Transurethral prostatectomy in patients with preoperative bacteriuria: double-blind study with oral fleroxacin and cefalexin.
Chemotherapy 1998 Jan-Feb;44(1):69-75 Unique Identifier : MEDLINE 98106817 Viitanen J; Malminiemi K; Kallio J; Puolakka VM; Rajala P; Tammela TL; North Karelian Central Hospital, Joensuu, Finland.
Abstract:
We compared oral fleroxacin and cefalexin in the prevention of postoperative infectious complications after transurethral prostatectomy (TURP) in patients with preoperative bacteriuria. 95 patients underwent TURP due to benign prostatic hyperplasia with preoperative bacteriuria. The therapy consisted of 7 days of oral fleroxacin 400 mg once a day or cefalexin 500 mg three times daily. After 2 weeks, 62% of the urine samples were sterile in the fleroxacin groups but only 37% in the cefalexin group (p = 0.047). Patients in the cefalexin group had also statistically significantly more symptoms of urinary tract infections. After 6 weeks, the bacterial eradication rate was 53% in the fleroxacin group and 37% in the cefalexin group. There were no septicemias. TURP can be performed with reasonable safety with this oral antibiotic therapy.
Keywords: CLINICAL TRIAL JOURNAL ARTICLE MULTICENTER STUDY RANDOMIZED CONTROLLED TRIAL Administration, Oral Aged Aged, 80 and over Anti-Infective Agents, Fluoroquinolone/*therapeutic use Bacteriuria/*drug therapy Cephalexin/*therapeutic use Cephalosporins/*therapeutic use Double-Blind Method Fleroxacin/*therapeutic use Human Male Middle Age Postoperative Complications/*prevention & control *Preoperative Care Prospective Studies *Prostatectomy Prostatic Hyperplasia/surgery
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