AEGiS-GMHC: DRUG WATCH: Boehringer Road Show

Important note: Information in this article was accurate in 1993. The state of the art may have changed since the publication date.

DRUG WATCH: Boehringer Road Show

Gay Men's Health Crisis: Treatment Issues, Volume 7 no. 5 - May, 1993
David Gold

Boehringer Ingelheim recently completed a series of meetings nationwide to discuss nevirapine, its non-nucleoside reverse transcriptase inhibitor, with activists. The company presented data from ongoing trials (mostly dosage, toxicities, CD4 changes, p24 changes) and outlined a series of planned trials of nevirapine, AZT, and ddI. Trials of this three drug combination, the basis for the recent convergent combination hypothesis, are planned for different patient populations. However, the company appears to focus its efforts on the asymptomatic population. In light of the recent questions about the use of CD4 cells in this population, most participants agreed that virological data from these studies are more important. Meanwhile, a number of activists are calling for an expanded access or compassionate use program for nevirapine and other RT inhibitors. Others suggest this is premature.

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