AEGiS-GMHC: In Brief: AZT Dosage Changed Gay Men's Health CrisisImportant note: Information in this article was accurate in 1990. The state of the art may have changed since the publication date.
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In Brief: AZT Dosage Changed

GMHC Treatment Issues; Volume 4 no. 1 January 29, 1990

FDA has approved a change in prescription guidelines for AZT. The package insert will now recommend that patients take 1200 mg for one month, followed by a dose reduction to 600 mg daily. This recommendation is based on data from a recently completed trial showing that those on lower dose had fewer adverse reactions and enjoyed equal benefit compared to those on full dose in terms of survival and frequency of infections. The package insert will also contain a sentence claiming that the effectiveness of 600 mg/day is unknown in HIV related neurological disease.


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