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Suspendido el estudio sobre la monoterapia con Reyataz


PI Perspective - periódico del tratamiento de Project Inform 44 - octubre, 2007


Como se reportó en el número de octubre de 2007 de la publicación “AIDS”, un estudio que examinaba el uso del Reyataz (atazanavir) como monoterapia fue suspendido tempranamente debido a la alta tasa de avance virológico. Los investigadores trataron de observar si existía una conexión entre los niveles de reyataz medidos en la sangre y el riesgo de un resurgimiento virológico, y no encontraron ninguna. Lo que sí encontraron fue una conexión entre la bilirrubina y los resultados del tratamiento con Reyataz.

Ha habido algún interés entre los investigadores de estudiar ciertos medicamentos contra el VIH para ser utilizados como monoterapia. Este interés surge principalmente de la investigación del Dr. Joel Gath sobre la monoterapia con Kaletra— la cual se encontró bastante exitosa, pero no tanto como la terapia antiretroviral de alta potencia tradicional. El Reyataz despertó interés debido a su combinación de potencia y alta barrera de resistencia. Este estudio sugiere que el riesgo de un avance virológico prematuro en la monoterapia con Reyataz es inaceptablemente alto.

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