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Abstract: The most common symptom is severe, burning, aching pain in the feet and legs, which may prevent walking. ...
http://www.aegis.com/topics/oi/oi-neuropathy.html
File Name: oi-neuropathy.html, Size: 7KB, Last Modified: Monday, January 12, 2009 at 9:53:40 PM
Abstract: An unexplained peripheral neuropathy was observed in five patients with positive serology for LAV/HTLV III. Three of them presented with polyneuropathy, one with chronic meningitis and oculomotor palsies, and one with a mononeuropathy. CSF was abnormal in 5/5, with el ...
http://www.aegis.com/news/ine/1987/may/m8750059.html
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Abstract: For people with mild symptoms of d4T-associated peripheral neuropathy, improvement was common without drug substitution. For people with severe neuropathy, most improved after a drug substitution with AZT, although improvement was more likely with baseline CD4 cell counts >200 cells/µL. ...
http://www.aegis.com/conferences/croi/2008/988.html
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Abstract: Chip-based whole mtDNA sequencing is technically feasible, was able to accurately haplogroup these HIV-infected individuals, and identified several known and potentially novel SNPs. In this small sample, the initial 7 mtDNA SNPs explored were not associated with NRTI-associated peripheral neuropathy. This technology co ...
http://www.aegis.com/conferences/lipo/2006/51.html
File Name: 51.html, Size: 7KB, Last Modified: Monday, September 25, 2006 at 6:29:23 AM
Abstract: zalcitabine, (ddC, Hivid) ...
http://www.aegis.com/factshts/network/simple/zalc.html
File Name: zalc.html, Size: 11KB, Last Modified: Sunday, August 20, 2006 at 9:21:39 PM
Abstract: What is Peripheral neuropathy? HIV drugs that can cause peripheral neuropathy, current treatments, relieving the pain, nutrients and peripheral neuropathy, on-going clinical trials ...
http://www.aegis.com/factshts/network/simple/neurop.html
File Name: neurop.html, Size: 12KB, Last Modified: Sunday, August 20, 2006 at 9:21:19 PM
Abstract: In this meta-analysis, d4T 40mg and 30mg BID showed equivalent antiviral efficacy by standard US FDA criteria. In cohort studies, the incidence of peripheral neuropathy and lipoatrophy was lower at the 30mg BID dosage. ...
http://www.aegis.com/conferences/iac/2006/thpe0120.html
File Name: thpe0120.html, Size: 9KB, Last Modified: Sunday, August 13, 2006 at 7:00:01 AM
Abstract: T4216C and A4917G, 2 non-synonymous mitochondrial DNA polymorphisms, were frequent among white ACTG 384 participants, and were associated with the development of peripheral neuropathy among those individuals randomized to receive ddI+d4T. These polymorphisms are known to alter amino acids in mitochondrial complex I sub ...
http://www.aegis.com/conferences/croi/2006/350.html
File Name: 350.html, Size: 8KB, Last Modified: Sunday, February 05, 2006 at 8:12:04 PM
Abstract: HOPS patients with higher pre-HAART CD4+ cell counts were less likely to develop renal insufficiency, peripheral neuropathy, and lipoatrophy in the HAART era, suggesting the benefit of earlier HAART treatment. Our findings also raise the possibility that use of HAART without interruptions may reduce the incidence of th ...
http://www.aegis.com/conferences/croi/2006/769.html
File Name: 769.html, Size: 8KB, Last Modified: Sunday, February 05, 2006 at 8:12:04 PM
Abstract: Iron-loading HFE polymorphisms may be associated with a decreased risk of NRTI-associated peripheral neuropathy. This finding has potential implications for the prevention and management of NRTI-associated peripheral neuropathy, particularly among populations at risk for iron deficiency. Further study of functional mec ...
http://www.aegis.com/conferences/croi/2006/78.html
File Name: 78.html, Size: 8KB, Last Modified: Sunday, February 05, 2006 at 8:12:04 PM
Abstract: Mitochondrial haplogroup T was more frequent in Caucasians who developed subjective peripheral neuropathy while on ddI/d4T during Study 384. The polymorphism that defines this haplogroup is located in the ND5 region of the mitochondrial gene encoding Complex I respiratory transport chain subunits and may point to varia ...
http://www.aegis.com/conferences/croi/2005/43.html
File Name: 43.html, Size: 8KB, Last Modified: Tuesday, February 22, 2005 at 8:12:04 PM
Abstract: Nerve regeneration occurs and can be rigorously measured over a period of several months in HIV+ subjects. Our results suggest that abnormalities in nerve regeneration precede the development of clinical neuropathy. Regeneration rates for HIV subjects are impaired compared to healthy control subjects and this differenc ...
http://www.aegis.com/conferences/croi/2005/13.html
File Name: 13.html, Size: 8KB, Last Modified: Tuesday, February 22, 2005 at 8:12:04 PM
Abstract: Peripheral neuropathy remains highly prevalent in HIV infection, and its course was relatively stable over 48 weeks. Previously established risk factors for peripheral neuropathy, including CD4 and HIV RNA, were not predictive for the presence or progression of neuropathy. While use of d-drugs did not predict progressi ...
http://www.aegis.com/conferences/croi/2005/397.html
File Name: 397.html, Size: 9KB, Last Modified: Tuesday, February 22, 2005 at 8:12:04 PM
Abstract: Plasma F2-IsoP levels were unexpectedly high at baseline in cryopreserved specimens from these study subjects compared to levels from a previous study that included HIV-infected adults not receiving ART. This may reflect ex vivo auto-oxidation of some plasma specimens. Although F2-IsoP increases tended to be somewhat g ...
http://www.aegis.com/conferences/croi/2005/399.html
File Name: 399.html, Size: 9KB, Last Modified: Tuesday, February 22, 2005 at 8:12:04 PM
Abstract: BACKGROUND: Pain and peripheral neuropathy are prevalent symptoms of HIV/AIDS that often do not respond to allopathic medical therapy. The present study was performed to determine the effect of 5 weeks of acupuncture treatment in a group setting on pain and symptoms of peripheral neuropathy in HIV-infected individuals. ...
http://www.aegis.com/conferences/iac/2004/b11024.html
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Abstract: Objectives: Evaluate the safety and tolerability of ddI/TDF in ARV for HIV-infected adults in the HOPS cohort. METHODS: Subjects identified using an electronic database of patients at 9 US clinics who received >14 days of ddI/TDF prior to Oct 2003. Adverse events that were examined in this analysis were ...
http://www.aegis.com/conferences/iac/2004/wepeb5922.html
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Abstract: Pathogenesis-based therapies may provide both analgesic and restorative effects in peripheral neuropathy. Recombinant human nerve growth factor produced pain relief in HIV neuropathy, but did not show regenerative effects. Within the ACTG, a novel agent, Prospatide, is under study for HIV neuropathy (A5180). Other agen ...
http://www.aegis.com/conferences/croi/2004/34.html
File Name: 34.html, Size: 8KB, Last Modified: Sunday, February 08, 2004 at 8:12:04 PM
Abstract: Adverse events, which lead to treatment interruption or change are frequent (37,3%). NRTIs are more frequently responsible for bone marrow suppression, peripheral neuropathy and diarrhea, Pis for gastrointestinal disorders, lipodystrophy, renal colic and nephrolithiasis and NNRTIs for allergic reactions. ...
http://www.aegis.com/conferences/eacs/2001/posters/491.html
File Name: 491.html, Size: 8KB, Last Modified: Tuesday, December 23, 2003 at 4:41:41 PM
Abstract: AEGIS, 8th EUROPEAN CONFERENCE ON CLINIC ASPECTS AND TREATMENT OF HIV - INFECTION. Abstract Form. REFERENCE NUMBER : 395. ECCATH ID : P260. 8th EUROPEAN CONFERENCE ON CLINIC ASPECTS AND TREATMENT OF HIV - INFECTION. Location of research or project (country). Greece. Thematic Areas:. Title. SIDE-EFFECTS OF ANTIRETRO ...
http://www.aegis.com/conferences/eacs/2001/papers/491.html
File Name: 491.html, Size: 7KB, Last Modified: Monday, December 01, 2003 at 5:53:50 AM
Abstract: SAN FRANCISCO, Nov. 20 /PRNewswire/ -- Prevention and reversal of damage to peripheral nerves -- peripheral neuropathy -- continues to confound clinicians and their patients worldwide. More than one million people in the U.S., Europe, and Japan suffer the symptoms of this frequently under-diagnosed and irreversi ...
http://www.aegis.com/news/pr/2003/pr031142.html
File Name: pr031142.html, Size: 10KB, Last Modified: Thursday, November 20, 2003 at 3:00:00 PM
Abstract: We found no evidence of a cumulative toxicity in any of the study arms. Age and CD4 were independently associated with peripheral neuropathy. ...
http://www.aegis.com/conferences/lipo/2003/48.html
File Name: 48.html, Size: 6KB, Last Modified: Wednesday, July 09, 2003 at 6:29:23 AM
Abstract: <p><b>BACKGROUND:</b> Stavudine and Didanosine are two nucleoside analogues. Their efficacy in antiretroviral combination therapy was largely demonstrated by many clinical trials. ...
http://www.aegis.com/conferences/iac/2002/mopeb3240.html
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Abstract: Peripheral neuropathy is the most frequent neurological complication associated with human immunodeficiency virus type 1 (HIV) infection and advanced acquired immunodeficiency syndrome (AIDS). There are at least 6 patterns of HIV-associated peripheral neuropathy , alth ...
http://www.aegis.com/aidsline/2000/dec/a00c0215.html
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Abstract: BACKGROUND: Peripheral neuropathy in children with human immunodeficiency virus (HIV) infection has not been systematically studied. Objectives. To describe the symptoms and signs of peripheral neuropathy in HIV-infected children and to determine their frequency. METH ...
http://www.aegis.com/pubs/ine/2000/nov/a00b0244.html
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Abstract: In our patient cohort gabapentin at a daily dose of 0.9–1.8 g is effective in the symptomatic treatment of HIV-related peripheral neuropathy when CD4 counts are > 200/cmm. Our findings support the suggestion that higher doses may be necessary in advanced HIV disease (CD4 < 200/cmm) [4] ...
http://www.aegis.com/conferences/hiv-glasgow/2000/p169.html
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Abstract: Zidovudine-naïve subjects failing on a stavudine-containing regimen with CDC classification C illnesses were significantly more likely to have higher HIV-1 RNA levels. More heavily ART-experienced subjects (more than four prior ART) had significantly increased incidence of peripheral neuropathy and wasting syndrome. ...
http://www.aegis.com/conferences/lipo/2000/p16.html
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Abstract: <p><b>BACKGROUND:</b> People living with HIV/AIDS experience perpheral neuropathy due to HIV disease, side effects of medication and treatment, and co-morbidities. This study describes the frequency and correlates (demographic and disease-related factors) of self-reported neuropathy and the self-care behaviors used t ...
http://www.aegis.com/conferences/iac/2000/thpeb5250.html
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Abstract: Peripheral neuropathy has been recognized as a dose-limiting adverse effect in Phase I studies of didanosine (ddI) therapy for HIV infection. To study the effect of the currently recommended lower dose of ddI, the databases of 4 randomized, controlled trials were used to assess the frequency of dose-limiting ...
http://www.aegis.com/aidsline/2000/jan/a0010932.html
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Abstract: The objective of the present study was to correlate electroneuromyography (ENMG) and evoked potentials findings with clinical aspects and intrathecal synthesis of HTLV-I antibodies production on HTLV-I myelopathy (HAM). Patients were seropositive for HTLV-I by different assays and seronegative for HIV and VDRL. They h ...
http://www.aegis.com/aidsline/1999/jul/a9970736.html
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Abstract: Distal symmetrical peripheral neuropathy is a common adverse experience in persons with HIV infection. This condition, which presents as a pain, numbness. burning and/or dysaethesia initially in the feet, is often multi-factorial in its origin. Nucleoside analogue rev ...
http://www.aegis.com/aidsline/1999/jun/a9960671.html
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