UT MD Anderson Clin Conf Cancer; 27:137-52 1984. Unique Identifier : AIDSLINE ICDB/85608654
Purtilo DT; Harada S; Manolov G; Tatsumi E; Lipscomb H; Manolova Y; The Dept. of Pathology and Laboratory Medicine, Univ. of Nebraska; Medical Center, Omaha, Nebraska 68105
The subject of lymphotropic viruses as etiologic agents in non-Hodgkin s lymphoma (NHL) is reviewed under the following section headings and subheadings: Epstein-Barr virus (EBV)-induced lymphoproliferative diseases (primary immune deficiency and EBV-induced NHL; organ allograft re
UT MD Anderson Clin Conf Cancer; 27:171-9 1984. Unique Identifier : AIDSLINE ICDB/85608657
Wong-Staal F; Gallo RC; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, MD 20205
The discovery of T-cell growth factor (TCGF) made it possible to grow both normal and neoplastic mature human T cells in long-term suspension culture. T cells from normal donors can be grown only after stimulation by lectin or antigen; in contrast, certain neoplastic mature T cells respond to TCGF without prior activa
UT MD Anderson Clin Conf Cancer; 27:277-98 1984. Unique Identifier : AIDSLINE ICDB/85608666
Koziner B; Urmacher C; Chaganti RS; Clarkson BD; Dept. of Medicine, Memorial Sloan-Kettering Cancer Center, New; York, NY 10021
An increased incidence of secondary neoplasms, including oral and rectal carcinomas and Burkitt s-like lymphoma, have recently been noted in immunodeficient homosexual men; also, the development of malignant non-Hodgkin s lymphoma (NHL) has been observed, not only in acute immunode
UT MD Anderson Clin Conf Cancer; 27:321-6 1984. Unique Identifier : AIDSLINE ICDB/85608669
Levine AM; Pavlova Z; Parker JW; Paganini-Hill A; Powars DR; Lukes RJ; Feinstein DI; Dept. of Medicine, Univ. of Southern California Sch. of Medicine,; Los Angeles, CA 90033
Burkitt s lymphoma, described as a tumor oriented about the jaw in children living in Uganda , is endemic not only in Uganda but also throughout the malaria belt of equatorial Africa. In these regions, an association between the Epstein-Barr virus (EBV) and the development of the ly
Z Naturforsch [C]. 1984 Nov-Dec;39(11-12):1199-202. Unique Identifier : AIDSLINE MED/85170339
Schwarz H; Thiel HJ; Weinhold KJ; Bolognesi DP; Schafer W
Antibody against viral gp71 is effective therapeutically for high leukemic AKR mice if injected immediately after birth. No corresponding effect could be observed after inoculation later in life when the endogenous virus burden is already high. However, if antibody treatment was supplemented by the injection of p15(E)
Over the last five years, the pattern and prevalence of the Acquired Immune Deficiency Syndrome (AIDS) has taxed microbiologists. The disease has increasingly looked like the result of a transmissible agent which though of low infectivity, has a predilection for certain well-defined social groups. Homosexual men are a
Ann Ophthalmol. 1984 Dec;16(12):1136-8. Unique Identifier : AIDSLINE MED/85173045
Buckman G; Yassur Y; Tamir R; Cohen S; Ben-Sira I
The syndrome of acquired immunodeficiency (AIDS) has previously been described. Originally thought to affect homosexuals and drug abusers exclusively, the disorder has also been observed in women associated with drug abuse, hemophiliacs, Haitians and, rarely, in heterosexual men. Several hundred cases have been report
Central nervous system (CNS) infections in the immunocompromised host are predictable according to the arm of the immune defense which is most defective. A limited number of organisms with a tendency to cause CNS infections will take advantage of the different types of immune defects. Signs and symptoms of CNS infecti
Cell surface receptors and antigens present on Langerhans cells (LC) suggest a close relationship between LC and interdigitating cells (IDC) in lymph node sections or lymphoid dendritic cells (LDC) in cell suspensions. One of the reported differences is that Fc receptors (FcR) which are present on LC, are absent on L
Scott Med J. 1984 Jan;29(1):25-6. Unique Identifier : AIDSLINE MED/85168199
Robertson AS; Pennington CR
A patient is described who developed multiple bacterial and fungal infections following a disseminated cytomegalovirus infection. The problem of infections in the debilitated host and the role of cytomegalovirus in suppressing immunity are discussed.
Two male homosexuals with laboratory features of the acquired immunodeficiency syndrome developed fulminating pneumonia requiring mechanical ventilatory support despite antibiotic therapy. Pathology consistent with bacterial pneumonia without other opportunistic pathogens were found at open lung biopsy. Cultures from
We reviewed the case records of 22 patients from whose pleural fluid a nontuberculous Mycobacterium (NTM) was isolated. Three patients had pleural effusions definitely due to NTM infection, with evidence of NTM infection in other tissues; 16 had pleural effusions of known etiology unrelated to the isolated NTM and no
We reviewed the clinical data and hepatic histologic findings of 25 patients with the acquired immunodeficiency syndrome who underwent 29 liver biopsies. Our experience indicates that the only hepatic feature characteristic of acquired immunodeficiency syndrome is serologic evidence of exposure to the hepatitis B viru
de la Loma A; Manrique A; Rubio R; Jimenez MS; Alvar J; Palencia E; Najera R
We describe a heroin addict who presented with cellular immunodeficiency, generalised tuberculosis, and pneumonia caused by Pneumocystis carinii, and discuss the risk of these associations.
Although the conference was not held to determine policy, certain issues emerged which should be of interest to all involved with the initiation of anti-HTLV-III testing. First, there was a consensus that an implementation period during which donors will not be notified of the test results is essential. During this pe
Z Hautkr. 1985 Jan;60(1-2):109-15. Unique Identifier : AIDSLINE MED/85170287
Rasokat H; Haussermann L; Bauermeister-Jasso K
We report on three patients suffering from Kaposi s sarcoma (KS) of the classical, endemic, and AIDS-related variant. We point out the uniformity of this tumor in terms of histomorphology. We found the characteristic findings of angiomatous structures and dense spindle cell formations. All variants of the tumor show h
Am J Public Health. 1985 May;75(5):493-6. Unique Identifier : AIDSLINE MED/85172354
McKusick L; Horstman W; Coates TJ
In November 1983, we surveyed 655 gay men in San Francisco regarding their sexual practices during the previous month and the same month one year ago. The sample was selected to include men in situations that would lead to high risk of sexual activities related to AIDS (acquired immune deficiency syndrome) transmissio
Diarrhea and weight loss may accompany the acquired immunodeficiency syndrome. We studied 30 patients with the syndrome, 20 of whom had diarrhea and weight loss and 10 of whom did not. Patients with identifiable enteric infections or small intestinal Kaposi s sarcoma were excluded. Malabsorption was common in the pati
A 30-year-old homosexual man presented with widespread Burkitt s lymphoma. On the basis of immunologic and viral studies, he was suspected of having the acquired immune deficiency syndrome. Following chemotherapy that included intrathecal cytosine arabinoside and methotrexate, brain stem edema, paraplegia, and an elev
Patients with acquired immunodeficiency syndrome (AIDS) characteristically present with repeated pulmonary infections. We present the pathologic findings in lung biopsy specimens from 12 patients with AIDS in whom the histologic spectrum ranged from mild diffuse alveolar damage to frank interstitial fibrosis. In all o
Four patients with acquired immunodeficiency syndrome with bacillemia from Mycobacterium avium-intracellulare presented with early pathologic clues of a disseminated mycobacterial infection. All had persistent fevers with negative diagnostic workups for other usual pathogens seen in patients with acquired immunodefici
This study examines the knowledge, beliefs, and sources of information of junior and senior high school students concerning AIDS. The students were found to have a very limited knowledge of AIDS. Males were more knowledgeable about AIDS than were females, but the majority of students were not personally worried about
46 cases of acquired immunodeficiency syndrome permit the authors to detail the particular aspects of the oral and facial lesions in AIDS. In patients at risk, a lymphadenopathic syndrome is thought to represent a prodromic phase of the illness. The authors insist upon the differences between the classic Kaposi s sarc
Froland SS; Oppedal B; Digranes S; Egge K; Skar AG; Hasvoll A; Onsrud M; Steinbakk M
The first case of acquired immunodeficiency syndrome (AIDS) in Norway , diagnosed in January 1983, is presented, with results of clinical, immunological, and microbiological studies and the results of autopsy. Immunological studies showed several immunological abnormalities, includi
A 45-year-old white male, bisexual, with a 2-year history of acquired immunodeficiency syndrome (AIDS) prodrome, developed a Burkitt cell-like acute lymphoblastic leukemia (ALL). Marker studies of marrow blasts show an unusual and possibly unique pattern, in that an unequivocal monoclonal B cell leukemia, having K-IgM
Blood and a variety of tissues from 97 patients with the acquired immunodeficiency syndrome (AIDS) and 25 with the AIDS prodrome were studied ultrastructurally. Tubuloreticular structures (TRS) were found in 85 per cent of the patients with AIDS and in 92 per cent of those with the prodrome. Test tube and ring-shaped
In addition to T-cell defects AIDS shows a separate B-cell dysfunction. Elevated spontaneous IgG-levels (not IgM) and a lacking proliferative and differentiation response to polyclonal B-cell activators can be demonstrated in vitro.
T-cell proliferative responses to the mitogenic monoclonal antibody anti-Leu 4 were assessed in healthy controls, lymphadenopathy syndrome (LAS) patients, and acquired immune deficiency syndrome (AIDS) patients. While 19% of the control group showed low anti-Leu 4 responses (less than 12,000 cpm), 60% of the LAS patie
We measured production of interleukin-2 ( IL-2 ) by phytohemagglutinin-stimulated peripheral blood mononuclear cells from 27 heterosexual persons, 43 asymptomatic homosexual men, 34 homosexual men with generalized lymphadenopathy syndrome (GLS), and 21 patients with acqu
Twelve homosexual patients with Kaposi s sarcoma associated with the acquired immune deficiency syndrome (AIDS) were treated with a preparation of purified human lymphoblastoid interferon (Wellferon [Burroughs Wellcome, Research Triangle Park, NC]). They were given a dose of 20 X 10(6) U/m2 intramuscularly daily for a
The immunocompromised human host may be subject to recurrent infection and/or malignant transformation. Signs and symptoms of depressed immunity generally reflect the degree of compromise. The laboratory diagnosis of the immune compromised host is presented. A review is given of the clinical manifestations and appropr
Patients with acquired immune deficiency syndrome (AIDS) frequently present with signs and symptoms referable to the head and neck. Three hundred ninety-nine patients with AIDS presented at the University of California, San Francisco and its affiliated hospitals from 1980 to April 1984. One hundred sixty-five patients
Bronchoalveolar lavage and transbronchial biopsy have been used as adjuncts to the management of patients with pneumonia associated with the acquired immunodeficiency syndrome (AIDS) at the Middlesex Hospital and the experience gained and difficulties encountered in the first five cases are reported. Widely varying or
Janossy G; Pinching AJ; Bofill M; Weber J; McLaughlin JE; Ornstein M; Ivory K; Harris JR; Favrot M; Macdonald-Burns DC
Recent evidence has shown that not only AIDS but also the majority of unexplained persistent, generalized lymphadenopathy (PGL) are related to HTLV-III/LAV infections. The early detection how these changes may proceed to AIDS then become a prime interest. Eleven patients with PGL (10 homosexual males and one heteros
Front Radiat Ther Oncol. 1985;19:52-8. Unique Identifier : AIDSLINE MED/85155543
Busch DF
Treatment of an AIDS patient with opportunistic infections is clearly complicated by the immunological and nutritional deficiencies associated with the syndrome. Clinical control of some individual infections may be achieved with traditional or investigational measures, but relapse or appearance of another serious inf
Profeta S; Forrester C; Eng RH; Liu R; Johnson E; Palinkas R; Smith SM
Salmonella infections occurred in six patients with acquired immunodeficiency syndrome (AIDS) and one patient with probable AIDS. The immune system defects increase the susceptibility of patients with AIDS to salmonella infections. Recognition of salmonellosis in patients with AIDS is important because of a high prope
Ricin-resistant variants of the SH9 T-cell line were selected after growth of this line in medium containing toxic amounts of ricin, a lectin derived from Ricinus communis. The ricin-resistant SH9 lines, SH9.R0 and SH9.R1, were demonstrated to be deficient in cell surface ricin-binding sites, but otherwise had the cel
A child with acquired immune deficiency syndrome became severely malnourished presumably as a result of multiple gastrointestinal infections, with numerous organisms including campylobacter, giardia, and cryptosporidium. These opportunistic infections preceded laboratory evidence of immune deficiency. Despite severe d
Kaposi s sarcoma and B-cell lymphomas have been reported to develop in homosexual men with the acquired immunodeficiency syndrome (AIDS) or chronic lymphadenopathy syndrome (CLS). We treated what we believe is the first documented case of multiple myeloma complicating CLS in a 31-year-old male homosexual. This broaden
Cancer. 1985 May 1;55(9):1899-901. Unique Identifier : AIDSLINE MED/85151630
Marinig C; Fiorini G; Boneschi V; Melotti E; Brambilla L
In order to establish if immunologic alterations seen in acquired immunodeficiency syndrome (AIDS)-associated Kaposi s sarcoma are also present in the primary form of this malignancy, peripheral blood T-lymphocyte characterization and HLA A, B, C, and DR phenotyping have been carried out in 18 patients with the primar
Increased levels of 3% PEG precipitable circulating immune complexes (CIC) were found in healthy homosexual men, in homosexual patients with the acquired immune deficiency syndrome (AIDS), and in the AIDS related lymphadenopathy syndrome (LAS). The degree of CIC elevation increases from healthy homosexual men to LAS a
This case report describes the first case of AIDS in Salzburg. The patient belonged to the male homosexual risk group. He presented with opportunistic infections: oral candidiasis, bilateral Pneumocystis carinii pneumonia and cerebral toxoplasmosis. The diagnosis of AIDS was corroborated by highly elevated urinary neo
Br Med J (Clin Res Ed). 1985 Mar 16;290(6471):808-10. Unique Identifier : AIDSLINE MED/85150890
Biggar RJ; Melbye M; Kestens L; de Feyter M; Saxinger C; Bodner AJ; Paluko L; Blattner WA; Gigase PL
A human retrovirus--human T cell lymphotropic virus-III (HTLV-III)--has recently emerged as the probable cause of acquired immunodeficiency syndrome (AIDS). In May 1984, 250 outpatients at a hospital in a remote area of eastern Zaire were surveyed for AIDS type illnesses and the p
In a patient with AIDS, severe cytomegalovirus ( CMV ) infection dominated with gastro-intestinal and retinal involvement. The gastro-intestinal signs--diarrhoea and recurrent vomiting--correlated with the destruction of the tu
Akagi T; Takeda I; Oka T; Ohtsuki Y; Yano S; Miyoshi I
Rabbits were successfully infected with human T-cell leukemia virus type I (HTLV-I) and produced antibodies to adult T-cell leukemia-associated antigens (ATLA) on intravenous inoculation of the HTLV-producing human cord T-cell line MT-2, or autologous cell lines established by cocultivation with MT-2 cells. Lymphocyte
In an extensive study involving unification of secondary structure prediction methods to predict peptide backbone angles, folding simulations, and interactive graphics we have calculated conformations for a 160 residue p28sis protein fragment. We demonstrate that the state of the art is sufficient to aid artificial va
Pink-stained (hematoxylin and eosin), variably sized, round-shaped, intracellular and extracellular eosinophilic bodies, commonly observed in African cases of Kaposi s sarcoma (KS), were discovered in cutaneous KS tumors of two American men with AIDS (the acquired immune deficiency syndrome). These bodies were also id
Lymphocyte subpopulations in patients with hemophilia were analyzed. The results were compared with those in age- and sex-matched controls. The patients had been receiving blood and blood products including Factor VIII or Factor IX for a number of years as required at the time of the onset of the disease. Heparinized
Klin Wochenschr. 1985 Jan 15;63(2):68-72. Unique Identifier : AIDSLINE MED/85161833
Kern P; Muller G; Schmitz H; Racz P; Meigel W; Riethmuller G; Dietrich M
Coronavirus-like particles were identified by electronmicroscopy in the feces of homosexual men. The particles banded at a density of 1.21 g/ml after cesium chloride density gradient centrifugation. To determine whether the presence of this virus might be related to clinical symptoms, several patient groups were studi
N Engl J Med. 1985 May 2;312(18):1151-9. Unique Identifier : AIDSLINE MED/85163647
Shearer WT; Ritz J; Finegold MJ; Guerra IC; Rosenblatt HM; Lewis DE; Pollack MS; Taber LH; Sumaya CV; Grumet FC; et al
A 12-year-old boy with severe combined immunodeficiency who had been kept in a gnotobiotic environment since birth received bone marrow from a histoincompatible sibling in an attempt to reconstitute immunologic function. To prevent graft versus host disease, the donor s marrow was treated in vitro with monoclonal anti
A 36-year-old homosexual man developed a lymphocytic meningoencephalitis, lymphadenopathy, decreased helper/suppressor ratio in peripheral blood, and Kaposi s sarcoma. After repetitive evaluations for bacterial and fungal agents were negative, viral cultures were positive for cytomegal
Proc Natl Acad Sci U S A. 1985 Mar;82(6):1721-5. Unique Identifier : AIDSLINE MED/85166203
Johnsson A; Betsholtz C; von der Helm K; Heldin CH; Westermark B
We have compared the functional properties of a growth factor partially purified from medium conditioned by simian sarcoma virus-transformed cells with those of platelet-derived growth factor (PDGF). The factor mimicked the effects induced by PDGF: it bound to and activated human fibroblast PDGF receptors and stimulat
Acquired immune deficiency syndrome (AIDS) can be transferred to patients by blood transfusions or human blood preparations, such as cryoprecipitates or factor VIII concentrates. Retroviruses have been discussed as infectious AIDS agents and more recently human T-lymphotropic retroviruses designated as HTLV type III a
AIDS associated retrovirus-like particles were identified in the salivary gland, prostate and/or testicle of two AIDS patients. These findings further suggest that saliva and semen may transmit the infection to susceptible individuals.
The envelope (env) and structural (gag) gene products of human T-cell leukemia (lymphotropic) virus type III were identified by immunoaffinity chromatography, immunoprecipitation, and two-dimensional oligopeptide mapping methods. The env gene specifies a glycosylated polypeptide with a molecular weight of 160,000 (gp1
S Afr Med J. 1985 Mar 23;67(12):445-9. Unique Identifier : AIDSLINE MED/85168569
Becker WB; Becker ML; Homma T; Brede HD; Kurth R
The prevalence of humoral antibodies to human T-cell leukaemia virus type I (HTLV-I) was investigated in different ethnic groups and in non-human primates in South Africa . Serum antibody levels were determined by enzyme-linked immunosorbent assay (ELISA) using either disrupted who
Kloster BE; Tomar RH; Stockman JA 3d; Lamberson HV; Merl SA; John PA; Groth DM; Poiesz BJ
Antibodies to the membrane antigens of human T-cell lymphotropic virus-I (anti-HTLV-MA) have been detected in patients with the acquired immune deficiency syndrome (AIDS) and in patients with hemophilia. The authors examined sera from 71 AIDS patients and 46 hemophiliac children for the presence of anti-HTLV-MA using
Am J Med. 1985 Apr;78(4):621-6. Unique Identifier : AIDSLINE MED/85171987
Dorsett B; Cronin W; Chuma V; Ioachim HL
Human lymphotropic retroviruses lymphadenopathy-associated virus/human T lymphoma virus III have been recently implicated in the pathogenesis of the acquired immune deficiency syndrome (AIDS). The mechanisms leading to the complex immune deregulations of this disease, however, are still largely unknown. To investigate
Ann Intern Med. 1985 May;102(5):623-6. Unique Identifier : AIDSLINE MED/85172924
Kreiss JK; Kitchen LW; Prince HE; Kasper CK; Essex M
To evaluate the risk of heterosexual transmission of the acquired immunodeficiency syndrome, lymphadenopathy, and infection with human T-lymphotropic virus type III (HTLV-III), we studied 42 hemophiliacs and their wives. By early 1984, 9 of the hemophiliacs had asymptomatic lymphadenopathy and 1 had the acquired immun
Amberson JB; DiCarlo EF; Metroka CE; Koizumi JH; Mouradian JA
We report the pathologic findings in specimens submitted for histologic and cytologic evaluation from 67 patients with the acquired immunodeficiency syndrome. A wide variety of opportunistic pathogens were identified in 41 patients. Mycobacterium avium-intracellulare evoked only a mild host response: granulomas, if pr
The cell surface marker profile and functional analysis of peripheral blood lymphocytes from 11 Japanese adult T cell leukemia patients were studied. The phenotypic analysis of Japanese adult T cell leukemia (ATL) cells by a series of 13 monoclonal antibodies showed that all ATL cells are anti-T4 reactive but some dif
The relative frequencies of non-Hodgkin s lymphoma (NHL) subtypes and primary sites of presentation in young men before and during the acquired immunodeficiency syndrome epidemic were studied. Diagnostic pathological specimens were reviewed and classified according to the Working F
The third child of a previously healthy woman was delivered by caesarean section. Because of intraoperative blood loss, a blood transfusion was given after the delivery. The baby was breast-fed for 6 weeks. One unit of blood came from a male in whom the acquired immunodeficiency syndrome (AIDS) developed 13 months lat
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