1994

Universal precautions : guidelines for hospital employees. [videorecording]: Control Committee [Houston, Tex.] : The Center, [1989] 1 videocassette (8 min.) : sd., col. ; 1/2 in Unique Identifier : AIDSLINE AV/9408957
Bloodborne pathogens. [videorecording]: Boston, Mass. : Jones & Bartlett Publishers, c1993 1 videocassette (20 min.) : sd., col. ; 1/2 in Unique Identifier : AIDSLINE AV/9421132; Hall K; Jackson M; McKinnon S; (Producer) Millions of workers around the world are at risk of occupational exposure to bloodborne pathogens, such as Human Immunodeficiency Virus (HIV) and Hepatitis B Virus. This video, developed by the National Safety Council s First Aid Institute, thoroughly reviews the new standards issued by the Occupational S
Facing AIDS : stories of healthcare workers : a documentary. [videorecording]: New York, N.Y. : National League for Nursing, c1993 1 videocassette (28 min.) : sd., col. ; 1/2 in. + 1 guide (19 p.) (Pub. / National League for Nursing ; no. 42-2594) Unique Identifier : AIDSLINE AV/9421275; Rosenberg R; Gold T
The:Medical informatics response to the HIV epidemic. [sound recording]: Elkridge, MD : Chesapeake Audio/Video Communications, [1993?] 1 sound cassette : analog Unique Identifier : AIDSLINE AV/9430918
Kaposi's sarcoma in Illinois : a comparison of AIDS cases to classic cases.: Springfield, Ill. : Illinois Dept. of Public Health, Division of Epidemiologic Studies, [1989] 14 leaves (Epidemiologic report series ; 89:4) Unique Identifier : AIDSLINE CAT/9404760; Lehnherr M; Howe HL
[Neunte und zehnte Alfred-Marchionini-Gedachtnisvorlesung.]: Reinbek bei Hamburg : Alfred-Marchionini-Stiftung, [1990] 96 p. : ill., ports (Schriften der Alfred-Marchionini-Stiftung ; Heft 15) Unique Identifier : AIDSLINE CAT/9407670
Positively aware : the monthly journal of the Test Positive Aware Network. Dec. 1990-: Chicago, Ill. : The Network, 1990- v. : ill., ports Unique Identifier : AIDSLINE CAT/9413754
Guidelines for the clinical management of HIV infection in adults : December 1991.: [Geneva, Switzerland] : World Health Organization, [1991] 1 v. (various pagings) : ill Unique Identifier : AIDSLINE CAT/9416170
HIV in the health care workplace.: Washington, DC : Congress of the United States, Office of Technology Assessment, [1991] 18 p (HIV-related issues. Background paper 7) Unique Identifier : AIDSLINE CAT/9413130
[Primera evaluacion del Plan Nacional a Mediano Plazo de Prevencion y Control del Sindrome de Inmunodeficiencia Adquirida (SIDA), de la Republica de Honduras.]: Tegucigalpa : Secretaria de Estado en los Despachos de Salud Publica, [1991] 57 leaves Unique Identifier : AIDSLINE CAT/9409882
[SIDA : la plaga del siglo XXI.]: Barcelona : Editorial CLIE, c1991 144 p. : ill., ports (Libros CLIE) Unique Identifier : AIDSLINE CAT/9410012; Sansano R
The:Challenge of HIV/AIDS in communities of color.: Syndrome Washington, DC : National Commission on AIDS, [1992] 1 v. (various pagings) : ill Unique Identifier : AIDSLINE CAT/9423410
[Investigacion de la seroepidemiologia de la infeccion por el virus de la inmunodeficiencia humana (VIH) : de los conocimientos, actitudes y practicas sobre el sindrome de inmunodeficiencia humana (SIDA) en el casco urbano de la ciudad de San Pedro Sula, Honduras, C.A., 1989.]: [Honduras] : Cruz Roja Hondurena, [1992?] 118 leaves : ill Unique Identifier : AIDSLINE CAT/9410082; Rivera Cardona AJ; Rivera Cardona AJ
Pediatric AIDS-related discharges in a sample of U.S. hospitals : demographics, diagnoses, and resource use.: Rockville, Md. (2101 E. Jefferson St., Suite 501, Rockville 20852) : U.S. Dept. of Health and Human Services, Public Health Service, Agency for Health Care Policy and Research, [1992] 13 p (Publication ; no. (AHCPR) 92-0031) Unique Identifier : AIDSLINE CAT/9414131; Ball JK; Thaul S
[Guia para enfermeras en la atencion del paciente con HIV/SIDA.]: Mexico, D.F. : El Hospital, [1992] xiii, 65 p. : ill Unique Identifier : AIDSLINE CAT/9413768
[AIDS--tabu : ursprung, utveckling, behandling.]: Stockholm : Carlsson, c1992 255 p. : ill., ports Unique Identifier : AIDSLINE CAT/9432613; Ljungqvist KI
Difficult-to-reuse needles for the prevention of HIV infection among injecting drug users.: Washington, D.C. : Congress of the United States, Office of Technology Assessment : For sale by the U.S. G.P.O., Supt. of Docs., [1992] vi, 17 p (HIV-related issues ; 9) Unique Identifier : AIDSLINE CAT/9411289
Abstracts of papers presented at the 1993 meeting on modern approaches to new vaccines including prevention of AIDS : September 20-September 24, 1993.: Cold Spring Harbor, N.Y. : Cold Spring Harbor Laboratory, [1993?] xxvi, 99 p Unique Identifier : AIDSLINE CAT/9417281; Brown F
Medical record abstraction form and guidelines for assessing quality of care for hospitalized patients with AIDS-related pneumocystis carinii pneumonia.: Santa Monica, CA : Rand, 1993 xv, 172 p (A Rand note ; N-3549-AHCPR) Unique Identifier : AIDSLINE CAT/9423398; Bennett CL
[Entrevista al SIDA.]: Santafe de Bogota, D.C. : Editorial Hojas e Ideas, 1993 131 p Unique Identifier : AIDSLINE CAT/9418232; Romero VJ
A:Guide for epidemiological studies of oral manifestations of HIV infections.: Geneva : World Health Organization, 1993 ix, 27 p Unique Identifier : AIDSLINE CAT/9431169; Melnick SL
Patients with human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS).: Affairs Chicago, Ill. : American Dental Association, Council on Community Health, Hospital, Institutional, and Medical Affairs, [1993] 13 leaves (Oral health care guidelines) Unique Identifier : AIDSLINE CAT/9431413
The:slow plague : a geography of the AIDS pandemic.: Oxford, UK ; Cambridge, USA : Blackwell Publishers, 1993 xvi, 228 p. : ill Unique Identifier : AIDSLINE CAT/9421103; Gould P
Learning about AIDS : scientific and social issues. 2nd ed.: Edinburgh ; New York : Churchill Livingstone, 1994 xii, 125 p. : ill Unique Identifier : AIDSLINE CAT/9431791; Aggleton P
HIV and the pathogenesis of AIDS.: Washington, D.C. : ASM Press, c1994 xiv, 359 p. : ill Unique Identifier : AIDSLINE CAT/9432520; Levy JA
An:atlas of differential diagnosis in HIV disease.: New York : Parthenon Pub. Group, 1995 139 p. : ill (The Encyclopedia of visual medicine series) Unique Identifier : AIDSLINE CAT/9432810; Lipman MC; Gluck TA; Johnson MA
Cytokines in health and disease.: Cytokines in Health and Disease. Kunkel SL and Remick DG, eds. New York, Marcel Dekker, 568 p., 1992.. Unique Identifier : AIDSLINE ICDB/94605808; Anonymous; No affiliation given; Cytokines as a group may be defined as soluble mediators secreted by one cell that acts on another cell or organ; the term is generally reserved for protein mediators. Recent advances in molecular biology have provided purified recombinant material for exacting studies of the unique roles of cytokines. The availabilit
Gastrointestinal and genitourinary tract tumors in patients at risk or with HIV infection (Meeting abstract).: Third Annual Pittsburgh Cancer Conference. November 19-20, 1992. Pittsburgh, PA, p. 10, 1992.. Unique Identifier : AIDSLINE ICDB/94698060; Douglas D; Patel A; Wolf B; Remick S; Albany Medical Coll., Albany, NY 12208; AIDS-defining neoplasms include Kaposi s sarcoma, primary central nervous system lymphoma, and non-Hodgkin s lymphoma . As we enter the second decade of the HIV epidemic, it is apparent that other solid tumors are seen in these patients (pts) as well. The AIDS Program of the Albany
Recurrent cervical intraepithelial neoplasia (CIN) in human immunodeficiency virus (HIV) seropositive women (Meeting abstract).: 24th Annual Meeting of the Society of Gynecologic Oncologists. February 7-10, 1993, Palm Desert, CA, A31 1993. Unique Identifier : AIDSLINE ICDB/94698472; Maiman M; Fruchter R; Serur E; Levine P; SUNY-Health Science Center at Brooklyn, Brooklyn, NY 11203; To determine the effect of HIV infection on patterns of recurrence of CIN, 184 patients of known HIV serostatus were followed after standard ablative therapy. The clinical course of 45 HIV positive (+) women was compared with 139 HIV negative (-) women. Patients were treated with cryotherapy, laser vaporization or con
International Association for Comparative Research on Leukemia and Related Diseases, 16th symposium. July 11-16, 1993, Montreal, Quebec, Canada.: International Association for Comparative Research on Leukemia and Related Diseases, 16th Symposium. July 11-16, 1993, Montreal, Quebec, Canada, 1993.. Unique Identifier : AIDSLINE ICDB/94698607; Anonymous; No affiliation given; The International Association for Comparative Research on Leukemia and Related Diseases held their 16th symposium on July 11-16, 1993 in Montreal, Quebec, Canada . The main topics covered at this meeting include molecular abnormalities in leukemia, mechanisms of signal transduction
Interactions between HTLV-1 Tax and NF-kappa B/rel oncoproteins in T cells (Meeting abstract).: International Association for Comparative Research on Leukemia and Related Diseases, 16th Symposium. July 11-16, 1993, Montreal, Quebec, Canada, A18, 1993.. Unique Identifier : AIDSLINE ICDB/94698625; Lanoix J; Lacoste J; Pepin N; Le L; Roulston A; Rice N; Hiscott J; Lady Davis Inst., Jewish General Hospital and Dept. of; Microbiology and Immunology, McGill Univ., Montreal H3T 1E2,; Canada; Molecular, biochemical and epidemiological evidence strongly implicate HTLV-1 as an etiologic agent of adult T cell leukemia (ATL). The Tax protein of HTLV-1, a positive transcriptional activator of HTLV-1 gene expression is a viral oncogene that also increases transcription of cellular genes. One of the cellular targ
No advantage for the use of an early high dose chemotherapy (HDCT) with autologous bone marrow transplant (ABMT) in first line treatment of poor risk nonseminomatous germ cell tumors (NSGCT) (Meeting abstract).: Fourth International Congress on Anti-cancer Chemotherapy. February 2-5, 1993, Paris, France, p. 131, 1993.. Unique Identifier : AIDSLINE ICDB/94697878; Cure H; Droz JP; Pico JL; Biron P; Kerbrat P; Heron JH; Chevreau C; Chevallier B; Fargeot P; Bouzy J; et al; French Federation of Cancer Centers, Clermont Ferrand, France; In order to evaluate the place of HDCT + ABMT in first line treatment of NSGCT we have conducted between 1/1988 and 6/1991 a randomized trial in 115 non-pretreated patients with poor risk characteristics according to the Institut Gustave Roussy prognostic mathematical model (Droz, Cancer 62:54, 1988). Arm A was the NC
Crucial needs in AIDS research.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 1. Unique Identifier : AIDSLINE PRIM11/94191593; Gallo RC; [No abstract appeared in the published proceedings]
AIDS animal models program.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 108. Unique Identifier : AIDSLINE PRIM11/94191594; April M; NIH, DHHS, Bethesda, Maryland 20892.; AIDS ANIMAL MODELS PROGRAM: The AIDS Animal Models Program promotes the characterization and validation of existing models, expands development of new models, and coordinates these common interests with other NIH institutes. Basic and clinical research on AIDS-related diseases has been greatly accelerated by the devel
Characterization of SIV isolates from macaques treated with the nucleoside analog, 9-(2-phosphonylmethoxyethyl)adenine (PMEA).: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 102. Unique Identifier : AIDSLINE PRIM11/94191595; Sabo A; Grant R; Follis K; Bischofberger N; Tsai CC; University of Washington Regional Primate Research Center,; Medical Lake 99022.; Simian immunodeficiency virus (SIVMne) was isolated from 2 macaques after 4 and 6 weeks of treatment with the reverse transcriptase inhibitor PMEA. The first animal was pretreated with PMEA for 48 hours prior to SIV inoculation and was maintained on drug therapy for a total of 4 weeks. The second animal was chronicall
Evaluation of antiviral drugs in cynomolgus monkeys infected with SIV or HIV-2.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 100. Unique Identifier : AIDSLINE PRIM11/94191596; Bottiger D; Oberg B; Dept. of Virology, Karolinska Institute, Stockholm, Sweden.; Results from the SIVsm/HIV-2SBL6669/cynomolgus macaque models for preclinical evaluation of drugs active against HIV/AIDS will be presented. Substances with proven clinical antiviral efficacy have been evaluated to validate the model ( AZT , ddI,
Evaluation of PMEA efficacy in macaques chronically infected with simian immunodeficiency virus (SIV).: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 101. Unique Identifier : AIDSLINE PRIM11/94191597; Follis KE; Tsai CC; Grant R; Sabo A; Bischofberger N; University of Washington Primate Research Center, Seattle.; Macaque monkeys infected with SIV can be utilized for preclinical evaluation of antiretroviral drugs/compounds. For this study we used 10 Macaca fascicularis which had been chronically infected with SIVmne for over 11 months to test 9-(-2-phosphonylmethoxyethyl)adenine (PMEA). PMEA was previously shown to inhibit in v
Immunotherapy of SIV-infected Macaca fascicularis with an inactivated whole SIV immunogen.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 104. Unique Identifier : AIDSLINE PRIM11/94191598; Titti F; De Rossi A; Geraci A; Corrias F; Panzini GL; Sernicola L; Baroncelli S; Turillazzi GB; Amadori A; Chieco-Bianchi L; et al; Lab. of Virology, Istituto Superiore di Sanita, Rome, Italy.; OBJECTIVE: To evaluate the hypothesis that appropriately formulated immunogens, while inducing an anamnestic response in SIV infected monkeys, could affect viral burden or delay the development of the disease. RESULTS: Six Macaca fascicularis (Mf) (23, 26, 8202, 4, C1, 8302) immunized with inactivated whole SIV virus
Serologic and molecular analysis of rhesus cytomegalovirus.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 107. Unique Identifier : AIDSLINE PRIM11/94191599; Barry PA; Vogel P; Weigler BJ; Kerr H; Powers M; Alcendor D; Luciw PA; Dept. of Medical Pathology, University of California, Davis; 95616.; Cytomegalovirus ( CMV ) is a ubiquitous infectious agent in humans that normally results in no overt pathology. CMV-induced disease is usually observed only in individuals without a fully competent immune system (e.g., fetuses/neonates, AIDS patients, and transpla
Toxic, prophylactic and therapeutic effects of AZT on SIVmac infection of newborn rhesus macaques.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 103. Unique Identifier : AIDSLINE PRIM11/94191600; Van Rompay K; Otsyula M; Joye S; Ghafourpour K; McChesney M; Pedersen N; Marthas M; California Reg. Primate Res. Center, Davis 95616.; GOAL: To study the toxic and antiviral effects of AZT on the course of SIV infection of newborn rhesus macaques. METHODS: TABULAR DATA, SEE ABSTRACT VOLUME. Twelve newborn (
Trans-dominant HIV-1 rev mutants inhibit replication of SIVmac.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 105. Unique Identifier : AIDSLINE PRIM11/94191601; Wong SW; Bergquam E; Endres CL; Axthelm MK; Division of Primate Medicine, Oregon Regional Primate Research; Center, Beaverton 97006.; Replication of SIV, as well as HIV-1 and -2, requires the functional expression of the virally encoded rev protein. The rev protein acts posttranscriptionally to control the cytoplasmic expression of certain viral RNAs that are otherwise retained in the nucleus. Results of transient transfection assays have shown that
Vaccine induction of SIVmac GAG-specific cytotoxic T lymphocytes in rhesus monkeys.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 10. Unique Identifier : AIDSLINE PRIM11/94191602; Letvin NL; Harvard Medical School, New England Regional Primate Research; Center, Southborough, MA 01772.; In view of the importance of cell-associated virus in AIDS virus transmission, an HIV vaccine should be able to induce a virus-specific cytotoxic T lymphocyte (CTL) response. We have employed the SIVmac/rhesus monkey model to explore approaches to vaccine induction of CD8+, major histocompatibility complex (MHC) class
Efficacy of inactivated whole-virus and subunit vaccines in preventing HIV-2 infection in cynomolgus monkeys.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 11. Unique Identifier : AIDSLINE PRIM11/94191603; Putkonen P; Thorstensson R; Ghavamzadeh L; Gilljam G; Biberfeld G; Department of Immunology, National Bacteriological Laboratory,; Stockholm, Sweden.; The goal with this study was to compare the protective effect of vaccination of cynomolgus monkeys with a whole-virus vaccine and viral envelope glycoprotein subunit vaccine following challenge with homologous cell-free HIV-2. The challenge virus was grown on cynomolgus monkey PBMC. The challenge dose was 10 to 100 MI
Whole inactivated SIV vaccine protects from disease but not infection after cell-associated SIV challenge.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 12. Unique Identifier : AIDSLINE PRIM11/94191604; Hirsch VM; Goldstein S; Hynes N; London WT; Elkins WR; Zack PM; Byrum R; Johnson PR; Laboratory of Infectious Diseases, NIAID, NIH, Rockville, MD.; Simian immunodeficiency virus (SIV) infection of macaques is an ideal model for evaluating candidate HIV vaccines since SIV induces an immunodeficiency syndrome similar to human AIDS. Thus, potential vaccines can be evaluated for their ability not only to prevent infection but also for efficacy in preventing or delayi
Selection of an SIVmac LTR sequence upon mucosal inoculation of rhesus macaques.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 13. Unique Identifier : AIDSLINE PRIM11/94191605; Meyer KK; Trivedi P; Streblow DN; Emau P; Pauza CD; University of Wisconsin, Madison 53706.; The primate retroviruses SIV and HIV, develop into complex virus populations in infected hosts. A less complex virus subset is established upon sexual transmission of HIV in man. The loss of complexity during transmission may be due to a titration effect (inefficient transmission or low doses of virus in the inoculum)
Mucosal immunization with a live, virulence-attenuated SIV vaccine elicits antiviral cytotoxic T lymphocytes and antibodies in rhesus macaques.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 14. Unique Identifier : AIDSLINE PRIM11/94191606; Marthas ML; Lohman BL; McChesney MB; Miller CJ; California Regional Primate Research Center, Davis.; An effective AIDS vaccine must protect against sexual transmission of HIV. Although intravenous (i.v.) inoculation with a molecularly cloned, live virulence-attenuated SIV (SIVmac1A11) provided durable protection against i.v. challenges with virulent SIVmac, intravaginal (IVAG) inoculation with SIVmac1A11 induced weak
Subtotal immunity and virus suppression induced by recombinant SIV vaccines.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 15. Unique Identifier : AIDSLINE PRIM11/94191607; Hoover EA; Israel ZR; Edmonson PF; Mossman SP; O'Neil SP; Bex F; Thiriart C; Fabry L; Van Opstal O; Bruck C; et al; Colorado State University, Fort Collins 80523.; We evaluated the efficacy of SIV recombinant envelope (env) and gag proteins and whole inactivated virus (wiv) vaccines, with or without recombinant live vaccinia vector (vv) priming, in protecting 23 rhesus macaques from SIVmac251 clone BK28 challenge. We used serial and terminal assessment of virus replication, prov
TH1/TH2 subset analysis in PBMC samples of sooty mangabeys and rhesus macaques naturally and experimentally infected with SIV.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 16. Unique Identifier : AIDSLINE PRIM11/94191608; Ansari AA; Mayne A; Hunt D; Villinger F; Dept of Pathology, Emory School of Medicine, Yerkes Reg. Primate; Res. Center, Emory Univ., Atlanta, GA.; Differential production of cytokines by T cell subsets during an immune response has been shown to have an important regulatory effect on the nature of the immune response and the eventual clinical outcome for the host. Based on the view that disease resistance vs susceptibility could be secondary to differential freq
Phases of SIV infection in rhesus macaques: role of lymphoid organs in pathogenesis.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 17. Unique Identifier : AIDSLINE PRIM11/94191609; Joag SV; Adams RJ; Foresman L; Narayan O; University of Kansas Medical Center, Kansas City 66160.; Pathogenesis studies were undertaken in 15 macaques inoculated with either lymphocyte-tropic SIVmac239 or a neurotropic variant of this virus. Both viruses caused typical persistent infection but studies on the dynamics of virus cell interactions during the infection showed 3 distinct phases that prognosticated clinic
Immunopathogenic events in the acute infection of rhesus monkeys with SIVmac.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 18. Unique Identifier : AIDSLINE PRIM11/94191610; Reimann KA; Yasutomi Y; Lin W; Tenner-Racz K; Racz P; Letvin NL; New England Regional Primate Research Center, Harvard Medical; School, Southborough, MA 01772.; Infection of the rhesus monkey with SIVmac was employed to explore the early immune events associated with the initial containment of an acute AIDS virus infection. In 9 rhesus monkeys infected intravenously with uncloned SIVmac251, p27 antigenemia was usually detected transiently from approximately day 7 through day
Pathogenesis of encephalitis caused by SIVmac.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 19. Unique Identifier : AIDSLINE PRIM11/94191611; Mankowski JL; Spelman JP; Ressetar HG; Clements JE; Zink MC; Div. Comparative Medicine, Johns Hopkins University School of; Medicine, Baltimore, MD 21205.; SIVmac causes an immune deficiency syndrome in Asian macaques that is very similar to AIDS in man. Like HIV, SIV induces encephalitis characterized by perivascular infiltrates of macrophages and giant cells. The perivascular localization of these signature histopathologic lesions strongly suggests that the virus enter
Intramucosal transmission of primate retroviruses.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 2. Unique Identifier : AIDSLINE PRIM11/94191612; Pauza CD; Trivedi P; Meyer KK; Streblow DN; Malkovsky M; Salvato MS; Schultz KT; Emau P; Wisconsin Regional Primate Research Center, University of; Wisconsin, Madison 53706.; The development of vaccines to block sexual transmission of HIV-1 in man, requires a thorough understanding of factors affecting intramucosal transmission. In particular, it is necessary to determine the inoculum size and complexity, the relationship between virus dose and disease progression, the factors affecting in
Cytotoxic T lymphocyte specificity in cynomolgus macaques--identification of viral epitopes using reverse immunogenetics.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 20. Unique Identifier : AIDSLINE PRIM11/94191613; Gotch F; Institute of Molecular Medicine, Oxford.; The nature of what would constitute a protective immune response in HIV-1, HIV-2 or experimental SIV infection is unclear and therefore the protective components of a putative vaccine are not known. High levels of virus specific MHC restricted cytotoxic T lymphocytes (CTL) are seen early in infection and during the as
Using SIV in rhesus monkeys for AIDS vaccine development.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 21. Unique Identifier : AIDSLINE PRIM11/94191614; Desrosiers RC; New England Regional Primate Research Center, Harvard Medical; School, Southborough, MA 01772.; Historically, vaccines have been our most potent weapon against viral diseases of medical importance. Development of an effective vaccine against HIV holds the greatest promise for preventing what will otherwise be a public health disaster of catastrophic proportions. Unfortunately, there are good reasons for believin
Association between immunological events and changes in viral DNA and RNA burden in lymphoid organs of SIV-infected macaques and disease progression.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 22. Unique Identifier : AIDSLINE PRIM11/94191615; Rosenberg YJ; Lewis MG; Leon EC; Eddy GA; Greenhouse J; Henry M. Jackson Foundation Research Laboratory, Rockville, MD.; Decline in the CD4+ T cells and HIV viral burden in the blood have been used as closely related correlates of disease progression. However since lymphocytes in the blood constitute only 1-2% of the total lymphocyte pool, it is important to understand how viral load in various organs in the lymphoid compartment are ass
Sequential analysis of viral load in lymph nodes of SIV infected rhesus macaques: correlates with disease evolution.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 23. Unique Identifier : AIDSLINE PRIM11/94191616; Chakrabarti L; Cumont MC; Montagnier L; Hurtrel B; Unite d'Oncologie Virale, Institut Pasteur, Paris, France.; Lymphoid organs are now recognized as the major reservoir of HIV and SIV viruses in the organism. To elucidate the initial pathogenic events in these organs, we performed a quantitative follow up of viral load and pathologic changes in lymph nodes (LN) early in the course of SIV infection. 8 Rhesus macaques were inocu
Cellular immune responses in rhesus macaques with low dose SIV infection.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 24. Unique Identifier : AIDSLINE PRIM11/94191617; Salvato MS; Emau P; Malkovsky M; Schultz K; McKenzie D; Johnson E; Pauza CD; University of Wisconsin, Dept. of Pathology and Laboratory; Medicine, Madison.; Ten juvenile rhesus monkeys were infected via the rectal mucosa with doses of SIVmac251 ranging from 0.1 to 1000 animal infectious doses (Pauza et al. J Med Primatol., in press, 1993). The infectious dose (ID) is the minimum intravenous inoculum needed to infect 50% of age and sex-matched animals. Two monkeys were inf
Conserved T cell receptor repertoire in SIVmac-infected rhesus monkeys.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 25. Unique Identifier : AIDSLINE PRIM11/94191618; Chen ZW; Kou ZC; Shen L; Reimann KA; Letvin NL; Harvard Medical School, New England Regional Primate Research; Center, Southborough, MA 01772.; Studies to assess the possibility that the human immunodeficiency virus (HIV) may encode a superantigen that plays a role in the depletion of functional CD4+ lymphocytes in the infected individual have yielded discrepant results. The problem in performing conclusive examinations of this issue may be attributed, at lea
Antiviral cytotoxic responses of primate gamma delta T cells isolated by magnetic cell separation.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 26. Unique Identifier : AIDSLINE PRIM11/94191619; Wallace M; Pauza CD; Malkovsky M; Dept. of Medical Microbiology and Immunology, Univ. of Wisconsin; at Madison.; We have previously reported that certain human or rhesus monkey gamma delta T cell clones lyse lymphoid cells infected with immunodeficiency viruses (Malkovsky et al., J. Med. Primatol. 21:113, 1992). The same uninfected lymphoid cells are not lysed. This observation and the report that elevated numbers of gamma delta
Species-specific responses to MHC molecules in SIV vaccination and infection.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 27. Unique Identifier : AIDSLINE PRIM11/94191620; Cranage M; Polyanskaya N; Cook N; Webster S; Dennis M; Sharpe S; Ashworth T; Hall G; Centre for Applied Microbiology and Research, Porton Down,; Salisbury, U.K.; It is known that some retroviruses, including HIV and SIV selectively incorporate host cell proteins into their envelopes during virus egress from the infected cell. Recent results have shown that vaccine mediated protection in macaques, seen when vaccine and challenge virus are prepared in human cells, is, at least i
Characterization of a highly pathogenic SIVagm isolate.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 28. Unique Identifier : AIDSLINE PRIM11/94191621; Dapolito GA; Elkins WR; London WT; Goldstein S; Johnson PR; Hirsch VM; LID, NIAID, NIH, Rockville, MD 20852.; SIV pathogenesis studies have been restricted primarily to viruses isolated from sooty mangabeys (SIVsm) or macaques (SIVmac) since these viruses induce immunodeficiency similar to human AIDS in inoculated macaques. In contrast, infection of macaques with SIV isolated from African green monkeys (SIVagm) generally resu
A mosaic SIVAGM genome provides evidence for simian/simian cross-species transmission in the wild (September 19-22, 1993).: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 29. Unique Identifier : AIDSLINE PRIM11/94191622; Hahn BH; Jin MJ; Hui H; Robertson DL; Allan JS; Shaw GM; Sharp PM; University of Alabama at Birmingham 35294.; African Green Monkeys (Cercopithecus aethiops) are naturally infected with a non-pathogenic lentivirus, termed SIVAGM. There are four major AGM species (vervet, grivet, tantalus, sabaeus), all of which are known to harbor SIVAGM. Because of their abundance, African green monkeys comprise the largest reservoir of prima
Analysis of genetic diversity in maternally-transmitted SIV-infected rhesus macaque neonates (September 19-22, 1993).: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 3. Unique Identifier : AIDSLINE PRIM11/94191623; Martin-Amedee A; Davison-Fairburn B; Trichel A; Murphey-Corb M; Tulane Regional Primate Research Center, Covington, LA 70433.; We have previously reported the delivery of two SIV-infected rhesus monkeys from females inoculated with SIV/DeltaB670. The females were inoculated prior to pregnancy or in the third trimester, and the infants were delivered vaginally. These females became immunodeficient during their pregnancies and histopathological
Viral genetic determinants in SIVsmmPBj pathogenesis.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 30. Unique Identifier : AIDSLINE PRIM11/94191624; Novembre FJ; Hirsch VM; Lewis MG; Johnson PR; Klumpp S; Anderson DC; McClure HM; Yerkes Regional Primate Research Center, Atlanta, GA.; SIVsmmPBj (PBj) induces an acutely lethal disease when inoculated into pigtailed macaques. This disease syndrome, characterized by a fulminant diarrhea, acidosis and wasting, has been likened to a cytokine induced enteritis. As a means to investigate the molecular basis of PBj-induced disease, we have utilized molecul
Extensive ENV gene heterogeneity in tissues from SIV infected macaques.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 31. Unique Identifier : AIDSLINE PRIM11/94191625; Campbell BJ; Hirsch VM; NIH/NIAID/LID, Rockville, MD 20852.; Recently investigations of SIV and HIV infections have demonstrated that the viral burden in the peripheral blood vastly underestimates the extent of lymphoid involvement. Therefore, tissues may be a reservoir for viruses of different biologic and pathogenic properties than those observed in the blood. However, little
Viral domains contributing to SIV replication in brain.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 32. Unique Identifier : AIDSLINE PRIM11/94191626; Kodama T; Kawahara T; Desrosiers R; Axthelm M; Oregon Regional Primate Research Center, Beaverton 97006.; We have isolated SIVmac155/NT variants from the brain of a rhesus macaque that displayed encephalitis after infection with cloned SIVmac239. Compared to parental SIVmac239, the NT variant exhibited high replicative capacity for peripheral macrophages and primary brain cell cultures from rhesus macaques, but it replica
Role of the lentivirus Vpu gene in virus replication.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 33. Unique Identifier : AIDSLINE PRIM11/94191627; Geraghty RJ; Callahan M; Harper W; Panganiban AT; McArdle Laboratory for Cancer Research, University of Wisconsin,; Madison 53706.; Lentiviruses such as SIV and HIV express a group of genes termed the accessory genes because they are not found in simpler retroviruses. Although SIV contains most of the accessory genes found in HIV-1, there is no obvious counterpart to the HIV-1 vpu gene. Vpu apparently functions in two separate ways during the proc
Are there roles for heat shock proteins in the replication of HIV and SIV?: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 34. Unique Identifier : AIDSLINE PRIM11/94191628; Bartz SR; Pauza CD; Ivanyi J; Jindal S; Welch WJ; Malkovsky M; Dept. of Medical Microbiology and Immunology, Univ. of Wisconsin.; The role of host cell proteins in the assembly of, the pathogenesis of, and the immune response to HIV and SIV is not well understood. Heat shock proteins (Hsp s) are potentially important for viral production because of their known functions in cellular protein maturation and assembly of macromolecular complexes. Als
Role of beta-2 microglobulin, HLA I and HLA II DR in protection of macaques from infection by SIV grown in HuT 78 cells.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 35. Unique Identifier : AIDSLINE PRIM11/94191629; Benveniste R; Henderson L; Bess J Jr; Sowder R; Mann D; Nolte R; Bartz C; Kuller L; Morton W; Arthur L; National Cancer Institute, Frederick, MD.; We have previously shown that beta-2 microglobulin (beta-2M), HLA I (alpha-chain), and HLA II DR (alpha- and beta- chains) are specifically associated with purified preparations of HIV-1, HIV-2, and SIV. These cellular antigens are each present at approximately 15% of the levels of gag on a molar basis, based on recov
In vivo anti-viral effect of CD4-specific monoclonal antibodies in SIVmac-infected rhesus monkeys.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 36. Unique Identifier : AIDSLINE PRIM11/94191630; Reimann KA; Waite BC; Cate RL; Wu Y; Olson D; Letvin NL; Burkly LC; New England Regional Primate Research Center, Harvard Medical; School, Southborough, MA 01772.; Since monoclonal antibodies (mAb) specific for CD4 are potent inhibitors of HIV and SIV replication in vitro, we explored their potential usefulness in vivo as an AIDS therapy. The anti-CD4 mAb 5A8 efficiently inhibits HIV and SIVmac replication in vitro and virus-induced cell fusion. This antibody binds to domain 2 o
Adaptation of HIV-1 to pig-tailed macaques.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 37. Unique Identifier : AIDSLINE PRIM11/94191631; Gartner S; Liu Y; Lewis M; Polonis V; Hunter E; Brown C; Elkins WR; Zack P; Eddy G; Henry M. Jackson Foundation, Rockville, MD.; Prior to animal studies, in vitro experiments were performed to assess the relative susceptibility of cells from various monkey species to HIV-1. We found: (1) Cultured T cells from pig-tailed macaques were more susceptible and/or permissive for HIV-1 than T cells from cynomolgus and rhesus monkeys, although peak expr
Antibody to the human IFN alpha receptor reduces the loss of CD4 + T cells in macaques infected with the simian immunodeficiency virus (SIV).: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 38. Unique Identifier : AIDSLINE PRIM11/94191632; Tovey MG; Lebon P; Meyer F; Hurtrel B; Gresser I; Venet A; Girard M; Aubertin AM; IRSC-CNRS, Villejuif, France.; Co-factors including cytokines are thought to play a determining role in the development of the acquired immunodeficiency syndrome (AIDS) following infection by the human immunodeficiency virus (HIV). The presence of acid-labile interferon (IFN) alpha in the sera of AIDS patients has been shown to correlate with disea
Cell-cell interactions regulating the expression of immunodeficiency viruses in CD4+ T lymphocytes.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 39. Unique Identifier : AIDSLINE PRIM11/94191633; Clark EA; University of Washington Regional Primate Research Center,; Seattle 98195.; A number of cell-cell interaction regulate CD4+ T cell responses to antigen presented on antigen presenting cells (APC) such as dendritic cells (DC) or B cells. In particular, reciprocal interactions between CD28 (or CTLA-4) and CD40 ligand (CD40L) on T cells and their coreceptors B7/BB1 and CD40 on APC are required f
Dual infection of rhesus macaques with SIVE11s and SIV239.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 4. Unique Identifier : AIDSLINE PRIM11/94191634; Lewis MG; Bellah S; McKinnon K; Yalley-Ogunro J; Greenhouse J; Elkins WR; Rosenberg Y; Gartner S; Eddy G; Henry M. Jackson Foundation, Rockville, MD.; The purpose for this study was to determine if dual infection by two virulent and pathogenic SIV isolates is possible in rhesus macaques. In addition, we wanted to determine if pre-existing immunity alters the anticipated course of infection. The two isolates used in this study, SIVmac239 and SIVmne/E11s, differ genet
NIAID research priorities in tuberculosis.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 40. Unique Identifier : AIDSLINE PRIM11/94191635; Rosenberg ZF; National Institute of Allergy and Infectious Diseases, National; Institutes of Health, Bethesda, MD 20892.; After decades of steady decline, the number of cases of tuberculosis in the U.S. has risen 20% between 1985 and 1992. In addition, the percentage of tuberculosis cases that are resistant to standard therapies is also increasing. The growth of the AIDS epidemic with significant numbers of immunocompromised, HIV-infecte
Total lymphoid irradiation of SIV-infected macaques as a potential therapy for HIV infection.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 41. Unique Identifier : AIDSLINE PRIM11/94191636; Fultz PN; Schwiebert R; Su L; Salter M; Department of Microbiology, University of Alabama at Birmingham; 35294.; Lymph nodes appear to be reservoirs for large amounts of virus in HIV-infected persons. It is also clear that many manifestations of HIV-related disease are due to immune activation and autoimmune reactions. Total lymphoid irradiation (TLI), an effective therapy for Hodgkin s disease, has been used more recently to tr
Passive immunization of rhesus macaques against SIV: failure to protect and apparent enhancement of infection and disease (September 19-22, 1993).: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 42. Unique Identifier : AIDSLINE PRIM11/94191637; Gardner MB; Jennings M; Rosenthal A; McKenzie M; University of California at Davis 95616.; We have used the macaque model to test the effect of passive immunization on SIV infection and disease. We had two goals in mind: 1) to investigate the role of humoral immunity in SIV vaccine protected as compared to SIV infected monkeys, in hopes of better understanding the mechanism of vaccine protection; and 2) to
Comparison of the efficacy of AZT and PMEA treatment on acute SIVMNE infection in macaques.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 43. Unique Identifier : AIDSLINE PRIM11/94191638; Tsai CC; Follis KE; Grant R; Sabo A; Nolte R; Bartz C; Bischofberger N; Benveniste R; University of Washington Primate Research Center, Seattle.; The efficacy of the antiviral agents azidothymidine ( AZT ) and 9-(-2-phosphonylmethoxyethyl)adenine (PMEA) against SIV was compared in long-tailed macaques (Macaca fascicularis). A total of 48 macaques were used for this study and treated employing the
Impairment of alveolar macrophage-mediated killing of Cryptococcus neoformans in rhesus monkeys with SIV-induced AIDS.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 44. Unique Identifier : AIDSLINE PRIM11/94191639; Brodie S; Sasseville V; Simon M; Sehgal P; Desrosiers R; Ringler D; Division of Pathology, Harvard Medical School, Southborough, MA.; Because alveolar macrophages (Mphi) play a major role in the host defense against inhaled microorganisms and are susceptible targets of lentivirus infection, we investigated if lentiviral infection of M phi alters microbicidal potential. Alveolar Mphi infected with SIVmac were assessed for their ability to kill encaps
How the nonhuman primate model serves the worldwide fight against AIDS: identification of crucial needs and priorities.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 45. Unique Identifier : AIDSLINE PRIM11/94191640; Bolognesi D; Duke University Center for AIDS Research.; [No abstract appeared in the published proceedings]
B-cell lymphomagenesis in SIV immunosuppressed cynomolgus monkeys.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 46. Unique Identifier : AIDSLINE PRIM11/94191641; Biberfeld P; Kaaya EE; Feichtinger H; Li SL; Ekman M; Ernberg I; Voevodin AF; Putkonen P; Biberfeld G; Immunopathology Lab., Karolinska Institute, Stockholm, Sweden.; OBJECTIVE: To characterize lymphomagenic mechanisms in SIV immunosuppressed cynomolgus monkeys (Macaca fascicularis). MATERIAL AND METHODS: Monkeys immunosuppressed by SIVsm (SMM3) developed malignant lymphoma in high frequency (approx. 40%). These lymphomas were studied by immunohistopathology, anticomplement immunof
Infection of Macaca nemestrina by human immunodeficiency virus types 1 and 2.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 47. Unique Identifier : AIDSLINE PRIM11/94191642; Morton WR; Schmidt AM; Agy MB; Katze MG; Florey MJ; Corey L; Frumkin LR; Ochs HD; Hu SL; McClure J; et al; Regional Primate Research Center, Univ Washington, Seattle.; We have previously reported acute HIV-1 infection in eight Macaca nemestrina (pigtailed macaques), inoculated with cell-associated and/or cell-free virus. HIV-1 was recovered from the PBMC from all eight animals during two to eight weeks post-inoculation and rarely thereafter. PCR analysis revealed HIV-1-specific DNA
Serosurvey of nonhuman primates in Kenya: evidence for SIVsmm-related infection in a baboon.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 48. Unique Identifier : AIDSLINE PRIM11/94191643; Novembre FJ; Chege G; Ishahakia M; McClure HM; Yerkes Regional Primate Research Center, Emory University,; Atlanta, GA.; The Yerkes Regional Primate Research Center and the Institute of Primate Research have an ongoing collaboration to examine the prevalence of lentiviral infections in feral nonhuman primates. A recent serosurvey was conducted with six species of nonhuman primates utilizing a standard HIV-2 ELISA kit. Positive samples b
Molecular investigations of higher primate foamy viruses.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 49. Unique Identifier : AIDSLINE PRIM11/94191644; Bieniasz PD; Ali M; McClure MO; Department of G.U. Medicine and Communicable Diseases, St Mary's; Hospital Medical School, Paddington, London, U.K.; We have undertaken a comparative study of foamy viruses isolated from higher primates: human (HFV), chimpanzee (SFV-6, SFV-7), gorilla (GFV) and orangutan (OFV) using serology, PCR, sequencing, and an assay for transactivation. Serologically, using virus infected BHK cells as antigen and sera from infected primates, H
In vivo passage of HIV-2EHO in Macaca nemestrina results in increased virulence.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 5. Unique Identifier : AIDSLINE PRIM11/94191645; McClure J; Steele J; Dorofeeva N; Scheibel M; Misher L; Schmidt A; Morton W; Hu SL; Bristol-Myers Squibb, Seattle, WA 98121.; HIV-2EHO is representative of a subgroup of HIV-2 which demonstrates enhanced cytopathogenicity, increased replicative rate, and extended host range in vitro as compared to the prototype HIV-2ROD. As previously reported, HIV-2EHO infects M. nemestrina and causes an AIDS-like disease in 50% of the infected animals. We
The mucosal barrier selects for SIV with unique envelope sequences.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 50. Unique Identifier : AIDSLINE PRIM11/94191646; Trivedi P; Emau P; Pauza CD; Wisconsin Regional Primate Research Center, University of; Wisconsin, Madison 53706.; One year old juvenile rhesus monkeys were infected intravenously or intrarectally with varying doses of SIVmac. This biological isolate proved to be a complex mixture of viruses based on extensive sequence analysis of viral long terminal repeats. Peripheral blood mononuclear cells (PBMC) were collected from infected a
Performance characteristics of HIV-2 serology reagents on blood from SIV/HIV-2 infected monkeys.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 52. Unique Identifier : AIDSLINE PRIM11/94191647; Yee JL; Jennings MB; Lowenstine LJ; Lerche NW; Dept. of Medical Pathology, University of California, Davis.; Over the past five years, we have tested more than 20,000 sera from humans and non-human primates for antibodies to SIV/HIV-2, using first generation reagents prepared from HIV-2 viral lysate. The increasing demands for testing, and the wider commercial availability of new generation reagents have led us to evaluate t
HIV-2 infected monkeys as a model for HIV seroprevalence studies on exchanged needles from intravenous drug users.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 53. Unique Identifier : AIDSLINE PRIM11/94191648; Yee J; Bucardo J; Guydish J; Jennings M; Dept. of Medical Pathology, University of California, Davis.; To evaluate and establish testing strategies for needles/syringes (as a minimally intrusive means of determining HIV seroprevalence in intravenous drug users in needle exchange programs) we have used blood from rhesus macaques experimentally infected with HIV-2. This model provides repeated, controlled access to blood
The molecular characterisation of vaccine trials using recombinant envelope immunogens and live SIV containing distinct nef genes.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 54. Unique Identifier : AIDSLINE PRIM11/94191649; Almond N; Rud E; Kent K; Chan L; Page M; Jones W; Mills K; Clarke B; Kitchin P; Stott J; NIBSC, Potters Bar, United Kingdom.; The effect of pre-existing anti-envelope immunity on the evolution of the SIVenv gene in vivo has been studied in immunised macaques, which were not protected upon challenge with SIVmav32H. Cynomolgus macaques have now been immunised with envelope immunogens derived from SIV clones homologous with or heterologous to S
Variation of HIV-2 env gene in vaccinated but not protected rhesus macaques.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 55. Unique Identifier : AIDSLINE PRIM11/94191650; Byon-Auboyer MH; Boussin FD; Vogt G; Legrand R; Vaslin B; Dormont D; CRSSA/CEA, Fontenayaux Roses, France.; We investigated molecular variations of HIV-2 env gene in experimentally infected rhesus macaques involved in a vaccinal trial. Fourteen rhesus macaques were treated as follows: 5 monkeys were vaccinated with recombinant vaccinia viruses expressing gag, pol, nef and vif, genes of HIV-2Rod, 5 monkeys received the same
Titration in pig-tailed macaques of the HIV-1 III-B chimpanzee virus challenge stock.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 56. Unique Identifier : AIDSLINE PRIM11/94191651; Benveniste R; Agy M; Arthur L; Bess J Jr; Katze M; Corey L; Schmidt A; Morton W; NCI, Frederick, MD.; Despite the similarities of SIV-induced AIDS in macaques and HIV-induced AIDS in humans, these two viruses differ in their regulatory genes and in the composition of their envelope genes to a sufficient extent so as to warrant performing vaccine and therapeutic studies with HIV-1 in animals. The expense of maintaining
Concomitant high level T helper and humoral responses in vaccinated rhesus monkeys do not protect against SIV challenge.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 57. Unique Identifier : AIDSLINE PRIM11/94191652; Benveniste O; Vaslin B; Le Grand R; Vogt G; Gras G; Salk J; Dormont D; Laboratoire de Neuropathologie Experimentale et Neurovirologie,; Commissariat a l'Energie Atomique, Fontenay aux Roses, France.; Two groups of 5 rhesus macaques received 3 intramuscular 100 microgram doses of inactivated SIV delta B670 virus, emulsified in adjuvant, at 0, 2, and 7 months. First group (A) received the immunogen in an oil-in-water emulsion consisting of RIBI detox with mycobacterial cell wall skeleton and monophosphoryl lipid A (
IgG antibodies predominate in mucosal and genital secretions of HIV-1 positive chimpanzees.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 58. Unique Identifier : AIDSLINE PRIM11/94191653; Israel ZR; Frost PA; Marx PA; Dept. of Biology, New Mexico State University, Holloman AFB; 88330.; Heterosexual transmission of HIV in Africa, Asia, North America and Europe emphasizes the need to identify immunization strategies that will protect against HIV infection at the genital mucosa. In previous studies in macaques, mucosal IgG was the predominant SIV vaginal antibody in SIV immunized and infected animals.
Animal model for anti-viral therapy: effect of AZT treatment on cellular and seric viral loads during early stages of SIVmac251 infection of macaques.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 59. Unique Identifier : AIDSLINE PRIM11/94191654; Le Grand R; Clayette P; Vaslin B; Noack O; Theodoro F; Roques P; Dormont D; Laboratoire de Neuropathologie Experimentale et Neurovirologie,; CEA/SSA, Fontenay aux Roses, France.; OBJECTIVES: To evaluate the efficiency of prophylactic treatment with AZT during primo-infection of SIVmac251 (monkey PBL grown virus stock) inoculated cynomolgus monkeys. MATERIALS AND METHODS: Two groups of four Macaca fascicularis were treated eith
Replication of SIVmac251 and SIVB670 in vitro in placental syncytiotrophoblasts.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 6. Unique Identifier : AIDSLINE PRIM11/94191655; Krugner-Higby LA; Schultz KT; Johnson KJ; Golos TG; Wisconsin Regional Primate Research Center, Madison.; We have infected rhesus placental cells with SIV as an in vitro model for studying mechanisms of maternal/fetal HIV transmission. Placental chorionic villi were obtained from rhesus macaques at Cesarean section and cytotrophoblast cells were isolated by differential centrifugation on a Percoll gradient. Cells were cul
SIV-GP120 recombinant viruses are avirulent and immunogenic.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 60. Unique Identifier : AIDSLINE PRIM11/94191656; Lohman BL; Van Rompay KK; McChesney MB; McGowan E; Joye S; Luciw P; Marthas M; Pedersen NC; California Regional Primate Research Center, University of; California, Davis 95616.; The molecularly cloned SIVmac1A11 is a model for a live virus vaccine because rhesus macaques infected with this virus are transiently viremic, do not develop disease, and withstand low-dose challenge with a pathogenic strain of SIVmac. The molecular clone SIVmac239 causes persistent viremia and a fatal immunodeficien
ADCC function in sera from infected but not from immunized rhesus monkeys.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 61. Unique Identifier : AIDSLINE PRIM11/94191657; Ohkawa S; Wilson LA; Miller M; Montelaro R; Martin L; Murphey-Corb M; Tulane Regional Primate Research Center, Covington, LA 70433.; Using vaccinia recombinants, we prepared target cells expressing SIV env specific for SIV/B670 or SIVmac251. Serum samples collected from SIV/B670 infected, SIVmacBK28 infected, or SIVmac251 recombinant glycoprotein immunized monkeys were assessed for complement-mediated lysis (ACC) or antibody dependent cellular cyto
Analysis of immune responses induced by whole killed SIV with various adjuvants.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 62. Unique Identifier : AIDSLINE PRIM11/94191658; Ohkawa S; Wilson LA; Yamamoto F; Kiyono H; Martin L; Murphey-Corb M; Tulane Regional Primate Res. Center, Covington, LA 70433.; Cellular and humoral immune responses were assessed in monkeys immunized with killed SIV virus alone or combined with different adjuvants. Adjuvant groups included no adjuvant (I), SAF-M (II), Freund s complete (III), alum (IV), detoxified lipid A (V), Freund s incomplete + MDP (VI), MTP-PE (VII), liposomes (VIII), li
Challenge of rhesus monkeys with SIV after immunization with a combination regimen.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 63. Unique Identifier : AIDSLINE PRIM11/94191659; Schlienger K; Mancini M; Riviere Y; Tiollais P; Michel ML; Unite de Recombinaison et Expression Genetique, Institut; Pasteur, Paris, France.; We recently reported that recombinant Hepatitis B surface antigen (HBsAg) particles presenting the HIV-1BRU envelope principal neutralizing determinant on their surface (V3/HBsAg) allowed us to generate proliferative T-cell responses, cellular cytotoxicity and neutralizing antibodies in immunized rhesus monkeys. To ev
The MHC class I loci of the rhesus monkey.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 65. Unique Identifier : AIDSLINE PRIM11/94191660; Watkins DI; Boyson JE; McAdam SN; Rojo S; Lopez de Castro JA; Wisconsin Regional Primate Research Center, University of; Wisconsin, Madison 53715.; Knowledge of MHC molecules play a crucial role in the design of vaccine strategies. Since alloantisera have been ineffective in the definition of MHC class I molecules in rhesus monkeys, we have initiated a biochemical and molecular biological analysis of rhesus monkey MHC class I genes and gene products. One-dimensio
Reduced virus load in rhesus macaques immunized with recombinant gp160 and challenged with simian immunodeficiency virus.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 66. Unique Identifier : AIDSLINE PRIM11/94191661; Yilma T; Lohman B; Marthas M; Giavedoni L; el-Amad Z; Haigwood N; Scandella C; Gardner M; Luciw P; Ahmad S; California Regional Primate Research Center, University of; California, Davis 95616.; We have evaluated the potential of SIVmac239 gp160 expressed by recombinant vaccinia virus (vSIVgp160) and baculovirus (bSIVgp160) to protectively immunize rhesus macaques against intravenous (i.v.) infection with pathogenic SIVmac isolates. The challenge viruses, propagated in rhesus peripheral blood mononuclear cell
HIV-1 infection and replication in PBMC from three macaque species in vitro: a comparative study.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 67. Unique Identifier : AIDSLINE PRIM11/94191662; Agy MB; Acker RL; Katze MG; University of Washington Regional Primate Research Center,; Seattle 98195.; We have previously reported in vitro infections of M. nemestrina PBMC where we showed de novo synthesis and accumulation of HIV-1 proteins, as well as production of a low levels of infectious virions, in the infected culture supernatants. We then decided to carefully examine HIV-1 infection of M. fascicularis and M. m
Monoclonal antibody to a cellular component and its potential for defining cellular tropism.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 68. Unique Identifier : AIDSLINE PRIM11/94191663; Allan JS; Whitehead E; Southwest Foundation for Biomedical Research, San Antonio, TX; 78228.; The process of viral entry is represented by a complex series of events beginning with the binding of the virus to its receptor, CD4, and culminating in viral fusion. Recent evidence has linked virus neutralization and cell tropism to the V3 loop domain of HIV. Additionally, previous studies in this laboratory have sh
Association between hematologic abnormalities and pregnancy outcome in SIV infected macaques.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 69. Unique Identifier : AIDSLINE PRIM11/94191664; Davison-Fairburn B; Baskin G; Harrison R; Murphey-Corb M; Tulane Regional Primate Research Center, Covington, LA 70433.; Eight of 21 pregnancies in rhesus monkeys inoculated with a pathogenic strain of SIV resulted in abortion, intrauterine death, term stillbirth, or an SIV infected infant. Of these 8, 6 were associated with anemia and/or thrombocytopenia in the dam prior to delivery or fetal demise. One abortion and 1 intrauterine deat
Whole inactivated SIV vaccine protects macaques from infection with cell-free SIV generated in human but not macaque cells.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 7. Unique Identifier : AIDSLINE PRIM11/94191665; Goldstein S; London WT; Elkins WR; Hirsch VM; Laboratory of Infectious Diseases, NIAID, NIH, Rockville, MD.; Previous studies demonstrated that the species of cell line used to generate SIV vaccine and challenge stocks influence protection mediated by whole inactivated SIV vaccine (WI-SIV). Thus, protection is observed if the vaccine and challenge are generated in human cells, but not if the challenge virus is grown in macaq
Differential localization of SIV replication in lymphoid tissues of rhesus monkeys after intravenous or intrarectal infection.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 70. Unique Identifier : AIDSLINE PRIM11/94191666; Emau P; Uno H; Zimbric M; Bro S; Pauza CD; Wisconsin Regional Primate Research Center, University of; Wisconsin, Madison 53706.; We studied the localization of virus replication and pathology in lymphoid tissues of rhesus monkeys infected intravenously (i.v., n = 2) or intrarectally (ir, n = 1) with uncloned SIVmac. At the end stage of disease the pathology of lymphoid tissues in the i.v.-infected animals was characterized by acute spleenitis a
Gonadal function in male rhesus macaques inoculated with simian immunodeficiency virus.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 71. Unique Identifier : AIDSLINE PRIM11/94191667; Nadler RD; Manocha AD; McClure HM; Yerkes Regional Primate Research Center, Emory University,; Atlanta, GA 30322.; A characteristic postmortem finding in men who die of AIDS is an absence of normal spermatogenesis, regardless of age at death, duration of the infection or cause of death. We sought to confirm this finding in the monkey animal model and to determine if the effect on the testes was a primary one or secondary to change
A neutralizing assay for SIV in an adherent CD4+ macaque cell line.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 72. Unique Identifier : AIDSLINE PRIM11/94191668; Goldstein S; Fomsgaard A; Hirsch VM; Laboratory of Infectious Diseases, NIAID, NIH, Rockville, MD; 20852.; The quantitation of neutralizing antibodies from SIV-infected or immunized animals would be assisted by a reliable and rapid neutralization assay. Current assays that measure inhibition of cell death are rapid, but are limited due to variation in cytopathology, and tropism of SIV isolates. In contrast, assays rely upo
Does the amount of MHC class II expressed on blood monocytes affect the pathology of macaques infected with SIV?: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 74. Unique Identifier : AIDSLINE PRIM11/94191669; Hall G; Ashworth T; Sharpe S; Cook R; Dennis M; Andrews C; Cranage M; Centre for Applied Microbiology and Research, Porton Down,; Salisbury, UK.; The severity of the pathology that develops in rhesus macaques inoculated experimentally with SIV and the speed of its development varies between animals, but the host cell factors responsible for this variability are poorly understood. Pathology was reviewed in 14 rhesus macaques used in vaccine trials that had been
Simian foamy virus and SIV expression in macaque lymphoid cells.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 75. Unique Identifier : AIDSLINE PRIM11/94191670; Hunter E; Lewis M; Brown C; Eddy G; Gartner S; Henry M. Jackson Foundation, Rockville, MD 20850.; Simian Spumaviruses, or foamy viruses (SFV), are ubiquitous retroviruses present in large numbers of macaques. These viruses exhibit lytic properties in vitro, but appear latent in vivo, and to date, have not been associated with any disease. Because SFV expression occurs spontaneously in macaque lymphocyte cultures,
Quantitative differences in the levels of IL-2 and IFN gamma produced by PBMC of naturally SIV infected sooty mangabeys and rhesus macaques experimentally infected with SIV.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 76. Unique Identifier : AIDSLINE PRIM11/94191671; Mayne A; Villinger F; Findley H; Ansari AA; Dept of Pathology, Emory School of Medicine, Yerkes Reg. Primate; Res. Center, Emory Univ., Atlanta, GA.; Equivalent numbers of PBMC from a group of sooty mangabeys naturally infected with SIV and a group of asymptomatic macaques experimentally infected with SIVsmm9 as well as uninfected macaques were cultured in vitro with a variety of mitogens in varying concentrations. Supernatant fluids were collected at 0, 24, 48 and
Enteropathy in pigtail macaques inoculated with SIVsmmPBj14-bcl.3.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 77. Unique Identifier : AIDSLINE PRIM11/94191672; Mossman SP; O'Neil SP; Maul DH; Fultz PN; Hoover EA; Department of Pathology, Colorado State University, Fort Collins; 80523.; Inoculation of pigtail macaques with SIVsmmPBj14-bcl.3, a biological clone, produces a fatal acute gastrointestinal disease characterized by profuse diarrhea. Characteristic lesions in the intestines of symptomatic animals include the blunting and fusion of villi, loss of the crypt and absorptive epithelial cells, ede
Comparative pathogenicity of molecular and biologic clones of SIVsmmPBj14.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 78. Unique Identifier : AIDSLINE PRIM11/94191673; O'Neil SP; Mossman SP; Maul DH; Israel ZR; Dean GA; Fultz PN; Hoover EA; Department of Pathology, Colorado State University, Fort Collins; 80523.; We have studied clinical, virologic, histopathologic, and hematologic parameters of the preclinical and clinical phases of the acute PBj14 syndrome produced in pigtailed macaques by either molecular or biologic clones of SIVsmmPBj14. We found that both molecular clone 1.9 and biologic clone bcl.3 consistently produced
Role of accessory cell molecules in dendritic cell-dependent HIV-replication.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 79. Unique Identifier : AIDSLINE PRIM11/94191674; Pinchuk L; Polacino P; Agy MB; Liang A; Clark EA; University of Washington, Regional Primate Research Center,; Seattle.; Previous studies have suggested that after exposure to HIV-1, dendritic cells (DC) continue to present normal antigens and superantigens, forming clusters with T cells that are driven to replicate. Infection of the DC cannot be detected, but the clustered T cells release virions and die (Cameron et al., Science, 257:3
Prior exposure to subinfectious doses of SIV protects macaques from subsequent virus challenge.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 8. Unique Identifier : AIDSLINE PRIM11/94191675; Benveniste R; Kuller L; Hu SL; Clark E; Clerici M; Shearer G; Morton W; National Cancer Institute, Frederick, MD 21702.; As part of an in vivo titration study of SIV/Mne molecular and single-cell clones, macaques were inoculated intravenously with various dilutions of these infectious virus stocks. Animals received dilutions containing from 10(4) to 10(-3) tissue culture infectious doses (TCID) of SIV. Seroconversion and evidence of inf
Effect of CD3 and CD28 stimulation on the initial infection of resting T-cells with simian immunodeficiency virus.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 80. Unique Identifier : AIDSLINE PRIM11/94191676; Polacino P; Liang A; Clark E; University of Washington, Primate Center, Seattle.; The simian immunodeficiency virus (SIV) is highly tropic for cells expressing CD4 receptor. The early molecular events that occur after infection of CD4 T cells with SIV are not yet well defined. After HIV enters host cells, viral DNA is synthesized and can be integrated into the host genome. In vitro, HIV can infect
Distribution of SIVMNE in tissues and organs of Macaca fascicularis treated with AZT or PMEA.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 81. Unique Identifier : AIDSLINE PRIM11/94191677; Tsai CC; Follis K; Sabo A; Grant R; University of Washington Primate Research Center, Seattle.; At necropsy, we examined the distribution of SIV in various tissues and organs of longtailed macaques (Macaca fascicularis) that were previously inoculated with SIV and treated with azidothymidine ( AZT ) or 9-(-2-phosphonylmethoxyethyl)adenine (PMEA).
Functional comparison of LTRs from acutely pathogenic and non-acutely pathogenic derivatives of SIVSMMPBJ14.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 83. Unique Identifier : AIDSLINE PRIM11/94191678; Dewhurst S; Dollard SC; Fultz PN; University of Rochester Medical Center, NY 14642.; Molecularly cloned SIVs capable of inducing acute fatal disease in pig-tailed macaques have been derived previously from a biological clone (bcl-3) of the PBj14 isolate of SIV from sooty mangabey monkeys (SIVSMMPBj14). A closely related biological clone (bcl-1), also derived from the PBj14 isolate, fails to induce acu
Neurobehavioral test battery for assessment of cognitive changes following SIV infection in rhesus monkeys.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 84. Unique Identifier : AIDSLINE PRIM11/94191679; Gold LH; Polis I; Roberts AC; Robbins TW; Bloom FE; Koob GF; Dept. of Neuropharmacology, Scripps Research Institute, La Jolla,; CA.; A computerized, neuropsychological testing battery has been developed to detect changes in cognitive performance in rhesus monkeys following infection with simian immunodeficiency virus (SIV). The neurobehavioral test battery consists of probes for memory (delayed non-matching to sample and spatial working memory task
Simian AIDS type D retrovirus serotype 2 and variant viruses: isolation of infectious molecular clones.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 85. Unique Identifier : AIDSLINE PRIM11/94191680; Marracci GH; Pilcher KY; Shiigi SM; Hallick LM; Axthelm MK; Machida CA; Department of Molecular Microbiology and Immunology, Oregon; Health Sciences University, Portland 97201.; Type D serogroup 2 simian retroviruses (D2 SRVs) have been associated with severe immunodeficiency and retroperitoneal fibromatosis in Celebes, pig-tailed, and long-tailed macaques; severe immunodeficiency, anemia, and thrombocytopenia in Japanese macaques; and immunodeficiency of variable severity in rhesus macaques.
New variant of simian T-lymphotropic retrovirus (STLV-1F) among Papio hamadryas of Sukhumi monkey stock.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 86. Unique Identifier : AIDSLINE PRIM11/94191681; Chikobava M; Schatzl H; Rose D; Bush U; Yakovleva L; von der Helm K; Deinhardt F; Lapin B; Institute of Medical Primatology, Russian Academy of Medical; Sciences.; Polymerase chain reaction (PCR) was developed for the detection of simian T-lymphotropic virus type 1 (STLV-1) infection of P.hamadryas and was used for direct sequencing using oligonucleotide primer pairs specific for the tax and env regions of the related human T-lymphotropic virus type 1 (HTLV-1). Perfect specifici
Foamy viruses (spumaretroviruses) from chimpanzees: genetic organization and relationship to other simian foamy viruses (SFVs) and human foamy virus (HFV).: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 87. Unique Identifier : AIDSLINE PRIM11/94191682; Herchenroeder O; Renne R; Mergia A; Loncar D; Murthy K; Luciw P; Department of Medical Pathology, University of California, Davis; 95616.; Foamy viruses, members of one of the seven genera of retroviruses, have been recovered from several species of non-human primates, and a foamy virus, designated HFV, has also been isolated from a human. In in vitro tissue culture systems, the SFVs and HFV display a wide cell tropism and cause extensive cytopathology;
Simian foamy virus type 3 (SFV-3) is a spumaretrovirus that exhibits a complex transcription pattern.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 88. Unique Identifier : AIDSLINE PRIM11/94191683; Renne R; Mergia A; Herchenroeder O; Barry PA; Neumann-Haefelin D; Luciw PA; Department of Medical Pathology, University of California, Davis; 95616.; Foamy viruses, also designated spumaviruses and spumaretroviruses, are one of seven genera in the retroviridae family, and unique isolates have been recovered from many mammalian species including cats, hamsters, cows, several non-human primates, and man. The genomes of two simian foamy viruses (i.e., SFV-1 from a rhe
Cis-acting elements required for lentivirus RNA encapsidation.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 89. Unique Identifier : AIDSLINE PRIM11/94191684; McBride MS; Panganiban AT; McArdle Laboratory for Cancer Research, University of Wisconsin,; Madison 53706.; Efficient and specific incorporation of viral RNA into the assembling particle is an essential process for all retroviruses. In the case of type-C retroviruses the cis acting signal required for encapsidation is typically located in the 5 untranslated leader region, at a site distal to the primary splice donor site.
Transmission of HIV-1 by the mucosal route in female chimpanzees.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 9. Unique Identifier : AIDSLINE PRIM11/94191685; Girard M; Rimsky L; Mahoney J; Muchmore E; Weinhold K; Fultz P; Institut Pasteur, Paris, France.; Adult female chimpanzees at the pre-ovulatory phase of their cycles were inoculated by the genital route with cryopreserved peripheral blood mononuclear cells (PBMC) from an HIV-1 LAI-infected chimpanzee. The titer of the inoculum, determined by end-point dilution and coculture with human or chimpanzee PBMC, was 30 in
Nucleotide sequence analysis of an HIV-2 isolate (EHO) that establishes persistent and pathogenic infection in pig-tailed macaques.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 90. Unique Identifier : AIDSLINE PRIM11/94191686; Misher L; Grant R; Morton WR; McClure J; Hu SL; Washington Regional Primate Research Center, University of; Washington, Seattle 98195.; We previously reported that HIV-2 EHO infects pig-tailed macaques (M. nemestrina) and causes an AIDS-like disease in about 50% of the infected animals (also see McClure et al., this volume). We have now determined the complete nucleotide sequence of the env-nef-LTR region of this isolate. Comparison of the deduced ami
Correlation of organ pathology and distribution of SIV detected by in-situ hybridization during SIVmac251/32H infection of Macaca mulatta.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 91. Unique Identifier : AIDSLINE PRIM11/94191687; Muller JG; Czub S; Rethwilm A; Muller-Hermelink HK; Institute of Pathology, University of Wurzburg, Germany.; The organ distribution of SIVmac251-32H was investigated by in-situ Hybridization during the time-course of the infection. Paraffin embedded tissues of the thymus, lymph nodes (axillary, mediastinal, mesenterial, inguinal, and other regions), the spleen, lung and other tissues were hybridized with a gag-specific 570 b
Simian AIDS type D serogroup 2 retrovirus: polymerase chain reaction (PCR) detection of proviral DNA from distinct immune cell subpopulations within virus-infected macaques.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 92. Unique Identifier : AIDSLINE PRIM11/94191688; Pilcher KY; Pangares N; Shiigi SM; Malley A; Axthelm MK; Machida CA; Division of Neuroscience, Oregon Regional Primate Research; Center, Beaverton 97006.; Most cases of Simian Acquired Immunodeficiency Syndrome (SAIDS)-associated morbidity and mortality in biomedical research colonies of Asian macaques are caused by Type D simian retrovirus (SRV) infection. Type D serogroup 2 retroviruses have been associated with severe immunodeficiency and retroperitoneal fibromatosis
In vitro and in vivo characteristics of SIVsmmPBj molecular clones.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 93. Unique Identifier : AIDSLINE PRIM11/94191689; Saucier MM; Novembre FJ; Hirsch VM; Goldstein S; Johnson PR; McClure HM; Yerkes Regional Primate Research Center, Emory University,; Atlanta, GA.; The acutely lethal syndrome induced in macaques by SIVsmmPBj (PBj) progresses rapidly with animals succumbing to infection by 14 days after inoculation. Our studies have been focused on identifying pathogenic determinants of PBj through the use of molecular clones and chimeras of PBj. In addition to investigating the
Viral proteins required for specific lentivirus RNA encapsidation.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 94. Unique Identifier : AIDSLINE PRIM11/94191690; Schwartz M; Panganiban AT; McArdle Laboratory for Cancer Research, University of Wisconsin,; Madison 53706.; We have taken several approaches to identify and characterize the transacting factors that facilitate lentivirus RNA encapsidation. We constructed lentivirus expression constructs that express subsets of the viral genes, quantified virus particle production, and measured the relative efficiency of RNA packaging. Our a
SIV infection of intestinal lymphoid tissues and clinical malabsorption in rhesus macaques (Macaca mulatta).: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 96. Unique Identifier : AIDSLINE PRIM11/94191691; Stone J; Heise C; Miller C; Dandekar S; Department of Internal Medicine, University of California, Davis.; The objectives of this study were to assess prospectively the association between SIV infection, histopathologic changes, jejunal bacterial and protozoal flora, clinical malabsorption and nutritional status. We prospectively studied 12 juvenile rhesus macaques (9 SIV infected and 3 controls). Samples were taken preino
Molecular and biologic analysis of quasispecies during evolution of virulent SIVsmmPBj14.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 97. Unique Identifier : AIDSLINE PRIM11/94191692; Tao B; Fultz PN; Department of Microbiology, University of Alabama at Birmingham; 35294.; SIVsmmPBj14, an acutely lethal virus, evolved during 14 months of infection of pig-tailed macaque PBj with SIVsmm9. In addition to inducing disease and death within 1 week, rather than causing an AIDS-like disease, SIV-PBj14 differs from its parent virus, SIVsmm9, in eight in vitro biologic properties. Furthermore, ex
Development of a T cell lymphoma in Macaca fascicularis acutely infected with SIVmac251/32H.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 98. Unique Identifier : AIDSLINE PRIM11/94191693; Titti F; Maggiorella T; Monardo; Koanga-Mogtomo ML; Sernicola L; Corrias F; Panzini GL; Borsetti A; Baroncelli S; Geraci A; et al; Lab. of Virology, Istituto Superiore Sanita, Rome, Italy.; An apparently healthy five year old male Macaca fascicularis (Mf) was experimentally infected i.v. with 10-20 MID50 of SIVmac251/32H. The monkey died 3 months after infection. SIV genome was detected in PBMC by PCR-DNA and the virus was rescued from PBMC cocultivated with CEMx174 cells. However, no detectable anti-SIV
Sequence analysis of the SIVsmm Nef gene in naturally and experimentally infected sooty mangabey monkeys and macaques.: Symp Nonhum Primate Models AIDS. 1993 Sep 19-22;11:abstract no. 99. Unique Identifier : AIDSLINE PRIM11/94191694; Villinger F; Lauro S; Mayne A; Folks TM; Ansari AA; Dept of Pathology, Emory University Sch. of Medicine, Atlanta,; GA.; Our laboratory has analysed a total of 29 SIV Nef genes cloned ex vivo from naturally infected mangabeys and from mangabeys and macaques experimentally infected with SIVsmm. Sequence analysis of 21 Nef clones derived from 7 asymptomatic naturally infected mangabeys revealed the presence of 2 families of SIV Nef. Seque
Does peripheral blood T-lymphocyte population distribution in sarcoidosis provide a prognostic clue?: Sarcoidosis. 1991 Sep;8(2):129-33. Unique Identifier : AIDSLINE MED/94196126; Desrues B; Delaval P; Genetet N; Pencole C; Merdrignac G; Dassonville J; L'Huillier JP; Bourguet P; Kernec J; Service de Pneumologie, Hopital Pontchaillou, Centre Hospitalier; Regional et Universitaire, Rennes, France.; In its pulmonary form, sarcoidosis generally resolves spontaneously, but it may lead to fibrosis of the lung. The clinical, radiological and functional tests, as well as activity markers such as the serum angiotensin converting enzyme, intrathoracic uptake of 67Gallium and the cytological data provided by bronchoalveo
Semiquantitative PCR in the diagnosis of HIV infection: correlation to clinical stage and serological status.: Boll Ist Sieroter Milan. 1991-92;70(1-2):403-7. Unique Identifier : AIDSLINE MED/94206477; De Socio GV; Falcinelli C; Francisci D; Pauluzzi S; Cosmi EV; Anceschi MM; II Institute of Obstetrics and Gynecology, University La; Sapienza, Rome, Italy.; Authors utilized the polymerase chain reaction (PCR) technique to detect the presence of HIV DNA in 31 subjects (12 seropositive patients, 4 seronegative, at risk persons and 15 seronegative, not at risk controls). PCR was highly sensitive (enabling the detection of as few as 10 proviral genomes) and specific. By comp
[Chemotaxis deficiency in patients with HIV infection]: Boll Ist Sieroter Milan. 1991-92;70(1-2):433-7. Unique Identifier : AIDSLINE MED/94206479; Ciaffoni S; Roata C; Turrini A; Gandini A; Crocco I; Mazzi R; Malena M; Luzzati R; Aprili G; Istituto di Malattie Infettive, Verona.; Increased susceptibility to bacterial recurrent infection is characteristically associated with impaired B cells function but also with a defective PMN function. We studied PMN CT in 15 HIV positive drug addicts patients with persistent generalized lymphoadenopathy (PGL), in 15 symptom free HIV negative drug addicts (
Association of non-Hodgkin's lymphoma and Kaposi's sarcoma in a patient with HIV infection: case report.: Boll Ist Sieroter Milan. 1991-92;70(1-2):453-5. Unique Identifier : AIDSLINE MED/94206483; Verani DA; Sezione Malattie Infettive, Ospedale degli Infermi, Biella.; We describe a case of an HIV-antibody positive male intravenous drug abuser who suffered from a low grade NHL associated with Kaposi s sarcoma. Both the grade of the NHL and the Kaposi s sarcoma are relatively rare in a patient like ours as the former are usually high grade NHLs and the latter is more common in homose
[Determination of HIV-RNA using in situ hybridization on myocardial tissue. Role of HIV in cardiomyopathy in AIDS]: Boll Ist Sieroter Milan. 1991-92;70(1-2):457-65. Unique Identifier : AIDSLINE MED/94206484; Mencarini P; Tamburrini E; Antinori A; Zannoni G; De Luca A; Capelli A; Ortona L; Istituto di Clinica delle Malattie Infettive, Universita; Cattolica S. Cuore, Roma.; Aim of this study was to evaluate the presence of HIV-1 and CMV genomic sequences in myocardial tissue from autopsy of AIDS patients by in situ hybridization technique and to make a correlation with clinical and/or pathological signs of myocarditis. Seven patien
[Respiratory complications in 44 patients with acquired immunodeficiency syndrome]: Boll Ist Sieroter Milan. 1991-92;70(1-2):487-93. Unique Identifier : AIDSLINE MED/94206489; Negri C; Saracco A; Tambussi G; Ruggieri A; Lazzarin A; Clinica delle Malattie Infettive, Ospedale L. Sacco, Universita; di Milano.; Observation was carried out of 44 patients affected with pulmonary pathology during the course of AIDS, each of whom presented a severe respiratory insufficiency, admitted to the Clinic of Infectious Diseases between May 1987 and March 1989. In the patients suffering from their first respiratory infection, a lower mor
HTLV-I and HIV-I antibody frequency in thalassemics and drug addicts in southeast Sicily.: Boll Ist Sieroter Milan. 1991-92;70(1-2):531-4. Unique Identifier : AIDSLINE MED/94206495; Gulisano G; Ciccia M; Ienna M; Cipolla A; Mauro L; Cattedra di Clinica delle Malattie Tropicale e Sub-Tropicali,; Universita degli Studi di Catania.; HTLV-I (Human T-Lymphotropic Virus Type 1) and HIV-1 (Human Immunodeficiency Virus Type 1) antibodies have been investigated in 702 sera samples from: 259 drug addicts nerve screened for HIV-1 (Group I), 43 drug addicts already identified as HIV-1 seropositive (Group II), 222 thalassemics (Group III) and 178 occasiona
[Levels of interleukin-4 (IL-4) in lymphocyte cultures of subjects with HIV-1 infection]: Boll Ist Sieroter Milan. 1991-92;70(1-2):471-4. Unique Identifier : AIDSLINE MED/94206486; Perrella O; Liguori G; Precchia E; Soscia E; Guarnaccia D; Caruso I; Marinelli P; Finelli L; Tartaglia G; 3rd Dpt. (Sez. 1/2), Hospital D. Cotugno, Naples.; The authors report IL-4 levels in peripheral blood mononuclear cells (PBMC), stimulated with MoAb anti-CD3, in subjects with HIV-1 infection, classified according to the criteria of Centers for Disease Control (CDC) in various stages. The results in vitro have indicate that PBMC IL-4 levels were in normal range also i
AIDS and infection control: experiences, attitudes, knowledge and perception of occupational hazards among Nigerian dentists.: Afr Dent J. 1992;6:1-7. Unique Identifier : AIDSLINE MED/94197883; Sote EO; Department of Child Dental Health, College of Medicine,; University of Lagos, Nigeria.; A questionnaire survey of 79 Nigerian dentists aged 21-60 years was carried out to evaluate their experiences, attitudes, knowledge, and infection control practices in relation to HIV infection. Their perceptions of various occupational hazards were also probed. 84.4% of them held the view that HIV-infected/AIDS patie
The role and responsibilities of oral health personnel in the control and prevention of HIV infection/AIDS in Africa [editorial]: Afr Dent J. 1992;6:1p.. Unique Identifier : AIDSLINE MED/94197884; Okoisor FE
[AIDS and lymphoma of the ear]: Rev Laryngol Otol Rhinol (Bord). 1992;113(3):201-4. Unique Identifier : AIDSLINE MED/94204413; Ouchchane M; Portmann D; Doutre MS; Brottier-Mancini E; C.H.U. Pellegrin Tripode, Clinique ORL, Bordeaux, France.; The authors describe the circumstances for detection of an AIDS lymphomatous complication revealed by an otological picture in one patient. The lymphomatous pathology not related to HIV is reviewed. The particularity of these lymphomas, when they are related to HIV, is their frequent initial extra-ganglionic location,
[Hearing aids and AIDS: apropos of a case]: Rev Laryngol Otol Rhinol (Bord). 1992;113(4):375-6. Unique Identifier : AIDSLINE MED/94204435; Sanguy C; Aids carriers must be fitted with hearing aids early due to their life expectancy. Hearing aids of which the electro-acoustic specificities make it possible to lessen the successive aggravations must be foreseen.
The retroviruses: classification and molecular biology.: Baillieres Clin Neurol. 1992 Apr;1(1):1-21. Unique Identifier : AIDSLINE MED/94207474; Shaunak S; Weber JN; Department of Medicine, Royal Postgraduate Medical School,; Hammersmith Hospital, London, UK.
Central nervous system opportunistic infections in HIV disease: clinical aspects.: Baillieres Clin Neurol. 1992 Apr;1(1):103-54. Unique Identifier : AIDSLINE MED/94207475; Guiloff RJ; Tan SV; Westminster Hospital, London, UK.; Nervous system opportunistic infections are seen in about one fifth of AIDS cases and account for over 40% of the patients with neurological manifestations. Serious infections are seen in severely immunosuppressed patients, usually with CD4 counts of 200 ml-1 or less. The commonest is
Cognitive impairment and dementia in HIV-1 infection.: Baillieres Clin Neurol. 1992 Apr;1(1):155-74. Unique Identifier : AIDSLINE MED/94207476; Burgess A; Riccio M; Charing Cross and Westminster Medical School, Westminster; Hospital, London, UK.
Other neurological diseases in HIV-1 infection: clinical aspects.: Baillieres Clin Neurol. 1992 Apr;1(1):175-209. Unique Identifier : AIDSLINE MED/94207477; Guiloff RJ; Fuller GN; Westminster Hospital, London, UK.; HIV-1-related neurological diseases, excluding opportunistic infections and HIV encephalitis, are considered here. Most occur in severely immunosuppressed patients, with CD4 counts of under 200 x 10(6) l-1. Primary brain lymphoma and metastases from systemic non-Hodgkin s lymphoma ,
Neuropathology of HIV-1 and HTLV-1 infection.: Baillieres Clin Neurol. 1992 Apr;1(1):211-38. Unique Identifier : AIDSLINE MED/94207478; Scaravilli F; Department of Neuropathology, National Hospital for Neurology and; Neurosurgery, London, UK.
The immunology of retrovirus disease.: Baillieres Clin Neurol. 1992 Apr;1(1):23-40. Unique Identifier : AIDSLINE MED/94207479; Dalgleish AG; St George's Hospital, London, UK.
Therapeutic aspects of retroviral disease.: Baillieres Clin Neurol. 1992 Apr;1(1):239-57. Unique Identifier : AIDSLINE MED/94207480; Peto T; John Radcliffe Hospital, Headington, Oxford, UK.; Retroviruses of the nervous system cause HTLV-1-associated myelopathy and HIV-associated diseases. The treatment of HTLV-1 disease is essentially conservative; there is no effective drug treatment and therefore patients should be simply supported and reassured. If appropriate, other members of the family should be tes
Neurological aspects of lentiviral infections in animals.: Baillieres Clin Neurol. 1992 Apr;1(1):41-59. Unique Identifier : AIDSLINE MED/94207481; Kennedy PG; Department of Neurology, University of Glasgow, UK.
HTLV-1 and neurological disease.: Baillieres Clin Neurol. 1992 Apr;1(1):61-81. Unique Identifier : AIDSLINE MED/94207482; Cruickshank JK; Corbin DO; Bucher B; Vernant JC; Centre for Clinical Epidemiology, University of Manchester; Medical School, UK.
HIV-1 and HIV-2: overview of disease spectrum.: Baillieres Clin Neurol. 1992 Apr;1(1):83-101. Unique Identifier : AIDSLINE MED/94207483; Lever AM; Dept of Medicine, University of Cambridge, Eddenbrookes Hospital,; UK.; This overview has attempted to cover the more common aspects of the clinical presentations of HIV infection and the differential diagnoses. These can only be generalizations as presentations differ dramatically from patient to patient. It is also important to be aware that in an individual the disease is continually e
Studies to define viral cofactors for human immunodeficiency virus.: Infect Agents Dis. 1992 Oct;1(5):237-44. Unique Identifier : AIDSLINE MED/94207551; Griffiths PD; Division of Communicable Diseases, Royal Free Hospital School of; Medicine, London, United Kingdom.; Results from molecular biologic, cell biologic and animal experiments show that HIV replication can be driven by a variety of other viruses. If such interactions took place in vivo, then they could help to explain some of the complex pathogenesis of AIDS. The problems incurred in attempting to address this question in
Risk of hepatitis B and human immunodeficiency virus transmission to a patient from an infected surgeon due to percutaneous injury during an invasive procedure: estimates based on a model.: Infect Agents Dis. 1992 Oct;1(5):263-9. Unique Identifier : AIDSLINE MED/94207554; Bell DM; Shapiro CN; Culver DH; Martone WJ; Curran JW; Hughes JM; Hospital Infections Program, National Center for Infectious; Diseases, Centers for Disease Control, Atlanta, Georgia 30333.; The objective was to estimate the probability of sporadic hepatitis B virus (HBV) and human immunodeficiency virus (HIV) transmission to a patient from an infected surgeon due to percutaneous injury during an invasive procedure. Risk was estimated based on a model involving three probabilities: A, the probability that
Prophylaxis and therapy for Pneumocystis pneumonia--where are we?: Infect Agents Dis. 1992 Oct;1(5):270-8. Unique Identifier : AIDSLINE MED/94207555; Masur H; Critical Care Medicine Department, National Institutes of Health,; Bethesda, Maryland 20892.; The armamentarium of drugs to treat and to prevent Pneumocystis pneumonia has expanded substantially over the past decade. In all patient populations trimethoprim-sulfamethoxazole is the preferred regimen for both acute treatment and prophylaxis. Clindamycin-primaquine and atovaquone are both effective agents for acut
Human papillomavirus, human immunodeficiency virus, and cervical cancer: newly recognized associations?: Infect Agents Dis. 1992 Dec;1(6):319-24. Unique Identifier : AIDSLINE MED/94207559; Vernon SD; Icenogle JP; Johnson PR; Reeves WC; Viral Exanthems and Herpesvirus Branch, Centers for Disease; Control, Atlanta, Georgia 30333.; There are now sufficient data to conclude that women infected with human immunodeficiency virus (HIV) have an increased risk of human papillomavirus (HPV) infection and preinvasive stages of cervical cancer. This association is not completely due to immunosuppression. It is likely that HPV pathogenesis is altered in H
Intellectual property issues in a clinical trial: a corporate perspective.: Qual Assur. 1992 Jun;1(3):237-48. Unique Identifier : AIDSLINE MED/94207568; Fersko RS; Connolly MJ; Tanner Propp & Fersko, New York, New York 10016.
[Pediatric AIDS: a report of the first fatal Cuban pediatric case]: Rev Cubana Med Trop. 1992;44(1):44-6. Unique Identifier : AIDSLINE MED/94211981; Gonzalez Nunez I; Capo de Paz V; Rodriguez Barreras ME; Diaz Jidy M; Fraga Castro M; Instituto de Medicina Tropical Pedro Kouri.; The case of a Cuban child with AIDS acquired by perinatal transmission is reported. Thirteen days after birth, the child had chronic diarrhoeas affecting its pondostatural development. It was hospitalized many times due to recurrent respiratory processes, in one of which Pneumocystis carinii was detected. Oral candidi
[Infections and other opportunistic processes in a group of Cuban stage-IV HIV patients]: Rev Cubana Med Trop. 1992;44(1):47-9. Unique Identifier : AIDSLINE MED/94211982; Menendez Capote R; Millan Marcelo JC; Instituto de Medicina Tropical Pedro Kouri.; Forty Cuban patients affected by the human immunodeficiency virus (HIV), belonging to Group IV, assisted during a year at the Pedro Kouri Tropical Medicine Institute, are reported. Pneumocystis carinii, cryptosporidiosis, mucocutaneous herpes simplex, oral candidiasis and multidermatoma herpes zoster were the most com
Lymphoid interstitial pneumonia not associated with HIV infection: role of Epstein-Barr virus.: Mod Pathol. 1992 Sep;5(5):487-91. Unique Identifier : AIDSLINE MED/94218349; Malamou-Mitsi V; Tsai MM; Gal AA; Koss MN; O'Leary TJ; Department of Cellular Pathology, Armed Forces Institute of; Pathology, Washington, DC.; The polymerase chain reaction (PCR) method was used to determine the presence of Epstein-Barr virus sequences in seven cases of pulmonary lymphoid interstitial pneumonia not associated with HIV infection. Evidence of Epstein-Barr virus genome was found in three of six cases in which beta-globin gene, used as an intern
Characterization of the topography of Epstein-Barr virus infection in human immunodeficiency virus-associated lymphoid tissues.: Mod Pathol. 1992 Sep;5(5):559-66. Unique Identifier : AIDSLINE MED/94218363; Arber DA; Shibata D; Chen YY; Weiss LM; Department of Pathology, City of Hope National Medical Center,; Duarte, California.; A highly sensitive in situ hybridization methodology for Epstein-Barr virus (EBV) RNA was used to determine the topography of EBV infection in 16 cases of human immunodeficiency virus-associated lymphoid tissues. Four lymphomas, 11 persistent generalized lymphadenopathy (PGL) lymph nodes, and one lymphoepithelial cyst
[AIDS. Professional risk in dental practice?]: Rev Med Chir Soc Med Nat Iasi. 1992 Jul-Dec;96(3-4):315-8. Unique Identifier : AIDSLINE MED/94218611; Barlean L; Disciplina policlinica stomatologica, Universitatea de; Medicina si Farmacie Iasi.
[Peripheral facial paralysis and HIV infection. 2 case reports]: Rev Med Interne. 1992 Sep-Oct;13(5):354-8. Unique Identifier : AIDSLINE MED/94218551; Doutre MS; Beylot C; Beylot J; Long P; Royer P; Lacoste D; Service de Dermatologie, Hopital Haut-Leveque, Pessac.; Two cases of peripheral facial paralysis in subjects with HIV infection are reported. On the basis of these two cases and data from the literature, the clinical and paraclinical features of this facial nerve lesion are described. The various aetiological hypotheses put forward are discussed, but it is probable that th
Health promotion for Aboriginal communities.: World Health Forum. 1994;15(1):25-8. Unique Identifier : AIDSLINE MED/94190423; Freeman P; University of Papua New Guinea, Boroko.
Community responses to AIDS.: World Health Forum. 1994;15(1):35-8. Unique Identifier : AIDSLINE MED/94190425; Anderson S; Health Care Support Unit, Office of Intervention Development and; Support, Global Programme on AIDS, World Health Organization,; Geneva, Switzerland.; Some examples of care in the community for people with HIV/AIDS are reported from Africa. Members of communities committed to fighting the AIDS epidemic cannot do so alone and should be given every possible help. Inadequate care favours the spread of HIV, as does the stigmatization of people with HIV infection and the
Role of HIV infection in the hematologic manifestations of HIV seropositive subjects.: Crit Rev Oncol Hematol. 1993 Dec;15(3):271-83. Unique Identifier : AIDSLINE MED/94190521; Zauli G; Davis BR; Institute of Human Anatomy, University of Ferrara, Italy.
Antigen detection in neutralization assays: high levels of interfering anti-p24 antibodies in some plasma [letter]: AIDS Res Hum Retroviruses. 1993 Dec;9(12):1173-4. Unique Identifier : AIDSLINE MED/94190621; Mascole JR; Burke DS
Improbability of harmful autoimmune responses resulting from immunization with HIV-1 envelope glycoproteins.: AIDS Res Hum Retroviruses. 1993 Dec;9(12):1195-208. Unique Identifier : AIDSLINE MED/94190624; Neurath AR; Strick N; Li YY; Jiang S; Lindsley F. Kimball Research Institute, New York Blood Center,; New York 10021.; Autoimmunity mediated by cross-reactive antibodies, elicited by HIV-1 envelope glycoproteins gp120/gp160, has been postulated to contribute to the pathogenesis of AIDS. Partial amino acid sequence homology between gp120/gp160 and several human host proteins, including MHC antigens and immunoglobulins, has been perceiv
Purification of an Escherichia coli-expressed Nef protein from the human immunodeficiency virus-type 2.: AIDS Res Hum Retroviruses. 1993 Dec;9(12):1225-31. Unique Identifier : AIDSLINE MED/94190627; Du Bois GC; Hodge DR; Hanson CA; Samuel KP; Zweig M; Showalter SD; Papas TS; Nucleic Acid and Protein Synthesis Laboratory, Program Resources,; Inc., National Cancer Institute, Frederick Cancer Research and; Development Center, Maryland 21701.; The entire nef gene sequence of HIV-2, NIH-Z strain, has been cloned into the pJL6 expression vector and used for the synthesis of a 23-kDa protein in E. coli. The expressed protein is a fusion between the N-terminal 13 amino acids of the cII gene, 8 amino acids resulting from the ligation procedure, and the 180 amino
Nonaffinity purification of recombinant gp120 for use in AIDS vaccine development.: AIDS Res Hum Retroviruses. 1993 Dec;9(12):1233-44. Unique Identifier : AIDSLINE MED/94190628; Scandella CJ; Kilpatrick J; Lidster W; Parker C; Moore JP; Moore GK; Mann KA; Brown P; Coates S; Chapman B; et al; Department of Process Development, Chiron Corporation,; Emeryville, California 94608.; The gene encoding the major envelope glycoprotein of the HIV-SF2 isolate was engineered for the secretion of recombinant gp120 (rgp120SF2) from permanent Chinese hamster ovary (CHO) cell lines. Cellular production methods were scaled up and a method for purification of the secreted glycoprotein was devised. Mild purif
Cellular topoisomerase I activity associated with HIV-1.: AIDS Res Hum Retroviruses. 1993 Dec;9(12):1245-50. Unique Identifier : AIDSLINE MED/94190629; Jardine D; Tachedjian G; Locarnini S; Birch C; Virology Department, Fairfield Hospital, Victoria, Australia.; Topoisomerase I activity was detected in detergent-disrupted human immunodeficiency virus type 1 (HIV-1) particles. The enzyme did not require ATP for its conversion of SC DNA to an RC form, had divalent cation requirements similar to those of eukaryotic topoisomerase I, and was significantly inhibited by the specific
Relationship between anti-p24 antibody levels and p24 antigenemia in HIV-infected patients [published erratum appears in AIDS Res Hum Retroviruses 1994 Apr;10(4):431]: AIDS Res Hum Retroviruses. 1993 Dec;9(12):1251-5. Unique Identifier : AIDSLINE MED/94190630; Fenouillet E; Blanes N; Coutellier A; Gluckman JC; CNRS URA 1463, Paris, France.; We studied the influence of HIV p24 antigen immune complexing with anti-p24 antibodies on the assessment of their respective levels in HIV-positive sera. ELISAs were used to evaluate anti-p24 antibody levels and p24 antigenemia, with or without acid dissociation. Observations include the following: (1) p24 antigenemia
An individual with a high prevalence of a tat-defective provirus in peripheral blood.: AIDS Res Hum Retroviruses. 1993 Dec;9(12):1265-8. Unique Identifier : AIDSLINE GENBANK/L20412; Sabino E; Cheng-Mayer C; Mayer A; Irwin Memorial Blood Centers, San Francisco, California 94118.; The first exon of tat was sequenced from 23 provirus genomes randomly amplified directly from an HIV-1-infected individual s peripheral blood. Twelve of the 23 sequences constituted a distinct subset of the quasi-species detected. This subset had in common two inactivating mutations in the tat gene. In addition, two o
Susceptibility of human-mouse T cell hybrids to HIV-productive infection.: AIDS Res Hum Retroviruses. 1993 Dec;9(12):1269-75. Unique Identifier : AIDSLINE MED/94190633; Ramarli D; Cambiaggi C; De Giuli Morghen C; Tripputi P; Ortolani R; Bolzanelli M; Tridente G; Accolla RS; Istituto di Immunologia e Malattie Infettive, Universita di; Verona, Italy.; Interspecies human x mouse cell hybrids were used to investigate the genetic basis of human permissivity to HTLV-IIIB infection. T cell hybrids between the mouse BW 51.47 T lymphoma line and normal, PHA- IL-2 activated, human peripheral mononuclear cells (PBMCs) were ge
Increased susceptibility of neonatal monocyte/macrophages to HIV-1 infection.: AIDS Res Hum Retroviruses. 1993 Dec;9(12):1277-85. Unique Identifier : AIDSLINE MED/94190634; Sperduto AR; Bryson YJ; Chen IS; Department of Pediatrics, UCLA School of Medicine 90024.; The relative susceptibility of neonatal/cord blood monocyte/macrophages to productive infection with human immunodeficiency virus type 1 (HIV-1) was investigated. In addition, the effect of HIV-1 infection of cord blood monocyte/macrophages in various stages of maturation/differentiation as represented by differing ag
Reverse transcription takes place within extracellular HIV-1 virions: potential biological significance.: AIDS Res Hum Retroviruses. 1993 Dec;9(12):1287-96. Unique Identifier : AIDSLINE MED/94190635; Zhang H; Zhang Y; Spicer TP; Abbott LZ; Abbott M; Poiesz BJ; Department of Microbiology/Immunology, SUNY Health Science Center; at Syracuse, New York 13210.; Extracellular HIV-1 virions purified from cell culture supernatants have been found to contain viral DNA that is the result of partial reverse transcription within the virus particles. Our data supported these observations and further indicated that the ratio of genomic RNA to viral DNA was approximately 10(3):1 for t
Detecting SIV gp120 and its interaction with soluble CD4 by ELISA.: AIDS Res Hum Retroviruses. 1993 Dec;9(12):1297-9. Unique Identifier : AIDSLINE MED/94190636; Moore JP; Sattentau QJ; Aaron Diamond AIDS Research Center, New York, New York 10018.
Acquired immunodeficiency syndrome (AIDS)--data as at 31 December 1993.: Wkly Epidemiol Rec. 1994 Jan 14;69(2):5-6. Unique Identifier : AIDSLINE MED/94190748
The current global situation of the HIV/AIDS pandemic.: Wkly Epidemiol Rec. 1994 Jan 14;69(2):7-8. Unique Identifier : AIDSLINE MED/94190749
[Indolent cutaneous ulcer in a patient with HIV infection]: Enferm Infecc Microbiol Clin. 1993 Dec;11(10):565-6. Unique Identifier : AIDSLINE MED/94191052; Santos J; Marquez M; Rivero A; Unidad de Infecciosos, Hospital Virgen de la Victoria, Malaga.
[Pyogenic liver abscess and HIV (letter)]: Enferm Infecc Microbiol Clin. 1993 Dec;11(10):576-7. Unique Identifier : AIDSLINE MED/94191061; de Otero J; Balcells E; Calvo F; Ribera E; Vicens JC; Martinez Vazquez JM
Efficient diagnosis of Pneumocystis carinii pneumonia [editorial]: Int J STD AIDS. 1994 Jan-Feb;5(1):1-7. Unique Identifier : AIDSLINE MED/94191062; Smith DE; In patients with HIV infection the diagnosis of PCP is relatively simple when patients present late, with advanced pneumonia. The diagnosis becomes more difficult when patients present with minimal symptoms, are receiving specific prophylactic therapy or have had previous AIDS-related pulmonary diseases. A number of n
A brighter image for genitourinary medicine clinics.: Int J STD AIDS. 1994 Jan-Feb;5(1):11-2. Unique Identifier : AIDSLINE MED/94191063; FitzGerald M; Goldsmith M; Belfield T; Hayton P; Musgrove Park Hospital, Taunton, Somerset, UK.
HIV/AIDS, advocacy and anti-discrimination legislation--the Australian response.: Int J STD AIDS. 1994 Jan-Feb;5(1):13-7. Unique Identifier : AIDSLINE MED/94191064; Neilsen GA; Young FJ; Sydney Sexual Health Centre, Sydney Hospital, NSW, Australia.; This paper will address the role of mass communication strategies in the reduction of HIV/AIDS discrimination in Australia . It will focus on the interdependence of mass communication and legislation in health promotion campaigns with particular reference to the Disability Discri
Meatoscopy: an important technique for assessing meatal warts in men.: Int J STD AIDS. 1994 Jan-Feb;5(1):18-20. Unique Identifier : AIDSLINE MED/94191065; Thin RN; St Peter's Hospital, London, UK.; A total of 506 meatoscopic examinations showed this is a simple, safe, rapid, well-tolerated, useful procedure to assess the extent of warts at the meatus and in the distal urethra of men. The procedure was performed in 307 patients. Sixty-five (52.5%) of 124 men with meatal warts had additional urethral lesions not r
How should an AIDS diagnosis be given? The views of patients.: Int J STD AIDS. 1994 Jan-Feb;5(1):21-4. Unique Identifier : AIDSLINE MED/94191066; Pergami A; Catalan J; Hulme N; Burgess A; Gazzard B; Department of Psychiatry, Charing Cross and Westminster Medical; School, London, UK.; The report aimed at obtaining information about patients experience of how the diagnosis of AIDS was given to them by their doctors, and about patients satisfaction with the consultation. Thirty people with AIDS completed a self-report questionnaire enquiring about their views and satisfaction with the process of co
Demonstration of Epstein-Barr virus DNA in acetowhite lesions of the vulva.: Int J STD AIDS. 1994 Jan-Feb;5(1):25-8. Unique Identifier : AIDSLINE MED/94191067; Voog E; Ricksten A; Lowhagen GB; Ternesten A; Department of Dermatovenereology, Sahlgrenska Hospital,; Gothenburg, Sweden.; Acetowhite lesions in the vulva disclosing koilocytosis have been related to infection by human papilloma virus (HPV). Because of the clinical resemblance of these lesions to oral hairy leukoplakia (OHL), and EBV-manifestation, 23 women with acetowhite koilocytotic lesions in the vulva were examined. The PCR-technique
The impact of lubricants on latex condoms during vaginal intercourse.: Int J STD AIDS. 1994 Jan-Feb;5(1):29-36. Unique Identifier : AIDSLINE MED/94191068; Steiner M; Piedrahita C; Glover L; Joanis C; Spruyt A; Foldesy R; Contraceptive Use and Epidemiology Division, Family Health; International, Research Triangle Park, NC 27709.; The objective was to evaluate the impact of additional lubricant on condom breakage and slippage. Two hundred and sixty-eight couples used 6 new and 6 aged condoms during vaginal intercourse and were instructed to use 2 of each type with either water-based lubricant, oil-based lubricant or no additional lubricant. The
Heterosexual partnership characteristics of university women.: Int J STD AIDS. 1994 Jan-Feb;5(1):37-40. Unique Identifier : AIDSLINE MED/94191069; Lindblade K; Foxman B; Koopman JS; Department of Epidemiology, University of Michigan School of; Public Health, Ann Arbor 48109-2029.; In order to assess the individual risk of acquiring sexually transmitted diseases (STDs), both characteristics of the partnership and the individual should be considered. Partnership characteristics have been used as risk markers for STD transmission but their distribution has not been well described. Using a self-adm
Age-related increase in sexual behaviours and decrease in regular condom use among adolescents in Australia.: Int J STD AIDS. 1994 Jan-Feb;5(1):41-7. Unique Identifier : AIDSLINE MED/94191070; Dunne MP; Donald M; Lucke J; Nilsson R; Ballard R; Raphael B; National Centre for HIV Social Research, University of; Queensland, Royal Brisbane Hospital, Herston, Australia.; The prevalence of sexual behaviours was estimated from a survey of 3854 Australian secondary school students. Self-reported prevalence of intercourse increased from 9.9% (age 13 years or less) to 23.9% (age 15) and 51.2% at age 17 and over. Among 932 sexually experienced youth in the final 3 years of secondary school,
Human immunodeficiency virus and Treponema pallidum infections in Nigerian patients with leprosy.: Int J STD AIDS. 1994 Jan-Feb;5(1):48-51. Unique Identifier : AIDSLINE MED/94191071; Nwosu CM; Nwosu SN; Okoye KC; Department of Medicine, College of Health Sciences, Nnamdi; Azikiwe University, Nnewi-Nigeria.; Fifty-one patients were selected from 4 leprosaria in eastern Nigeria and were examined for evidence of syphilis. They were screened serologically for treponemal and human immunodeficiency virus (HIV) infections. Information about their sexual behaviour and demographic data were o
The determination of amines in the vaginal secretions of women in health and disease.: Int J STD AIDS. 1994 Jan-Feb;5(1):52-5. Unique Identifier : AIDSLINE MED/94191072; Jones BM; al-Fattani M; Gooch H; Department of Experimental and Clinical Microbiology, University; of Sheffield Medical School, UK.; The presence of amines in vaginal fluid is thought to be an important contributory factor in the pathogenesis of bacterial vaginosis (BV). As part of on-going work investigating the aetiology of this infection, two separate studies were performed in which gas chromatography was used to measure and compare the amines p
Experience of HIV prevention interventions among female sex workers in Delhi, India.: Int J STD AIDS. 1994 Jan-Feb;5(1):56-7. Unique Identifier : AIDSLINE MED/94191073; Singh YN; Malaviya AN; Department of Medicine, All India Institute of Medical Sciences,; New Delhi.; This paper describes the effect of HIV prevention intervention among female sex workers in Delhi. Over a 2-year period we found a marked increase in condom use with little increase in HIV seroprevalence. The prevalence of HIV infection did not increase during the study period (1 positive among 701 in 1988 vs 1 positiv
Recurrent bullous balanitis: an unusual presentation of balanitis xerotica obliterans.: Int J STD AIDS. 1994 Jan-Feb;5(1):58-9. Unique Identifier : AIDSLINE MED/94191074; Estcourt CS; Higgins SP; Goorney BP; Department of Genitourinary Medicine, Manchester Royal Infirmary,; UK.
Treatment of AIDS-associated oral hairy leukoplakia with cryotherapy.: Int J STD AIDS. 1994 Jan-Feb;5(1):60-2. Unique Identifier : AIDSLINE MED/94191075; Goh BT; Lau RK; Ambrose King Centre, Royal London Hospital, Whitechapel, UK.
Disseminated aspergillosis in the acquired immunodeficiency syndrome.: Int J STD AIDS. 1994 Jan-Feb;5(1):63-6. Unique Identifier : AIDSLINE MED/94191076; Singh G; Wijesurendra CS; Green JT; Department of Genitourinary Medicine, Cardiff Royal Infirmary,; UK.; The relationship of disseminated aspergillosis with human immunodeficiency virus (HIV) infection is unclear. In the initial case definition of acquired immunodeficiency syndrome (AIDS) developed by the Centres for Disease Control (CDC), Atlanta, aspergillosis was included as an AIDS-defining opportunistic infection. I
Rupial syphilides in a single male.: Int J STD AIDS. 1994 Jan-Feb;5(1):67-8. Unique Identifier : AIDSLINE MED/94191077; Williams J; Veluchamy V; Sundararaj AS; Government Rajaji Hospital, Madurai, India.
An audit of the value of microscopy of gram-stained and wet film preparations for the diagnosis of bacterial vaginosis in a department of genitourinary medicine.: Int J STD AIDS. 1994 Jan-Feb;5(1):69-70. Unique Identifier : AIDSLINE MED/94191078; Thompson C; McCabe K; Department of Genitourinary Medicine, Victoria Hospital,; Kirkcaldy, Scotland.
Ulcerative colitis and balanoposthitis [letter]: Int J STD AIDS. 1994 Jan-Feb;5(1):72-3. Unique Identifier : AIDSLINE MED/94191080; Lyttle PH
The role of aerosol pentamidine prophylaxis [letter; comment]: Int J STD AIDS. 1994 Jan-Feb;5(1):73. Unique Identifier : AIDSLINE MED/94191081; Reynolds MT; Monteiro E; Waugh MA
Contact tracing of patients with pelvic inflammatory disease [letter]: Int J STD AIDS. 1994 Jan-Feb;5(1):73-4. Unique Identifier : AIDSLINE MED/94191082; Markos AR
Treatment of anorectal manifestations of AIDS: past and present [editorial]: Int J STD AIDS. 1994 Jan-Feb;5(1):8-10. Unique Identifier : AIDSLINE MED/94191083; Schmitt SL; Wexner SD
Qualitative and quantitative studies of cytokines synthesized and secreted by non-human primate peripheral blood mononuclear cells.: Cytokine. 1993 Sep;5(5):469-79. Unique Identifier : AIDSLINE MED/94191164; Villinger F; Hunt D; Mayne A; Vuchetich M; Findley H; Ansari AA; Department of Pathology, Emory University School of Medicine,; Atlanta, GA 30322.; Non-human primates are being utilized in a variety of pre-clinical studies, including those involved with mechanisms of organ transplant rejection and those being used as models to test the efficacy of vaccines against a variety of infectious diseases, most notably AIDS. These studies clearly involve immunological eff
Chromosomal translocations in leukaemia.: Semin Cancer Biol. 1993 Dec;4(6):333-40. Unique Identifier : AIDSLINE MED/94191180; Gauwerky CE; Croce CM; Jefferson Cancer Institute, Thomas Jefferson University,; Philadelphia, PA 19107.; Many haematologic malignancies carry characteristic chromosomal translocations, which are thought to play an important role in the pathogenesis of these tumours. The t(8; 14) translocation in Burkitt s lymphoma was one of the first characterized at the molecular level. In this translocation the c-myc oncogene at chrom
Multiple cis-acting elements in the human immunodeficiency virus type 2 enhancer mediate the response to T-cell receptor stimulation by antigen in a T-cell hybridoma line.: Blood. 1994 Apr 1;83(7):1839-46. Unique Identifier : AIDSLINE MED/94191249; Hannibal MC; Markovitz DM; Nabel GJ; Howard Hughes Medical Institute, Department of Internal Medicine,; University of Michigan Medical Center, Ann Arbor 48109-0650.; Transcription directed by the human immunodeficiency virus type 2 long terminal repeat (HIV-2 LTR) responds to T-cell antigen receptor signaling. Agents that stimulate T-cell signaling pathways activated by the antigen receptor, such as phorbol ester, plant lectin, or anti-CD3 antibody treatment, have been shown to in
Pneumonia and pneumococcal immunization in human immunodeficiency virus-seropositive hemophiliacs [letter]: Blood. 1994 Apr 1;83(7):2005. Unique Identifier : AIDSLINE MED/94191270; Lederman MM; Kroner B; Kiger K; Goedert JJ
A transmission model for HIV with application to the Australian epidemic.: Math Biosci. 1994 Feb;119(2):205-24. Unique Identifier : AIDSLINE MED/9419