Important note: Information in this article was accurate in January 2009. The state of the art may have changed since the publication date.
Drug interactions with integrase inhibitors
HIV Treat Bull - 2009 Jan-Feb;10(1/2): 25
This is an outstanding review on the pharmacology of integrase inhibitors with a substantial section on raltegravir drug-drug interactions and elvitegravir drug-drug interactions. There are four tables summarising all known interactions to date. The authors conclude that overall raltegravir has a low propensity for clinically meaningful drug interactions, whereas elvitegravir (with the presence of ritonavir) has modest potential for interactions.
The review is highly recommended and will appear in 2009. An advance version is available online, but minor changes may still occur before final publication.
Ref: Hazuda DJ et al. Emerging pharmacology: Inhibitors of Human Immunodeficiency Virus integration. Annual Review of Pharmacology and Toxicology 2009 Feb; 49:377-394 (doi:10.1146/annurev.pharmtox.011008.145553) [Epub ahead of print]
2009-02-10
IB2009-01-25
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