AEGiS-GMHC: Nonoxynol 9

Important note: Information in this article was accurate in 1992. The state of the art may have changed since the publication date.

Nonoxynol 9

TREATMENT ISSUES, Volume 6, Number 8 - September, 1992; The Gay Men's Health Crisis Newsletter of Experimental Therapies
David Gold

A study recently published in JAMA (July 22/29, 1992) raised concerns that nonoxynol-9 may not be as effective in preventing transmission of HIV and other sexually transmitted diseases as had been hoped. In the study, the use of a nonoxynol-9 contraceptive sponge among women in Nairobi, Kenya, was associated with an increased frequency of genital ulcers and vulvitis. In addition, there was a small, but statistically insignificant, higher rate of HIV seroconversion among women using the nonoxynol-9 sponges as compared to those using placebo over a 24-month period. However, the nonoxynol sponge was associated with a 60% lower frequency of gonorrhea. The nonoxynol-9 gel has been shown in the test tube to be active against a variety of sexually transmitted bacteria and viruses, including HIV. Given the widespread use of nonoxynol-9, more research to determine its effectiveness in preventing HIV transmission is clearly needed.

Copyright (c) 1992. Treatment issues is published ten times yearly. All rights reserved. Non-commercial reproduction is encouraged. Distributed by AEGIS, your online gateway to a world of people, knowledge, and resources. Direct Dial: v.34+: 714.248.2836; v.120/ISDN: 714.248.0433 Internet: telnet:aegis.com www: www.aegis.com

9209
GM060806

Copyright © 1992 - Treatment Issues. Reproduced with permission. Treatment Issues is published twelve times yearly by GMHC, Inc. All rights reserved. Noncommercial reproduction is encouraged. Subscription lists are kept confidential. GMHC Treatment Issues, The Tisch Building, 119 West 24th Street, New York, NY 10011 fredg@gmhc.org http://www.gmhc.org

AEGiS is made possible through unrestricted grants from Boehringer Ingelheim, Elton John AIDS Foundation, iMetrikus, Inc., John M. Lloyd Foundation, the National Library of Medicine, and donations from users like you. Always watch for outdated information. This article first appeared in 2003. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 2003. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .