AEGiS-GMHC: TREATMENT BRIEFS: gp160 Vaccine

Important note: Information in this article was accurate in 1991. The state of the art may have changed since the publication date.

TREATMENT BRIEFS: gp160 Vaccine

Gay Men's Health Crisis Treatment Issues, Vol. 5, No. 8 - November 1991

Additional data were released on recombinant gp160, the vaccine that made a splash earlier this year. Initial reports from June showed that 19 of 30 HIV-positive, asymptomatic individuals in the trial developed an increased antibody and cellular immunity to HIV. Dr. Redfield, principal investigator of gp-160 trial, confirms that the remaining 10 individuals (one died in a car accident) experienced immune responses when given higher gp160 doses. Immunization appears to be safe. Patients receiving gp160 experienced T4 count declines of 6% compared to an historicals group not receiving the vaccine, whose T4 counts dropped by 23%. A placebo-controlled phase II trial began in November 1990 at Walter Reed Research Center, and preliminary analysis of that trial should be ready by March 1992.

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