AEGiS-GMHC: Protease Drug Interactions

Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

Protease Drug Interactions

GMHC Treatment Issues, 9(10) - October 1995
Theo Smart

The following drug interactions have been reported for the protease inhibitors:

Ritonavir (Abbott): Cannot be taken together safely with codeine, Demerol, Darvon, Feldene, Nizoral, Monostat-4, Tranxene, Valium, Versed (anesthesia), Halcion, Zanax, Tambocor, Rythmol, Vascor, Hismanol, Seldane, Tagamet, Paxil, Clozaril. Also: the dosage of clarithromycin should be reduced when taken concurrently with ritonavir.

Indinavir (Merck): elevates blood levels of rifabutin, so the dose of rifabutin must be halved when administered with indinavir.

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