PI Perspective 21: Drug Interactions with Nelfinavir

Important note: Information in this article was accurate in March, 1997. The state of the art may have changed since the publication date.

PI Perspective 21: Drug Interactions with Nelfinavir

Project Inform - March, 1997

Some important information on interactions between nelfinavir and other commonly used drugs have recently been made available:

Nelfinavir increases saquinavir (Invirase) levels by 4-fold and saquinavir increases nelfinavir levels by 18%
Nelfinavir increases indinavir (Crixivan) levels by 51% and indinavir increase nelfinavir levels by 83%
Nelfinavir increases ritonavir (Norvir) levels by 9% and ritonavir increases nelfinavir levels by 152%
Nelfinavir increases rifabutin (Mycobutin) levels by 3-fold and rifabutin decreases nelfinavir levels by 32%
Rifampin decreases nelfinavir levels by 82% and therefore these two drugs should not be used together
Ketoconazole increases nelfinavir levels by 35%
Nelfinavir decreases ethinyl estradiol (oral contraceptives) levels by 50%
Nelfinavir should not be used in combination with terfenadine (Seldane)

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Always watch for outdated information. This article first appeared in 1997. This material is designed to support, not replace, the relationship that exists between you and your doctor.

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The original of this article can be found at http://www.projinf.org/pub/21/Nelfinavir.html

This information is designed to support, not replace, the relationship that exists between you and your doctor.
©1997. AEGiS.