by homologous complement. Due to its size, IgM might enable the initiation of the complement cascade away from membrane c
HIV envelope-directed signaling aberrancies and cell death of CD4+ T cells in the absence of TCR co-stimulation.: Int Immunol. 1996 Jan;8(1):65-74. Unique Identifier : AIDSLINE MED/96324746; Tian H; Lempicki R; King L; Donoghue E; Samelson LE; Cohen DI; Cell Biology and Metabolism Branch, National Institute of Child; Health and Human Development, National Institute of Health,; Bethesda, MD 20892, USA.; HIV-1 infection in CD4(+) T cells initiates a viral cytopathic effect (CPE) that is dependent on the activation of intracellular protein tyrosine kinases (PTK). PTK in T cells are also activated during the course of TCR or CD4 receptor engagement and the manner of receptor engagement may generate signals leading eithe
Hormone regulation of murine T cells: potent tissue-specific immunosuppressive effects of thyroxine targeted to gut T cells.: Int Immunol. 1996 Feb;8(2):231-5. Unique Identifier : AIDSLINE MED/96324764; Wang J; Klein JR; Department of Biological Science, University of Tulsa, OK 74104,; USA.; Recent studies in athymic mice indicate that the neuroendocrine hormones thyrotropin-releasing hormone (TRH) and thyroid-stimulating hormone (TSH) can significantly influence the development of lymphoid cells associated with intestinal intraepithelial lymphocytes (IEL). In the present study we have examined the effect
Lymphocyte activation effect of (1-->6)-2,5-anhydro-D-glucitol and it derivatives with 3,4-di-O-methyl and sulfate groups.: Int J Biol Macromol. 1996 Feb;18(1-2):147-8. Unique Identifier : AIDSLINE MED/97005465; Kakuchi T; Umeda S; Satoh T; Yokota K; Yuhta T; Kikuchi A; Murabayashi S; Division of Bioscience, Hokkaido University, Sapporo, Japan.; (1-->6)-2,5-Anhydro-3,4-di-O-methyl-D-glucitol (2a) and (1-->6)-2,5-anhydro-D-glucitol (2c) and its sulfated derivative (2d) were synthesized and their biological activities were evaluated in regards to the effects on murine lymphocytes. The polymers showed different effects on the lymphocytes depending on the substit
Clinical utility of cytomegalovirus urine cultures for ophthalmic care in patients with HIV.: Br J Ophthalmol. 1996 Sep;80(9):818-22. Unique Identifier : AIDSLINE MED/97097836; Gellrich MM; Baumert E; Rump JA; Vaith P; Hufert FT; Hansen LL; Universitats-Augenklinik, Universitat Freiburg, Germany.; BACKGROUND: The utility of cytomegalovirus ( CMV ) urine cultures was checked in patients with HIV (a) to identify those at risk for CMV retinitis and (b) to guide clinical decisions on treatment and prophylaxis of CMV retiniti
Differential expression of the down-regulatory function of CD8 cells in trichosanthin-induced immunosuppression and its genetic control in humans.: Eur J Immunogenet. 1996 Feb;23(1):29-40. Unique Identifier : AIDSLINE MED/96431839; Chou KY; Chan M; Bias WB; Shanghai Institute of Immunology, Shanghai Second Medical; University, China.; Trichosanthin (Tk), a plant protein isolated from a Chinese medicinal herb, was shown in our previous experiments to suppress mitogenic, antigenic and allogeneic responses of human lymphocytes. Two non-toxic pathways, the CD8-dependent and the CD8-independent, were identified as being involved in inducing the suppress
Inhibition of HIV-1 Rev-RRE interaction by diphenylfuran derivatives.: Biochemistry. 1996 Oct 22;35(42):13689-96. Unique Identifier : AIDSLINE MED/97040536; Ratmeyer L; Zapp ML; Green MR; Vinayak R; Kumar A; Boykin DW; Wilson WD; Department of Chemistry, Georgia State University, Atlanta 30303,; USA.; The interactions between RNA structures, such as RRE in the HIV-1 genome, and proteins, such as Rev of HIV-1, are essential for efficient viral replication. Compounds that bind specifically to such RNAs and disrupt their protein complexes offer a novel mechanism for inhibition of replication of the virus. As a step in
HIV-1 membrane fusion mechanism: structural studies of the interactions between biologically-active peptides from gp41.: Biochemistry. 1996 Oct 22;35(42):13697-708. Unique Identifier : AIDSLINE MED/97040537; Lawless MK; Barney S; Guthrie KI; Bucy TB; Petteway SR Jr; Merutka G; Trimeris, Inc., Research Triangle Park, North Carolina 27709,; USA.; Two synthetic peptides corresponding to sequences in HIV-1LAI gp41, (aa558-595) and T20 (aa 643-678), are strong inhibitors of HIV-1 viral fusion, having EC50 values of 1 microgram/mL and 1 ng/mL, respectively. Previous work suggested that T21 forms a coiled-coil structure in PBS solution, while T20 is primarily nonhe
Inhibition of the human immunodeficiency virus type 1 integrase by guanosine quartet structures.: Biochemistry. 1996 Oct 29;35(43):13762-71. Unique Identifier : AIDSLINE MED/97057179; Mazumder A; Neamati N; Ojwang JO; Sunder S; Rando RF; Pommier Y; Laboratory of Molecular Pharmacology, National Cancer Institute,; Bethesda, Maryland 20892-4255, USA.; An oligonucleotide (T30177) composed entirely of deoxyguanosine and thymidine has previously been shown to fold upon itself in the presence of potassium into a highly stable four-stranded DNA structure containing two stacked deoxyguanosine quartets (G4s). T30177 also protects host cells from the cytopathic effects of
HIV-1 gp41 tertiary structure studied by EPR spectroscopy.: Biochemistry. 1996 Nov 5;35(44):13922-8. Unique Identifier : AIDSLINE MED/97065808; Rabenstein MD; Shin YK; Department of Chemistry, University of California, Berkeley; 94720, USA.; HIV gp41 is the transmembrane glycoprotein responsible for fusion of viral and cellular membranes, enabling viral entry. The structure of gp41 was studied using two synthetic peptides derived from the ectodomain of gp41: a 38-residue peptide from the heptad repeat region (hr.wt), and a 34-residue peptide from a regi
The major homology region of the HIV-1 gag precursor influences membrane affinity.: Biochemistry. 1996 Nov 12;35(45):14268-75. Unique Identifier : AIDSLINE MED/97074485; Ebbets-Reed D; Scarlata S; Carter CA; Department of Molecular Genetics and Microbiology, State; University of New York at Stony Brook 11794, USA.; Assembly of retroviruses, including HIV-1, involves movement of newly synthesized viral proteins and RNA to the plasma membranes of host cells. The major homology region (MHR, aa 285-304), a highly conserved sequence in the capsid domain of the HIV-1 Gag precursor polyprotein, plays a critical, but unknown, role in in
Evaluate thyself! [editorial; comment]: J Adolesc Health. 1996 Jun;18(6):379. Unique Identifier : AIDSLINE MED/96396607; Litt IF
Design issues addressed in published evaluations of adolescent HIV-risk reduction interventions: a review [see comments]: J Adolesc Health. 1996 Jun;18(6):387-96. Unique Identifier : AIDSLINE MED/96396610; Stanton B; Kim N; Galbraith J; Parrott M; Center for Minority Health Research, University of Maryland,; Baltimore 21201, USA.; OBJECTIVE: This study was conducted to determine: (1) issues in intervention design that have been addressed in behavioral interventions targeting human immunodeficiency virus (HIV)-risk behaviors among adolescents; (2) specific choices made in intervention design; (3) historic changes in the likelihood that issues in
Clinical manifestations of infection with human immunodeficiency virus among adolescents in Louisiana.: J Adolesc Health. 1996 Jun;18(6):422-8. Unique Identifier : AIDSLINE MED/96396614; Fuller C; Clark RA; Kissinger P; Abdalian SE; HIV Outpatient Program, Medical Center of Louisiana at New; Orleans, USA.; PURPOSE: There is limited information regarding the clinical manifestations of human immunodeficiency virus (HIV) infection among adolescents. To better define the clinical presentation and course of HIV disease in this population, a retrospective review of all HIV-infected persons age 13-21 years at entry into a publ
HIV risk behaviors among adolescents at a sexually transmitted disease clinic in New York City.: J Adolesc Health. 1996 Jun;18(6):429-34. Unique Identifier : AIDSLINE MED/96396615; Heffernan R; Chiasson MA; Sackoff JE; Bureau of Disease Intervention Research, New York City Department; of Health, New York 10013, USA.; PURPOSE: The purpose of this study was to describe human immunodeficiency virus (HIV)-associated risk behaviors among adolescents attending a clinic for the treatment of sexually transmitted disease in New York City. METHODS: A total of 4,585 volunteers were interviewed and HIV-tested, including 456 adolescents (aged
Substance use, coping, and safer sex practices among adolescents with hemophilia and human immunodeficiency virus. The Hemophilia Behavioral Intervention Evaluative Project Committee.: J Adolesc Health. 1996 Jun;18(6):435-41. Unique Identifier : AIDSLINE MED/96396616; King G; Delaronde SR; Dinoi R; Forsberg AD; University of Connecticut Health Center, Department of Community; Medicine, Farmington 06030-1910, USA.; PURPOSE: To examine the use of alcohol and other drugs (AOD) to cope with the human immunodeficiency virus (HIV), the use of AOD before or during sex by 306 adolescent males with HIV and hemophilia, and its association with safer sex practices. METHODS: A survey instrument was administered to adolescents at 11 sites o
Lymphoid infiltrates of the salivary glands: pathology, biology and clinical significance.: Curr Opin Oncol. 1996 May;8(3):232-7. Unique Identifier : AIDSLINE MED/96397925; DiGiuseppe JA; Corio RL; Westra WH; Department of Pathology, Johns Hopkins Hospital, Baltimore, MD; 21287-6971, USA.; Lymphoid infiltrates of the salivary glands are common to a variety of pathologic conditions including autoimmune disorders, malignant lymphomas, and immunoregulatory responses to parenchymal neoplasms. Clearly, the correct identification of these salivary gland lymphoid infiltrates has important implications regardin
[Community-acquired cavitating pneumonia in a HIV-infected patient [letter]: Enferm Infecc Microbiol Clin. 1995 Dec;13(10):633-4. Unique Identifier : AIDSLINE MED/96404204; Morano LE; Guerra JL; Vazquez-Alvarez O; Rodriguez-Mendez MJ
[Intestinal tuberculosis and AIDS (letter)]: Enferm Infecc Microbiol Clin. 1995 Dec;13(10):635-7. Unique Identifier : AIDSLINE MED/96404206; Llena J; Miro JM; Trilla A; Soriano E
[Epidemiological profile of non-typhi salmonellosis in a hospital in urban Madrid (1980-1994)]: Enferm Infecc Microbiol Clin. 1996 Jun-Jul;14(6):345-51. Unique Identifier : AIDSLINE MED/96344575; Ramos JM; Cuenca-Estrella M; Ales JM; Soriano F; Departamento de Microbiologia Medica, Fundacion Jimenez; Diaz, Madrid.; BACKGROUND: The aim of this study was to describe the epidemiologic profile of non-typhoid salmonellosis at a general hospital in the metropolitan area of Madrid. METHODS: A descriptive and retrospective study of non-typhoid salmonellosis diagnosed at Microbiology Department of Fundacion Jimenez Diaz from May 1980 to
[Bacterial pneumonia as a risk marker for new bacterial diseases in patients with HIV infection]: Enferm Infecc Microbiol Clin. 1996 Jun-Jul;14(6):361-6. Unique Identifier : AIDSLINE MED/96344578; Teira R; Virosta M; Zubero Z; Baraia-Etxaburu J; Munoz J; Cisterna R; Santamaria JM; Seccion de Enfermedades Infecciosas, Hospital de Basurto,; Bilbao.; BACKGROUND: Bacterial pneumonias are a main cause of morbidity and mortality among patients infected by the HIV. Furthermore, recent data suggest that, under certain circumstances, they can be prognostic markers. METHODS: The evolution of a cohort of HIV-infected patients, prospectively defined by having suffered a pn
[Sensitivity of Mycobacterium tuberculosis in our environment (letter)]: Enferm Infecc Microbiol Clin. 1996 Jun-Jul;14(6):399-400. Unique Identifier : AIDSLINE MED/96344590; Unzaga MJ; Sota M; Melero P; Berdonces P; Ezpeleta C; Cisterna R
[Sinusitis caused by Mycobacterium avium-M. intracellulare in a patient with HIV infection (letter)]: Enferm Infecc Microbiol Clin. 1996 Jun-Jul;14(6):401-2. Unique Identifier : AIDSLINE MED/96344592; Cibrian F; Quiles I; Anaut P; Gainzarain JC; Vega L; Andia A
[Bacteremia caused by Erysipelothrix rhusiopathiae in an HIV-positive patient (letter)]: Enferm Infecc Microbiol Clin. 1996 Jun-Jul;14(6):403-4. Unique Identifier : AIDSLINE MED/96344595; Marne C; Lopez de Juan; Lorenzo JF; Galdos M
Loss of tumorigenicity and increased immunogenicity induced by interleukin-10 gene transfer in B16 melanoma cells.: Hum Gene Ther. 1996 Jan;7(1):23-31. Unique Identifier : AIDSLINE MED/96423264; Gerard CM; Bruyns C; Delvaux A; Baudson N; Dargent JL; Goldman M; Velu T; Institut de Recherche Interdisciplinaire, Brussels, Belgium.; Because interleukin-10 (IL-10) has potent immunosuppressive and anti-inflammatory properties and is produced by some cancers, we hypothesized that its production might play a role in carcinogenesis by inhibiting adequate antitumoral immune responses. To test this hypothesis, retroviral vectors containing the IL-10 cDN
Herpesvirus vector-mediated gene delivery to human monocytes.: Hum Gene Ther. 1996 Jul 10;7(11):1331-8. Unique Identifier : AIDSLINE MED/96415813; Weir JP; Dacquel EJ; Aronovitz J; Division of Viral Products, Food and Drug Administration,; Bethesda, MD 20892, USA.; In vitro delivery of interferon-alpha (IFN-alpha) to cultured human monocytes by means of a replication-incompetent herpesvirus vector inhibits human immunodeficiency virus (HIV) replication. To explore the possibility of IFN-alpha gene delivery by vector-infected human monocytes, monocytes were isolated and the cultu
A phase I/II pilot study of the safety of the adoptive transfer of syngeneic gene-modified cytotoxic T lymphocytes in HIV-infected identical twins.: Hum Gene Ther. 1996 Feb 10;7(3):367-400. Unique Identifier : AIDSLINE MED/96432157; Walker RE; National Institute of Allergy and Infectious Disease, National; Institutes of Health, Bethesda, Maryland 20892, USA.
Lack of stereospecificity of some cellular and viral enzymes involved in the synthesis of deoxyribonucleotides and DNA: molecular basis for the antiviral activity of unnatural L-beta-nucleosides.: Biochimie. 1995;77(11):861-67. Unique Identifier : AIDSLINE MED/96422148; Spadari S; Maga G; Verri A; Bendiscioli A; Tondelli L; Capobianco M; Colonna F; Garbesi A; Focher F; Istituto di Genetica Biochimica ed Evoluzionistica CNR, Pavia,; Italy.; Among enzymes involved in the synthesis of nucleotides and DNA, some exceptions have recently been found to the universal rule that enzymes act only on one enantiomer of a chiral substrate and that only one of the enantiomeric forms of chiral molecules may bind effectively at the catalytic site, displaying biological
HIV Behavioural Interventions. Proceedings of a conference. 21-23 June 1995.: Int J STD AIDS. 1996;7 Suppl 2:1-90. Unique Identifier : AIDSLINE MED/97086185
Global priorities for HIV/AIDS intervention research.: Int J STD AIDS. 1996;7 Suppl 2:13-6. Unique Identifier : AIDSLINE MED/96393001; Aggleton P; Thomas Coram Research Unit, Institute of Education, University of; London, UK.
Association of sexually transmitted diseases and infection with the human immunodeficiency virus: biological cofactors and markers of behavioural interventions.: Int J STD AIDS. 1996;7 Suppl 2:17-24. Unique Identifier : AIDSLINE MED/96393002; Quinn TC; National Institute of Allergy and Infectious Diseases, Bethesda,; Maryland, USA.
Designing behavioural and social science to impact practice and policy in HIV prevention and care. The Executive Committee of the Center for AIDS Prevention Studies (CAPS).: Int J STD AIDS. 1996;7 Suppl 2:2-12. Unique Identifier : AIDSLINE MED/96393000; Coates TJ; Chesney M; Folkman S; Hulley SB; Haynes-Sanstad K; Lurie P; Marin BV; Roos L; Bunnett V; Du Wors R; Center for AIDS Prevention Studies, University of California, San; Francisco 94105, USA. tom-coates.psg@quick-mail.ucsf.edu
The evaluation of behavioural interventions for gay men: obstacles to evidence-based prevention.: Int J STD AIDS. 1996;7 Suppl 2:25-9. Unique Identifier : AIDSLINE MED/96393003; Hart GJ; MRC Medical Sociology Unit, University of Glasgow, UK.
Measuring outcomes of behavioural interventions for STD/HIV prevention.: Int J STD AIDS. 1996;7 Suppl 2:30-8. Unique Identifier : AIDSLINE MED/96393004; Aral SO; Peterman TA; Centers for Disease Control and Prevention, Atlanta, Georgia; 30333, USA.
Developing HIV-preventive behavioural interventions for young people in Scotland.: Int J STD AIDS. 1996;7 Suppl 2:39-42. Unique Identifier : AIDSLINE MED/96393005; Abraham C; Wight D; School of Social Sciences, University of Sussex, Brighton, UK.
HIV behavioural interventions in young people in The Netherlands.: Int J STD AIDS. 1996;7 Suppl 2:43-6. Unique Identifier : AIDSLINE MED/96393006; Schaalma H; Kok G; Paulussen T; Department of Health Education, University of Limburg,; Maastricht, The Netherlands.
Reflections on the first decade of the HIV/AIDS pandemic: opportunities and priorities for international behavioural research and interventions.: Int J STD AIDS. 1996;7 Suppl 2:47-51. Unique Identifier : AIDSLINE MED/96393007; Krause RM; Fogarty International Center, NIH, Bethesda, MD 20892-6705, USA.; AIDS, a sexually transmitted disease, is unlikely to respond in the near term to either common sense or scientific innovation. Other forces are at play here that embrace the psychobiology of reproduction, addictive behaviour, and the social sciences. We must explore these matters within the historical and cultural con
Interventions with drug injectors in the UK: trends in risk behaviour and HIV prevalence.: Int J STD AIDS. 1996;7 Suppl 2:52-6. Unique Identifier : AIDSLINE MED/96393008; Stimson GV; Hunter G; Department of Psychiatry, Charing Cross and Westminster Medical; School, University of London, UK.
HIV epidemiology and interventions among injecting drug users.: Int J STD AIDS. 1996;7 Suppl 2:57-61. Unique Identifier : AIDSLINE MED/96393009; Des Jarlais DC; Friedman SR; Chemical Dependency Institute, Beth Israel Medical Center, New; York, NY 10003, USA.
Behaviour in Latin American men: implications for HIV/AIDS interventions.: Int J STD AIDS. 1996;7 Suppl 2:62-5. Unique Identifier : AIDSLINE MED/96393010; Parker RG; Department of Health Policy and Institutions, Institute of Social; Medicine, State University of Rio de Janeiro, Brazil.
Interventions for homeless men and women with mental illness: reducing sexual risk behaviours for HIV.: Int J STD AIDS. 1996;7 Suppl 2:66-70. Unique Identifier : AIDSLINE MED/96393011; Susser E; Valencia E; Sohler N; Gheith A; Conover S; Torres J; HIV Centre for Clinical and Behavioral Studies, New York State; Psychiatric Institute, Presbyterian Hospital, New York, USA.
Behavioural interventions required in South East Asia to minimize infections with HIV.: Int J STD AIDS. 1996;7 Suppl 2:71-4. Unique Identifier : AIDSLINE MED/96393012; Dwyer JM; AIDS Treatment and Research Centre, Prince Henry Hospital,; Sydney, NSW, Australia.
Coping effectiveness training for men living with HIV: preliminary findings.: Int J STD AIDS. 1996;7 Suppl 2:75-82. Unique Identifier : AIDSLINE MED/96393013; Chesney M; Folkman S; Chambers D; Center for AIDS Prevention Studies, School of Medicine,; University of California at San Francisco 94105, USA.
HIV/AIDS: the twenty injunctions of London summary of the conference.: Int J STD AIDS. 1996;7 Suppl 2:83-90. Unique Identifier : AIDSLINE MED/96393014; Kirby MD; WHO Global Commission on AIDS, Sydney, Australia.
Subtyping of human T-lymphotropic virus type I by amplification of long terminal repeat sequences and restriction fragment length polymorphism analysis in carriers with multiple transfusions.: Ann Hematol. 1996 Sep;73(3):127-34. Unique Identifier : AIDSLINE +; Lin MT; Yang YC; Chen PJ; Tang JI; Tseng LH; Wang CW; Chen YC; Department of Laboratory Medicine and Oncology, National Taiwan; University Hospital, No. 7, Taipei.; Five major subtypes of human T-lymphotropic virus type I (HTLV-I) have been proposed: cosmopolitan, Japanese, West African, Central African, and Melanesian. Based on nucleotide variations specific to particular subtypes, it was possible to genotype HTLV-I rapidly by restriction fragment length polymorphism (RFLP) stud
Immunodeficiency and its relation to lymphoid and other malignancies.: Ann Hematol. 1996 Oct;73(4):163-7. Unique Identifier : AIDSLINE MED/97045769; Tossing G; Essex Pharma GmbH, Geschaftsbereich Onkologie, Munich, Germany.; The reasons why immunodeficiency leads to malignant disorders are multifactorial. The overall incidence of malignancies in persons infected with the human deficiency virus (HIV) is estimated to be 40%. Other infecting agents, especially herpesvirus species, play a pivotal role in HIV-associated
Characterization of T cells expanded in vivo during primary mouse hepatitis virus infection in mice.: J Vet Med Sci. 1996 May;58(5):431-7. Unique Identifier : AIDSLINE MED/96348892; Kyuwa S; Machii K; Okumura A; Toyoda Y; Department of Animal Pathology, University of Tokyo, Japan.; After intraperitoneal infection with mouse hepatitis virus, strain JHM (JHMV), JHMV replicated in the spleen of C57BL/6 mice for a few days but cleared within a week. The acute viral clearance coincided with moderate expansion of CD8+T cells and modest expansion of CD4+T cells, and was impaired moderately in mice depl
Detection of antibodies against bovine immunodeficiency-like virus in daily cattle in Hokkaido.: J Vet Med Sci. 1996 May;58(5):455-7. Unique Identifier : AIDSLINE MED/96348897; Hirai N; Kabeya H; Ohashi K; Sugimoto C; Onuma M; Department of Disease Control, Graduate School of Veterinary; Medicine, Hokkaido University, Japan.; Serological survey of bovine immunodeficiency-like virus (BIV) infection was performed in cattle of 3 different farms in Hokkaido, where a relatively high seroprevalence was recorded for bovine leukemia virus (BLV). About a half of 120 cattle tested were seropositive for BLV, while 7.5% of the cattle were seropositive
Isolation of virulent and intermediately virulent Rhodococcus equi from soil and sand on parks and yards in Japan.: J Vet Med Sci. 1996 Jul;58(7):669-72. Unique Identifier : AIDSLINE MED/97001613; Takai S; Fukunaga N; Ochiai S; Sakai T; Sasaki Y; Tsubaki S; Department of Animal Hygiene, School of Veterinary Medicine and; Animal Sciences, Kitasato University, Aomori, Japan.; Rhodococcus equi is an emerging opportunistic pathogen of human immunodeficiency virus-infected patients. However, little is known about the distribution of virulent and intermediately virulent R. equi in human environment. In the present study, R. equi was isolated from 173 of 234 (73.9%) samples collected from soil
Sulfated polysaccharides inhibit lymphocyte-to-epithelial transmission of human immunodeficiency virus-1.: Biol Reprod. 1996 Jan;54(1):173-82. Unique Identifier : AIDSLINE MED/96435129; Pearce-Pratt R; Phillips DM; Population Council, New York, New York 10021, USA.; We have previously suggested that sulfated polysaccharides could be used in a vaginal formulation to inhibit infection by human immunodeficiency virus (HIV-1). This supposition was based on studies in which we developed and employed an in vitro model to simulate the mechanism of HIV-1 transmission during coitus. We fo
HIV prevention in U.S. Asian Pacific Islander communities: an innovative approach.: J Health Care Poor Underserved. 1996 Nov;7(4):364-76. Unique Identifier : AIDSLINE MED/97065345; Loue S; Lloyd L; Loh L; Case Western Reserve University, USA.; Few HIV prevention efforts have focused on Asian Pacific Islander communities in the United States . Prevention messages developed for the general U.S. population have failed to reach many Asian Pacific Islanders. This article describes the development of an HIV prevention strategy for
Pyrimethamine-clindamycin vs. pyrimethamine-sulfadiazine as acute and long-term therapy for toxoplasmic encephalitis in patients with AIDS.: Clin Infect Dis. 1996 Feb;22(2):268-75. Unique Identifier : AIDSLINE MED/96435297; Katlama C; De Wit S; O'Doherty E; Van Glabeke M; Clumeck N; Department of Infectious Diseases and Tropical Medicine,; Pitie-Salpetriere Hospital, Paris, France.; This European multicenter study compares the efficacy and tolerance of the combination of pyrimethamine-clindamycin (Pyr-Cm) with the standard therapy pyrimethamine-sulfadiazine (Pyr-Sdz) for the treatment of toxoplasmic encephalitis (TE) in patients with AIDS. Two hundred ninety-nine human immunodeficiency virus-infe
Amphotericin B lipid complex compared with amphotericin B in the treatment of cryptococcal meningitis in patients with AIDS [see comments]: Clin Infect Dis. 1996 Feb;22(2):315-21. Unique Identifier : AIDSLINE MED/96435303; Sharkey PK; Graybill JR; Johnson ES; Hausrath SG; Pollard RB; Kolokathis A; Mildvan D; Fan-Havard P; Eng RH; Patterson TF; Pottage JC Jr; Simberkoff MS; Wolf J; Meyer RD; Gupta R; Lee LW; Gordon DS; Department of Medicine, UTHSCSA, San Antonio, Texas 78284, USA.; The study objective was to obtain preliminary information regarding the safety and efficacy of amphotericin B (AmB) lipid complex (ABLC) in the treatment of AIDS-associated cryptococcal meningitis. Of 55 patients randomly assigned to 6 weeks of therapy with ABLC (1.2-5.0 mg/[kg.d], with ascending doses for three seque
Identification of patients with acute AIDS-associated cryptococcal meningitis who can be effectively treated with fluconazole: the role of antifungal susceptibility testing [see comments]: Clin Infect Dis. 1996 Feb;22(2):322-8. Unique Identifier : AIDSLINE MED/96435304; Witt MD; Lewis RJ; Larsen RA; Milefchik EN; Leal MA; Haubrich RH; Richie JA; Edwards JE Jr; Ghannoum MA; Division of Allergy and Immunology, Harbor-UCLA Medical Center,; Torrance 90509, USA.; No method currently exists to predict which patients with acute AIDS-associated cryptococcal meningitis can be effectively treated with fluconazole. The objective of this study was to determine the relationship of cryptococcal susceptibility to fluconazole, along with clinical variables, to the risk of treatment failu
Editorial response: management of cryptococcal meningitis--have we answered all the questions? [editorial; comment]: Clin Infect Dis. 1996 Feb;22(2):329-30. Unique Identifier : AIDSLINE MED/96435305; Powderly WG
AIDS-associated infections in salivary glands: autopsy survey of 60 cases.: Clin Infect Dis. 1996 Feb;22(2):369-71. Unique Identifier : AIDSLINE MED/96435313; Wagner RP; Tian H; McPherson MJ; Latham PS; Orenstein JM; Division of Pulmonary Diseases and Allergy, George Washington; University School of Medicine, Washington, DC 20037, USA.; We reviewed the autopsy findings for the submandibular glands of 60 patients with AIDS who were autopsied at the George Washington University Medical Center (Washington, DC) from 1982 to 1992. AIDS-associated infections in the submandibular glands were compared with those in the pancreas and lung. Cytomegalovirus intr
Pyomyositis caused by Morganella morganii in a patient with AIDS.: Clin Infect Dis. 1996 Feb;22(2):372-3. Unique Identifier : AIDSLINE MED/96435314; Arranz-Caso JA; Cuadrado-Gomez LM; Romanik-Cabrera J; Garcia-Tena J; Servicio de Medicina Interna, Hospital Principe de Asturias,; Carretera de Alcala-Meco, Madrid, Spain.
Dermonodular and visceral leishmaniasis due to Leishmania infantum with a new isoenzyme pattern: report of a case involving a patient with AIDS.: Clin Infect Dis. 1996 Feb;22(2):376-7. Unique Identifier : AIDSLINE MED/96435318; Scaglia M; Malfitano A; Douville H; Sacchi P; Gatti S; Gradoni L; Gramiccia M; Clinical Parasitology Laboratory, University-IRCCS San Matteo,; Pavia, Italy.
Rapid development of renal insufficiency with the simultaneous administration of amphotericin B and foscarnet.: Clin Infect Dis. 1996 Feb;22(2):378. Unique Identifier : AIDSLINE MED/96435319; Zaman MM; Burney S; Landman D; Quale JM; Infectious Diseases Section, Department of Veterans Affairs; Medical Center, Brooklyn, New York 11209, USA.
Destructive mucocutaneous phagedenic herpes simplex virus infection in an HIV-infected patient who had a partial response to interferon and ultraviolet rays.: Clin Infect Dis. 1996 Feb;22(2):381-2. Unique Identifier : AIDSLINE MED/96435322; Giani G; Quirino T; Sacrini F; Carbone A; Vaccher E; Resta M; Monti M; First Department of Infectious Disease and Allergy, Luigi Sacco; Hospital, Milan, Italy.
Desensitization to trimethoprim-sulfamethoxazole in patients infected with human immunodeficiency virus [letter]: Clin Infect Dis. 1996 Feb;22(2):396. Unique Identifier : AIDSLINE MED/96435334; Quirino T; Bonfanti P; Niero F; Rizzardini G; Iemoli E; Milazzo F
Secondary prophylaxis for tuberculosis in patients infected with human immunodeficiency virus [letter]: Clin Infect Dis. 1996 Feb;22(2):398-9. Unique Identifier : AIDSLINE MED/96435336; Shuter J; Bellin E
Risk factors for isolation of Streptococcus pneumoniae with decreased susceptibility to penicillin G from patients infected with human immunodeficiency virus.: Clin Infect Dis. 1996 Mar;22(3):437-40. Unique Identifier : AIDSLINE MED/97005660; Meynard JL; Barbut F; Blum L; Guiguet M; Chouaid C; Meyohas MC; Picard O; Petit JC; Frottier J; Service des Maladies Infectieuses et Tropicales, Hopital; Saint-Antoine, Paris, France.; We conducted a retrospective study of all hospitalized human immunodeficiency virus (HIV)-infected patients from whom a strain of Streptococcus pneumoniae was isolated (n = 45) between January 1992 and September 1994, in order to determine the clinical manifestations and outcome of and risk factors for infection by S.
Protozoal colonization of the intestinal tract in institutionalized Romanian children.: Clin Infect Dis. 1996 Mar;22(3):456-61. Unique Identifier : AIDSLINE MED/97005663; Brannan DK; Greenfield RA; Owen WL; Welch DF; Kuhls TL; Department of Pediatrics, University of Oklahoma Health Sciences; Center, Oklahoma City, USA.; To determine the prevalence of intestinal parasitic infections in 92 Romanian children institutionalized at Colentina Hospital (Bucharest, Romania) and at the Dystrophic Center (Vidra, Romania), medical charts were reviewed and complete physical examinations were performed. The nutritional status of each child was eva
Signs and symptoms of prevalent and incident cases of gonorrhea and genital chlamydial infection among female prostitutes in Kinshasa, Zaire.: Clin Infect Dis. 1996 Mar;22(3):477-84. Unique Identifier : AIDSLINE MED/97005667; Alary M; Laga M; Vuylsteke B; Nzila N; Piot P; Department of Infection and Immunity, Institute of Tropical; Medicine, Antwerp, Belgium.; Most studies that have examined the clinical features of gonorrhea and chlamydial infection have been based on prevalent cases (cases of undetermined onset). In our investigation, we compared signs and symptoms of incident (new) cases of these infections with those observed in prevalent cases (involving the same women
CD4+ T lymphocyte counts and patterns of mortality among patients infected with human immunodeficiency virus who were enrolled in community programs for clinical research on AIDS.: Clin Infect Dis. 1996 Mar;22(3):513-20. Unique Identifier : AIDSLINE MED/97005673; Saravolatz L; Neaton JD; Sacks L; Deyton L; Rhame F; Sherer R; Division of Infectious Diseases, Henry Ford Hospital, Detroit,; Michigan 48202, USA.; CD4+ T lymphocyte measurements are used frequently in clinical practice and have important prognostic implications. In this study, we describe mortality patterns for 5,204 human immunodeficiency virus (HIV)-infected patients classified in different CD4+ cell strata; patients with and patients without a history of dise
Immunologic and molecular characteristics of Encephalitozoon-like microsporidia isolated from humans and rabbits indicate that Encephalitozoon cuniculi is a zoonotic parasite.: Clin Infect Dis. 1996 Mar;22(3):557-9. Unique Identifier : AIDSLINE MED/97005679; Deplazes P; Mathis A; Baumgartner R; Tanner I; Weber R; Institute of Parasitology, University of Zurich, Switzerland.; To assess the zoonotic potential of Encephalitozoon-like microsporidia, we isolated and cultivated spores from specimens of urine, respiratory secretions, and stool from six patients infected with human immunodeficiency virus and from nine rabbits. Because spores of Encephalitozoon-like species are indistinguishable b
Granulomatous Pneumocystis carinii myositis presenting as an intramuscular mass.: Clin Infect Dis. 1996 Mar;22(3):577-8. Unique Identifier : AIDSLINE MED/97005687; Pearl GS; Sieger B; Department of Pathology, Orlando Regional Healthcare System,; Florida 32806, USA.
Bronchoesophageal fistula due to Mycobacterium tuberculosis and cytomegalovirus in a patient with AIDS.: Clin Infect Dis. 1996 Mar;22(3):581. Unique Identifier : AIDSLINE MED/97005690; Vartian CV; Septimus EJ; Infectious Diseases Program, Memorial Hospital System, Houston,; Texas, USA.
Meningitis due to Pseudomonas stutzeri in a patient infected with human immunodeficiency virus.: Clin Infect Dis. 1996 Mar;22(3):587-8. Unique Identifier : AIDSLINE MED/97005696; Roig P; Orti A; Navarro V; Infectious Disease Service, University of Valencia, Spain.
Hypertrophic osteoarthropathy associated with Pneumocystis carinii pneumonia and human immunodeficiency virus infection.: Clin Infect Dis. 1996 Mar;22(3):590-1. Unique Identifier : AIDSLINE MED/97005698; Gunnarsson G; Karchmer AW; Department of Medicine, New England Deaconess Hospital, Harvard; Medical School, Boston, Massachusetts, USA.
Fatal Pasteurella bettyae pleuropneumonia in a patient infected with human immunodeficiency virus.: Clin Infect Dis. 1996 Mar;22(3):591-2. Unique Identifier : AIDSLINE MED/97005699; Moritz F; Martin E; Lemeland JF; Bonmarchand G; Leroy J; Escande F; Service de Reanimation, Centre Hospitalier Universitaire Charles; Nicolle, Rouen, France.
Urethritis associated with disseminated microsporidiosis: clinical response to albendazole.: Clin Infect Dis. 1996 Mar;22(3):592-3. Unique Identifier : AIDSLINE MED/97005700; Corcoran GD; Isaacson JR; Daniels C; Chiodini PL; Department of Clinical Parasitology, Hospital for Tropical; Diseases, London, United Kingdom.
Mania due to clarithromycin therapy in a patient who was not infected with human immunodeficiency virus.: Clin Infect Dis. 1996 Mar;22(3):595-6. Unique Identifier : AIDSLINE MED/97005703; Cone LA; Sneider RA; Nazemi R; Dietrich EJ; Department of Medicine, Eisenhower Medical Center, Rancho Mirage,; California, USA.
Transmission of Mycobacterium tuberculosis among health care workers infected with human immunodeficiency virus.: Clin Infect Dis. 1996 Mar;22(3):597-8. Unique Identifier : AIDSLINE MED/97005705; Blumberg HM; Moore P; Blanchard DK; Ray SM; Department of Medicine, Emory University School of Medicine and; Grady Memorial Hospital, Atlanta, Georgia, USA.
Tremors associated with trimethoprim-sulfamethoxazole therapy in a patient with AIDS: case report and review.: Clin Infect Dis. 1996 Mar;22(3):598-600. Unique Identifier : AIDSLINE MED/97005706; Aboulafia DM; Section of Hematology and Oncology, Virginia Mason Medical; Center, Seattle, U
Microsporidia and AIDS-associated diarrhea.: Clin Infect Dis. 1996 Mar;22(3):603-4, reply 604-5. Unique Identifier : AIDSLINE MED/97005709; Cleveland KO; Gelfand MS
Early initiation of antiretroviral therapy for infection with human immunodeficiency virus: considerations in 1996.: Clin Infect Dis. 1996 Aug;23(2):227-30. Unique Identifier : AIDSLINE MED/96439943; Nadler JP; College of Medicine, University of South Florida, Tampa, USA.; In this AIDS Commentary, Dr. Nadler provides a rationale for early initiation of antiretroviral therapy in patients infected with human immunodeficiency virus (HIV). Although no definitive clinical trials have been published that are relevant to the question of whether early treatment will produce long-term benefit, m
Photo quiz. Syphilis of the skin (nodular syphilids).: Clin Infect Dis. 1996 Aug;23(2):231, 377. Unique Identifier : AIDSLINE MED/96439944; Glatt AE; Rabbat A; Division of Infectious Diseases, Catholic Medical Center of; Brooklyn and Queens, Jamaica, New York, USA.
Changing patterns of infections in patients with AIDS: a study of 279 autopsies of prison inmates and nonincarcerated patients at a university hospital in eastern Texas, 1984-1993 [see comments]: Clin Infect Dis. 1996 Aug;23(2):241-7. Unique Identifier : AIDSLINE MED/96439946; Lyon R; Haque AK; Asmuth DM; Woods GL; Department of Pathology, University of Texas Medical Branch,; Galveston 77555-0740, USA.; Reports on autopsies of 279 persons infected with human immunodeficiency virus (HIV) were reviewed retrospectively to determine changes in survival rates and infections and to identify differences between prison inmates and nonincarcerated patients. The 78 cases from 1984 through 1988 were compared with 201 from 1989
Causes of fever in patients infected with human immunodeficiency virus who were admitted to Boston City Hospital.: Clin Infect Dis. 1996 Aug;23(2):320-8. Unique Identifier : AIDSLINE MED/96439960; Barat LM; Gunn JE; Steger KA; Perkins CJ; Craven DE; Maxwell Finland Laboratory for Infectious Diseases, Section of; Infectious Diseases, Boston City Hospital, Massachusetts, USA.; We prospectively studied causes of fever in patients with human immunodeficiency virus (HIV) infection that required admission to a municipal hospital. A total of 168 HIV-infected persons were admitted for 220 episodes of fever: 72% were male, 80% were nonwhite, 65% reported prior injection drug use, and 74% had a bas
Managed care and the infectious diseases specialist.: Clin Infect Dis. 1996 Aug;23(2):341-68. Unique Identifier : AIDSLINE MED/96439964; Tice AD; Slama TG; Berman S; Braun P; Burke JP; Cherney A; Gross PA; Harris P; Reid-Hatton M; Hoffman R; Joseph P; Lawton S; Massanari RM; Miller ZI; Osheroff WJ; Poretz D; Shalowitz M; Simmons B; Turner JP; Wade B; Nolet BR; Infections Limited, P.S., University of Washington, Tacoma 98405,; USA.; There is growing demand to contain health care costs and to reassess the value of medical services. The traditional hospital, academic, and research roles of the infectious disease (ID) specialist are threatened, yet there is an increasing need for expertise because of growing antimicrobial resistance and emerging pat
Cryptococcus neoformans infection in France: epidemiologic features of and early prognostic parameters for 76 patients who were infected with human immunodeficiency virus.: Clin Infect Dis. 1996 Aug;23(2):369-76. Unique Identifier : AIDSLINE MED/96439965; Darras-Joly C; Chevret S; Wolff M; Matheron S; Longuet P; Casalino E; Joly V; Chochillon C; Bedos JP; Departement des Maladies Infectieuses, Groupe Hospitalier; Bichat-Claude Bernard, Paris, France.; We retrospectively carried out a descriptive and prognostic study of 76 human immunodeficiency virus-infected patients with cryptococcosis diagnosed by a positive culture of cerebrospinal fluid (CSF), blood, urine, or other body fluid or tissue. We focused on the 65 patients with cryptococcal meningitis. At diagnosis,
Prevalence of Bartonella henselae antibodies among human immunodeficiency virus-infected patients from Bahrain.: Clin Infect Dis. 1996 Aug;23(2):398-9. Unique Identifier : AIDSLINE MED/96439975; Yousif A; Farid I; Baig B; Creek J; Olson P; Wallace M; Department of Pathology, Salmaniya Medical Center, Manama,; Bahrain.
Catheter-related bacteremia due to Mycobacterium avium complex.: Clin Infect Dis. 1996 Aug;23(2):405-6. Unique Identifier : AIDSLINE MED/96439981; Dube MP; Sattler FR; Department of Medicine, Section of Infectious Diseases,; University of Southern California School of Medicine, Los; Angeles, California, USA.
Kaposi's sarcoma herpesvirus-like DNA sequences in the saliva of individuals infected with human immunodeficiency virus.: Clin Infect Dis. 1996 Aug;23(2):406-7. Unique Identifier : AIDSLINE MED/96439982; Boldogh I; Szaniszlo P; Bresnahan WA; Flaitz CM; Nichols MC; Albrecht T; Department of Microbiology and Immunology, University of Texas; Medical Branch, Galveston, Texas, USA.
Management of coinfection with human immunodeficiency virus and human T-cell lymphotropic virus type I [letter]: Clin Infect Dis. 1996 Aug;23(2):415. Unique Identifier : AIDSLINE MED/96439988; Nadler JP; Bach MC; Godofsky E
An albumin-coated polyester arterial graft: in vivo assessment of biocompatibility and healing characteristics.: Biomaterials. 1996 Jan;17(1):3-14. Unique Identifier : AIDSLINE MED/96402517; Marois Y; Chakfe N; Guidoin R; Duhamel RC; Roy R; Marois M; King MW; Douville Y; Department of Surgery, Medicine and Pathology, Laval University,; Quebec, Canada.; The albumin-coated vascular graft (ACG) and its uncoated polyester substrate, the Vascular II (V-II), were evaluated in terms of biocompatibility and biofunctionality using two in vivo animal studies. Biocompatibility and immunoreactivity were assessed by implanting intraperitoneally in the rat small segments of the A
[Retrospective and comparative study of pneumococcal bacteremia in patients with chronic hepatopathy]: An Med Interna. 1996 Jul;13(7):313-6. Unique Identifier : AIDSLINE MED/96399320; Ramos Rincon JM; Cuenca Estrella M; Fernandez Guerrero ML; Servicio de Microbiologia, Fundacion Jimenez Diaz,; Universidad Autonoma, Madrid.; BACKGROUND: The chronic hepatopathy predispose to severe infections due to Streptococcus pneumoniae, including bacteremia. METHODS: We have reviewed the clinic characteristics and outcome of 34 patients without HIV infection and compared with 140 HIV-negative patients with pneumococcal bacteremia. RESULTS: From 34 pat
[Colony-stimulating factors and HIV-related neoplasms]: An Med Interna. 1996 Jul;13(7):317-21. Unique Identifier : AIDSLINE MED/96399321; Valencia ME; Moreno V; Soriano V; Polo R; Verdejo J; Laguna F; Gonzalez Lahoz J; Servicio de Enfermedades Infecciosas, Instituto de Salud Carlos; III, Madrid.; OBJECTIVE: it is analyzed a group of patients with HIV related malignancy treated with myelosuppressive therapy with granulocyte colony stimulating factor (G-CSF) to study the efficacy of hematopoietic growth factors in these subjects. PATIENTS AND METHODS: it was studied the clinical and hematological evolution of 20
[Chronic monoarthritis caused by osteoid osteoma]: An Med Interna. 1996 Jul;13(7):344-6. Unique Identifier : AIDSLINE MED/96399327; Garcia-Vivar ML; Galindez E; Arostegui J; Garcia Llorente F; Uriarte E; Aramburu JM; Seccion de Reumatologia, Hospital de Basurto, Bilbao.; Osteoid osteoma is a nonmalignant tumour that rarely localizes intraarticularly. When this happens, the tumour provokes arthritis and its recognition is delayed from months to years. We report the case of a 34 year old man with a previously known HIV infection, but no evidence of immunosuppression. He develops a chron
[Superantigens: concept and applications in the pathogenesis and treatment of infectious and autoimmune diseases]: An Med Interna. 1996 Jul;13(7):347-52. Unique Identifier : AIDSLINE MED/96399328; Quiros E; Maroto MC; Departamento de Microbiologia, Facultad de Medicina, Granada.; The aim of this study was to review the characteristics of conventional antigens and the way they work, as well as to remark their differences with superantigens. They bind exclusively to the lymphocytic TCR V beta portion, are not processed by macrophages, are related to dependent HLA but not restrained HLA and are a
Reduced frequency of memory CD8+ T lymphocytes in cerebrospinal fluid and blood of patients with multiple sclerosis [see comments]: Autoimmunity. 1995;21(4):231-9. Unique Identifier : AIDSLINE MED/97005202; Svenningsson A; Andersen O; Hansson GK; Stemme S; Department of Clinical Neuroscience, University of Gothenburg,; Sweden.; Three color flow cytometry was used to analyze immunoregulatory lymphocyte subsets in peripheral blood (PB) and cerebrospinal fluid (CSF) of 21 patients with multiple sclerosis (MS) and 15 age-matched healthy control subjects. Two cell surface antigens associated with T lymphocyte memory and activation, CD45R0 and CD2
Abnormalities of lymphocyte subsets in canine systemic lupus erythematosus.: Autoimmunity. 1995;22(1):1-8. Unique Identifier : AIDSLINE MED/97036769; Chabanne L; Fournel C; Caux C; Bernaud J; Bonnefond C; Monier JC; Rigal D; Departement de Pathologie, Ecole Veterinaire de Lyon, Marcy; L'Etoile, France.; Canine systemic lupus erythematosus (SLE) is a disease clinically very similar to its human counterpart. But so far, no study has reported an accurate evaluation of the lymphocyte subsets in the canine disease. Here, we present a study in which lymphocyte subsets have been evaluated in the peripheral blood of 20 dogs
Characterization of T cell receptor repertoire and anti-Ro/SSA autoantibodies in relation to sialadenitis of NOD mice.: Autoimmunity. 1995;22(1):9-16. Unique Identifier : AIDSLINE MED/97036770; Skarstein K; Wahren M; Zaura E; Hattori M; Jonsson R; Broegelmann Research Laboratory for Microbiology, University of; Bergen, Norway. Kathrine.Skarstein@gades.uib.no; Non-obese diabetic (NOD) mice develop sialadenitis which morphologically resembles the exocrinopathy in human Sjogren s syndrome (SS). The sialadenitis is characterized by focal infiltrates of inflammatory cells. Immunoenzyme staining (ABC-technique) and monoclonal antibodies defining CD4, CD8, CD11b, TCR alpha/beta,
Increased utilization of polyreactive B cells during periods of generalized immune activation.: Autoimmunity. 1995;22(2):113-9. Unique Identifier : AIDSLINE MED/96293807; Ishigatsubo Y; Steinberg AD; Krieg A; Klinman DM; First Department of Internal Medicine, Yokohama City University; Medical School, Japan.; This work examines the hypothesis that B cells secreting polyreactive antibodies (antibodies capable of binding to more than one self or foreign antigen) are preferentially utilized during periods of generalized immune stimulation. Four conditions characterized by such stimulation were examined: chronic virus infectio
Suppression by IL-10 and IL-4 of cytokine production induced by two-way autologous mixed lymphocyte reaction.: Cytokine. 1996 Jun;8(6):501-6. Unique Identifier : AIDSLINE MED/96415638; Sagawa K; Mochizuki M; Sugita S; Nagai K; Sudo T; Itoh K; Department of Immunology, University School of Medicine, Fukuoka,; Japan.; The immune response of T cells to self-HLA antigens on autologous non-T cells is known as the autologous mixed lymphocyte reaction (AMLR), and is defective in various diseases. We have investigated the effects of exogenous IL-10, a potential agent to treat various inflammatory diseases, on cytokine production induced
Are we missing an epidemic of HIV-associated nephropathy?: J Am Soc Nephrol. 1996 Jan;7(1):1-7. Unique Identifier : AIDSLINE MED/96403825; Winston JA; Klotman PE; Division of Nephrology, Mount Sinai Medical Center, New York, NY; 10029, USA.; HIV-associated nephropathy is infrequently cited as a common cause of ESRD. It is likely, however, that by the end of the decade, HIV-associated nephropathy will be the third leading cause of ESRD in African Americans between the ages of 20 and 64. Underreporting for reasons of confidentiality and a failure to track t
Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons.: Neuroreport. 1996 Apr 10;7(5):1045-9. Unique Identifier : AIDSLINE MED/96396945; Wu P; Price P; Du B; Hatch WC; Terwilliger EF; Division of Hematology/Oncology, New England Deaconess Hospital,; MA 02215, USA.; A new in vitro system comprising a pure population of neurons, human NT cells, was used to characterize the direct neurotoxic effect of HIV-1 envelope protein gp120. Cytotoxicity was monitored by a quantitative assay after exposure to recombinant gp120 in the presence or absence of other reagents. Treatment of mature
Expression and biology of neutrophil and endothelial cell-derived chemokines.: Semin Cell Biol. 1995 Dec;6(6):327-36. Unique Identifier : AIDSLINE MED/96351695; Kunkel SL; Lukacs N; Strieter RM; Department of Pathology and Internal Medicine, University of; Michigan Medical School, Ann Arbor 48109, USA.; The elicitation of polymorphonuclear leukocytes or neutrophils to an area of tissue injury is one of the most fundamental of all cell responses during the initiation of host defense. Historically, the neutrophil has been identified as an important phagocytic cell with a limited capacity to synthesize de-novo proteins.
CD46, a complement regulatory protein/measles virus receptor, and its relation to hematological disorders.: Int J Hematol. 1996 Aug;64(2):101-9. Unique Identifier : AIDSLINE MED/97007292; Seya T; Interitance and Variation' in PRESTO, Research Development; Cooperation of Japan (JRDC), Kyoto, Japan.; During measles virus (MV) infection, lymphopenia and immune suppression are observed in humans, yet the mechanisms underlying these effects remain unknown except that membrane cofactor protein (MCP, CD46) acts as a receptor for MV, accelerating entry of the virus into host cells. CD46 is a complement regulator, the ro
Increased production of interferon gamma but not interleukin 4 in human T-lymphotropic virus type I carriers.: Int J Hematol. 1996 Aug;64(2):111-8. Unique Identifier : AIDSLINE MED/97007293; Shimamoto Y; Funai N; Watanabe M; Suga K; Department of Internal Medicine, Saga Medical School, Japan.; We investigated the production of interferon gamma (IFN-gamma), interleukin 4 (IL-4), IL-1 alpha, and tumor necrosis factor alpha (TNF-alpha) by peripheral blood mononuclear cells (PBMCs) from human T-lymphotropic virus type I(HTLV-I) carriers during short-term in vitro culture, in comparison with that by those from H
HIV disease symptom management in the context of committed relationships.: J Assoc Nurses AIDS Care. 1996 May-Jun;7(3):19-28. Unique Identifier : AIDSLINE MED/96413139; Powell-Cope GM; College of Nursing, University of South Florida, Tampa, USA.; Grounded theory was used to explore the meanings of HIV symptom management that occur within the context of committed relationships between gay men when at least one is infected with HIV. In-depth interviews were completed with nine couples. Mutual protection, the mechanism by which the person attempted to ward off lo
Knowledge and risk behaviors of people seeking HIV antibody testing at a community site.: J Assoc Nurses AIDS Care. 1996 May-Jun;7(3):33-41. Unique Identifier : AIDSLINE MED/96413140; Sowell RL; Seals BF; Phillips KD; Department of Administrative and Clinical Nursing, College of; Nursing, University of South Carolina, Columbia, USA.; People seeking HIV antibody testing at a community-based AIDS service organization (N = 342) were asked to complete a self-report questionnaire to determine knowledge of HIV transmission, source(s) of HIV-related knowledge, and recent risk behaviors. The overall knowledge level of risk for transmitting HIV associated
Sleep quality in people with HIV disease.: J Assoc Nurses AIDS Care. 1996 May-Jun;7(3):43-50. Unique Identifier : AIDSLINE MED/96413141; Nokes KM; Kendrew J; CUNY, Hunter College, Hunter-Bellevue School of Nursing, New; York, USA.; This study examined sleep quality in HIV infected people. The research explored the incidence of the study variables (sleep quality, anxiety, well-being, and symptom severity) and found differences on the variables between subjects who reported HIV infection through male/male sex (n = 18) as compared to injecting drug
Lamivudine.: J Assoc Nurses AIDS Care. 1996 May-Jun;7(3):51-3. Unique Identifier : AIDSLINE MED/96413142; Porche DJ
Acupuncture and AIDS.: J Assoc Nurses AIDS Care. 1996 May-Jun;7(3):54-6. Unique Identifier : AIDSLINE MED/96413143; Moffet H
Demonstration of antibodies to human T-cell lymphotropic virus-I tax in patients with the cutaneous T-cell lymphoma, mycosis fungoides, who are seronegative for antibodies to the structural proteins of the virus.: Blood. 1996 Oct 15;88(8):3004-9. Unique Identifier : AIDSLINE MED/97028183; Pancake BA; Wassef EH; Zucker-Franklin D; Department of Medicine, New York University Medical Center, New; York 10016, USA.; Although most patients with the cutaneous T-cell lymphoma, mycosis fungoides (MF), are seronegative for human T-cell lymphotropic virus-I or -II (HTLV-I/II) when tested by assays that measure only antibodies to the viral structural proteins, the majority of such patients harbor HTLV-I-related pol and tax proviral sequ
Identification of an unusual Fc gamma receptor IIIa (CD16) on natural killer cells in a patient with recurrent infections.: Blood. 1996 Oct 15;88(8):3022-7. Unique Identifier : AIDSLINE MED/97028185; de Vries E; Koene HR; Vossen JM; Gratama JW; von dem Borne AE; Waaijer JL; Haraldsson A; de Haas M; van Tol MJ; Department of Pediatrics, Leiden University Hospital, The; Netherlands.; We found an unusual fc gamma receptor IIIa (CD16) phenotype on the natural killer (NK) cells of a 3-year-old boy, who suffered from recurrent viral respiratory tract infections since birth. He also had severe clinical problems after Bacille Calmette-Geerin (BCG) vaccination and following Epstein-Barr virus and Varicel
Two types of defective human T-lymphotropic virus type I provirus in adult T-cell leukemia.: Blood. 1996 Oct 15;88(8):3065-73. Unique Identifier : AIDSLINE MED/97028190; Tamiya S; Matsuoka M; Etoh K; Watanabe T; Kamihira S; Yamaguchi K; Takatsuki K; Second Department of Internal Medicine, Kumamoto University; School of Medicine, Japan.; Adult T-cell leukemia (ATL), an aggressive neoplasm of mature helper T cells, is etiologically linked with human T lymphotropic virus type I (HTLV-1). After infection, HTLV-I randomly integrates its provirus into chromosomal DNA. Since ATL is the clonal proliferation of HTLV-I-infected T lymphocytes, molecular methods
Primary effusion lymphoma in women: report of two cases of Kaposi's sarcoma herpes virus-associated effusion-based lymphoma in human immunodeficiency virus-negative women.: Blood. 1996 Oct 15;88(8):3124-8. Unique Identifier : AIDSLINE MED/97028197; Said JW; Tasaka T; Takeuchi S; Asou H; de Vos S; Cesarman E; Knowles DM; Koeffler HP; Department of Pathology, Cedars Sinai Medical Center, School of; Medicine 90048, USA.; Recent molecular evidence suggests an association with a new herpes virus, Kaposi s sarcoma-associated herpes virus (KSHV/HHV-8), and primary effusion lymphomas (PEL). PELs have a characteristic morphology, phenotype, and clinical presentation with malignant effusions in the absence of a contiguous solid tumor mass. M
Lack of beta-oxidation defects in human immunodeficiency virus-positive subjects with and without chronic zidovudine exposure [letter]: Blood. 1996 Oct 15;88(8):3243-4. Unique Identifier : AIDSLINE MED/97028213; Wachsman M; Barditch-Crovo P; Lietman PS; Trapnell CB
Mobilization of CD34+ progenitor cells by granulocyte colony-stimulating factor in human immunodeficiency virus type 1-infected adults.: Blood. 1996 Nov 1;88(9):3329-35. Unique Identifier : AIDSLINE MED/97051762; Slobod KS; Bennett TA; Freiden PJ; Kechli AM; Howlett N; Flynn PM; Head DR; Srivastava DK; Boyett JM; Brenner MK; Garcia JV; Department of Infectious Diseases, St Jude Children's Research; Hospital, Memphis, TN 38105, USA.; We conducted a clinical trial to determine the feasibility of growth factor mobilization of CD34+ progenitor cells in human immunodeficiency virus type 1 (HIV-1)-infected individuals. Eight asymptomatic, HIV-1-infected adults (median CD4+ T-cell count, 415 cells/microL), received 480 micrograms/d of granulocyte colony
Differential regulation of proinflammatory and hematopoietic cytokines in human macrophages after infection with human immunodeficiency virus.: Blood. 1996 Nov 1;88(9):3474-81. Unique Identifier : AIDSLINE MED/97051778; Esser R; Glienke W; von Briesen H; Rubsamen-Waigmann H; Andreesen R; Georg-Speyer-Haus, Frankfurt am Main, Germany.; Cells of the macrophage lineage (MAC) play an important role in human immunodeficiency virus (HIV) infection. However, the knowledge on the extent of macrophage involvement in the pathogenesis of HIV infection is still incomplete. In this study we examined the secretory repertoire of HIV-infected MAC with respect to t
[AIDS seminar for personnel managers in japanese companies--application of health belief model and health norm model]: Nippon Koshu Eisei Zasshi. 1996 Jun;43(6):479-85. Unique Identifier : AIDSLINE MED/96347487; Tanaka H
[The effect of the AIDS campaign on case numbers of male urethritis]: Nippon Koshu Eisei Zasshi. 1996 Jul;43(7):545-50. Unique Identifier : AIDSLINE MED/97070173; Kojima H; Urological Department, Japanese Red Cross Medical Center.; In an attempt to investigate the influence of the AIDS campaign on the number of cases of STD in Japan , the case numbers of both gonococcal and chlamydial urethritis diagnosed in Japanese Red Cross Medical Center (JRMC) from 1980 to 1992 were surveyed. The case number of gonococcal
[Personal opinion on "the problem of women and AIDS in developing countries" (letter)]: Nippon Koshu Eisei Zasshi. 1996 Jul;43(7):586-7. Unique Identifier : AIDSLINE MED/97105809; Furuse Y
[Surveillance study of HIV/AIDS epidemic in Asia by questionnaire]: Nippon Koshu Eisei Zasshi. 1996 Aug;43(8):644-50. Unique Identifier : AIDSLINE MED/97070183; Okamoto M; Morio S; Kamakura M; Ichikawa S; Shinmura K; Soda K; Nakayama H
Induction of whole body hyperthemia with venovenous perfusion.: ASAIO J. 1996 Jul-Aug;42(4):250-4. Unique Identifier : AIDSLINE MED/96426500; Vertrees RA; Tao W; Pencil SD; Sites JP; Althoff DP; Zwischenberger JB; Department of Surgery, University of Texas Medical Branch,; Galveston 77554-0528, USA.; Whole body hyperthermia can be used for the treatment of metastatic cancer and human immunodeficiency virus infections. The therapeutic effects of hyperthermia are dependent upon the actual temperature of the target tissues. Therefore, homogeneous distribution of heat and precise control of temperature gradients is cr
Dermatologic findings in HIV-1-infected patients: a prospective study with emphasis on CD4+ cell count.: Dermatology. 1996;192(4):325-8. Unique Identifier : AIDSLINE MED/97017749; Reynaud-Mendel B; Janier M; Gerbaka J; Hakim C; Rabian C; Chastang C; Morel P; Sexually Transmissible Diseases Center, Hopital Saint-Louis,; Paris, France.; BACKGROUND: Skin manifestations are common in patients infected with the human immunodeficiency virus (HIV) but the prognostic significance of may of them is not clear. METHODS: Skin disorders were studied in a cohort of 267 HIV-infected patients followed prospectively and were correlated to the CD4+ cell count. RESUL
Ivermectin-responsive crusted scabies in HTLV1 carrier.: Dermatology. 1996;192(4):351-2. Unique Identifier : AIDSLINE MED/97017756; Cordoliani F; Vasseur E; Baccard M; Fournier S; Feuilhade de Chauvin M; Tancrede E; Morel P; Department of Dermatology, Hopital Saint-Louis, Paris, France.; We report a case of HTLV1 infection revealed by crusted scabies and widespread dermatophytosis in an African woman. HTLV1 infection was not complicated by adult T cell leukemia or myelopathy. Crusted scabies is a marker of HTLV1 infection. The importance of oral ivermectin therapy in crusted scabies is emphasized.
Intravitreal ganciclovir for cytomegalovirus retinitis in patients with AIDS.: Ann Pharmacother. 1996 Jul-Aug;30(7-8):717-23. Unique Identifier : AIDSLINE MED/96423947; Montero MC; Pastor M; Buenestado C; Lluch A; Atienza M; University Hospital Virgen del Rocio, Sevilla, Spain.; OBJECTIVE: To assess the evolution of cytomegalovirus ( CMV ) retinitis and evaluate the possible complications associated with the use of intravitreal injections to treat this disease. DESIGN: A nonrandomized, retrospective st
Nontuberculous mycobacterial infections.: Ann Pharmacother. 1996 Jul-Aug;30(7-8):819-30. Unique Identifier : AIDSLINE MED/96423967; Guay DR; Section of Clinical Pharmacology, St. Paul-Ramsey Medical Center,; MN 55101, USA.; OBJECTIVE: To review the epidemiology, clinical manifestations, diagnosis, and treatment of nontuberculous mycobacterial infections other than Mycobacterium avium complex (MAC). DATA SOURCES: A MEDLINE search of English-language literature pertaining to nontuberculous mycobacteria other than MAC was performed. Additio
Pharmacologic management of postdural puncture headache.: Ann Pharmacother. 1996 Jul-Aug;30(7-8):831-9. Unique Identifier : AIDSLINE MED/96423968; Choi A; Laurito CE; Cunningham FE; Department of Pharmacy Practice, College of Pharmacy, University; of Illinois at Chicago 60612, USA.; OBJECTIVE: To discuss the pathogenesis, incidence, and clinical presentation of postdural puncture headaches (PDPHs) and to provide a comprehensive evaluation on the pharmacologic management of PDPH. DATA SOURCE: A MEDLINE search was used to identify pertinent literature published in English including review articles,
Human T-cell lymphotropic virus type-I (HTLV-I)-associated myelopathy/tropical spastic paraparesis with acute type of adult T-cell leukemia.: Intern Med. 1995 Nov;34(11):1130-3. Unique Identifier : AIDSLINE MED/96371144; Furukawa Y; Okadome T; Tara M; Niina K; Izumo S; Osame M; Third Department of Internal Medicine, Kagoshima University.; We report a 47-year-old Japanese woman with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) combined with acute type adult T-cell leukemia (ATL). The susceptibility for HAM/TSP and acute type of ATL is hitherto explained by human leukocyte antigen (HLA) haplotype-linked immune responsiveness to HTL
Lactic dehydrogenase-immunoglobulin G kappa complex in a patient with idiopathic interstitial pneumonia.: Intern Med. 1996 May;35(5):413-5. Unique Identifier : AIDSLINE MED/96389965; Fujishima T; Morita S; Shijubo N; Nakata H; Shigehara K; Koba H; Abe S; Third Department of Internal Medicine, Sapporo Medical University; School of Medicine.; A female patient with idiopathic interstitial pneumonia (IIP) was admitted again 40 months after the diagnosis due to progression of clinical findings and increased activity of serum lactic dehydrogenase (LDH). Analysis of LDH isoenzyme disclosed a broad band between LDH4 and LDH5. Gel filtration and immunoelectrophor
On the development of mycobacterial infections II. Changing mycobacterial infection spectrum in the Cologne area 1983-1993.: Zentralbl Bakteriol. 1995 Dec;283(2):225-38. Unique Identifier : AIDSLINE MED/96422497; Schutt-Gerowitt H; Institut fur Medizinische Mikrobiologie und Hygiene,; Universitat zu Koln, Germany.; The overall detection rate of mycobacteria in the Cologne area did not change between 1983 and 1993. But a significant shift of the rate of Mycobacterium tuberculosis to nontuberculous mycobacteria, especially Mycobacterium avium-intracellulare complex, could be observed. Whereas the portion of Mycobacterium tuberculo
Seroprevalence of HIV and HCV infections in Alexandria, Egypt.: Zentralbl Bakteriol. 1995 Dec;283(2):239-44. Unique Identifier : AIDSLINE MED/96422498; Quinti I; Renganathan E; El Ghazzawi E; Divizia M; Sawaf G; Awad S; Pana A; Rocchi G; Department of Public Health and Cell Biology, University of Rome; Tor Vergata, Italy.; During the years 1992-1994, we tested 948 individuals from different population groups for HIV-1 and HIV-2 infections by ELISA and WB and for HCV infection by ELISA. Repeated ELISA reactivity for HIV was found in 2.12% of blood donors, 2.95% of fire brigade personnel and 1.61% of prisoners. Western blotting studies, h
Detection of Mycoplasma sp. in bronchoalveolar lavage of AIDS patients with pulmonary infiltrates.: Zentralbl Bakteriol. 1996 Jun;284(1):75-9. Unique Identifier : AIDSLINE MED/96434404; Sloot N; Hollandt H; Gatermann S; Dalhoff K; Institute for Medical Microbiology, Hospital of Ludwigshafen,; Germany.; We examined 486 bronchoalveolar lavages (BAL) including 32 from AIDS patients with pulmonary infiltrates and 20 from patients with leukemia or after transplantation. Mycoplasmas were found in 4/32 (12.5%) HIV-positive patients compared to 4/454 (
Vitamins and immunomodulation in AIDS.: Nutrition. 1996 Jan;12(1):1-7. Unique Identifier : AIDSLINE MED/96435943; Liang B; Chung S; Araghiniknam M; Lane LC; Watson RR; Department of Family and Community Medicine, University of; Arizona, Tucson 85724, USA.; Acquired immune deficiency syndrome (AIDS) is a clinical disorder caused by a retrovirus infection and represents the end point in a progressive sequence of immunosuppressive changes. Vitamins can enhance disease resistance in animals and humans. As such they are important co-factors in optimal functioning of the immu
Viral infection.: EXS. 1996;77:337-57. Unique Identifier : AIDSLINE MED/97009880; Santoro MG; Institute of Experimental Medicine, CNR, Rome, Italy.; The relationship between viruses and the cellular stress response is a multifaceted and complex phenomenon which depends on the structural and genetic characteristics of the virus, on the type of infection, as well as on the environmental conditions. It is now well documented that infection of mammalian cells by sever
Iron withholding: a defense against viral infections.: Biometals. 1996 Oct;9(4):393-9. Unique Identifier : AIDSLINE MED/96434494; Weinberg ED; Department of Biology, Indiana University, Bloomington 47405,; USA.; A variety of laboratory and clinical investigations during the past 15 years have observed that one of the dangers of excessive iron is its ability to favor animal viral infections. The metal is essential for host cell synthesis of virions and can also impair defense cell function and increase oxidative stress. In bot
[Clinical and experimental study of RA mixture in treatment of rheumatoid arthritis]: Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. 1996 Jan;16(1):14-7, 23. Unique Identifier : AIDSLINE MED/96331870; Xu DS; Shen ZY; Lu W; Visceral Manifestation Lab. of Huashan Hospital, Shanghai Medical; University.; The RA mixture is composed of Tripterygium Wilfordii (TW) and other Chinese medicinal herbs with effect of expelling Wind, activiting blood circulation, invigorating the Kidney and Qi. The authors treated rheumatoid arthritis (RA) patients with RA mixture and compared it with D-penicillamine as control. The two group
[Clinical observation of Qi deficiency syndrome in 72 patients with chronic obstructive pulmonary disease treated with yiqi mianyi granule]: Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. 1996 Feb;16(2):81-3. Unique Identifier : AIDSLINE MED/96286722; Xu XY; Liu QR; Chen J; Luzhou Medical College, Sichuan.; Seventy-two patients of chronic obstructive pulmonary disease (COPD) of Qi deficiency syndrome with abnormal immune indices were treated with Yiqi Mianyi Granule (YQMYG) and the efficacy was compared with 30 cases treated with Zhenqi Fuzheng Granule (ZQFZG) for control. Results showed that the marked effective rate of
Treatment of clinically resistant cytomegalovirus retinitis in AIDS patients: combination of intravenous ganciclovir and intravitreal foscarnet.: Eur J Ophthalmol. 1995 Oct-Dec;5(4):199-203. Unique Identifier : AIDSLINE MED/96215755; Pivetti-Pezzi P; Accorinti M; Ciapparoni V; Vullo V; Ocular Immunovirology Service, University of Roma La Sapienza,; Italy.; The treatment of clinically resistant cytomegalovirus retinitis in AIDS patients requires a combination of foscarnet and ganciclovir, but the poor clinical condition of some patients may weigh against this intravenous regimen. We treated three patients with high-dose intravitreal f
Intravitreal and systemic foscarnet in the treatment of AIDS-related CMV retinitis.: Eur J Ophthalmol. 1996 Apr-Jun;6(2):179-82. Unique Identifier : AIDSLINE MED/96420896; Tognon MS; Turrini B; Masiero G; Scaggiante R; Cadrobbi P; Baldanti F; Gerna G; Secchi AG; Chair of Physiopathological Optics, University of Padova, School; of Medicine, Italy.; Cytomegalovirus retinitis is the most frequent ocular opportunistic infection in AIDS patients. Untreated, it is always a progressive and destructive disease of the retina that results in blindness. Specific treatment is therefore mandatory to halt the progression of the retinal lesions. The authors report their exper
"About last night": the social ecology of sexual behavior relative to alcohol use among adolescents and young adults in substance abuse treatment.: J Subst Abuse. 1995;7(4):449-61. Unique Identifier : AIDSLINE MED/96435741; Tubman JG; Langer LM; Department of Psychology, Florida International University, Miami; 33199, USA. tubman@servax.fiu.edu; Data were collected in face-to-face interviews from 120 substance-abusing adolescents and young adults (87 men, 33 women; M age = 17.2 years old) recruited from residential and nonresidential treatment facilities in South Florida. Participants described two recent sexual events, one with and one without concurrent alc
Cloning, high-yield expression in Escherichia coli, and purification of biologically active HIV-1 Tat protein.: Protein Expr Purif. 1996 Aug;8(1):75-84. Unique Identifier : AIDSLINE MED/96410767; Kirsch T; Boehm M; Schuckert O; Metzger AU; Willbold D; Frank RW; Rosch P; Lehrstuhl fur Biopolymere, Universitat Bayreuth, Bayreuth,; D-95440, Germany.; We have established an expression system for full-length HIV-1 transactivator (Tat) protein in Escherichia coli. By constructing a synthetic gene for high level expression in enteric bacteria, the recombinant protein can be obtained in high yield. Fusion of the Tat sequence to an N-terminal histidine tag allows the ra
Purification and functional characterization of wild-type and mutant HIV-1 and HIV-2 Tat proteins expressed in Escherichia coli.: Protein Expr Purif. 1996 Sep;8(2):238-46. Unique Identifier : AIDSLINE MED/96410786; Orsini MJ; Garcia-Martinez LF; Mavankal G; Gaynor RB; Debouck CM; Department of Molecular Genetics, SmithKline Beecham; Pharmaceuticals, King of Prussia, Pennsylvania, 19406, USA.; We describe a single method to purify milligram amounts of authentic wild-type and mutant HIV-1 and HIV-2 Tat proteins overexpressed in Escherichia coli. This method takes advantage of the highly basic, positively charged RNA binding domain present in both HIV-1 and HIV-2 Tat, which also facilitated purification of HI
Characterization of the spontaneous apoptosis of rat thymocytes in vitro.: Int Arch Allergy Immunol. 1996 Nov;111(3):230-7. Unique Identifier : AIDSLINE MED/97074690; Rinner I; Felsner P; Hofer D; Globerson A; Schauenstein K; Institute of General and Experimental Pathology, University of; Graz, Austria.; Unlike splenic or blood lymphocytes, rat thymocytes spontaneously undergo continuously increasing apoptosis during culture. In this study we characterized apoptotic thymus cells of rats according to cell size, nuclear dye binding and surface marker expression. Furthermore, the effects of cell density in culture, the a
Expression of CD23, CD32, Mac-1 and other adhesion molecules in eosinophils in strongyloidiasis and HTLV-I-positive patients.: Int Arch Allergy Immunol. 1996;111 Suppl 1:46-50. Unique Identifier : AIDSLINE MED/97062374; Kakazu T; Saito A; Chihara J; Nakajima S; First Department of Internal Medicine, Faculty of Medicine,; University of the Ryukyu, Okinawa, Japan.; The relationship between human T-lymphotropic virus I (HTLV-I) infection and strongyloidiasis has recently become an important problem. This study compared the expression of CD23, CD32, Mac-1 and other adhesion molecules in eosinophils of patients with strongyloidiasis positive for anti-(HTLV-I) antibodies and in thos
Infectious agents and environmental factors in lymphoid malignancies.: Blood Rev. 1996 Jun;10(2):89-94. Unique Identifier : AIDSLINE MED/96408328; Toren A; Ben-Bassat I; Rechavi G; Institute of Hematology, Chaim Sheba Medical Center, Tel; Hashomer, Israel.; A strong association was found to exist between patterns of lymphoid malignancies and socioeconomic status. B-cell lymphomas and T-acute lymphoblastic leukemia are much more prevalent in developing countries where the chances of acquiring infections especially at a younger age are high. B-cell precursor acute lymphati
The pathology of the chronic lymphoid leukaemias.: Blood Rev. 1995 Dec;9(4):234-50. Unique Identifier : AIDSLINE MED/96436528; Kroft SH; Finn WG; Peterson LC; The chronic lymphoid leukaemias, though they all possess relatively mature lymphoid phenotypes, are a diverse group of diseases at the clinical, morphological, immunophenotypical, and biological levels. Generally accepted entities within this category include B-cell chronic lymphocytic leukaemia of classical and mixed
[Correlation between histocompatibility antigens, tumor necrosis factor-alpha, and HIV infection]: Vestn Ross Akad Med Nauk. 1996;(8):13-7. Unique Identifier : AIDSLINE MED/96438428; Kalinina NM; The expression of tumor necrosis alpha-factor (TNF-alpha) may be characterized by autocrine loop operating at the transcriptional level through the NF-kB rel-protein family. The same family of transcriptional factors contributes to the control of expression of HIV LTR. These regulatory patterns linked expression of TN
[Structural and functional analysis of the human immunodeficiency glycoprotein gp120 with homologous synthetic peptides]: Vestn Ross Akad Med Nauk. 1996;(8):9-12. Unique Identifier : AIDSLINE MED/96438427; Ketlinskii SA; Kalinina NM; Prusakov AN; Kaurov OA; The purpose of the study was to identify sites of gp 120, which are responsible for CD4 binding and induce tumor necrosis factor-alpha (TNF-alpha) synthesis. Seven peptides were synthesized from gp 120. The peptides were studied in the following biological tests: binding to CD4 molecules of the Jurkat cell clones 3G6
Alternative theories about AIDS should not be dismissed out of hand [letter]: BMJ. 1996 Nov 2;313(7065):1147-8. Unique Identifier : AIDSLINE MED/97074294; Strohman R
Rights and responsibilities in HIV prevention [letter]: BMJ. 1996 Nov 9;313(7066):1206. Unique Identifier : AIDSLINE MED/97074345; Danziger R
Molecular characterization of Mycobacterium avium complex isolates from Caribbean patients by DT1/DT6-PCR, nonradioactive Southern hybridization, and the Accuprobe system.: Curr Microbiol. 1996 Dec;33(6):352-8. Unique Identifier : AIDSLINE MED/97059070; Sola C; Devallois A; Goh KS; Legrand E; Rastogi N; Unite de la Tuberculose et des Mycobacteries, Institut Pasteur,; Morne Joliviere B.P. 484, 97165 Pointe a Pitre Cedex,; Guadeloupe, French West Indies.; A genetic fingerprinting analysis of Caribbean isolates of M. avium complex (MAC) from AIDS patients by a Southern blotting technique after Pstl digestion with nonradioactive DNA probes coding for single-copy sequences DT1 and DT6 was performed. In parallel, a selective amplification of a 187-bp fragment within the DT
Overcoming the mind/body dichotomy in drug abuse treatment [editorial]: Addiction. 1996 Jan;91(1):11-3. Unique Identifier : AIDSLINE MED/96419236; Selwyn PA
Health status at entry to methadone maintenance treatment using the SF-36 health survey questionnaire.: Addiction. 1996 Jan;91(1):39-45. Unique Identifier : AIDSLINE MED/96419240; Ryan CF; White JM; Department of Clinical and Experimental Pharmacology, University; of Adelaide, Australia.; This study used the SF-36 general health questionnaire to measure the health status of heroin users at entry to a public methadone maintenance programme. Their results were compared to those from the general population and from three clinical groups: patients with minor medical, major medical and psychiatric problems.
Once more unto the breach: controlling hepatitis C in injecting drug users.: Addiction. 1996 Feb;91(2):181-4. Unique Identifier : AIDSLINE MED/96432209; Wodak A; Crofts N; Alcohol and Drug Service, St. Vincent's Hospital, Darlinghurst,; NSW, Australia.
Longitudinal neuropsychological evaluation of HIV-infected intravenous drug users.: Addiction. 1996 Feb;91(2):263-8. Unique Identifier : AIDSLINE MED/96432215; Bono G; Mauri M; Sinforiani E; Barbarini G; Minoli L; Fea M; IRCCS C. Mondino, University of Pavia, Italy.; The present study aimed to describe the cognitive status of a group of HIV-positive asymptomatic intravenous drug users (IVDU) and changes which occurred over a 12-month follow-up period. Forty-two HIV positive IVDU were selected and matched for age, sex, educational level and pattern of drug abuse with 39 seronegativ
Recent advances in the uses and applications of ribosome-inactivating proteins from plants.: Cell Mol Biol (Noisy-le-grand). 1996 Jun;42(4):461-71. Unique Identifier : AIDSLINE MED/96426622; Girbes T; Ferreras JM; Iglesias R; Citores L; De Torre C; Carbajales ML; Jimenez P; De Benito FM; Munoz R; Departamento de Bioquimica y Biologia Molecular, Facultad de; Ciencias, Universidad de Valladolid, Spain.; Plant ribosome-inactivating proteins (RIPs) are inhibitors present in all parts of plants that irreversibly inactivate eukaryotic ribosomes, thus impairing protein synthesis. RIPs are enzymes with N-glycosidase activity on the large rRNA. Their powerful inhibitory activity has been made use of advantageously to constr
Rifabutin-associated anterior uveitis in patients infected with human immunodeficiency virus.: Ger J Ophthalmol. 1996 Jul;5(4):195-201. Unique Identifier : AIDSLINE MED/97006826; Schimkat M; Althaus C; Becker K; Sundmacher R; Augenklinik, Heinrich-Heine-Universitat Dusseldorf, Germany.; Iridocyclitis, arthralgia, and pseudojaundice have been identified as dose-dependent adverse effects in patients with acquired immunodeficiency syndrome (AIDS) who are treated orally with rifabutin for Mycobacterium avium intracellulare complex (MAC) infections. Nine episodes of acute anterior uveitis of varying sever
Hepatitis C virus and non-Hodgkin's lymphomas.: Leuk Lymphoma. 1996 Jun;22(1-2):53-60. Unique Identifier : AIDSLINE MED/96330911; Pozzato G; Mazzaro C; Santini G; Burrone O; Institute of Medicina Clinica, University of Trieste, School of; Medicine, Italy.; The etiology of non-Hodgkin s lymphomas (NHL) remains a controversial matter, but, in the last few years, considerable evidence suggests that aberrations of the immune system and viruses may act as etiologic agents, in at least some cases of NHL. In fact, patients with primary immuno-deficiencies, or those suffering f
[Telomerase activity in murine cells during spontaneous transformation]: Dokl Akad Nauk. 1996 Jul;349(1):121-3. Unique Identifier : AIDSLINE MED/97019766; Chernov DN; Egorov EE; Akimov SS
Effect of organic acids in the prevention of aggregation on rapid refolding of proteins.: Biochem Mol Biol Int. 1996 Feb;38(2):393-99. Unique Identifier : AIDSLINE MED/97003196; Yang PW; Kumar TK; Jayaraman G; Yu C; Department of Chemistry, National Tsing Hua University, Taiwan,; R.O.C.; The effect of organic acids on the aggregation of protein(s) during rapid refolding is studied. Using egg white lysozyme, it is observed that acetic acid not only prevents aggregation, but also aids the protein to refold back to its native, biologically active state. In contrast, formic acid, propionic acid and butyri
Health services for urban underserved children.: Bull N Y Acad Med. 1996 Summer;73(1):105-12. Unique Identifier : AIDSLINE MED/96397850; Heagarty MC; College of Physicians & Surgeons of Columbia University, New; York, NY 10037, USA.
Therapy of HIV infections: problems and prospects.: Bull N Y Acad Med. 1996 Summer;73(1):37-45. Unique Identifier : AIDSLINE MED/96397843; Ho DD; Aaron Diamond AIDS Research Center, New York, NY 10017, USA.
Primary pulmonary hypertension in a HIV+ patient.: Monaldi Arch Chest Dis. 1995 Dec;50(6):451-2. Unique Identifier : AIDSLINE MED/96431889; Speciale A; Ramundi M; Fabiani F; Fiorucci F; Schmid G; Dept of Cardiovascular and Respiratory Sciences, University of; Rome La Sapienza, Italy.; Recent reports have suggested a possible association between HIV infection and primary pulmonary hypertension (PPH). We report the case of a HIV+ patient, without manifestations of the acquired immune deficiency syndrome (AIDS), who presented with signs of elevated pulmonary arterial pressure.
Surveillance of the HIV/AIDS pandemic.: Bull Pan Am Health Organ. 1996 Sep;30(3):275. Unique Identifier : AIDSLINE MED/97053118
Mandatory prenatal HIV testing: why not?: Midwifery Today Childbirth Educ. 1996 Summer;(38):53-4. Unique Identifier : AIDSLINE MED/96423785; Edmunds J
Opportunist mycobacteria in England and Wales: 1982 to 1994.: Commun Dis Rep CDR Rev. 1996 Oct 11;6(11):R147-51. Unique Identifier : AIDSLINE MED/97075598; Lamden K; Watson JM; Knerer G; Ryan MJ; Jenkins PA; Mycobacterium Reference Unit, Cardiff Public Health Laboratory,; University Hospital of Wales.; Three thousand and fifty-two infections with opportunist mycobacteria were reported to the PHLS Communicable Disease Surveillance Centre from 1982 to 1994. The commonest reported species was Mycobacterium avium-intracellulare (MAI), followed by M. kansasii and M. malmoense. The annual totals of opportunist mycobacteri
AIDS and HIV-1 infection in the United Kingdom: monthly report.: Commun Dis Rep CDR Wkly. 1996 Sep 20;6(38):337-8. Unique Identifier : AIDSLINE MED/97040009
HIV-1 encephalopathy in children.: Curr Opin Pediatr. 1995 Dec;7(6):655-62. Unique Identifier : AIDSLINE MED/96372192; Gelbard HA; Epstein LG; University of Rochester, New York, USA.; HIV-1 infection is a worldwide pandemic, with an estimate of one to two million children infected by the end of the decade. The neurologic manifestations of primary HIV-1 infection in children are a major cause of morbidity and contribute to the fatal outcome in this condition. In the Unit
Risks and benefits of intravenous immunoglobulin treatment in children.: Curr Opin Pediatr. 1995 Dec;7(6):688-94. Unique Identifier : AIDSLINE MED/96372197; Fasano MB; Bowman Gray School of Medicine, Winston-Salem, North Carolina USA; 27157-1042.; Intravenous immunoglobulin has been used in the treatment of a variety of disorders since the 1970s. Its safety and efficacy, however, have been evaluated in only a minority of these conditions. At present, intravenous immunoglobulin is licensed for use in primary immunodeficiencies, idiopathic thrombocytopenic purpur
Screening for cytomegalovirus retinitis in children.: Arch Pediatr Adolesc Med. 1996 Nov;150(11):1186-92. Unique Identifier : AIDSLINE MED/97060815; Baumal CR; Levin AV; Kavalec CC; Petric M; Khan H; Read SE; Department of Ophthalmology, University of Toronto, Ontario.; OBJECTIVES: To identify immunosuppressed children who are at risk of cytomegalovirus ( CMV ) retinitis developing and to evaluate the use of laboratory results for identifying this risk. DESIGN: Prospective cohort and retrospec
[The brain in children and the human immunodeficiency virus (HIV-1) (editorial)]: Arch Pediatr. 1996 Jun;3(6):523-7. Unique Identifier : AIDSLINE MED/97035647; Tardieu M
Causes of chronic diarrhea in patients with AIDS in Thailand: a prospective clinical and microbiological study.: J Gastroenterol. 1996 Aug;31(4):533-7. Unique Identifier : AIDSLINE MED/97001482; Manatsathit S; Tansupasawasdikul S; Wanachiwanawin D; Setawarin S; Suwanagool P; Prakasvejakit S; Leelakusolwong S; Eampokalap B; Kachintorn U; Department of Medicine, Siriraj Hospital, Mahidol University,; Bangkok, Thailand.; A prospective study was designed to investigate the causes of chronic diarrhea in AIDS patients in Thailand . Forty-five patients from Bamrasnaradura Infectious Diseases Hospital were enrolled. Extensive investigations included multiple stool examinations for ova and parasites, us
Antioxidant activity of diethyldithiocarbamate.: Free Radic Res. 1996 Jun;24(6):461-72. Unique Identifier : AIDSLINE MED/96398111; Liu J; Shigenaga MK; Yan LJ; Mori A; Ames BN; Division of Biochemistry and Molecular Biology, University of; California, Berkeley 94720, USA.; Diethyldithiocarbamate (DDC), a potent copper chelating agent, has long been used for the treatment of oxygen toxicity to the central nervous system, as an immunomodulator to treat cancer, and in HIV-infected patients. We evaluated the antioxidant properties of DDC, including its scavenging of reactive oxygen species,
Human T-lymphotropic virus type I (HTLV-I) [letter]: J Neuroophthalmol. 1996 Mar;16(1):68-9. Unique Identifier : AIDSLINE MED/96271043; Merle H; Smadja D; Vernant JC
Human immunodeficiency virus infection and the thyroid gland.: Eur J Endocrinol. 1996 Jun;134(6):669-74. Unique Identifier : AIDSLINE MED/96301263; Heufelder AE; Hofbauer LC; Medizinische Klinik, Klinikum Innenstadt,; Ludwig-Maximilians-Universitat, Munchen, Germany.
[Identification and information on patients transfused between 1980 and 1985 at Alexis Vautrin Center]: Transfus Clin Biol. 1996;3(2):125-31. Unique Identifier : AIDSLINE MED/96384674; Dartois D; Carolus J; Bey P; Pennequin JC; Salm B; Montange F; Centre Alexis Vautrin, Vandoeuvre-Les-Nancy.; In 1993, in Centre Alexis Vautrin, we took quite easily the census of 3,170 patients transfused between 1980 and 1985. In our institution, the systematic long-term follow-up of patients treated allowed to select rapidly the patients alive and to ask family doctors to inform and propose screening tests for a possible c
Multi-center European evaluation of HIV testing on serum and saliva samples.: Transfus Clin Biol. 1996;3(2):89-98. Unique Identifier : AIDSLINE MED/96384670; Francois-Gerard C; Thortensson R; Luton P; Zumpe P; Maniez-Montreuil M; Massip AB; Saelen MO; Sondag-Thull D; Centre de Reference SIDA, Universite de Liege, Belgium.; OBJECTIVE: to evaluate the reliability of HIV antibody testing on saliva. DESIGN: matched serum and saliva samples were collected from both seronegative (n = 344) and seropositive (n = 125) individuals in five European countries. Duplicate saliva samples collected with Omni-Sal devices provided by Saliva Diagnostic Sy
Inflammatory disease.: Curr Opin Neurol. 1996 Jun;9(3):B65-76. Unique Identifier : AIDSLINE MED/96436806
Inflammation in AIDS and the role of the macrophage in brain pathology.: Curr Opin Neurol. 1996 Jun;9(3):221-5. Unique Identifier : AIDSLINE MED/96436800; Achim CL; Wiley CA; University of Pittsburgh School of Medicine, Division of; Neuropathology, Pennsylvania 15213, USA.; HIV-associated dementia complex is the most severe neurologic complication of AIDS. The pathologic substrate of the complex, termed HIV encephalitis, is marked by abundant infection and activation of brain macrophages. The pathogenesis of neurologic damage in HIV encephalitis is es
Changes in HIV risk behavior following alternative residential programs of drug abuse treatment and AIDS education.: Ann Epidemiol. 1996 Mar;6(2):119-25. Unique Identifier : AIDSLINE MED/96371768; McCusker J; Stoddard AM; Hindin RN; Garfield FB; Frost R; School of Public Health, University of Massachusetts, Amherst,; USA.; We compared the effectiveness in changing human immunodeficiency virus (HIV) risk behavior of two different approaches to acquired immunodeficiency syndrome (AIDS) education given by residential drug abuse treatment programs differing in their planned duration. Two randomized controlled trials compared (a) a 6-month w
Neuropathology of early HIV-1 infection.: Brain Pathol. 1996 Jan;6(1):1-15. Unique Identifier : AIDSLINE MED/97020364; Gray F; Scaravilli F; Everall I; Chretien F; An S; Boche D; Adle-Biassette H; Wingertsmann L; Durigon M; Hurtrel B; Chiodi F; Bell J; Lantos P; Hopital Raymond Poincare-Faculte de Medecine Paris-Ouest,; Garches, France.; Early HIV-1 invasion of the central nervous system has been demonstrated by many cerebrospinal fluid studies; however, most HIV-1 carriers remain neurologically unimpaired during the so called asymptomatic period lasting from seroconversion to symptomatic AIDS. Therefore, neuropathological studies in the early pre-A
Living versus dying "with dignity": a new perspective on the euthanasia debate.: Camb Q Healthc Ethics. 1996 Winter;5(1):50-61. Unique Identifier : AIDSLINE MED/96432406; Koch T; David-See-Chai Lam Centre for International Communications, Simon; Fraser University, Vancouver, Canada.
Lack of association of induration size with HIV infection among drug users reacting to tuberculin.: Am J Respir Crit Care Med. 1996 Oct;154(4 Pt 1):1029-33. Unique Identifier : AIDSLINE MED/97042402; Gourevitch MN; Hartel D; Schoenbaum EE; Klein RS; Department of Epidemiology and Social Medicine, Montefiore; Medical Center, Albert Einstein College of Medicine, Bronx, New; York, USA.; Smaller tuberculin test induration sizes suggest eligibility for tuberculosis chemoprophylaxis in HIV-seropositive than in HIV-seronegative persons. To determine whether human immunodeficiency virus (HIV) infection is associated with induration size among tuberculin reactors, a cross-sectional study of HIV-seropositiv
Six-month supervised intermittent tuberculosis therapy in Haitian patients with and without HIV infection.: Am J Respir Crit Care Med. 1996 Oct;154(4 Pt 1):1034-8. Unique Identifier : AIDSLINE MED/97042403; Chaisson RE; Clermont HC; Holt EA; Cantave M; Johnson MP; Atkinson J; Davis H; Boulos R; Quinn TC; Halsey NA; Department of Medicine, Johns Hopkins University, Baltimore,; Maryland, USA.; We enrolled 427 consecutive patients with tuberculosis diagnosed in Cite Soleil, Haiti in a trial of short-course intermittent therapy. All patients received supervised therapy with isoniazid, rifampin, pyrazinamide, and ethambutol thrice weekly for 8 wk, followed by isoniazid and r
Selective malabsorption and the origin of mono-rifampin-resistant Mycobacterium tuberculosis [letter]: Am J Respir Crit Care Med. 1996 Oct;154(4 Pt 1):1213. Unique Identifier : AIDSLINE MED/97042422; Perlman DC; Salomon N
Zidovudine glucuronidation in human liver: interindividual variability.: Int J Clin Pharmacol Ther. 1996 Aug;34(8):329-34. Unique Identifier : AIDSLINE MED/97018178; Pacifici GM; Evangelisti L; Giuliani L; Metelli RM; Giordani R; Department of Biomedicine, University of Pisa, Medical School,; Italy.; Zidovudine 3 -azido-3 -deoxythymidine is the drug chosen for the treatment of patients suffering from AIDS; zidovudine being a potent inhibitor of HIV replication. The drug is extensively metabolized by conjugation with glucuronic acid into an inactive compound, and 30-40% of the dose is eliminated presystemically. We
Nuclear export and its significance in retroviral infection.: Trends Microbiol. 1996 Jan;4(1):1-2. Unique Identifier : AIDSLINE MED/96422169; Yoneda Y; Dept of Anatomy and Cell Biology, Osaka University Medical; School, Japan.
Rhodococcus equi: an emerging opportunistic pathogen.: Trends Microbiol. 1996 Jan;4(1):29-33. Unique Identifier : AIDSLINE MED/96422175; Mosser DM; Hondalus MK; Dept of Microbiology and Immunology, Temple University School of; Medicine, Philadelphia, PA 19140, USA.; dmmosser@astro.ocis.temple.edu; Rhodococcus equi is emerging as a cause of pneumonia in immunocompromised people, especially those with AIDS. Like mycobacteria, R. equi is phagocytosed by alveolar macrophages and replicates within them. Recent work is beginning to elucidate the cell and molecular biology of this opportunistic pathogen and the host i
Wheel keeps turning for antiviral combination chemotherapy.: Trends Microbiol. 1996 Feb;4(2):51-2. Unique Identifier : AIDSLINE MED/96417775; Coen DM; Department of Biological Chemistry and Molecular Pharmacology,; Harvard Medical School, Boston, MA 02115, USA.
Lymphocyte activation by CpG dinucleotide motifs in prokaryotic DNA.: Trends Microbiol. 1996 Feb;4(2):73-6. Unique Identifier : AIDSLINE MED/96417780; Krieg AM; Department of Internal Medicine, University of Iowa College of; Medicine, Iowa City 52246, USA. arthur-krieg@uniowa.edu; CpG dinucleotides are present at the expected frequency in prokaryotic DNA, but are underrepresented ( CpG suppression ) and methylated in vertebrate DNA. The vertebrate immune system has apparently evolved the ability to recognize these unmethylated CpG motifs and respond with a rapid and coordinated cytokine respons
Lymphocyte dynamics, apoptosis and HIV infection.: Trends Microbiol. 1996 Feb;4(2):77-82. Unique Identifier : AIDSLINE MED/96417781; Frost SD; Michie CA; Department of Zoology, Oxford University, UK, sfrost@vax.ox.ac.uk; Death of HIV-infected CD4+ cells and HIV-induced death of uninfected CD4+ cells by apoptosis have been suggested to be important factors in causing the gradual progressive decline of CD4+ cells in the blood of HIV-positive patients. Recent advances in our knowledge of the dynamics of infection and the mechanism of apo
Retrovirus variation: a finger on the pulse.: Trends Microbiol. 1996 Jun;4(6):218-9. Unique Identifier : AIDSLINE MED/96387686; Meyerhans A
Recent developments in theories of pathogenesis of AIDS.: Trends Microbiol. 1996 Jul;4(7):282-5. Unique Identifier : AIDSLINE MED/96427088; Antia R; Halloran ME; Dept of Biology, Emory University, Atlanta, GA 30322, USA.; Experimental and theoretical progress in HIV research includes an improved resolution of the spatial heterogeneity and the dynamics (time course and turnover rates) of virus and CD4+ cells. Some of these advances have resulted from the joint work of experimental and theoretical groups, demonstrating that interdiscipli
Recent developments in theories of pathogenesis of AIDS [letter]: Trends Microbiol. 1996 Aug;4(8):299. Unique Identifier : AIDSLINE MED/97009761; Michie CA
Reduced CD8+ T-cell concentration in peripheral blood of patients with carotid artery stenosis: relation to arteritis temporalis.: Br J Rheumatol. 1996 Jul;35(7):649-51. Unique Identifier : AIDSLINE MED/96302487; Elling P; Olsson AT; Elling H; Department of Medicine, Randers Central Hospital, Denmark.; The percentage and numbers of CD8+ T cells are markedly decreased in peripheral blood from patients with arteritis temporalis. Transient cerebral ischaemic attacks (TIA) or brain infarctions have been frequently reported as the first and only clinical manifestation, and signs of carotid artery stenosis have been repor
Bone bacillary angiomatosis in an HIV-infected patient.: Br J Rheumatol. 1996 Sep;35(9):901-4. Unique Identifier : AIDSLINE MED/96406561; Olive A; Tena X; Raventos A; Romeu J; Lorenzo JC; Ojanguren I; Perez R; Rheumatology Section, Hospital Universitari Germans Trias i; Pujol, Badalona, Barcelona, Spain.; Bacillary angiomatosis (BA) is a recently discovered multisystem bacterial infectious disease seen in the setting of immune suppression due to the human immunodeficiency virus (HIV). A case of an HIV-infected patient with osteolytic bone involvement is reported.
[Causes of false-positive results in serological studies of HIV infection]: Klin Lab Diagn. 1993 May-Jun;(3):44-7. Unique Identifier : AIDSLINE MED/97007381; Orlova VM; Siziakina LP; Dosiagaeva LI; Analysis of the results of testing 150880 serum samples with the Antigen and Recombinant-HIV types test systems, manufactured in Russia , has demonstrated the relationship between the false-positive results and the type of the test system employed and the category of the examined su
[Postmortem detection of antibodies to human immunodeficiency virus]: Klin Lab Diagn. 1993 May-Jun;(3):47-50. Unique Identifier : AIDSLINE MED/97007382; Leshchinskaia NP; Smol'skaia TT; The authors have demonstrated the possibility of detecting antibodies to HIV in cadaveric blood by enzyme immunoassay, agglutination tests, dot- and immune blotting tests with Russian and imported commercial test systems. The qualitative and quantitative results of anti-HIV antibody indication, as well as of HBsAg ind
"HIV-peplotion vaccine"--a novel approach to protection against AIDS by transepithelial transport of viral peptides to Langerhans cells for long-term antiviral CTL response. (A review).: Acta Microbiol Immunol Hung. 1996;43(1):1-17. Unique Identifier : AIDSLINE MED/96400562; Becker Y; Department of Molecular Virology, Faculty of Medicine, Hebrew; University of Jerusalem, Israel.; Viral vaccines which stimulate the humoral immune response in humans have been successful in preventing most of the known virus diseases except dengue fever, respiratory syncytial virus infections and HIV-1-related AIDS. Burke [1] raised a concern that anti-HIV-1 antibodies may add a risk factor to immunized individua
Production of interferon-gamma and interleukin-4 by splenocytes in mice infected with Paragonimus westermani.: Korean J Parasitol. 1996 Sep;34(3):185-9. Unique Identifier : AIDSLINE MED/97000610; Shin MH; Min DY; Department of Parasitology, College of Medicine, Ewha Womans; University, Seoul, Korea.; The TH cytokine responses of spleen cells stimulated with Con A from mice infected with Paragonimus westermani were examined. The spleen cell culture supernatants were assayed for TH1-specific IFN-gamma and TH2-specific IL-4. Cytokine responses for IL-4 peaked at three days (410 +/- 60.9 pg/ml), persisted at a high le
How Tat targets TAR: structure of the BIV peptide-RNA complex.: Structure. 1996 Jan 15;4(1):5-9. Unique Identifier : AIDSLINE MED/96419130; Greenbaum NL; Department of Biochemistry and Molecular Biophysics, Columbia; University College of Physicians and Surgeons, New York, NY; 10032, USA.; Two new NMR structures describing the complex formed by a peptide from the BIV Tat protein with the TAR RNA provide a significant advance in our understanding of the ways in which peptides interact with specific sites in the major groove of their RNA targets.
The catalytic domain of avian sarcoma virus integrase: conformation of the active-site residues in the presence of divalent cations.: Structure. 1996 Jan 15;4(1):89-96. Unique Identifier : AIDSLINE MED/96419139; Bujacz G; Jaskolski M; Alexandratos J; Wlodawer A; Merkel G; Katz RA; Skalka AM; Macromolecular Structure Laboratory, NCI-Frederick Cancer; Research and Development Center, ABL-Basic Research Program,; Frederick, MD 21702, USA.; BACKGROUND: Members of the structurally-related superfamily of enzymes that includes RNase H, RuvC resolvase, MuA transposase, and retroviral integrase require divalent cations for enzymatic activity. So far, cation positions are reported in the X-ray crystal structures of only two of these proteins, E. coli and human
Reading between the lines: SH3 recognition of an intact protein.: Structure. 1996 Jun 15;4(6):657-9. Unique Identifier : AIDSLINE MED/96399711; Lim WA; Department of Molecular Biophysics & Biochemistry, Yale; University, New Haven, CT 06520-8114, USA.; The structure of Nef-SH3 domain complex reveals how an SH3 domain can more effectively read its linear proline-rich recognition element when it is presented within the context of a folded protein.
Immune function early in acute pancreatitis [letter]: Br J Surg. 1996 Oct;83(10):1480-1. Unique Identifier : AIDSLINE MED/97099913; Wyllie JH; Myint F
Nephrotoxicity of antiviral therapies.: Curr Opin Nephrol Hypertens. 1996 Jul;5(4):375-9. Unique Identifier : AIDSLINE MED/96420841; Becker BN; Schulman G; Department of Medicine, Vanderbilt University School of Medicine,; Nashville, Tennessee, USA.; An ever-increasing variety of antiviral medications are being used clinically for an array of viral infections ranging from hepatitis to HIV. Some of these medications, such as acyclovir and foscarnet, have significant nephrotoxicity, whereas others are associated only rarely wi
Intravenous immunoglobulin therapy [editorial]: QJM. 1996 Sep;89(9):641-3. Unique Identifier : AIDSLINE MED/97075347; Chapel H
Central venous catheter infections in AIDS patients receiving daily home therapy for cytomegalovirus disease.: QJM. 1996 Sep;89(9):695-9. Unique Identifier : AIDSLINE MED/97075354; Casado JL; Navas E; Garcia A; Antela A; Redondo E; Fortun J; Guerrero A; Department of Microbiology, Hospital Ramon y Cajal, Madrid,; Spain.; We studied the infection rate of long-term intravenous access used for daily home treatment of cytomegalovirus ( CMV ) disease in 61 AIDS patients who had 75 central venous catheters implanted for antiviral maintenance therapy
Tuberculous erythema nodosum in patients with human immunodeficiency virus infection [letter]: Rev Rhum Engl Ed. 1996 May;63(5):377. Unique Identifier : AIDSLINE MED/96381873; Narvaez J; Rodriguez-Moreno J; Clavaguera MT; Campoy E
Septic arthritis due to Haemophilus parainfluenzae in a patients infected with the human immunodeficiency virus type 1 [letter]: Rev Rhum Engl Ed. 1996 May;63(5):380. Unique Identifier : AIDSLINE MED/96381875; Blanche P; Abad S; Sicard D
Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine.: Brain Res. 1996 Jan 15;706(2):303-7. Unique Identifier : AIDSLINE MED/96419614; Toggas SM; Masliah E; Mucke L; Department of Neuropharmacology, Scripps Research Institute, La; Jolla, CA 92037, USA.; To investigate the in vivo role of NMDA receptor stimulation in HIV-1-related CNS neurotoxicity, we evaluated the neuroprotective potential of the NMDA receptor antagonist memantine in transgenic mice which have gp120-induced CNS damage. Brains of mice treated chronically with memantine and of untreated controls were
TTP following ITP in an HIV-positive boy.: J Pediatr Hematol Oncol. 1996 Nov;18(4):384-6. Unique Identifier : AIDSLINE MED/97043675; Prasad VK; Kim IK; Farrington K; Bussel JB; Pediatric Hematology-Oncology Department, Memorial; Sloan-Kettering Cancer Center, New York, New York, USA.; PURPOSE: To report the previously undescribed development of thrombotic thrombocytopenic purpura (TTP) in a human immunodeficiency virus (HIV)-positive child and discuss the differential diagnosis. PATIENT AND METHODS: Our patient was a 9-year-old boy with vertically acquired HIV infection and a previous history of im
Myopathy and spontaneous Pasteurella pneumotropica-induced abscess formation in an HIV-1 transgenic mouse model.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Oct 1;13(2):101-16. Unique Identifier : AIDSLINE MED/97015626; Dickie P; Mounts P; Purcell D; Miller G; Fredrickson T; Chang LJ; Martin MA; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, National Institutes of Health,; Bethesda, Maryland 20892, USA.; In an effort to augment human immunodeficiency virus type 1 (HIV-1) gene expression in transgenic mice, an infectious proviral DNA clone was modified by deleting the two NF kappa B binding sites and some adjacent upstream LTR sequences and replacing them with the core enhancer of Moloney murine leukemia virus (MLV). T
Development of T-cell lines expressing functional HIV-1 envelope glycoproteins for evaluation of immune responses in HIV-infected individuals.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Oct 1;13(2):117-26. Unique Identifier : AIDSLINE MED/97015627; Keler T; Li H; Cloyd MW; Vitale LA; Deo YM; Medarex, Inc., Annandale, New Jersey 08801, USA.; The human T-lymphoid cell line, CEM, was transfected with gp 160 cDNA of human immunodeficiency virus type 1 (HIV-1)pm213. Three clones expressing the envelope glycoproteins (env), designated CEM-213env1, -env4, and -env7, were isolated. These clones expressed high levels of surface gp41 and gp120, as demonstrated by
Quantification of HIV-1 RNA in plasma: comparable results with the NASBA HIV-1 RNA QT and the AMPLICOR HIV monitor test.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Oct 1;13(2):127-39. Unique Identifier : AIDSLINE MED/97015628; Vandamme AM; Schmit JC; Van Dooren S; Van Laethem K; Gobbers E; Kok W; Goubau P; Witvrouw M; Peetermans W; De Clercq E; Desmyter J; Rega Institute for Medical Research and University Hospitals,; Katholieke Universiteit Leuven, Belgium.; We investigated and compared the reproducibility, accuracy, detection limits, and dynamic ranges of two commercial kits for quantification of RNA viral load using a titrated virus stock (laboratory strain HIV-1 IIIB) and 107 plasma samples of 25 HIV-1-infected patients. The high reproducibility of both methods (SD = 0
Reverse transcriptase mutations in HIV-1-infected children treated with zidovudine.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Oct 1;13(2):140-5. Unique Identifier : AIDSLINE MED/97015629; Unal A; Lorenzo E; Brown M; Smith L; Matsuura S; Scott G; Scott W; Department of Biochemistry and Molecular Biology, University of; Miami School of Medicine, FL 33101, USA.; Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) mutations were detected in DNA from peripheral blood mononuclear cells from 11 of 12 HIV-1-infected children after 11-20 months of zidovudine monotherapy. The number of children with mutations detected at each codon were as follows: codon 41, 4; co
Infections associated with totally implantable venous access devices (TIVAD) in human immunodeficiency virus-infected patients.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Oct 1;13(2):146-54. Unique Identifier : AIDSLINE MED/97015630; Dega H; Eliaszewicz M; Gisselbrecht M; Fleury J; Pialoux G; Janssen B; de Saint-Martin L; Gonzalez-Canali G; Dupont B; Department of Infectious Diseases, Hopital de l'Institut; Pasteur, Paris, France.; We report on a retrospective study evaluating infectious morbidity associated with totally implantable venous access devices (TIVAD) (Port-A-Cath) in HIV-infected patients. This study of 84 consecutive HIV-infected patients requiring 89 TIVAD between January 1990 and October 1993 was performed in the Department of Inf
Human immunodeficiency virus infection in children with tuberculosis in Santo Domingo, Dominican Republic: prevalence, clinical findings, and response to antituberculosis treatment.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Oct 1;13(2):155-9. Unique Identifier : AIDSLINE MED/97015631; Espinal MA; Reingold AL; Perez G; Camilo E; Soto S; Cruz E; Matos N; Gonzalez G; Division of Public Health Biology and Epidemiology, School of; Public Health, University of California, Berkeley, USA.; We studied human immunodeficiency virus (HIV)-seroprevalence among children with clinically diagnosed tuberculosis (TB) and compared the clinical features and response to short-term anti-TB therapy of children with and without HIV infection in Santo Domingo,
Model of the impact of HIV infection on the size of future hemophilia and carrier birth cohorts.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Oct 1;13(2):160-8. Unique Identifier : AIDSLINE MED/97015632; Ragni MV; Weissfeld JL; Department of Medicine, University of Pittsburgh, Hemophilia; Center of Western Pennsylvania 15213-4306, USA.; The introduction of human immunodeficiency virus (HIV) infection in almost half of the U.S. hemophilia population during the late 1970s and early to mid-1980s has resulted in significant mortality and morbidity. The predict the quantitative impact of HIV infection through HIV-contaminated clotting factor on the size o
Determinants of HIV seroprevalence rates among sites participating in a community-based study of drug users.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Oct 1;13(2):169-76. Unique Identifier : AIDSLINE MED/97015633; Montoya ID; Atkinson JS; Affiliated Systems Corporation, Houston, Texas 77027-6022, USA.; The National Institute on Drug Abuse s National Cooperative Agreement Project is a nationwide study of the injection and sexual behaviors of three populations of out-of-treatment drug users: injecting drug users (IDUs) who did not smoke crack cocaine, non-injecting crack smokers, and those engaging in both types of us
Tuberculosis and HIV infection among female inmates in Sao Paulo, Brazil: a prospective cohort study.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Oct 1;13(2):177-83. Unique Identifier : AIDSLINE MED/97015634; Ferreira MM; Ferrazoli L; Palaci M; Salles PS; Medeiros LA; Novoa P; Kiefer CR; Schechtmann M; Kritski AL; Johnson WD; Riley LW; Ferreira Junior OC; Instituto de Infectologia Emilio Ribas, Universidade de Sao; Paulo, Brazil.; Prison populations are at increased risk of both human immunodeficiency virus (HIV) and Mycobacterium tuberculosis infections, but among female inmates information on such risks remains scarce, especially in developing countries. Between October 1992 and November 1993, 350 women incarcerated at a prison in Sao Paulo,
Role of neopterin and 7,8-dihydroneopterin in human immunodeficiency virus infection: marker for disease progression and pathogenic link.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Oct 1;13(2):184-93. Unique Identifier : AIDSLINE MED/97015635; Baier-Bitterlich G; Wachter H; Fuchs D; Institute for Medical Chemistry and Biochemistry, University of; Innsbruck, Austria.; Human immunodeficiency virus (HIV) infection is associated with increased concentrations of neopterin derivatives, released in large quantities by human macrophages on stimulation with interferon-gamma (INF-gamma). Neopterin concentrations thus inversely correlate with absolute CD4+ T-cell numbers and strongly predict
Absence of human herpesvirus 8 DNA sequences in neoplastic Kaposi's sarcoma cell lines.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Oct 1;13(2):194-7. Unique Identifier : AIDSLINE MED/97015636; Flamand L; Zeman RA; Bryant JL; Lunardi-Iskandar Y; Gallo RC; Institute of Human Virology, University of Maryland Biotechnology; Institute, University of Maryland, Baltimore 21201, USA.; The recent detection of herpesvirus-like DNA sequences in Kaposi s sarcoma (KS) lesions has led to numerous speculations regarding the role of this new agent in KS pathogenesis. However, recent studies indicate a far wider distribution of such viral sequences, shadowing the potential etiologic role of this agent in KS
Altered trimethoprim-sulfamethoxazole ratios for prophylaxis and treatment of Toxoplasma gondii and Pneumocystis carinii dual infections in rat model.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Nov 1;13(3):201-7. Unique Identifier : AIDSLINE MED/97054367; Brun-Pascaud M; Chau F; Garry L; Farinotti R; Derouin F; Girard PM; Institut National de la Sante et de la Recherche Medicate; Unite 13, Hopital Bichat, Paris, France.; Trimethoprim-sulfamethoxazole (TMP-SMX) is the first-line drug for prophylaxis and treatment of Pneumocystis carinii pneumonia (PCP) and for prophylaxis of toxoplasmosis in HIV-infected patients. Evidence indicating intolerance related to the dose of SMX led us to examine the efficacy of altered TMP-SMX ratios in a co
Interleukin-10 gene expression induced by HIV-1 Tat and Rev in the cells of HIV-1 infected individuals.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Nov 1;13(3):208-14. Unique Identifier : AIDSLINE MED/97054368; Blazevic V; Heino M; Lagerstedt A; Ranki A; Krohn KJ; Institute of Medical Technology, University of Tampere, Finland.; The role of cytokines in the regulation and function of the immune system is of great importance. In human immunodeficiency virus (HIV) infection, with progressive deterioration of cell-mediated immune response, cytokines are dysregulated. We have therefore investigated cytokine mRNA expression in type-1 and type-2 he
The natural history and molecular heterogeneity of HIV-associated primary malignant lymphomatous effusions.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Nov 1;13(3):215-26. Unique Identifier : AIDSLINE MED/97054369; Komanduri KV; Luce JA; McGrath MS; Herndier BG; Ng VL; Department of Medicine, University of California, San Francisco,; USA.; Primary malignant lymphomatous effusions arising in individuals infected with the human immunodeficiency virus, type 1 (HIV-1) represent a rare subset of HIV-associated lymphomas. Previous studies have demonstrated that the malignant cells are monoclonal (as defined by rearrangement of the immunoglobulin gene), expres
Association of maternal HIV infection with low birth weight.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Nov 1;13(3):227-34. Unique Identifier : AIDSLINE MED/97054370; Markson LE; Turner BJ; Houchens R; Silverman NS; Cosler L; Takyi BK; Center for Research in Medical Education and Health Care,; Jefferson Medical College, Philadelphia, Pennsylvania, USA.; We evaluated factors associated with low birth weight (LBW) in an HIV-infected cohort (n = 772) and a general sample (n = 2,377) of women delivering a live singleton in federal fiscal years 1989 and 1990 while enrolled in New York State Medicaid. The association of LBW and HIV infection was studied in logistic models,
A phase-I study of the safety, pharmacokinetics, and antiviral activity of combination didanosine and ribavirin in patients with HIV-1 disease. AIDS Clinical Trials Group 231 Protocol Team.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Nov 1;13(3):235-46. Unique Identifier : AIDSLINE MED/97054371; Japour AJ; Lertora JJ; Meehan PM; Erice A; Connor JD; Griffith BP; Clax PA; Holden-Wiltse J; Hussey S; Walesky M; Cooney E; Pollard R; Timpone J; McLaren C; Johanneson N; Wood K; Booth D; Bassiakos Y; Crumpacker CS; Beth Israel Hospital, Harvard Medical School, Boston,; Massachusetts, USA.; A phase-I study was conducted to examine the safety, pharmacokinetics, and activity of combination 2 ,3 -dideoxyinosine (ddI) and ribavirin against human immunodeficiency virus type 1 (HIV-1)-positive individuals with CD4+ cell counts of
Proton spectroscopy in asymptomatic HIV-infected adults: initial results in a prospective cohort study.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Nov 1;13(3):247-53. Unique Identifier : AIDSLINE MED/97054372; Jarvik JG; Lenkinski RE; Saykin AJ; Jaans A; Frank I; Department of Radiology, University of Washington School of; Medicine, Seattle, USA.; The purpose of our study was to determine whether proton magnetic resonance spectroscopy (MRS) could detect early brain involvement by human immunodeficiency virus (HIV). We recruited 19 asymptomatic HIV-infected patients, 9 with and 10 without a history of intravenous drug use (IDU), as well as 10 control subjects. A
HIV DNA blood levels in vertically infected pediatric patients: variations with age, association with disease progression, and comparison with blood levels in infected mothers.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Nov 1;13(3):254-61. Unique Identifier : AIDSLINE MED/97054373; Brandt CD; Sison AV; Rakusan TA; Kaufman TE; Saxena ES; O'Donnell RM; Ellaurie M; Sever JL; Center for Virology, Immunology, and Infectious Diseases; Research, Children's National Medical Center, Washington, DC; 20010-2970, USA.; Blood levels of HIV DNA in our vertically infected pediatric patients typically followed a characteristic age-related pattern: continuously increasing with increasing age to a peak between ages 4 and 8 months, and thereafter rather steadily declining. Median HIV DNA levels peaked about 3 months earlier in children who
Serum beta 2-microglobulin at HIV-1 seroconversion as a predictor of severe immunodeficiency during 10 years of followup.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Nov 1;13(3):262-6. Unique Identifier : AIDSLINE MED/97054374; Phillips AN; Sabin CA; Elford J; Bofill M; Timms A; Janossy G; Lee CA; Department of Haematology, Royal Free Hospital School of; Medicine, London, UK.; In order to examine the relevance of early immune activation to the long-term course of HIV infection, we evaluated the ability of the serum beta 2-microglobulin level measured in 63 haemophiliacs on average 4.9 months from HIV seroconversion to predict the rate of development of server immunodeficiency (CD4) lymphocy
HIV testing behaviors in a population of inner-city women at high risk for HIV infection.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Nov 1;13(3):267-72. Unique Identifier : AIDSLINE MED/97054375; Solomon L; Moore J; Gleghorn A; Astemborski J; Vlahov D; AIDS Administration, Department of Health and Mental Hygiene,; Baltimore, MD 21202, USA.; The relationship between HIV testing history. HIV serostatus, and risk behaviors was examined to investigate factors associated with obtaining an HIV test, returning for results, or receiving multiple tests. Seven hundred and five volunteers for an HIV study were questioned about prior HIV testing, drug and sexual pra
People and places: behavioral settings and personal network characteristics as correlates of needle sharing.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Nov 1;13(3):273-80. Unique Identifier : AIDSLINE MED/97054376; Latkin C; Mandell W; Vlahov D; Oziemkowska M; Celentano D; Department of Mental Hygiene, Johns Hopkins University School of; Hygiene and Public Health, Baltimore, MD 21205, USA.; Sharing of contaminated needles constitutes one of the primary modes of HIV transmission in the U.S. This study examined social and environmental factors as possible correlates of needle sharing in a sample of inner-city drug users in Baltimore, Maryland. Drug users social context was assessed through an analysis of
Highly endemic human T-lymphotropic virus type II (HTLV-II) infection in a Venezuelan Guahibo Amerindian group.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Nov 1;13(3):281-6. Unique Identifier : AIDSLINE MED/97054377; Leon-Ponte M; Noya O; Bianco N; Echeverria de Perez G; Institute of Immunology, Faculty of Medicine, Central University; of Venezuela, Caracas, Venezuela.; Sera from 166 Guahibo Indians (55% of the population) living in southwest Venezuela were screened by enzyme-linked immunoassay for antibodies to human T-cell lymphotropic virus (HTLV) I and II. Positive samples were confirmed by immunofluorescence and Western blot. Forty-one Gua
Risk factors for HIV infection at enrollment in an urban male factory cohort in Harare, Zimbabwe.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Nov 1;13(3):287-93. Unique Identifier : AIDSLINE MED/97054378; Bassett MT; McFarland WC; Ray S; Mbizvo MT; Machekano R; van de Wijgert JH; Katzenstein DA; University of Zimbabwe Medical School.; Between March 1993 and March 1995, volunteers at 40 Harare factories were interviewed regarding sociodemographic characteristics and behavior; HIV serostatus was also determined. Among 2,691 men enrolled, HIV prevalence was 19.4%. Prevalence rose 2-fold with each year of age in young men (
Karnofsky performance status and assessment of global health status [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Nov 1;13(3):294-5. Unique Identifier : AIDSLINE MED/97054379; Murri R; Scoppettuolo G; Damiano F; Ammassari A; Fantoni M; Antinori A
Influence of HIV disease on serum anti-HCV antibody titers: a study of intravenous drug users [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Nov 1;13(3):295-6. Unique Identifier : AIDSLINE MED/97054380; Sorbi D; Shen D; Lake-Bakaar G
Evaluation of a confirmatory HIV testing strategy in Thailand not using western blot [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Nov 1;13(3):296-7. Unique Identifier : AIDSLINE MED/97054381; Ittiravivongs A; Likanonsakul S; Mastro TD; Tansuphasawadikul S; Young N; Naiwatanakul T; Kitayaporn D; Limpakarnjanarat K
HIV-1 pol sequences from India fit distinct subtype pattern.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Dec 1;13(4):299-307. Unique Identifier : AIDSLINE GENBANK/U31246; Soto-Ramirez LE; Tripathy S; Renjifo B; Essex M; Harvard AIDS Institute, Harvard School of Public Health, Boston,; Massachusetts 02115, USA.; HIV-1 isolates are classified phylogenetically in several subtypes or clades according to env and gag coding sequences. Viral subtypes tend to cluster geographically. DNA sequences encoding the p51 subunit of reverse transcriptase were obtained by nested polymerase chain reaction from peripheral blood mononuclear cell
Detection of HIV-1 infection with a green fluorescent protein reporter system.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Dec 1;13(4):308-13. Unique Identifier : AIDSLINE MED/97104209; Dorsky DI; Wells M; Harrington RD; Division of Infectious Diseases, University of Connecticut Health; Center, Farmington, USA.; Several systems for the detection of HIV-1 have been described in which HIV-1-susceptible cells contain a reporter gene (chloramphenicol acetyltransferase, beta-galactosidase, or alkaline phosphatase) under the control of the HIV-1 long terminal repeat (LTR). Upon infection by HIV-1, the expression of the viral tat pr
The difficulty of detecting HTLV-1 proviral sequences in patients with mycosis fungoides.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Dec 1;13(4):314-9. Unique Identifier : AIDSLINE MED/97104210; Pancake BA; Zucker-Franklin D; Department of Medicine, New York University Medical Center, New; York 10016, USA.; Although most patients with cutaneous T cell lymphomas, including mycosis fungoides (MF) and its leukemic variant, the Sezary syndrome, are seronegative for antibodies to the human T cell lymphotropic viruses (HTLV-I/II), it has recently been shown that > 95% of such patients harbor proviral DNA sequences related to t
CD8+ lymphocyte responses to antiretroviral therapy of HIV infection.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Dec 1;13(4):320-6. Unique Identifier : AIDSLINE MED/97104211; Carr A; Emery S; Kelleher A; Law M; Cooper DA; HIV Medicine Unit, St. Vincent's Hospital, Sydney, Australia.; CD8+ T lymphocytes may mediate important host responses to human immunodeficiency virus (HIV) infection by human leukocyte antigen (HLA)-restricted cytotoxicity and production of soluble HIV suppressor factors. CD8+ lymphocytes are also important for the suppression of many latent pathogens responsible for opportunist
Access to community-based medical services and number of hospitalizations among patients with HIV disease: are they related?: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Dec 1;13(4):327-35. Unique Identifier : AIDSLINE MED/97104212; Cunningham WE; Mosen DM; Hays RD; Andersen RM; Shapiro MF; Department of Medicine, School of Medicine, University of; California, Los Angeles 90024, USA.; To assess whether better access to community-based outpatient medical services was associated with fewer HIV-related hospitalizations, we studied 217 patients hospitalized at seven southern California hospitals. During hospital admission, patients completed an interview that included one item about the reported diffic
Evaluation of a new self-screening chart for cytomegalovirus retinitis in patients with AIDS.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Dec 1;13(4):336-42. Unique Identifier : AIDSLINE MED/97104213; Teich SA; Saltzman BR; Department of Ophthalmology, Beth Israel Medical Center, New; York, USA.; AIDS patients often present without visual symptoms despite severe vision-threatening cytomegalovirus ( CMV ) retinitis. A new self-examination chart, the Teich Target (copyright 1993, Steven A. Teich, pat. no. 370259), which t
Idiopathic genital ulcers in women infected with human immunodeficiency virus.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Dec 1;13(4):343-7. Unique Identifier : AIDSLINE MED/97104214; Anderson J; Clark RA; Watts DH; Till M; Arrastia C; Schuman P; Cohn SE; Young M; Bessen L; Greenblatt R; Vogler M; Swindells S; Boyer P; Johns Hopkins University, Baltimore Maryland, USA.; A national survey of investigators caring for human immunodeficiency virus (HIV)-infected women was undertaken to describe the clinical presentation of idiopathic genital ulcer disease. Patients with negative syphilis and herpes simplex testing and/or negative genital ulcer biopsy were included in this study. Study pa
Treatment of severe diarrhea caused by Cryptosporidium parvum with oral bovine immunoglobulin concentrate in patients with AIDS.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Dec 1;13(4):348-54. Unique Identifier : AIDSLINE MED/97104215; Greenberg PD; Cello JP; Division of Gastroenterology, Hepatology, and Clinical Nutrition,; San Francisco General Hospital 94110, USA.; We prospectively evaluated the safety and efficacy of colostrum-derived bovine immunoglobulin concentrate in the treatment of diarrhea caused by Cryptosporidium parvum in patients with AIDS. A total of 24 patients with severe chronic diarrhea and AIDS were stratified to one of three cohorts: (1) C. parvum infection al
Serial CD4 and CD8 T-lymphocyte counts and associated mortality in an HIV-2-infected population in Guinea-Bissau.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Dec 1;13(4):355-62. Unique Identifier : AIDSLINE MED/97104216; Lisse IM; Poulsen AG; Aaby P; Knudsen K; Dias F; Department of Pathology, Hvidovre Hospital, Denmark.; In an urban community in Guinea-Bissau , we followed a cohort of human immunodeficiency virus type 2 (HIV-2) seropositive individuals (N = 47) and seronegative controls (N = 82). T-lymphocyte subset determinations were done in 1988, 1990, and 1992. Serial determinations of CD4 perc
Reporting delays of deaths with AIDS in the United States.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Dec 1;13(4):363-7. Unique Identifier : AIDSLINE MED/97104217; Bacchetti P; Department of Epidemiology and Biostatistics, University of; California, San Francisco 94143-0840, USA.; The 1993 change in the AIDS case definition used in the United States has disrupted AIDS incidence trends. Death incidence is not disrupted by the change, but, like AIDS incidence, must be corrected for reporting delays. This article uses data from the national AIDS surveillance system
Absence of edema in HIV-infected patients with end-stage renal disease.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Dec 1;13(4):368-73. Unique Identifier : AIDSLINE MED/97104218; Perinbasekar S; Brod-Miller C; Mattana J; Department of Medicine, Long Island Jewish Medical Center, New; Hyde Park, NY 11040, USA.; In attempting to identify variables that might account for the frequent absence of edema in HIV-infected patients with end-stage renal disease, we evaluated 24 consecutive patients at our institution who had HIV infection and developed end-stage renal disease. Clinical and laboratory data prior to the initiation of he
Cigarette smoking, bacterial pneumonia, and other clinical outcomes in HIV-1 infection. Terry Beirn Community Programs for Clinical Research on AIDS.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Dec 1;13(4):374-83. Unique Identifier : AIDSLINE MED/97104219; Burns DN; Hillman D; Neaton JD; Sherer R; Mitchell T; Capps L; Vallier WG; Thurnherr MD; Gordin FM; Division of Infectious Diseases, Veterans Affairs Medical Center,; Washington, DC 20422, USA.; Cigarette smoking has been associated with impaired immune defenses and an increased risk of certain infectious and neoplastic diseases in HIV-1 seronegative populations. We examined the relationship between cigarette smoking and clinical outcome in a prospective cohort of 3221 HIV-1-seropositive men and women enrolle
Nucleotide sequence and restriction fragment-length polymorphism analysis of human T-cell lymphotropic virus type II (HTLV-II) in southern Europe: evidence for the HTLV-IIa and HTLV-IIb subtypes.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Dec 1;13(4):384-91. Unique Identifier : AIDSLINE +; Vallejo A; Ferrante P; Soriano V; Calabro ML; Mancuso R; Heredia A; Mannella E; Favero A; Garcia-Saiz A; Chieco-Bianchi L; Gonzalez-Lahoz J; Hewlett IK; Laboratory of Molecular Virology, CBER/FDA, Rockville, Maryland,; USA.; Human T-cell lymphotropic virus type II (HTLV-II) has been subtyped into two major groups, IIa and IIb, according to molecular studies involving env gene sequencing. Subsequently, this retrovirus was further subclassified by examining the long terminal repeat (LTR), the most divergent genomic region. Sequence analysis
Correlation of genetic and serologic approaches to HIV-1 subtyping in Thailand.: J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Dec 1;13(4):392-6. Unique Identifier : AIDSLINE MED/97104221; Gaywee J; Artenstein AW; VanCott TC; Trichavaroj R; Sukchamnong A; Amlee P; de Souza M; McCutchan FE; Carr JK; Markowitz LE; Michael R; Nittayaphan S; Royal Thai Army, Armed Forces Research Institute of Medical; Sciences, Bangkok, Thailand.; The aim of this study was to compare the performance of differential polymerase chain reaction (PCR) typing and peptide enzyme-linked immunosorbent assay (V3-EIA) for human immunodeficiency virus type 1 (HIV-1) subtyping in Thailand using heteroduplex mobility assay (HMA) as the
Detection of HIV, hepatitis B and hepatitis C markers in discarded syringes and bloodstains.: Sci Justice. 1996 Oct-Dec;36(4):271-4. Unique Identifier : AIDSLINE MED/97080395; Cattaneo C; Nuttall PA; Sokol RJ; Istituto di Medicina Legale e delle Assicurazioni, Milano, Italy.; Puncture injuries from discarded syringes continue to increase and testing these syringes for viral markers of HIV, HBV and HCV infection is now frequently requested. Workers in forensic medicine also regularly deal with potentially infected material. A simulation study was carried out. Syringes (with attached needles
A potentially novel approach for the gene therapy of HIV-1 disease [editorial]: J Mol Med. 1995 Dec;73(12):581-2. Unique Identifier : AIDSLINE MED/96423152; Berneman ZN
Inhibition of HIV-1 expression by HIV-2.: J Mol Med. 1995 Dec;73(12):583-9. Unique Identifier : AIDSLINE MED/96423153; Rappaport J; Arya SK; Richardson MW; Baier-Bitterlich G; Klotman PE; Division of Nephrology, Mount Sinai School of Medicine, New York,; NY 10029, USA.; HIV-1 and HIV-2 are co-endemic in certain geographic areas. HIV-2 is more weakly pathogenic than HIV-1, and progression to AIDS occurs less frequently and over a longer period of time. Recent epidemiologic studies suggest that individuals infected with HIV-2 have a lower risk of HIV-1 infection. Both immune mechanisms
Fas (CD95) expression on CD4+ T cells from HIV-infected patients increases with disease progression.: J Mol Med. 1995 Dec;73(12):591-3. Unique Identifier : AIDSLINE MED/96423154; Aries SP; Schaaf B; Muller C; Dennin RH; Dalhoff K; Department of Internal Medicine, Medical University of Lubeck,; Germany.; Active T cell suicide (apoptosis) is supposed to be involved in the CD4+ T cell depletion in the course of HIV infection. We investigated the expression of the apoptosis-related antigen Fas on CD4+ T cells from 25 HIV-positive individuals (CDC I-III) and 8 HIV-negative controls by two-colour flowcytometry. In addition
Human herpesvirus-8: detection of novel herpesvirus-like DNA sequences in Kaposi's sarcoma and other lesions.: J Mol Med. 1995 Dec;73(12):603-9. Unique Identifier : AIDSLINE MED/96423156; Memar OM; Rady PL; Tyring SK; Department of Microbiology, University of Texas Medical Branch,; Galveston 77555-1019, USA.; Kaposi s sarcoma (KS) is a malignancy suspected of having an infectious etiology. Unique viral DNA sequences were recognized in KS lesions, using a novel technique that identifies small differences between two complex genomes. The virus had homology with the herpesvirus family, especially Epstein Barr virus (EBV), yet
Elevated venous glutamate levels in (pre)catabolic conditions result at least partly from a decreased glutamate transport activity.: J Mol Med. 1996 Jun;74(6):337-43. Unique Identifier : AIDSLINE MED/97015878; Hack V; Stutz O; Kinscherf R; Schykowski M; Kellerer M; Holm E; Droge W; Department of Immunochemistry, Deutsches Krebsforschungszentrum,; Heidelberg, Germany.; Abnormally high postabsorptive venous plasma glutamate levels have been reported for several diseases that are associated with a loss of body cell mass including cancer, human/simian immunodeficiency virus infection, and amyotrophic lateral sclerosis. Studies on exchange rates in well-nourished cancer patients now sho
Low plasma glutamine in combination with high glutamate levels indicate risk for loss of body cell mass in healthy individuals: the effect of N-acetyl-cysteine.: J Mol Med. 1996 Jul;74(7):393-400. Unique Identifier : AIDSLINE MED/96439637; Kinscherf R; Hack V; Fischbach T; Friedmann B; Weiss C; Edler L; Bartsch P; Droge W; Division of Immunochemistry, Deutsches Krebsforschungszentrum,; Heidelberg, Germany.; Skeletal muscle catabolism, low plasma glutamine, and high venous glutamate levels are common among patients with cancer or human immunodeficiency virus infection. In addition, a high glycolytic activity is commonly found in muscle tissue of cachectic cancer patients, suggesting insufficient mitochondrial energy metab
Comparative analysis of the frequency of house dust mite specific and nonspecific Th1 and Th2 cells in skin lesions and peripheral blood of patients with atopic dermatitis.: J Mol Med. 1996 Jul;74(7):401-6. Unique Identifier : AIDSLINE MED/96439638; Neumann C; Gutgesell C; Fliegert F; Bonifer R; Herrmann F; Abteilung fur Dermatologie und Venerologie, Universitat; Gottingen, Germany.; Until recently it was believed that the T cell response of atopic dermatitis patients challenged with inhalant allergens originates almost exclusively and specifically from Th2 cells capable of secreting an abundance of interleukin (IL)-4 while producing no interferon (IFN)-gamma. To reevaluate this concept in a large
[The therapeutic strategy in controlling HIV infection, its hindrances and by-products]: Bull Acad Natl Med. 1996 May;180(5):1053-78. Unique Identifier : AIDSLINE MED/97028100; Frottier J; Katlama C; Hopital Saint-Antoine, Paris.
Phenotypic analysis of intestinal non-inflamed mucosa in Crohn's disease: evidence of mononuclear cell depletion in lamina propria.: Eur J Gastroenterol Hepatol. 1996 Jun;8(6):563-8. Unique Identifier : AIDSLINE MED/96420874; Souza HS; Carvalho AT; Madi K; Lapa e Silva JR; Elia CS; Laboratorio Multidisciplinar, University Hospital, Federal; University of Rio de Janeiro (UFRJ), Brazil.; OBJECTIVE: The objective of this study was to examine mononuclear cell subpopulations and evidence of cellular activation in unaffected jejunal mucosa in Crohn s disease. DESIGN: A cross-sectional study was performed in patients with Crohn s disease from the ambulatory unity of the University Hospital, UFRJ. METHODS:
Inflammatory bowel disease in individuals seropositive for the human immunodeficiency virus.: Eur J Gastroenterol Hepatol. 1996 Jun;8(6):575-8. Unique Identifier : AIDSLINE MED/96420876; Sharpstone DR; Duggal A; Gazzard BG; Kobler Centre, Chelsea and Westminster Hospital, London, UK.; OBJECTIVE: CD4 lymphocytes mediate disease expression in both human immunodeficiency virus (HIV) infection and inflammatory bowel disease (IBD). Analysis of the clinical course of IBD in HIV-seropositive individuals may elucidate aspects of the role of CD4 lymphocytes in the pathogenesis of these conditions. DESIGN: A
Ionization states of the catalytic residues in HIV-1 protease.: Nat Struct Biol. 1996 Nov;3(11):946-50. Unique Identifier : AIDSLINE MED/97057534; Smith R; Brereton IM; Chai RY; Kent SB; Department of Biochemistry, University of Queensland, Australia.; ross@biosci.uq.edu.au stevek@chemical.ligation.com; Chemical synthesis was used to prepare the HIV-1 protease specifically 13C-labelled in the catalytically essential Asp 25 in each monomer. The NMR chemical shift of the 13C-enriched homodimeric enzyme was measured in the presence of the inhibitor pepstatin, a mimic of the tetrahedral intermediate formed in enzyme cata
[Gene transfer in human hematopoietic stem cells isolated from peripheral blood]: C R Seances Soc Biol Fil. 1996;190(1):67-75. Unique Identifier : AIDSLINE MED/97035622; Mannoni P; Centre de Therapie genique, Institut Paoli-Calmettes,; Marseille.; To insert a new genetic information by gene transfer into haemopoietic stem cells would result in expression of the transgene in progenitors and progeny of cell blood lineages. If successfull, such an approach would open interesting prospectives in the field of experimental research and in the possibility to treat gen
Development of provider networks for specific diseases.: J Health Care Finance. 1995 Winter;22(2):27-41. Unique Identifier : AIDSLINE MED/96417505; Pristave RJ; Becker S; Gutierrez L; Health Care Department, Ross & Hardies, Chicago, Illinois, USA.; Carve out contracting for specific diseases and specialty services has become extremely common in a very short time. The goal of carve out contracting is simple: to place responsibility for managing care and its cost in the hands of those best suited to provide and manage care. This article provides an overview of car
PHS updates guidelines on chemoprophylaxis after occupational HIV exposure [news]: Am J Health Syst Pharm. 1996 Aug 1;53(15):1764-6. Unique Identifier : AIDSLINE MED/96439995
Successful oral desensitization to trimethoprim-sulfamethoxazole in acquired immune deficiency syndrome.: Ann Allergy Asthma Immunol. 1996 Nov;77(5):394-400. Unique Identifier : AIDSLINE MED/97087839; Kalanadhabhatta V; Muppidi D; Sahni H; Robles A; Kramer M; Division of Allergy/Clinical Immunology, Department of Medicine,; Medicine State University of New York, Health Science Center at; Brooklyn, USA.; OBJECTIVE: To study the outcome of a modified oral desensitization protocol for trimethoprim-sulfamethoxazole in human immunodeficiency virus infected patients with Pneumocystis carinii pneumonia and acquired immune deficiency syndrome. DESIGN: A prospective study. SETTING: Tertiary care referral center. PATIENTS: Thi
Elevated cortisol levels in whole saliva in HIV infected individuals.: Eur J Oral Sci. 1996 Jun;104(3):322-4. Unique Identifier : AIDSLINE MED/96427753; Enwonwu CO; Meeks VI; Sawiris PG; Department of OCBS (Biochemistry), University of Maryland,; Baltimore 21201-1586, USA.; Free cortisol concentrations in unstimulated whole saliva samples, collected at 10.00 to 11.00 h, from 23 unmedicated HIV-positive patients and 14 control subjects were measured by radioimmunoassay. Mean cortisol level (nmol/l +/- SD) was significantly higher in the HIV patients than in control subjects (27.4 +/0 9.3
Unique telomeric expression site of major-surface-glycoprotein genes of Pneumocystis carinii.: DNA Res. 1996 Apr 30;3(2):55-64. Unique Identifier : AIDSLINE GENBANK/D82031; Wada M; Nakamura Y; Department of Tumor Biology, University of Tokyo, Japan.; Major cell surface glycoproteins (MSG) of Pneumocystis carinii play a crucial role in the host-parasite interactions involved in P. carinii pneumonia in AIDS patients. Genes encoding MSGs are repeated, highly polymorphic, and distributed among all of the 14-15 chromosomes. Here we show, by BAL-31 exonuclease cleavage
Ex vivo transduction and expansion of CD4+ lymphocytes from HIV + donors: prelude to a ribozyme gene therapy trial.: Gene Ther. 1996 Jul;3(7):599-606. Unique Identifier : AIDSLINE MED/96415740; Leavitt MC; Yu M; Wong-Staal F; Looney DJ; Department of Medicine and Biology, University of California San; Diego, USA.; Preparations for a phase I trial of ex vivo, anti-HIV ribozyme gene therapy have included optimization of transduction and expansion of CD4+ lymphocytes from HIV-1 infected donors, using reagents suitable for production of cell products for human infusion. We also determined whether transduction by the ribozyme vector
Replication-competent retrovirus produced by a 'split-function' third generation amphotropic packaging cell line.: Gene Ther. 1996 Jul;3(7):624-9. Unique Identifier : AIDSLINE MED/96415743; Chong H; Vile RG; Imperial Cancer Research Fund Laboratory of Cancer Gene Therapy,; Rayne Institute, St Thomas' Hospital, London, UK.; We report the discovery, on routine screening, of a replication-competent retrovirus (RCR) produced from a third generation amphotropic packaging cell line, GP + envAM12. In this line, the gag-pol and env helper genes are located on separate plasmids to minimise the chances of recombination events that may lead to RCR
Role of T cells in inflammation caused by adenovirus vectors in the brain.: Gene Ther. 1996 Jul;3(7):644-51. Unique Identifier : AIDSLINE MED/96415746; Byrnes AP; Wood MJ; Charlton HM; Department of Human Anatomy, University of Oxford, UK.; In many organs, E1-deleted human adenovirus vectors trigger antiviral T cell responses which limit the duration of vector-encoded gene expression. When injected into the brain, however, long-term expression is possible in spite of the ensuing inflammatory response. To examine the role of T cells in the immune response
Sustained retroviral gene marking and expression in lymphoid and myeloid cells derived from transduced hematopoietic progenitor cells.: Gene Ther. 1996 Aug;3(8):717-24. Unique Identifier : AIDSLINE MED/97006821; Plavec I; Voytovich A; Moss K; Webster D; Hanley MB; Escaich S; Ho KE; Bohnlein E; DiGiusto DL; SyStemix, Palo Alto, CA 94304, USA.; The expression of antiviral genes in human hematopoietic stem or progenitor cells has been proposed as a strategy for gene therapy of AIDS. To be successful, this strategy requires safe and efficient transfer of the therapeutic gene into hematopoietic cells and gene expression has to be maintained in HIV susceptible c
Evaluation of relative promoter strengths of the HIV-1-LTR and a chimeric RSV-LTR in T lymphocytic cells and peripheral blood mononuclear cells: promoters for anti-HIV-1 gene therapies.: Gene Ther. 1996 Aug;3(8):725-30. Unique Identifier : AIDSLINE MED/97006822; Mukhtar M; Duan L; Bagasra O; Pomerantz RJ; Dorrance H Hamilton Laboratory, Department of Medicine, Jefferson; Medical College, Thomas Jefferson University, Philadelphia,; Pennsylvania 19107, USA.; Gene therapy approaches for human immunodeficiency virus type 1 (HIV-1) infections focus on the transfer of critical genetic elements into CD4+ T lymphocytes and CD34+ stem cells. Ideally, expression of the anti-HIV-1 gene constructs should be induced during early stages of infection to combat high turnover of the rep
Regulation of LMP2 and TAP1 genes by IRF-1 explains the paucity of CD8+ T cells in IRF-1-/- mice.: Immunity. 1996 Oct;5(4):365-76. Unique Identifier : AIDSLINE MED/97040556; White LC; Wright KL; Felix NJ; Ruffner H; Reis LF; Pine R; Ting JP; University of North Carolina Lineberger Comprehensive Cancer; Center, Department of Microbiology and Immunology, University of; North Carolina at Chapel Hill 27599, USA.; The TAP1 and LMP2 genes are central for class I MHC function and share a common promoter. Here, we analyze the molecular mechanism of IFN gamma up-regulation of TAP1 and LMP2. In vivo footprinting indicates IFN gamma up-regulates protein-DNA contacts at an IRF-E that is essential for the up-regulation of TAP1 and LMP2
[Present condition and prospect of gene therapy]: Nihon Rinsho Meneki Gakkai Kaishi. 1995 Dec;18(6):578-80. Unique Identifier : AIDSLINE MED/96433176; Takahisa F
[Recent topics on AIDS research-- study of AIDS viruses and the application for development of prevention and therapeutic methods of AIDS]: Nihon Rinsho Meneki Gakkai Kaishi. 1995 Dec;18(6):606-7. Unique Identifier : AIDSLINE MED/96433184; Honda M
[Immune mechanism of mucous membrane and mucous membrane vaccines: Expression of level 1 and 2 Th2-type cytokine and IgA immune response]: Nihon Rinsho Meneki Gakkai Kaishi. 1995 Dec;18(6):690. Unique Identifier : AIDSLINE MED/96433210; Kiyono H
[A case of acquired immunodeficiency syndrome associated with cryptococcemia and cryptococcal meningitis]: Nihon Rinsho Meneki Gakkai Kaishi. 1996 Jun;19(3):251-8. Unique Identifier : AIDSLINE MED/96406419; Inami T; Nakayama T; Tomita Y; Hashimoto S; Nishinarita S; Horie T; Third Department of Internal Medicine, Nihon University School of; Medicine.; A case of acquired immunodeficiency syndrome (AIDS) developed cryptococcosis which was successfully treated with amphotericin B (AMPH) and fluconazole (FLCZ) is reported. A 52-year-old man was admitted because of pyrexia and oral candidiasis. He had a history of multiple sexual exposures to persons at risk for AIDS in
Inhibition of human immunodeficiency virus-1 reverse transcriptase by heme and synthetic heme analogs.: Proc Assoc Am Physicians. 1996 Jan;108(1):47-54. Unique Identifier : AIDSLINE MED/96430982; Staudinger R; Abraham NG; Levere RD; Kappas A; Rockefeller University Hospital, New York, NY 10021-6399, USA.; Heme and a series of synthetic heme analogs were tested for inhibition of human immunodeficiency virus-1 (HIV-1) reverse transcriptase (RT) activity. Heme and the protoporphyrin complexes of cadmium, magnesium, and tin significantly inhibited HIV-1 RT, whereas other metalloporphyrins had a lesser or no effect on the e
An HIV vaccine: breaking the paradigms.: Proc Assoc Am Physicians. 1996 Jan;108(1):6-13. Unique Identifier : AIDSLINE MED/96430976; Fauci AS; National Institute of Allergy and Infectious Diseases, National; Institutes of Health, Bethesda, MD 20892, USA.
Initial experience with an eight-month sustained-release intravitreal ganciclovir implant for the treatment of CMV retinitis associated with AIDS.: Ophthalmic Surg Lasers. 1995 Sep-Oct;26(5):442-8. Unique Identifier : AIDSLINE MED/96227658; Duker JS; Robinson M; Anand R; Ashton P; New England Eye Center, Boston, MA 02111, USA.; BACKGROUND AND OBJECTIVE: An intravitreal device administering ganciclovir in a sustained-release fashion has been developed for site-specific therapy of cytomegalovirus ( CMV ) retinitis. The initially tested devices released
Effect of cetirizine on the inflammatory cells in mosquito bites.: Clin Exp Allergy. 1996 Jun;26(6):703-9. Unique Identifier : AIDSLINE MED/96405288; Karppinen A; Rantala I; Vaalasti A; Palosuo T; Reunala T; Department of Dermatology, University Hospital of Tampere,; Finland.; BACKGROUND: Mosquito bites frequently cause wealing and delayed papules which appear within a few hours after the bites and may persist for several days. Cetirizine is an effective drug against mosquito bites by decreasing wealing and also the size and pruritus of the delayed bite papules. OBJECTIVES: To characterize
A quantitative test (HCMV-hybrid-capture(TM)) to detect human cytomegalovirus DNA in the blood of immunocompromised patients compared with antigenemia and polymerase chain reaction.: New Microbiol. 1996 Jul;19(3):193-201. Unique Identifier : AIDSLINE MED/96438674; Lazzarotto T; Campisi T; Dal Monte P; Galli S; Spezzacatena P; Guglielmi P; Landini MP; Institute of Microbiology, University of Bologna, Italy.; A quantitative assay is necessary to differentiate between low and high Cytomegalovirus load in the blood, a high load frequently being correlated with clinical disease. A new method for the quantitative determination of viral DNA (HCMV-hybrid-capture) was compared with antigenemia and PCR. Hybrid-capture proved to be
Detection of Mycoplasma genitalium from urethral swabs of human immunodeficiency virus-infected patients.: New Microbiol. 1996 Jul;19(3):203-9. Unique Identifier : AIDSLINE MED/96438675; Savio ML; Caruso A; Allegri R; Fallacara F; Pollara CP; Foresti I; Comberti E; Gargiulo F; Dima F; Cadeo GP; Turano A; Institute of Microbiology, University of Brescia, Italy.; Mycoplasma have been suggested as co-factors in the pathogenesis of acquired immune deficiency syndrome (AIDS). The prevalence of urethral infection by Mycoplasma genitalium was determined by polymerase chain reaction (PCR) with urethral swabs from 35 HIV-infected patients at different stages of the disease (all of th
Drug and alcohol user treatment/intervention services in Russia--a Western perspective.: Subst Use Misuse. 1996 Jan;31(1):103-14. Unique Identifier : AIDSLINE MED/96435510; Fleming PM; Drug Advice Centre, Northern Road Clinic, Portsmouth, Hampshire,; UK.; This paper reviews the state of drug and alcohol treatment/intervention services in Russia . The background and the development of addiction services in Russia is described, and the current problems of alcohol and particularly drug misuse are discussed. Current methods of treatment
Migrant injecting users: characteristics of Italian drug users living in Amsterdam.: Subst Use Misuse. 1996 Jan;31(1):127-39. Unique Identifier : AIDSLINE MED/96435512; Davoli M; Fennema H; Perucci CA; Montiroli PM; van den Hoek A; Epidemiology Unit Lazio Regional Health Authority, Rome, Italy.; The aim of the study was to compare the behavior of Italian injecting drug users (IDUs) in Amsterdam with Italian IDUs who moved abroad but returned with those who never moved. The Italian IDUs in Amsterdam showed a pattern of drug use very similar to the Dutch IDUs. They also reported a high prevalence of needle borr
Toward the year 2000 [editorial]: Subst Use Misuse. 1996 Jan;31(2):207-13. Unique Identifier : AIDSLINE MED/96430926; Leshner AI
HIV risk behaviors among women in methadone maintenance treatment.: Subst Use Misuse. 1996 Feb;31(3):277-301. Unique Identifier : AIDSLINE MED/96431181; Grella CE; Anglin D; Annon JJ; UCLA Drug Abuse Research Center, Los Angeles, CA, USA.; This article reports on the HIV risk behaviors of a sample of 158 women heroin addicts admitted into the Los Angeles Enhanced Methadone Maintenance Project. Risk behaviors for HIV were associated with age, lack of education, ethnicity, relationship with a drug user, HIV status, and higher scores on measures of illegal
Sex, drugs, intervention, and research: from the individual to the social.: Subst Use Misuse. 1996 Feb;31(3):375-407. Unique Identifier : AIDSLINE MED/96431185; Rhodes T; Stimson GV; Quirk A; Centre for Research on Drugs and Health Behaviour, University of; London, England.; Epidemiological estimates of the sexual risk behavior of drug users have provided essential indicators to the current and future prevalence of HIV transmission. An overview of recent research shows the majority of drug injectors to be sexually active, low levels of reported condom use, a significant minority of female
Crack cocaine: an increase in use among patients attending clinics in Sao Paulo: 1990-1993.: Subst Use Misuse. 1996 Mar;31(4):519-27. Unique Identifier : AIDSLINE MED/97004504; Dunn J; Laranjeira RR; Da Silveira DX; Formigoni ML; Ferri CP; Departamento de Psiquiatria, 3 degrees Andar, Escola Paulista de; Medicina, Sao Paulo-SP, Brazil.; Unsubstantiated reports suggest that the availability and use of crack are increasing in Sao Paulo. To investigate this claim we used the databases from two outpatient clinics for drug users at a public hospital and examined the changes in the reported routes of administration of cocaine among 245 patients who had att
Base pairing probabilities in a complete HIV-1 RNA.: J Comput Biol. 1996 Summer;3(2):253-74. Unique Identifier : AIDSLINE MED/96407433; Huynen MA; Perelson A; Vieira WA; Stadler PF; Theoretical Division and Center for Non-Linear Studies, Los; Alamos Natl. Lab. NM 87545, USA.; We have calculated the base pair probability distribution for the secondary structure of a full length HIV-1 genome using the partition function approach introduced by McCaskill (1990). By analyzing the full distribution of base pair probabilities instead of a restricted number of secondary structures, we gain more co
The expression of hepatitis B virus polymerase in hepatocytes during chronic HBV infection.: J Viral Hepat. 1996 Mar;3(2):67-73. Unique Identifier : AIDSLINE MED/96407587; McGarvey MJ; Goldin RD; Karayiannis P; Thomas HC; Department of Medicine, Imperial College School of Medicine at St; Mary's, London, UK.; A recombinant protein corresponding to part of the amino-terminal domain of hepatitis B virus (HBV) polymerase was expressed in Escherichia coli. Antisera raised against this protein stained hepatocytes, from human liver biopsies, predominantly in the nucleus but some cytoplasmic staining was also observed. No stainin
Arrests made in HIV blood scandal [news]: Nat Med. 1996 Nov;2(11):1169. Unique Identifier : AIDSLINE MED/97054436; Nathan R
The role of a mutant CCR5 allele in HIV-1 transmission and disease progression.: Nat Med. 1996 Nov;2(11):1240-3. Unique Identifier : AIDSLINE MED/97054455; Huang Y; Paxton WA; Wolinsky SM; Neumann AU; Zhang L; He T; Kang S; Ceradini D; Jin Z; Yazdanbakhsh K; Kunstman K; Erickson D; Dragon E; Landau NR; Phair J; Ho DD; Koup RA; Aaron Diamond AIDS Research Center, New York, New York, USA.; A 32-nucleotide deletion (delta 32) within the beta-chemokine receptor 5 (CCR5) gene has been described in subjects who remain uninfected despite extensive exposure to HIV-1. This allele was found to be common in the Caucasian population with a frequency of 0.0808, but was not found in people of African or Asian ances
The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection.: Nat Med. 1996 Nov;2(11):1244-7. Unique Identifier : AIDSLINE MED/97054456; Cocchi F; DeVico AL; Garzino-Demo A; Cara A; Gallo RC; Lusso P; Institute of Human Virology, University of Maryland Biotechnology; Institute & School of Medicine, Baltimore, Maryland 21201, USA.; The ability of CD8 T cells derived from human immunodeficiency virus (HIV)-infected patients to produce soluble HIV-suppressive factor(s) (HIV-SF) has been suggested as an important mechanism of control of HIV infection in vivo. The C-C chemokines RANTES, MIP-1 alpha and MIP-1 beta were recently identified as the majo
A model of measles virus-induced immunosuppression: enhanced susceptibility of neonatal human PBLs.: Nat Med. 1996 Nov;2(11):1250-4. Unique Identifier : AIDSLINE GENBANK/K01711; Tishon A; Manchester M; Scheiflinger F; Oldstone MB; Scripps Research Institute, Department of Neuropharmacology, La; Jolla, California 92037, USA.; Measles virus (MV) still incites one of the most contagious infections of humankind. Despite the development and use of an excellent live attenuated virus vaccine, over one million infants and children continue to die each year from measles. The main cause of morbidity and mortality is virus-induced immunosuppression
Generation of CD4+ and CD8+ T-cell clones from PBLs of HIV-1 infected subjects using herpesvirus saimiri.: Nat Med. 1996 Nov;2(11):1272-5. Unique Identifier : AIDSLINE MED/97054462; Saha K; Sova P; Chao W; Chess L; Volsky DJ; Molecular Virology Laboratory, St. Luke's-Roosevelt Hospital; Center, College of Physicians & Surgeons, Columbia University,; New York, New York 10019, USA.
Infection control [letter]: J Can Dent Assoc. 1996 Oct;62(10):763-4. Unique Identifier : AIDSLINE MED/97091124; Mathias RG; Epstein JB
Infection control [letter]: J Can Dent Assoc. 1996 Oct;62(10):764. Unique Identifier : AIDSLINE MED/97091125; Hardie J
Chemical burns of the oral mucosa: report of a case.: J Can Dent Assoc. 1996 Mar;62(3):262-4. Unique Identifier : AIDSLINE MED/97021810; Isenberg SR; Hier LA; Chauvin PJ; Department of Pathology, Montreal General Hospital, Quebec.; Clinical diagnosis of a chemical burn of the oral mucous membranes may be a diagnostic challenge. This article s intent is to illustrate the typical appearance of a chemical mucosal burn and to increase awareness of the various compounds which, when in contact with the mucous membranes, can result in a burn. The autho
Vaccines on the horizon: HIV and cancer.: J Am Pharm Assoc (Wash). 1996 Jan;NS36(1):14-5. Unique Identifier : AIDSLINE MED/96432370; Brazeau GA; Hughes JA; College of Pharmacy, University of Florida, Gainesville, USA.
Drug updates [news]: J Am Pharm Assoc (Wash). 1996 Jan;NS36(1):7-8. Unique Identifier : AIDSLINE MED/96432369
A novel approach to the determination and characterization of HIV dementia.: Can J Neurol Sci. 1996 May;23(2):104-9. Unique Identifier : AIDSLINE MED/96328589; Brouwers P; Mohr E; Hildebrand K; Hendricks M; Claus JJ; Baron IS; Young M; Pierce P; Pediatric Branch, National Cancer Institute, NIH, Bethesda,; Maryland 20892, USA.; BACKGROUND: Neuropsychological studies of the pattern and extent of cognitive impairment in HIV-infected patients have mostly used deviations from control values and/or cut-off scores as criteria for classification of dementia . There is, however, no agreement as to how to define im
T-cell predominant balanitis in a traumatic tetraplegic patient: a case report.: Spinal Cord. 1996 Apr;34(4):243-6. Unique Identifier : AIDSLINE MED/96425618; Van Velzen D; Vaidyanathan S; Krishnan KR; Soni BM; Parsons KF; Regional Spinal Injuries Centre, Southport, Merseyside, UK.; T-cell predominant balanitis is described in a 38 year old uncircumcised tetraplegic man whose presenting feature was non-progressive red lesions over the inner prepuce and the glans penis without signs of infection, phimosis, or meatal stenosis. There was no regional lymphadenopathy. He was not exposed to any of the
Costs and benefits of screening pregnant women for HIV [letter]: Can Med Assoc J. 1996 Nov 15;155(10):1387. Unique Identifier : AIDSLINE MED/97099343; Bueckert H
Bioethics for clinicians: 5. Substitute decision-making.: Can Med Assoc J. 1996 Nov 15;155(10):1435-7. Unique Identifier : AIDSLINE MED/97099355; Lazar NM; Greiner GG; Robertson G; Singer PA; University of Toronto. nlazar@torhosp.toronto.on.ca; Substitute decision-making is a means of making health care decisions on behalf of people who are incapable of making these decisions for themselves. It is based on the ethical principle of respect for autonomy. Substitute decision-making poses two main questions: Who-should make the decision for the incapable person,
AIDS info available over phone, Internet [news]: Can Med Assoc J. 1996 Nov 15;155(10):1467. Unique Identifier : AIDSLINE MED/97099358
Should prisons ease drug prohibition to help reduce disease spread?: Can Med Assoc J. 1996 Nov 15;155(10):1489-91. Unique Identifier : AIDSLINE MED/97099365; Kent H; A session at this summer s international AIDS conference in Vancouver focused on the use of harm-reduction policies to reduce the spread of disease caused by injection drug use. The concept, which is gaining popularity, focuses on the need to limit the harm caused by drug use, not on elimination of the problem.
Special consideration for bloodborne pathogens in the PACU.: J Perianesth Nurs. 1996 Aug;11(4):223-30. Unique Identifier : AIDSLINE MED/97003592; Csete M; Routine care of postoperative patients implies considerable exposure to blood products as well as to coughs and secretions. In the PACU, coughed secretions are often frankly contaminated with blood, and coughing is unpredictable after airway irritation. For these reasons, PACU nurses are exposed to many small inocula
Tuberculosis: disease of the past, disease of the present.: J Perianesth Nurs. 1996 Aug;11(4):240-5. Unique Identifier : AIDSLINE MED/97003594; Griffith DE; Kerr CM; Once thought to be under control, tuberculosis is now the number one cause of infection-related death worldwide and the sixth most significant cause of death overall. Transmission occurs by inhalation of airborne droplet nuclei that can be viable for days, and is facilitated by substance abuse, poverty, overcrowding,
The post anesthesia care unit: unique contribution, unique risk.: J Perianesth Nurs. 1996 Aug;11(4):248-58. Unique Identifier : AIDSLINE MED/97003596; Allen A; Badgwell JM; The environment in the postanesthesia care unit (PACU) is unique in the modern hospital. It was born of necessity and continues of necessity. The modern PACU has evolved from a simple room designed to house a single patient and a nurse to a modern, bustling room of great proportions. Today s PACU is an open ward, prob
Feachem's report on Australia's National HIV/AIDS Strategy [editorial]: Aust N Z J Public Health. 1996 Aug;20(4):342-3. Unique Identifier : AIDSLINE MED/97065205; Kaldor J
Valuing the past...investing in the future.: Aust N Z J Public Health. 1996 Aug;20(4):343-5. Unique Identifier : AIDSLINE MED/97065206; Blewett N; Australian High Commission, Australia House, Strand, London, UK.
Destined to repeat history?: Aust N Z J Public Health. 1996 Aug;20(4):345-7. Unique Identifier : AIDSLINE MED/97065207; Dowsett GW; Department of Sociology, Macquarie University, NSW.
Assessing the National HIV/AIDS Strategy evaluation.: Aust N Z J Public Health. 1996 Aug;20(4):347-51. Unique Identifier : AIDSLINE MED/97065208; Kault D; Department of Mathematics and Statistics, James Cook University,; Townsville. david.kault@jcu.edu.au; The report is a useful compilation of data on Australia s HIV/AIDS epidemic and the response to it. The report produces firm evidence for endorsing Australia s success in limiting the spread of HIV by a number of routes. Australia has been successful in preventing iatrogenic spread, spread through commercial sex and s
Indicators of male bisexual activity in semimetropolitan New South Wales: implications for HIV prevention strategies.: Aust N Z J Public Health. 1996 Aug;20(4):386-92. Unique Identifier : AIDSLINE MED/97065215; Prestage G; Drielsma P; National Centre in HIV Epidemiology and Clinical Research,; Sydney.; Between July 1993 and March 1994, advertising in the personal columns of local print media was used as a subterfuge to obtain access to homosexually active men living on the Central Coast of New South Wales. The men were invited to make contact by phone and were then requested to answer 44 survey questions. The survey
Demographic pattern of AIDS in Australia, 1991 to 1993. The National HIV Surveillance Committee.: Aust N Z J Public Health. 1996 Aug;20(4):421-5. Unique Identifier : AIDSLINE MED/97065220; Li Y; Gold J; McDonald AM; Kaldor JM; National Centre in HIV Epidemiology and Clinical Research, Prince; of Wales Hospital, Sydney.; Population-based acquired immune deficiency syndrome (AIDS) incidence in Australia in 1991-1993 was ascertained. The National Centre in HIV Epidemiology and Clinical Research obtained information on AIDS cases from notification by doctors of AIDS diagnoses through the Department
Who works in the sex industry? A profile of female prostitutes in Victoria.: Aust N Z J Public Health. 1996 Aug;20(4):431-3. Unique Identifier : AIDSLINE MED/97065223; Pyett PM; Haste BR; Snow JD; Centre for the Study of Sexually Transmissible Diseases, La Trobe; University, Melbourne.; A large-scale survey was conducted to obtain a comprehensive picture of the range of women involved in prostitution in Victoria and to document their concerns about health in relation to sex work. There was considerable diversity in the ages, education levels, family situations and attitudes to sex work among women wo
The Feather of Hope Aboriginal AIDS Prevention Society: a community approach to HIV/AIDS prevention.: Can J Public Health. 1996 Jul-Aug;87(4):268-71. Unique Identifier : AIDSLINE MED/97023988; Mill JE; DesJardins DA; Faculty of Nursing, University of Alberta, Edmonton.; Infection with the human immunodeficiency virus (HIV) is a complex and challenging issue for Aboriginal people in Canada . There is a need for HIV/AIDS prevention programs that address the specific needs of Canadian Aboriginal communities in a culturally accepted manner. The Feather
Onychomycosis.: Clin Podiatr Med Surg. 1996 Jan;13(1):13-29. Unique Identifier : AIDSLINE MED/97002582; Hoffman AF; Driver VR; Department of Basic Sciences and Podiatric Medicine, California; College of Podiatric Medicine, San Francisco, USA.; The prevalence and clinical types of onychomycosis and diagnostic methods are reviewed in this article. The need for correct identification of the causative organism is emphasized. The use of oral and topical therapeutic agents is outlined, with specific emphasis on relevant research data and potential side effects of
AIDS knowledge and high-risk behaviour in the chronic mentally ill.: Can J Psychiatry. 1996 Jun;41(5):269-72. Unique Identifier : AIDSLINE MED/96385286; Chuang HT; Atkinson M; Calgary Community Centre, University of Calgary Department of; Psychiatry, Alberta.; OBJECTIVE: To ascertain the degree of HIV-risk knowledge among patients attending a downtown program and to identify the extent of high-risk behaviour for HIV infection. METHOD: A total of 151 patients were selected at the Calgary Community Mental Health Clinic (N = 110) and the nearby Self Help Association (N = 41).
Neuroscience of HIV infection. Basic research and clinical frontiers. Paris, France, March 6-9, 1996. Abstracts.: J Neurovirol. 1996 Feb;2(1):1-55. Unique Identifier : AIDSLINE MED/97112522
Neuropathogenesis of AIDS.: Mol Med Today. 1996 Jan;2(1):16-23. Unique Identifier : AIDSLINE MED/96389551; Dewhurst S; Gelbard HA; Fine SM; Department of Microbiology and Immunology, University of; Rochester Medical Center, NY 14642, USA.; DWRT@bphvax.biophysics.rochester.edu; Neurological disease directly attributable to HIV-1 infection (HIV dementia ) is one of the most frequent disorders in persons with AIDS. HIV-1 dementia is associated with neuronal loss, but occurs in the absence of direct viral infection of neurons, suggesting that neurological dam
Differences that show up in translation [news]: Mol Med Today. 1996 Feb;2(2):49. Unique Identifier : AIDSLINE MED/96389559; O'Brien C
Resources for HIV/AIDS on the Internet.: Mol Med Today. 1996 Feb;2(2):52-7. Unique Identifier : AIDSLINE MED/96389560; Dewhurst S; Sander DM; Sgro JY; Department of Microbiology and immunology, University of; Rochester Medical Center, NY 14642, USA.; DWRT@bphvax.biophysics.rochester.edu
Pharmaceuticals from plants: promises and progress.: Mol Med Today. 1996 Feb;2(2):60-4. Unique Identifier : AIDSLINE MED/96389561; Senior K
Clinical use of quantitative molecular methods in studying human immunodeficiency virus type 1 infection.: Clin Microbiol Rev. 1996 Apr;9(2):135-47. Unique Identifier : AIDSLINE MED/96402063; Clementi M; Menzo S; Bagnarelli P; Valenza A; Paolucci S; Sampaolesi R; Manzin A; Varaldo PE; Dipartimento di Scienze Biomediche, Universita di Trieste,; Italy.
Epidemiology of infection by nontuberculous mycobacteria.: Clin Microbiol Rev. 1996 Apr;9(2):177-215. Unique Identifier : AIDSLINE MED/96402066; Falkinham JO 3rd; Department of Biology, Virginia Polytechnic Institute and State; University, Blacksburg, Virginia 24061-0406, USA. JOFIII@VT.edu
Bartonella (Rochalimaea) quintana infections.: Clin Microbiol Rev. 1996 Jul;9(3):273-92. Unique Identifier : AIDSLINE MED/96405320; Maurin M; Raoult D; Unite des Rickettsies, Centre National de la Recherche; Scientifique EP J0054, Faculte de medecine de la Timone,; Marseille, France.; Bartonella (formerly Rochalimaea) quintana is the etiological agent of trench fever, a disease extensively reported during the World Wars. Recent molecular biology approaches have allowed dramatic extension of the spectrum of Bartonella infections. B. quintana is now also recognized as an etiological agent of fever an
Transgenic cell lines for detection of animal viruses.: Clin Microbiol Rev. 1996 Jul;9(3):321-34. Unique Identifier : AIDSLINE MED/96405323; Olivo PD; Department of Medicine, Washington University School of Medicine,; St. Louis, Missouri 63110, USA. olivo@borcim.wustl.edu; Rapid diagnostic assays based on direct detection of viral antigen or nucleic acid are being used with increasing frequency in clinical virology laboratories. Virus culture, however, remains the only way to detect infectious virus and to analyze clinically relevant viral phenotypes, such as drug resistance. Growth of
Immunopathogenesis of recurrent vulvovaginal candidiasis.: Clin Microbiol Rev. 1996 Jul;9(3):335-48. Unique Identifier : AIDSLINE MED/96405324; Fidel PL Jr; Sobel JD; Division of Infectious Diseases, Wayne State University School of; Medicine, Detroit, Michigan 48201, USA. pFidel@NOMVS.LSUMC.edu; Recurrent vulvovaginal candidiasis (RVVC) is a prevalent opportunistic mucosal infection, caused predominantly by Candida albicans, which affects a significant number of otherwise healthy women of childbearing age. Since there are no known exogenous predisposing factors to explain the incidence of symptomatic vaginiti
Unraveling mysteries associated with cat-scratch disease, bacillary angiomatosis, and related syndromes.: Emerg Infect Dis. 1995 Jan-Mar;1(1):16-21. Unique Identifier : AIDSLINE MED/97064019; Regnery R; Tappero J; National Center for Infectious Diseases, Centers for Disease; Control and Prevention, Atlanta, GA 30333, USA.; rur1@ciddvd1.em.cdc.gov; The search for the infectious agents responsible for cat-scratch disease, bacillary angiomatosis , and related syndromes has a long and often circuitous history. Recognition of the etiologic agents and a new understanding of the fundamental features of the epidemiology and nat
USPHS and IDSA collaborate on guidelines to prevent opportunistic infections in HIV-infected persons [news]: Emerg Infect Dis. 1995 Jul-Sep;1(3):102-3. Unique Identifier : AIDSLINE MED/97064048; Kaplan JE; Holmes KK
Tenth Annual ASTPHLD Conference on Human Retrovirus Testing [news]: Emerg Infect Dis. 1995 Jul-Sep;1(3):105. Unique Identifier : AIDSLINE MED/97064050; Pearson JL
HIV-1 patients may harbor viruses of different phylogenetic subtypes: implications for the evolution of the HIV/AIDS pandemic.: Emerg Infect Dis. 1995 Jul-Sep;1(3):86-8. Unique Identifier : AIDSLINE MED/97064041; Pieniazek D; Janini LM; Ramos A; Tanuri A; Schechter M; Peralta JM; Vicente AC; Pieniazek NK; Schochetman G; Rayfield MA; National Center for Infectious Diseases, Centers for Disease; Control and Prevention, Atlanta, Georgia, USA.
Epidemiologic and evolutionary relationships between Romanian and Brazilian HIV-subtype F strains.: Emerg Infect Dis. 1995 Jul-Sep;1(3):91-3. Unique Identifier : AIDSLINE MED/97064043; Bandea CI; Ramos A; Pieniazek D; Pascu R; Tanuri A; Schochetman G; Rayfield MA; National Center for Infectious Diseases, Centers for Disease; Control and Prevention, Atlanta, Georgia, USA.
Diagnosis of tuberculosis in children: increased need for better methods.: Emerg Infect Dis. 1995 Oct-Dec;1(4):115-23. Unique Identifier : AIDSLINE MED/97064052; Kahn EA; Starke JR; Baylor Collge of Medicine, Houston, Texas, USA.; jstarke@msmailpo2.is5.tch.tmc.edu; In the last decade tuberculosis (TB) has reemerged as a major worldwide public health hazard with increasing incidence among adults and children. Although cases among children represent a small percentage of all TB cases, infected children are a reservoir from which many adult cases will arise. TB diagnosis in childre
Emerging disease issues and fungal pathogens associated with HIV infection.: Emerg Infect Dis. 1996 Apr-Jun;2(2):109-16. Unique Identifier : AIDSLINE MED/97064086; Ampel NM; University of Arizona College of Medicine, Tuscon Veterans; Affairs Medical Center, Tucson, Arizona 85713, USA. namp@aol.com; Fungal diseases are increasing among patients infected with human immunodeficiency virus (HIV) type 1. Infections due to Candida and Cryptococcus are the most common. Although mucocutaneous candidiasis can be treated with oral antifungal agents, increasing evidence suggests that prolonged use of these drugs results in
Nosocomial transmission of multidrug-resistant Mycobacterium tuberculosis in Spain.: Emerg Infect Dis. 1996 Apr-Jun;2(2):125-9. Unique Identifier : AIDSLINE MED/97064089; Rullan JV; Herrera D; Cano R; Moreno V; Godoy P; Peiro EF; Castell J; Ibanez C; Ortega A; Agudo LS; Pozo F; Instituto de Salud Carlos III, Ministerio de Sanidad y Consumo,; Madrid, Spain.
Coccidioidomycosis: a reemerging infectious disease.: Emerg Infect Dis. 1996 Jul-Sep;2(3):192-9. Unique Identifier : AIDSLINE MED/97064107; Kirkland TN; Fierer J; Department of Pathology, University of California, San Diego; School of Medicine, California 92161, USA. tkirkland@ucsd.edu; Coccidioides immitis, the primary pathogenic fungus that causes coccidioidomycosis , is most commonly found in the deserts of the southwestern United States and Central and South America. During the early 1990s, the incidence of coccid
HIV-1 group O virus identified for the first time in the United States.: Emerg Infect Dis. 1996 Jul-Sep;2(3):209-12. Unique Identifier : AIDSLINE MED/97064109; Rayfield MA; Sullivan P; Bandea CI; Britvan L; Otten RA; Pau CP; Pieniazek D; Subbarao S; Simon P; Schable CA; Wright AC; Ward J; Schochetman G; National Center for Infectious Diseases, Centers for Disease; Control and Prevention, Atlanta, Georgia, USA.
A highly heterogeneous HIV-1 epidemic in the Central African Republic.: Emerg Infect Dis. 1996 Jul-Sep;2(3):222-4. Unique Identifier : AIDSLINE MED/97064112; Massanga M; Ndoyo J; Hu DJ; Pau CP; Lee-Thomas S; Hawkins R; Senekian D; Rayfield MA; George JR; Zengais A; Yatere NN; Yossangang V; Samori A; Schochetman G; Dondero TJ; Ministere de la Sante Publique et de la Population, Central; African Republic.
Acute cervical lymphadenopathy [letter]: Emerg Infect Dis. 1996 Jul-Sep;2(3):241. Unique Identifier : AIDSLINE MED/97064118; Pasticci MB; Baldelli F; Bistoni F; Piersimoni C; Sbaraglia G; Stagni G; Pauluzzi S; Infectious Disease Institute, Perugia University, Policlinico; Monteluce, Perugia, Italy.
Aids: deja vu in ancient Egypt? [letter]: Emerg Infect Dis. 1996 Jul-Sep;2(3):242. Unique Identifier : AIDSLINE MED/97064119; Ablin RJ
An economic evaluation of oral compared with intravenous ganciclovir for maintenance treatment of newly diagnosed cytomegalovirus retinitis in AIDS patients.: Clin Ther. 1996 May-Jun;18(3):546-58. Unique Identifier : AIDSLINE MED/96426751; Sullivan SD; Mozaffari E; Johnson ES; Wolitz R; Follansbee SE; University of Washington, Seattle, USA.; This prospective, clinical economic study was done to determine the cost impact of oral compared with intravenous (i.v.) ganciclovir for the maintenance treatment of newly diagnosed cytomegalovirus ( CMV ) retinitis in patients
HIV and dentistry: public perceptions from two towns in Kent.: Prim Dent Care. 1995 Mar;2(1):26-8. Unique Identifier : AIDSLINE MED/97096971; Harwood P; Newton T; Gibbons D; Unit of Dental Public Health (UDPH), UMDS Guy's Hospital, London.; A survey of general public attitudes towards dentists who are HIV-positive or who have AIDS was carried out on two occasions three months apart, in the Kentish towns of Dartford and Tunbridge Wells. The BBC television programme, Panorama discussing this issue was screened between the two survey times. The results show
Primary dental care: the educational and ethical implications of treating patients with HIV infection.: Prim Dent Care. 1995 Mar;2(1):4-5. Unique Identifier : AIDSLINE MED/97096965; Cooper H; Mortimer Market Dental Clinic, University College London.
'London dentist in HIV scare': HIV and dentistry in popular discourse.: Prim Dent Care. 1995 Sep;2(2):59-60. Unique Identifier : AIDSLINE MED/97096979; Thorogood N; UMDS Guy's Hospital, London.; This is a qualitative analysis of the non-structured responses to a survey (see Notes ) which elicited people s attitudes towards being treated by HIV-positive dentists. These findings are discussed in terms of a sociology of knowledge, that is, an understanding of how individuals come to believe what they do. It use
Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene.: Cell. 1996 Oct 18;87(2):307-17. Unique Identifier : AIDSLINE MED/97015086; Holtschke T; Lohler J; Kanno Y; Fehr T; Giese N; Rosenbauer F; Lou J; Knobeloch KP; Gabriele L; Waring JF; Bachmann MF; Zinkernagel RM; Morse HC 3rd; Ozato K; Horak I; Institute of Virology and Immunobiology, University of Wurzburg,; Federal Republic of Germany.; Interferon consensus sequence binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Mice with a null mutation of ICSBP exhibit two prominent phenotypes related to previously described activities of the IRF family. The first is enhanced susceptibility to virus infecti
Telomeres and telomerase: a simple picture becomes complex.: Cell. 1996 Nov 1;87(3):369-75. Unique Identifier : AIDSLINE MED/97053777; Lundblad V; Wright WE; Department of Molecular and Human Genetics, Baylor College of; Medicine, Houston, Texas 77030, USA.
Regions in beta-chemokine receptors CCR5 and CCR2b that determine HIV-1 cofactor specificity.: Cell. 1996 Nov 1;87(3):437-46. Unique Identifier : AIDSLINE MED/97053783; Rucker J; Samson M; Doranz BJ; Libert F; Berson JF; Yi Y; Smyth RJ; Collman RG; Broder CC; Vassart G; Doms RW; Parmentier M; Department of Pathology and Laboratory Medicine, University of; Pennsylvania, Philadelphia 19104, USA.; Macrophage-tropic (M-tropic) HIV-1 strains use the beta-chemokine receptor CCR5, but not CCR2b, as a cofactor for membrane fusion and infection, while the dual-tropic strain 89.6 uses both. CCR5/2b chimeras and mutants were used to map regions of CCR5 important for cofactor function and specificity. M-tropic strains r
An activated form of Notch influences the choice between CD4 and CD8 T cell lineages.: Cell. 1996 Nov 1;87(3):483-92. Unique Identifier : AIDSLINE MED/97053787; Robey E; Chang D; Itano A; Cado D; Alexander H; Lans D; Weinmaster G; Salmon P; Department of Molecular and Cell Biology, University of; California, Berkeley 94720, USA.; Notch is a transmembrane receptor that controls cell fate decisions in Drosophila and whose role in mammalian cell fate decisions is beginning to be explored. We are investigating the role of Notch in a well-studied mammalian cell fate decision: the choice between the CD8 and CD4 T cell lineages. Here we report that e
Regulatory interactions between virgin and memory CD4 T lymphocytes.: Cell Immunol. 1996 Sep 15;172(2):141-8. Unique Identifier : AIDSLINE MED/97081026; Dozmorov IM; Miller RA; Department of Pathology, University of Michigan, Ann Arbor; 48109-0642, USA.; Naive and memory CD4 T cells from mouse spleen, alone or in a 1:1 mixture, were tested for Con A-induced proliferation in limiting dilution cultures. Dose-response curves for naive cells were linear, but curves for memory cells were hyperbolic, suggesting that positive responses required the activation of several cell
Difference in signal transduction for IL-10 and IFN-gamma production in a CD8+ T cell clone.: Cell Immunol. 1996 Sep 15;172(2):200-4. Unique Identifier : AIDSLINE MED/97081033; Minai Y; Goto M; Kohyama M; Hisatsune T; Nishijima KI; Kaminogawa S; Department of Applied Biological Chemistry, University of Tokyo,; Japan.; CD8+ T cell clones produced both interleukin 10 (IL-10) and interferon-gamma (IFN-gamma) when these cells were stimulated with a T-cell-specific mitogen, concanavalin A (Con A). One of these CD8+ T cell clones, 13G2, secreted IFN-gamma at similar levels with calcium ionophore, A23187, as well as by Con A, but IL-10 pr
Induction of inhibitory activity for B cell differentiation in human CD8 T cells with pokeweed mitogen, dimaprit, and cAMP upregulating agents: countersuppressive effect of platelet factor 4.: GY JOURNAL ARTICLE Cell Immunol. 1996 Sep 15;172(2):205-16. Unique Identifier : AIDSLINE MED/97081034; Crisi GM; Katz IR; Zucker MB; Thorbecke GJ; Department of Pathology, New York University School of Medicine; 10016, USA.
Coexpression of GD3 ganglioside with CD45RO in resting and activated human T lymphocytes.: Cell Immunol. 1996 Oct 10;173(1):131-48. Unique Identifier : AIDSLINE MED/97025419; Merritt WD; Taylor BJ; Der-Minassian V; Reaman GH; Center for Cancer and Transplantation Biology, Children's; Research Institute, Washington, DC 20010, USA.; The ganglioside GD3 is preferentially expressed on the surface of malignant T cell lymphoblasts and on resting T cells which express the memory cell phenotype, CD45RA-CD29+. However, GD3 expression in activated T cells and its potential function in proliferating normal and malignant T cells are unclear. Utilizing thre
The effect of a selective estrogen receptor modulator on the progression of spontaneous autoimmune disease in MRL lpr/lpr mice.: Cell Immunol. 1996 Oct 10;173(1):55-63. Unique Identifier : AIDSLINE MED/97025411; Apelgren LD; Bailey DL; Fouts RL; Short L; Bryan N; Evans GF; Sandusky GE; Zuckerman SH; Glasebrook A; Bumol TF; Division of Cardiovascular Research, Lilly Research Labs,; Indianapolis, Indiana 46285, USA.; The MRL lpr/lpr mouse strain is an animal model for the autoimmune disorder systemic lupus erythematosus (SLE). Pathologic changes in the mice include a severe proliferative glomerulonephritis, lymph node and spleen enlargement, increase in autoantibody titers, and shortened life spans. In the present investigation, f
Characterization of in vivo primary and secondary CD8+ T cell responses induced by recombinant influenza and vaccinia viruses.: Cell Immunol. 1996 Oct 10;173(1):96-107. Unique Identifier : AIDSLINE MED/97025415; Murata K; Garcia-Sastre A; Tsuji M; Rodrigues M; Rodriguez D; Rodriguez JR; Nussenzweig RS; Palese P; Esteban M; Zavala F; Department of Medical and Molecular Parasitology, New York; University School of Medicine, New York, New York 10010, USA.; We characterized the in vivo primary and secondary murine CD8+ T cell responses induced by immunization with influenza and vaccinia viruses, which were engineered to express the same H-2K(k)- and H-2K(d)-restricted epitopes. Our results show that the induction and magnitude of the primary CD8+ T cell response closely
Multiple levels of regulation for self-tolerance in beef insulin transgenic mice.: Cell Immunol. 1996 Nov 1;173(2):183-91. Unique Identifier : AIDSLINE MED/97069895; Teng YT; Williams DB; Hozumi N; Gorczynski RM; Samuel Lunenfeld Research Institute, Mount Sinai Hospital,; University of Toronto, Ontario, Canada.; To characterize the mechanism(s) of tolerance toward soluble self-antigens (Ags), beef insulin (BI) transgenic (Tg) mice were generated in which the transgene was expressed in pancreatic beta-cells. Our previous data showed that: (i) Ag-specific tolerance can be induced and/or maintained in peripheral T cells in thyme
Interferon-gamma-inducing factor, a novel cytokine, enhances Fas ligand-mediated cytotoxicity of murine T helper 1 cells.: Cell Immunol. 1996 Nov 1;173(2):230-5. Unique Identifier : AIDSLINE MED/97069901; Dao T; Ohashi K; Kayano T; Kurimoto M; Okamura H; Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc.,; Okayama, Japan.; Fas ligand (FasL), expressed on activated T cells, plays a central role in regulating the immune response by inducing apoptosis in activated lymphocytes through binding to its receptor, Fas. We report here that a newly discovered cytokine, interferon-gamma-inducing factor (IGIF) (H. Okamura et al., Nature 378, 88, 199
Elevation of intracellular cyclic AMP induces an anergic-like state in Th1 clones.: Cell Immunol. 1996 Nov 1;173(2):246-51. Unique Identifier : AIDSLINE MED/97069903; Cone RE; Cochrane R; Lingenheld EG; Clark RB; Department of Pathology, University of Connecticut Health Center,; School of Medicine and Dental Medicine, Farmington 06030-3105,; USA.; Because elevated intracellular cAMP suppresses T cell receptor (TCR)-mediated effector activity and/or proliferation in response to antigen but does not always affect IL-2-stimulated proliferation, the effects of cAMP on a T lymphocyte response to antigen resemble antigen-induced anergy. To test the hypothesis that el
Altered kinetics of CD4+ T cell proliferation and interferon-gamma production in the absence of CD8+ T lymphocytes in virus-infected beta2-microglobulin-deficient mice.: Cell Immunol. 1996 Nov 1;173(2):261-8. Unique Identifier : AIDSLINE MED/97069905; Vikingsson A; Pederson K; Muller D; Department of Medicine, University of Wisconsin--Madison, 53706,; USA.; CD8+ T cells are the major mediators of cytotoxic T cell activity controlling viral infections in normal mice. CD8+ T cells have also been implicated in regulating the activity of other immune cells. We have examined the possible regulatory role of CD8+ T cells on CD4+ T cells by comparing immune responses in mice exp
Collagen-induced arthritis in DBA/1 mice: cytokine gene activation following immunization with type II collagen.: Cell Immunol. 1996 Nov 1;173(2):269-75. Unique Identifier : AIDSLINE MED/97069906; Stasiuk LM; Abehsira-Amar O; Fournier C; INSERM Unite 283, Universite Rene Descartes, Paris, France.; Immunization of DBA/1 mice with bovine type II collagen (CII) in complete Freund s adjuvant (CFA) leads to collagen-induced arthritis as evidenced by joint inflammation. In this study, reverse transcription-polymerase chain reaction (RT-PCR) was used to demonstrate the activation of genes encoding for
TCR alpha beta+ anti-tumor cytolytic T lymphocytes express NKR-P1 whilethe anti-tumor activity of TCR gamma delta+ T lymphocytes is not correlated to NKR-P1 expression.: Cell Immunol. 1996 Nov 1;173(2):287-94. Unique Identifier : AIDSLINE MED/97069909; Yrlid U; Petersson E; Dohlsten M; Hedlund G; The Wallenberg Laboratory, Lund University, Sweden.; The CD8 alpha alpha homodimer as well as the NK cell receptor-protein 1 (NKR-P1) have been implicated to be preferentially expressed by T cells that develop extrathymically. We have earlier shown that intraperitoneal administration of radiated syngeneic W439 lymphoma cells in rat induces tumor-specific cytotoxic T cel
A kinetic comparative study on lymphocyte responses to superantigen and phytohemagglutinin: reciprocal presentation of superantigen on the surface of activated lymphocytes.: Cell Immunol. 1996 Nov 1;173(2):312-6. Unique Identifier : AIDSLINE MED/97069912; Ijichi S; Yamano Y; Osame M; Hall WW; Third Department of Internal Medicine, Faculty of Medicine,; Kagoshima University, Sakuragaoka, Japan.; s-ijichi@jms09.jeton.or.jp.; The kinetics of thymidine incorporation into fractionated T lymphocytes responding to bacterial superantigens were compared to those of cells activated by phytohemagglutinin (PHA). Evident differences between the kinetics of cell proliferation induced by PHA-P and staphylococcal enterotoxin B (SEB) emerged after Day 4
Functional expression of Fas (CD95) protein in autoimmune lpr mice.: Cell Immunol. 1996 Nov 25;174(1):35-41. Unique Identifier : AIDSLINE MED/97083494; Cui H; Ju ST; Sherr DH; Arthritis Center, Boston University Schools of Medicine and; Public Health, Massachusetts 02118, USA.; Fas (CD95) has been shown in multiple systems to play a critical role in deletion of autoreactive lymphocytes by transducing cell death signals. The role of Fas in clonal deletion may best be exemplified in autoimmune lpr mice, in which a defect in the lpr gene leads to persistence of autoreactive clones in the periph
Production of high levels of Th1 and Th2 cytokines in mice with acquired transplantation tolerance.: Cell Immunol. 1996 Nov 25;174(1):7-12. Unique Identifier : AIDSLINE MED/97083490; Holan V; Sedlackova K; R~uzickova M; Institute of Molecular Genetics, Academy of Sciences of the Czech; Republic, Prague.; Specific transplantation tolerance was induced in newborn mice by the intravenous injection of hematopoietic cells from semiallogeneic donors. Success of tolerance induction was tested by skin allografts. Spleen cells from mice bearing tolerated allografts for more than 60 days after transplantation spontaneously prod
Transgenic mice expressing the thymus leukemia antigen fail to control cutaneous herpes simplex virus infection.: Cell Immunol. 1996 Nov 25;174(1):84-9. Unique Identifier : AIDSLINE MED/97083499; Sharma P; Johnson CA; Bonneau RH; Lang CM; Chorney MJ; Department of Microbiology and Immunology, The Pennsylvania State; University College of Medicine, Hershey 17033, USA.; TL-transgenic mice expressing the thymus leukemia antigen demonstrate a lack of viral clearance following cutaneous HSV infection of the footpad. In this study, both uninfected and HSV-infected TL-transgenic mice demonstrate increased concentrations of IL-4 as well as decreased concentrations of IFN-gamma which may po
Saponins as vaccine adjuvants.: Crit Rev Ther Drug Carrier Syst. 1996;13(1-2):1-55. Unique Identifier : AIDSLINE MED/97006665; Kensil CR; Cambridge Biotech Corporation, Worcester, MA 01605, USA.; Naturally occurring triterpene glycosides (saponins) from Quillaja saponaria have considerable adjuvant activity. Adjuvant functions include stimulation of high levels of antibody to T-dependent and T-independent antigens, induction of mouse IgG1, IgG2b, and IgG2a isotypes, and induction of cytotoxic T lymphocyte resp
Identification of fusion regulatory protein (FRP)-1/4F2 related molecules: cytoskeletal proteins are associated with FRP-1 molecules that regulate multinucleated giant cell formation of monocytes and HIV-induced cell fusion.: Cell Struct Funct. 1995 Dec;20(6):473-83. Unique Identifier : AIDSLINE MED/96422451; Suga S; Tsurudome M; Ohgimoto S; Tabata N; Watanabe N; Nishio M; Kawano M; Komada H; Ito Y; Department of Microbiology, Mie University School of Medicine,; Japan.; Fusion regulatory proteins (FRPs) regulate virus-mediated cell fusion and multinucleated giant cell formation of monocytes. Anti-FRP-1 mAbs immunoprecipitated 80 kDa and 38 kDa proteins from HeLa cells. After long exposure other bands were detected, suggesting the presence of molecule(s) associated with FRP-1. To iden
Pericardial effusion and AIDS [letter]: Circulation. 1996 Nov 1;94(9):2312. Unique Identifier : AIDSLINE MED/97057357; Blanchard DG
Increased survival of AIDS patients with heart disease within 10 years? [letter]: Circulation. 1996 Nov 1;94(9):2312-3. Unique Identifier : AIDSLINE MED/97057358; Monsuez JJ; Vittecoq D; Kinney EL
Increased plasma thiobarbituric acid-reactive substances (TBARS) before opportunistic infection symptoms in HIV infected individuals.: Clin Chim Acta. 1996 Mar 29;247(1-2):181-7. Unique Identifier : AIDSLINE MED/97077670; Lopez O; Bonnefont-Rousselot D; Mollereau M; Olivier R; Montagnier L; Emerit J; Gentilini M; Delattre J; Hopital de la Pitie Salpetriere, Paris, France.
Erythema elevatum diutinum in human immunodeficiency virus-infected patients--report of a case and review of the literature.: Clin Exp Dermatol. 1996 May;21(3):222-5. Unique Identifier : AIDSLINE MED/97071442; Dronda F; Gonzalez-Lopez A; Lecona M; Barros C; Hospital General Penitenciario, Madrid, Spain.; Erythema elevatum diutinum (EED) is a rare chronic disease of unknown origin, part of the spectrum of cutaneous leucocytoclastic vasculitis. A case of EED in a 32-year-old HIV-infected male patient, with no previous opportunistic infections and a CD4+ cell count of less than 200/mm3, is reported. Therapy with oral dap
Isolated cutaneous non-tuberculous mycobacterial infection as a manifestation of AIDS.: Clin Exp Dermatol. 1996 May;21(3):226-9. Unique Identifier : AIDSLINE MED/97071443; Paige DG; Price DA; Crook T; Main J; Fry L; Weber JN; Department of Dermatology, St Mary's Hospital, London, UK.
Localized cutaneous infection caused by Mycobacterium avium complex in an AIDS patient.: Clin Exp Dermatol. 1996 May;21(3):230-1. Unique Identifier : AIDSLINE MED/97071444; Esteban J; Gorgolas M; Fernandez-Guerrero ML; Soriano F; Department of Medical Microbiology, Fundacion Fimenez Diaz,; Madrid, Spain.; Although infection due to Mycobacterium avium complex (MAC) has long been recognized, it was not until the current AIDS epidemic that isolation of these mycobacteria became common in microbiology laboratories. The disseminated form of the disease is the commonest type. Localized disease as the first manifestation of M
Site-directed serology of HIV-1 subtype B infection: relation between virus specific antibody levels and disease progression.: Clin Exp Immunol. 1996 Oct;106(1):35-9. Unique Identifier : AIDSLINE MED/97024467; Brostrom C; Sonnerborg A; Kim S; Sallberg M; Department of Immunology, Microbiology, Pathology, and Infectious; Diseases, Karolinska Institute, Huddinge, Sweden.; Activated T helper (Th) cell-dependent (TD) antibody responses were determined over an 8-10 year period in 28 patients infected with HIV-1 subtype B. Twelve patients remain asymptomatic with normal CD4+ cell counts for 101-114 months. These individuals were defined as long-term asymptomatic (LTA). Sixteen patients pro
Anti-CD8 treatment reduces the severity of inflammatory arthritis, but not vasculitis, in mercuric chloride-induced autoimmunity.: Clin Exp Immunol. 1996 Nov;106(2):280-5. Unique Identifier : AIDSLINE MED/97076257; Kiely PD; O'Brien D; Oliveira DB; Division of Renal Medicine, St George's Hospital Medical School,; London, UK.; Mercuric chloride (HgCl2) induces a T cell-dependent autoimmune syndrome in Brown- Norway (BN) rats characterized by a humoral response, tissue injury with an accumulation of CD8+ and CD4+ T cells, and an increase in tissue IL-4 mRNA and serum IgE suggesting Th2 cell activation. In
Ligation of CR1 (C3b receptor, CD35) on CD4+ T lymphocytes enhances viral replication in HIV-infected cells.: Clin Exp Immunol. 1996 Nov;106(2):297-303. Unique Identifier : AIDSLINE MED/97076259; Mouhoub A; Delibrias CC; Fischer E; Boyer V; Kazatchkine MD; INSERM U430, Hopital Broussais, Paris, France.; The present study provides evidence for a role of the C3b receptor, CR1 (CD35), in activation of HIV replication in CD4+ T lymphocytes. Ligation of CR1 with cross-linked anti-receptor MoAbs or with aggregated C3b enhanced transcription of viral genes and the release of p24 and RT activity from cultures of purified nor
Abundance of intraepithelial gamma delta T cells in hypertrophic obstructive but not in chronically infected adenoids.: Clin Exp Immunol. 1996 Nov;106(2):396-403. Unique Identifier : AIDSLINE MED/97076273; Olofsson K; Hellstrom S; Hammarstrom ML; Department of Otorhinolaryngology, Ume~a University Hospital,; Sweden.; Using quantitative morphometric analysis of immunohistochemically stained tissue sections we compared hypertrophic obstructive adenoids (HOA, n = 10) from children without middle ear disease with chronically infected adenoids (CIA, n = 10) from children with middle ear disease. gamma delta T cell receptor (TCR)+ cells
A genetic approach to the aetiology of giant cell arteritis: depletion of the CD8+ T-lymphocyte subset in relatives of patients with polymyalgia rheumatica and arteritis temporalis.: Clin Exp Rheumatol. 1995 Nov-Dec;13(6):745-8. Unique Identifier : AIDSLINE MED/96432183; Johansen M; Elling P; Elling H; Olsson A; Department of Internal Medicine, Randers Central Hospital,; Denmark.; OBJECTIVE: To investigate the CD8+ T-cell concentrations in first degree relatives of patients with giant cell arteritis (GCA) in order to evaluate whether the low CD8+ T-cell values found in most patients with GCA are acquired or hereditary. METHODS: Probands were 5 patients with arteritis temporalis (TA) and 15 with
Still's disease in a patient infected with human immunodeficiency virus type I.: Clin Exp Rheumatol. 1995 Nov-Dec;13(6):759-61. Unique Identifier : AIDSLINE MED/96432186; Antinori S; Rusconi S; Ridolfo AL; Orlando G; Clinica delle Malattie Infettive, Universita degli Studi di; Milano, Italy.; An autoreactive cellular immune response may be a part of HIV-1 infection. This autoimmune phenomenon also includes antibodies to collagen that can be associated to arthritis as a clinical condition. In this paper we describe a case of Still s disease in an adult HIV-1 infected patient who presented a marked ameliorat
CD4 cytopenia and occasional expansion of CD4+CD8+lymphocytes in Sjogren's syndrome.: Clin Exp Rheumatol. 1996 Mar-Apr;14(2):125-30. Unique Identifier : AIDSLINE MED/96353510; Ferraccioli GF; Tonutti E; Casatta L; Pegoraro I; De Vita S; Sala P; Ravaioli T; Bartoli E; Rheumatic Disease Unit, General Hospital, Udine, Italy.; OBJECTIVES: To define whether Sjogren s syndrome (SS) patients have lymphocytopenia compared to healthy controls, and to assess which lymphocyte subset might be involved. The presence of any concurrent infection was recorded. METHODS: A cohort of ten consecutive patients with SS was studied, and the results were compa
HIV infection in a male patient with systemic lupus erythematosus.: Clin Exp Rheumatol. 1996 May-Jun;14(3):317-20. Unique Identifier : AIDSLINE MED/96405309; Cimmino MA; De Maria A; Moggiana G; Parisi M; Querci G; Accardo S; Cattedra di Reumatologia, Dipartimento di Medicina Interna,; Genova, Italy.; The association between systemic lupus erythematosus and human immunodeficiency virus infection is extremely rare. We report a case of this association and discuss the possible reasons for its rarity, together with the difficulties encountered in the interpretation of the clinical and laboratory features.
Clinical experience with Octagam, a solvent detergent (SD) virus inactivated intravenous gammaglobulin.: Clin Exp Rheumatol. 1996 May-Jun;14 Suppl 15:S115-9. Unique Identifier : AIDSLINE MED/96426679; Brenner B; Institute of Hematology, Rambam Medical Center, Haifa, Israel.; OBJECTIVE: The safety and efficacy of Octagam, a solvent detergent (SD) virus inactivated intravenous gammaglobulin, were evaluated in 54 patients who received 301 infusions of Octagam for a total amount of 9301 grams, during 24 months. METHODS: Adverse reactions during and after Octagam infusion were carefully record
Effect of intravenous gammaglobulin on organ specific antibodies and lymphocyte subsets.: Clin Exp Rheumatol. 1996 May-Jun;14 Suppl 15:S37-40. Unique Identifier : AIDSLINE MED/96426667; Kahaly GJ; Department of Medicine III, Gutenberg-University Hospital, Mainz,; Germany.; OBJECTIVE: The intravenous (i.v.) administration of immunoglobulins (Ig) has resulted in clinical improvement and decreased autoantibody titers in a large number of autoimmune diseases. In this study, the in vivo effects of polyvalent Ig for i.v. use (IVIG) on the level and course of organ-specific antibodies and lymp
Virus validation studies of immunoglobulin preparations.: Clin Exp Rheumatol. 1996 May-Jun;14 Suppl 15:S47-52. Unique Identifier : AIDSLINE MED/96426669; Biesert L; Virological Research Group, Octapharma AG, Frankfurt, Germany.; OBJECTIVE: A validation study of the viral safety of a new polyvalent intravenous immunoglobulin (OCTAGAM) according to EU-guideline III/8115/89-EN and the requirements of the Federal Agency for Sera and Vaccines in Germany was undertaken in May 1994. The following processing step
HIV-related tuberculosis in British Columbia: indications of a rise in prevalence and a change in risk groups.: Clin Invest Med. 1996 Aug;19(4):271-8. Unique Identifier : AIDSLINE MED/97006281; Blenkush MF; Korzeniewska-Kozela M; Elwood RK; Black W; FitzGerald JM; Department of Medicine, University of British Columbia,; Vancouver.; OBJECTIVES: To identify patients with coexisting HIV infection and tuberculosis (TB) and recent trends in prevalence and factors associated with coinfection. DESIGN: Case review. PARTICIPANTS: All known patients with TB and HIV infection in British Columbia, in whom TB was diagnosed between 1990 and 1994. This group w
Symptomatic myopathies in HIV-1 infected patients untreated with antiretroviral agents--a clinico-pathological study of 30 consecutive patients.: Clin Neuropathol. 1996 Jul-Aug;15(4):221-5. Unique Identifier : AIDSLINE MED/96433627; Masanes F; Pedrol E; Grau JM; Coll-Vinent B; Casademont J; Miro O; Mallolas J; Urbano-Marquez A; Service of Internal Medicine, Hospital Clinic i Provincial,; University of Barcelona, Spain.; OBJECTIVE: To assess the clinico-pathological profile of symptomatic myopathies developing in HIV-1 infected patients before use of any antiretroviral therapy. DESIGN: Prospective, cross-sectional study. SETTING: University-referral, tertiary care Hospital. PATIENTS: Thirty consecutively admitted, HIV-1 infected patie
Human immunodeficiency virus infection of human bone derived cells.: Clin Orthop. 1996 Oct;(331):291-9. Unique Identifier : AIDSLINE MED/97050913; Campbell DG; Stephenson AJ; Li P; Oakeshott RD; Department of Orthopaedic Surgery and Trauma, Royal Adelaide; Hospital, Australia.; Human immunodeficiency virus infection of a human bone derived cell line was initiated by either cell free virus or with a cell to cell transmission method. The human bone derived cells were examined for 8 weeks, and virus infection was not detected when assessed by microscopy, immunofluorescence, reverse transcriptas
[Multiple sclerosis viewed from the point of HTLV-I associated myelopathy]: Rinsho Shinkeigaku. 1995 Dec;35(12):1498-500. Unique Identifier : AIDSLINE MED/96325749; Osame M; Arimura K; Nakagawa M; Third Department of Internal Medicine, Kagoshima University.; Several interesting facts are observed in multiple sclerosis (MS) when it was viewed from the point of HTLV-I-associated myelopathy (HAM). The distribution of the two diseases is completely segregated each other and deeply related to races as shown in the figure. Both diseases have significant linkage to HLA; HAM bein
Augmentation of leukocyte count with G-CSF in a patient with neutropenia before In-111 WBC scintigraphy.: Clin Nucl Med. 1996 Jul;21(7):544-6. Unique Identifier : AIDSLINE MED/96415543; Lin S; Marcus CS; Department of Radiology, Harbor-UCLA Medical Center, Torrance,; USA.; Neutropenia with persistent fevers and a wound infection developed in a patient with AIDS after an uncomplicated hysterectomy. After a single dose of G-CSF (granulocyte-colony stimulating factor), the WBC count transiently recovered, and an In-111 labeled WBC scan was successfully performed to exclude an intra-abdomin
Disseminated mycobacterium avium complex. Review of Ga-67 and TI-201 scans and autopsy findings.: Clin Nucl Med. 1996 Jul;21(7):547-56. Unique Identifier : AIDSLINE MED/96415544; Abdel-Dayem HM; Omar WS; Aziz M; Labombardi V; Difabrizio L; Kempf JS; Gillooley J; Department of Radiology, St. Vincent's Hospital and Medical; Center, New York, NY 10011, USA.; A retrospective analysis of the files and Ga-67 scan findings of 32 AIDS patients with established diagnosis of disseminated Mycobacterium avium complex (MAC) was conducted in order to determine the sensitivity of Ga-67 scans for the diagnosis of this disease and the sites of MAC organ involvement. Fourteen of the 32
Disposition of didanosine in HIV-seropositive patients with normal renal function or chronic renal failure: influence of hemodialysis and continuous ambulatory peritoneal dialysis.: Clin Pharmacol Ther. 1996 Nov;60(5):535-42. Unique Identifier : AIDSLINE MED/97096002; Knupp CA; Hak LJ; Coakley DF; Falk RJ; Wagner BE; Raasch RH; van der Horst CM; Kaul S; Barbhaiya RH; Dukes GE; Department of Metabolism and Pharmacokinetics, Bristol-Myers; Squibb Company, Princeton, NJ 08543, USA.; OBJECTIVE: To evaluate the pharmacokinetics of didanosine in patients with normal kidney function or chronic kidney failure. METHODS: Three groups of patients with human immunodeficiency virus (HIV) infection were studied: group I, six men with normal kidney function (creatinine clearance > 90 ml/min/1.73 m2); group I
Psychopathology in 90 consecutive human immunodeficiency virus-seropositive and acquired immune deficiency syndrome patients with mostly intravenous drug use history.: Compr Psychiatry. 1996 Jul-Aug;37(4):267-72. Unique Identifier : AIDSLINE MED/96424091; Perretta P; Nisita C; Zaccagnini E; Lorenzetti C; Nuccorini A; Cassano GB; Akiskal HS; Psychiatric Clinic I, University of Pisa, Italy.; This report presents systematic clinical data regarding psychiatric diagnoses, personal and family psychiatric histories, and symptomatologic aspects of 90 consecutive human immunodeficiency virus (HIV)-seropositive and acquired immune deficiency syndrome (AIDS) patients, of whom slightly less than two thirds were at
Transmission of rabies by corneal graft.: Cornea. 1996 Jul;15(4):431-3. Unique Identifier : AIDSLINE MED/96372777; Javadi MA; Fayaz A; Mirdehghan SA; Ainollahi B; Department of Ophthalmology, Shaheed Beheshti University of; Medical Sciences, Tehran, I.R. Iran.; Viruses such as human immunodeficiency virus, herpes simplex virus, cytomegalovirus , hepatitis B, hepatitis C, and rabies can be transmitted to the recipient by corneal transplantation. Very few cases of rabies have been reported. Here we report two cases of rabies transmitted by t
Herpes zoster peripheral ulcerative keratitis in patients with the acquired immunodeficiency syndrome.: Cornea. 1996 Sep;15(5):446-50. Unique Identifier : AIDSLINE MED/97016284; Neves RA; Rodriguez A; Power WJ; Muccioli C; Lane L; Belfort R Jr; Foster CS; Department of Ophthalmology, Massachusetts Eye & Ear Infirmary,; Harvard Medical School, Boston, Massachusetts, USA.; The purpose of this study was to describe the clinical characteristics and course of peripheral ulcerative keratitis (PUK) secondary to herpes varicella-zoster virus in patients with the acquired immunodeficiency syndrome (AIDS). Three AIDS patients with ocular herpes zoster infection (mean age at onset, 33.0 years; r
The politics of marginalization: the appropriation of AIDS prevention messages among injection drug users.: Cult Med Psychiatry. 1995 Dec;19(4):425-52. Unique Identifier : AIDSLINE MED/96435408; Connors MM; Department of Social Medicine, Harvard Medical School, Boston, MA; 02115, USA.; This essay addresses the space between a cultural critique and a class analysis of HIV transmission. It explores how injection drug users, as a disempowered group, resist hegemony through dissent. Distrust of the medical establishment and severe social and legal constraints force injection drug users to reconstruct th
RNA packaging.: Curr Top Microbiol Immunol. 1996;214:177-218. Unique Identifier : AIDSLINE MED/96383568; Berkowitz R; Fisher J; Goff SP; Gladstone Institute for Virus Research, University of California,; San Francisco 94110-9100, USA.
Role of auxiliary proteins in retroviral morphogenesis.: Curr Top Microbiol Immunol. 1996;214:219-35. Unique Identifier : AIDSLINE MED/96383569; Cohen EA; Subbramanian RA; Gottlinger HG; Departement de Microbiologie et Immunologie, Universite de; Montreal,Canada.
Use of heterologous expression systems to study retroviral morphogenesis.: Curr Top Microbiol Immunol. 1996;214:237-60. Unique Identifier : AIDSLINE MED/96383570; Boulanger P; Jones I; Laboratoire de Virologie Moleculaire, Centre National de la; Recherche Scientifique (URA-1487), Montpellier, France.
Intracellular transport of retroviral capsid components.: Curr Top Microbiol Immunol. 1996;214:25-63. Unique Identifier : AIDSLINE MED/96383564; Krausslich HG; Welker R; Department of Cell Biology and Virology, Heinrich Pette Institute; of Experimental Virology and Immunology, Hamburg, Germany.
Dynamic interactions of the Gag polyprotein.: Curr Top Microbiol Immunol. 1996;214:65-94. Unique Identifier : AIDSLINE MED/96383565; Craven RC; Parent LJ; Department of Microbiology and Immunology, The Pennsylvania State; University School of Medicine, Hershey 17033, USA.
Proteolytic processing and particle maturation.: Curr Top Microbiol Immunol. 1996;214:95-131. Unique Identifier : AIDSLINE MED/96383566; Vogt VM; Section of Biochemistry, Molecular and Cell Biology, Cornell; University, Ithaca, NY 14853, USA.
Role of nitric oxide-induced immune suppression in toxoplasmosis during pregnancy and in infection by a virulent strain of Toxoplasma gondii.: Curr Top Microbiol Immunol. 1996;219:141-54. Unique Identifier : AIDSLINE MED/96383536; Candolfi E; Villard O; Thouvenin M; Kien TT; Institut de Parasitologie et de Pathologie Tropicale de la; Faculte de Medecine de Strasbourg, France.
AIDS-associated cerebral toxoplasmosis: an update on diagnosis and treatment.: Curr Top Microbiol Immunol. 1996;219:209-22. Unique Identifier : AIDSLINE MED/96383542; Ammassari A; Murri R; Cingolani A; De Luca A; Antinori A; Department of Infectious Diseases, Catholic University, Rome,; Italy.
Co-infection of Toxoplasma gondii with other pathogens: pathogenicity and chemotherapy in animal models.: Curr Top Microbiol Immunol. 1996;219:223-33. Unique Identifier : AIDSLINE MED/96383543; Lacroix C; Brun-Pascaud M; Maslo C; Chau F; Romand S; Derouin F; INSERM Unite 13, Hopital Bichat-Claude Bernard, Paris, France.
Cutaneous T-cell lymphoma of the eyelid in a patient with acquired immunodeficiency syndrome.: Cutis. 1996 Jun;57(6):437-40. Unique Identifier : AIDSLINE MED/96397966; Gibertson EO; Hunt SJ; Spellman MC; University of California, San Diego, School of Medicine, Division; of Dermatology 92103, USA.; Cutaneous T-cell lymphoma (CTCL) is significantly less common than B-cell lymphoma in patients with acquired immunodeficiency syndrome (AIDS). Periocular involvement by CTCL usually occurs in the setting of more widespread plaque or tumor-stage disease; therefore, CTCL localized solely to the periocular region is rare
Assessment of right ventricle function and pulmonary artery circulation by cine-MRI in patients with AIDS.: Chest. 1996 Nov;110(5):1243-7. Unique Identifier : AIDSLINE MED/97072462; Casalino E; Laissy JP; Soyer P; Bouvet E; Vachon F; Infectious Disease Intensive Care Unit, Bichat-Claude Bernard; University Hospital, Paris, France.; OBJECTIVE: To evaluate right ventricle (RV) anatomy and performance and its relationships with pulmonary circulation in AIDS patients. DESIGN: We conducted a prospective blinded study by using cine-MRI, a well-accepted method to assess RV and pulmonary circulation. SETTING: A university hospital. PARTICIPANTS: Ten hea
[Responsibility of the patient for preoperative disclosure of HIV infection]: Chirurg. 1996 Aug;67(8):Suppl 193-4. Unique Identifier : AIDSLINE MED/96413992
[Immunohistochemical study of T and B cells in dental pulp]: Chung Hua Kou Chiang Hsueh Tsa Chih. 1995 Nov;30(6):346-8. Unique Identifier : AIDSLINE MED/96349213; Wu H; Wen L
Elevated relative fluorescence intensity of CD38 antigen expression on CD8+ T cells is a marker of poor prognosis in HIV infection: results of 6 years of follow-up.: Cytometry. 1996 Mar 15;26(1):1-7. Unique Identifier : AIDSLINE MED/96405334; Liu Z; Hultin LE; Cumberland WG; Hultin P; Schmid I; Matud JL; Detels R; Giorgi JV; Department of Epidemiology, UCLA School of Public Health, USA.; Relative fluorescence intensity measurements from a flow cytometer were used to evaluate expression of CD38 and HLA-DR antigens. These molecules are associated with cellular activation and are present at increased levels on the CD8+ lymphocytes of HIV-infected subjects. In the current study, the prognostic value of me
Use of CD45 fluorescence and side-scatter characteristics for gating lymphocytes when using the whole blood lysis procedure and flow cytometry.: Cytometry. 1996 Mar 15;26(1):16-21. Unique Identifier : AIDSLINE MED/96405336; Nicholson JK; Hubbard M; Jones BM; Immunology Branch, National Center for Infectious Diseases,; Centers for Disease Control and Prevention, U.S. Department of; Health and Human Services, Atlanta, Georgia, USA.; The light-scatter characteristics of lymphocytes are commonly used to gate lymphocytes for further analysis in a lysed whole-blood assay. Because lymphocytes can be identified by antigens that they possess, a light-scatter gate can be validated by measuring parameters other than light scatter. When a specimen possesse
Lymphocyte immunoregulatory cells present in semen from human immunodeficiency virus (HIV)-infected individuals: a report from the HIV Heterosexual Transmission Study.: Cytometry. 1996 Mar 15;26(1):47-51. Unique Identifier : AIDSLINE MED/96405340; Denny TN; Skurnick JH; Garcia A; Perez G; Passannante MR; Colon J; Sheffet A; Weiss SH; Louria D; Department of Pediatrics, New Jersey Medical School, Newark; 07013, USA.; The purpose of this study was to determine the types and distribution of immune subsets present in semen from human immunodeficiency virus (HIV)-infected (HIV+) individuals and to compare these values with those measures in semen from HIV-negative (HIV-) individuals. To accomplish this, a direct three-color monoclonal
Performance evaluation of the FACSCount System: a dedicated system for clinical cellular analysis.: Cytometry. 1996 Mar 15;26(1):52-9. Unique Identifier : AIDSLINE MED/96405341; Strauss K; Hannet I; Engels S; Shiba A; Ward DM; Ullery S; Jinguji MG; Valinsky J; Barnett D; Orfao A; Kestens L; Becton Dickinson Immunocytometry Systems Europe, Erembodegem,; Belgium.; Flow cytometers are instruments that can determine multiparameter data simultaneously and have a great potential in providing unique information about cells. The FACSCount System is designed as the first dedicated flow cytometer for the clinical laboratory. Its current configuration provides CD4, CD8, and CD3 absolute
Initial results of Central European Immunophenotyping Quality Control Program (CEQUAL).: Cytometry. 1996 Jun 15;26(2):108-12. Unique Identifier : AIDSLINE MED/96414025; Vesely R; Barths J; Vanlangendonck F; Hannet I; Strauss K; Medical Faculty University P.J. Safarik, Kosice, Slovakia.; The new Quality Control Program in Immunophenotyping for Central Europe (CEQUAL) was created in 1993. Its first formal send-around proficiency exercise, consisting of a stained stabilised preparation of leukocytes, took place in November 1993. Forty-one laboratories from Slovakia
Immunophenotypic analysis of the T cell receptor V beta repertoire in CD4+ and CD8+ lymphocytes from normal peripheral blood.: Cytometry. 1996 Jun 15;26(2):148-53. Unique Identifier : AIDSLINE MED/96414031; McCoy JP Jr; Overton WR; Schroeder K; Blumstein L; Donaldson MH; Division of Pediatric Hematology/Oncology, Cooper; Hospital/University Medical Center, University of Medicine and; Dentistry of New Jersey-Robert Wood Johnson Medical School,; Camden 08103, USA.; The antigenic specificity of the majority of T lymphocytes in the peripheral blood is determined by the combination of alpha and beta variable region chains present in the T cell receptor complex. Currently, the V beta chains are grouped into 25 families. Historically, determination of V beta usage has relied on detec
Survey of quality assurance/quality control practices for CD4+ lymphocyte counting.: Cytometry. 1996 Jun 15;26(2):178-80. Unique Identifier : AIDSLINE MED/96414036; Koepke JA; Duke University Medical Center, Durham, North Carolina 27710,; USA.
Diagnosis of Cryptosporidium parvum in patients with severe diarrhea and AIDS.: Dig Dis Sci. 1996 Nov;41(11):2286-90. Unique Identifier : AIDSLINE MED/97099408; Greenberg PD; Koch J; Cello JP; Division of Gastroenterology, Hepatology, and Clinical Nutrition,; San Francisco General Hospital, California 94110, USA.; The sensitivity of noninvasive stool microscopy and endoscopic biopsies from the upper and lower gastrointestinal tract in the diagnosis of Cryptosporidium parvum in patients with AIDS is not known. We evaluated 30 severely immunocompromised patients with AIDS and diarrhea caused by C. parvum. C. parvum was diagnosed
Cytomorphology of progressive multifocal leukoencephalopathy (PML): review of sixteen cases occurring in HIV-positive patients.: Diagn Cytopathol. 1996 Feb;14(1):4-9. Unique Identifier : AIDSLINE MED/96430987; Yu GH; Hidvegi DF; Cajulis RS; Brody BA; Levy RM; Department of Pathology, Northwestern University Medical School,; Chicago, IL 60611, USA.; Progressive multifocal leukoencephalopathy (PML) is a fatal demyelinating disorder of the central nervous system (CNS) resulting from infection of oligodendrocytes by JC virus. Although all patients immunocompromised by any congenital, acquired, or iatrogenic condition are at risk, the population which currently accou
Cytomorphology of primary CNS lymphoma: review of 23 cases and evidence for the role of EBV.: Diagn Cytopathol. 1996 Mar;14(2):114-20. Unique Identifier : AIDSLINE MED/96253439; Yu GH; Montone KT; Frias-Hidvegi D; Cajulis RS; Brody BA; Levy RM; Department of Pathology, Northwestern University Medical School,; Chicago, IL, USA.; Primary non-Hodgkin s lymphoma of the central nervous system (PCNSL) has recently increased in incidence, due primarily to an enlarging immunosuppressed patient population. The pathogenetic role of Epstein-Barr virus (EBV) is of interest due to its established role in other lymphop
Role of cytochrome P450 3A4 in human metabolism of MK-639, a potent human immunodeficiency virus protease inhibitor.: Drug Metab Dispos. 1996 Mar;24(3):307-14. Unique Identifier : AIDSLINE MED/96417630; Chiba M; Hensleigh M; Nishime JA; Balani SK; Lin JH; Department of Drug Metabolism, Merck Research Laboratories, West; Point, PA 19486, USA.; MK-639 (L-735,524) is a potent human immunodeficiency virus protease inhibitor under investigation in the treatment of acquired immunodeficiency syndrome. Five in vitro approaches have been used to identify the cytochrome P450 isoform(s) responsible for the human microsomal oxidative metabolism of MK-639. These approa
Gender, cocaine and during-treatment HIV risk reduction among injection opioid users in methadone maintenance.: Drug Alcohol Depend. 1996 May;41(1):1-7. Unique Identifier : AIDSLINE MED/96385460; Camacho LM; Bartholomew NG; Joe GW; Cloud MA; Simpson DD; Institute of Behavioral Research, Texas Christian University,; TCU, Fort Worth 76129, USA.; HIV risk behavior was examined in relation to gender and cocaine use among a sample of 327 daily opioid users in methadone maintenance treatment. Women and cocaine users tended to be at higher risk than men and non-users prior to treatment entry. Significant reductions in both injection and sex-related risks occurred
Retention in a low-threshold methadone maintenance program.: Drug Alcohol Depend. 1996 May;41(1):55-9. Unique Identifier : AIDSLINE MED/96385466; Torrens M; Castillo C; Perez-Sola V; Department of Psychiatry, Hospital del Mar, Universitat Autonoma; de Barcelona, Spain.; In 370 opioid-dependent patients included consecutively in a low-threshold methadone maintenance program, the effect of different variables on the retention rate was assessed. The variables included the patients age, sex, family situation, employment status, length of heroin use, current route of drug consumption, pr
[The HIV viral load: new aspects and limits of its clinical use]: Dtsch Med Wochenschr. 1996 Oct 18;121(42):1303-8. Unique Identifier : AIDSLINE MED/97062359; Muhlhofer A; Bogner JR; Goebel FD; Medizinische Poliklinik, Klinikum Innenstadt, Universitat; Munchen.
[HIV protease inhibitors. A new drug class in antiretroviral therapy]: Dtsch Med Wochenschr. 1996 Nov 1;121(44):1369-74. Unique Identifier : AIDSLINE MED/97080414; Mauss S; Seidlitz B; Jablonowski H; Haussinger D; Klinik fur Gastroenterologie, Hepatologie und Infektiologie,; Universitat Dusseldorf.
Peripheral neuropathy in AIDS patients at Kenyatta National Hospital.: East Afr Med J. 1996 Aug;73(8):538-40. Unique Identifier : AIDSLINE MED/97054092; Mbuya SO; Kwasa TO; Amayo EO; Kioy PG; Bhatt SM; Nyeri Provincial General Hospital, Kenya.; Between June and December 1992 forty AIDS patients as defined by the CDC criteria, admitted to the medical wards of the Kenyatta National Hospital, were studied to determine the prevalence and pattern of peripheral neuropathy . Their mean age was 33 +/- 3 years with a
Human immunodeficiency virus type 1 reverse transcriptase: role of Tyr115 in deoxynucleotide binding and misinsertion fidelity of DNA synthesis.: EMBO J. 1996 Aug 15;15(16):4434-42. Unique Identifier : AIDSLINE MED/97015142; Martin-Hernandez AM; Domingo E; Menendez-Arias L; Centro de Biologia Molecular Severo Ochoa, CSIC-Universidad; Autonoma de Madrid, Spain.; Tyr115 is located in the vicinity of the polymerase catalytic site of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. Site-directed mutagenesis was used to generate variant enzymes having Phe, Trp, Ala, Ser, Asp or Lys instead of Tyr115. The substitution of Tyr115 by Phe renders a fully active polym
Purification and biochemical heterogeneity of the mammalian SWI-SNF complex.: EMBO J. 1996 Oct 1;15(19):5370-82. Unique Identifier : AIDSLINE MED/97050842; Wang W; Cote J; Xue Y; Zhou S; Khavari PA; Biggar SR; Muchardt C; Kalpana GV; Goff SP; Yaniv M; Workman JL; Crabtree GR; Howard Hughes Medical Institute, Department of Developmental; Biology, Stanford University, CA 94305-5428, USA.; We have purified distinct complexes of nine to 12 proteins [referred to as BRG1-associated factors (BAFs)] from several mammalian cell lines using an antibody to the SWI2-SNF2 homolog BRG1. Microsequencing revealed that the 47 kDa BAF is identical to INI1. Previously INI1 has been shown to interact with and activate h
A nuclear role for the Fragile X mental retardation protein.: EMBO J. 1996 Oct 1;15(19):5408-14. Unique Identifier : AIDSLINE MED/97050845; Fridell RA; Benson RE; Hua J; Bogerd HP; Cullen BR; Department of Genetics, Duke University Medical Center, Durham,; NC 27710, USA.; Fragile X syndrome results from lack of expression of a functional form of Fragile X mental retardation protein (FMRP), a cytoplasmic RNA-binding protein of uncertain function. Here, we report that FMRP contains a nuclear export signal (NES) that is similar to the NES recently identified in the Rev regulatory protein
Epidemiology of HIV-2 infection in Spain. The HIV-2 Spanish Study Group.: Eur J Clin Microbiol Infect Dis. 1996 May;15(5):383-8. Unique Identifier : AIDSLINE MED/96385552; Soriano V; Gutierrez M; Caballero E; Cilla G; Fernandez JL; Aguilera A; Tuset C; Dronda F; Martin AM; Carballo E; Lopez I; Gonzalez-Lahoz J; Service of Infectious Diseases, CIC, Instituto de Salud Carlos; III, Madrid, Spain.; Human immunodeficiency virus type 2 (HIV-2) infection is endemic in West Africa, where it is responsible for many cases of AIDS. HIV-2-infected subjects have been described in other countries, mainly African immigrants, although infection in native individuals has been reported as well. The first cases of HIV-2 infect
Recurrent brain abscesses in an HIV-positive patient with hereditary hemorrhagic telangiectasia and arteriovenous malformations of the lung.: Eur J Clin Microbiol Infect Dis. 1996 May;15(5):407-10. Unique Identifier : AIDSLINE MED/96385558; Thurnheer R; Vernazza PL; Galeazzi RL; Department of Medicine, Kantonsspital St. Gallen, Switzerland.; Patients with hereditary hemorrhagic telangiectasia are at risk for the development of brain abscesses. The history of a 47-year-old man infected with the human immunodeficiency virus and with hereditary hemorrhagic telangiec