Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.
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Gay Men's Health Crisis: Treatment Issues, Volume 7 no. 11/12 - Winter, 1993/94
Bree Scott-Hartland
In the test tube, concentrations of QHS (0.4 micrograms/ml for five days) inhibited Toxoplasmosa gondii in human fibroblast cells.[2] At a dose of 1.3 micrograms/ml for fourteen days, T. gondii was completely eliminated. Cells exposed to this dose for up to 27 days showed no toxic effects. Six derivatives of QHS showed equal or greater activity. QHS has also shown activity in test tube and animal studies against other human parasites, such as Schistosoma species.[2]
The World Health Organization and the U.S. Department of Defense are currently developing QHS and its derivatives as anti-malaria therapies; the Ou- Yang study suggests that these compounds may also have a place as anti-toxoplasmic agents.
1. China Cooperative Research Group on Qinghaosu and Its Derivatives as Antimalarials. Journal of Traditional Chinese Medicine. 1982;2:31-38.
2. Ou-Yang K, et al. Antimicrobial Agents and Chemotherapy, 1990; 34:1961-65.
Copyright (c) 1993 - Gay Men's Health Crisis. All rights reserved. Noncommercial reproduction is encouraged.
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