AEGiS-GMHC: DRUG WATCH: Viagene Begins New Gene Therapy Trial

Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date.

DRUG WATCH: Viagene Begins New Gene Therapy Trial

Gay Men's Health Crisis: Treatment Issues, Volume 8 no. 4 - June 1994
David Gold and Dave Gilden

A 20-person trial of Viagene's HIV gene therapy product has begun in HIV-infected individuals with CD4 counts between 200 and 500 at the University of California San Diego. Participants will receive three injections over six weeks. The injections contain the participants' own cells genetically altered to express HIV protein on their surfaces. It is hoped these cells will stimulate immune system cytotoxic "killer cells" to attack HIV-containing cells. An ongoing study is following the therapy in HIV-positive patients with over 500 CD4 cells. Green Cross, a Japanese company has agreed to continue funding development of this immune therapy through 1996.

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