AEGiS-GMHC: TREATMENT BRIEFS: Oral Ganciclovir, ddI, and Pancreatitis

Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

TREATMENT BRIEFS: Oral Ganciclovir, ddI, and Pancreatitis

Gay Men's Health Crisis: Treatment Issues, Volume 7 no. 9 - October, 1993
David Gold

Preliminary data suggest that oral ganciclovir, an experimental drug under development for CMV prophylaxis, may increase the risk of pancreatitis in patients taking ddI. Oral ganciclovir is a new form of intravenous ganciclovir, an approved treatment for CMV disease. Eight cases of pancreatitis occurred in oral ganciclovir studies, seven in those on drug, and one case in a person on placebo. Five patients who developed pancreatitis received both oral ganciclovir and ddI. Syntex, ganciclovir's manufacturer, has alerted FDA, study investigators and study participants of the findings. Thus far, no information suggests an increased pancreatitis risk in patients receiving intravenous ganciclovir and ddI.

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