ACRIA - Winter - 2003Important note: Information in this article was accurate in 2003. The state of the art may have changed since the publication date.
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What Ever Happened To . . .?

AIDS Community Research Initiative of America (ACRIA) - Winter 2002/2003
Liz Highleyman

What Ever Happened To . . .?
  • dOTC (BCH-10652) - discontinued after deaths in monkey studies.
  • DPC-681 and DPC-684 - halted due to toxicity in animal and human studies.
  • DPC-961 - abandoned after study participants reported suicidal feelings.
  • emivirine (Coactinon, MKC-442) - discontinued due to poor effectiveness.
  • GW420867X - halted due to potential interactions with other anti-HIV drugs (powerful cytochrome P450 3A4 inducer).
  • L-756,423 (MK-944) - discontinued due to kidney toxicity in animal studies.
  • lodenosine (FddA) - terminated due to life-threatening liver toxicity in some patients.
  • mozenavir (DMP-450) - stopped due to disappointing effectiveness in early clinical trials.
  • TMC-126 - dropped in favor of other agents in development.

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CR030107

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