PI Perspective 25: Effect of HAART on HPV

PI Perspective 25: Effect of HAART on HPV

Project Inform - September, 1998

Results from a study of 40 people with HIV showed that highly active antiretroviral therapy (HAART) could help reduce recurrence of genital warts after surgical treatment. Genital warts, like cervical and anal cancers, are a result of infection by human papillomavirus (HPV). Current treatment for genital warts is surgical removal, and the rate of recurrence tends to be higher in HIV-infected people. In this observational study, 13 people used a 3-drug treatment regimen, 21 used two drugs of the nucleoside analogue class (e.g. AZT, ddI, d4T, ddC and/or 3TC) and 6 used no anti-HIV therapy. Relapse rates 6 months after surgical treatment in 24 people were 0% among those receiving three drugs, 10% among those using two drugs and 75% among those receiving none. Relapse rates at only 1 and 3 months after surgery were equal among all three groups, suggesting that the effects of anti-HIV therapy in contributing to improved treatment of genital warts become increasingly apparent over time. The relapse rates also correlated with viral load such that as they decreased, people were less likely to experience a relapse in genital warts.

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Always watch for outdated information. This article first appeared in 1998. This material is designed to support, not replace, the relationship that exists between you and your doctor.

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The original of this article can be found at http://www.projinf.org/pub/25/gynecol.html

This information is designed to support, not replace, the relationship that exists between you and your doctor.
©1998. AEGiS.