Dapsone-Pyrimethamine for the Treatment of Toxoplasma Encephalitis: Highlights of Neurological Research from the VIII International Conference on AIDS, Amsterdam, July 19-24, 1992
Seattle Treatment Education Project: STEP Perspective - Volume 4, Number 3 - October 1992 Lyn Frumkin, M.D., Ph.D.
Although the standard treatment of Toxoplasma encephalitis often begins with the usually effective regimen of sulfadiazene- pyrimethamine, significant drug intolerance-side effects have caused researchers to assess alternative regimens. Dr. D. Ward of Washington, D.C. assessed dapsone-pryimethamine because of its effectiveness against Toxoplasma in animal models. He reported that dapsone (100mg daily) plus pyrimethamine (25mg daily) was successful in all eight persons studied in both improving their signs and symptoms of Toxoplasma encephalitis and continued "suppression" of the disease for the period of time they were observed (six-22 months).
COMMENT. Although the author notes that his study is "uncontrolled and anecdotal," it clearly suggest that clinical trials may need to evaluate the efficacy of this regimen, which may be effective and well tolerated for the treatment of Toxoplasma encephalitis.
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Always watch for outdated information. This article first appeard in 1992. This material is designed to support, not replace, the relationship that exists between you and your doctor.
This information is designed to support, not replace, the relationship that exists between you and your doctor.