Table of Contents: CATIE TreatmentUpdate - 2002


Canadian AIDS Treatment Information Exchange
Edited by: Sean Hosein

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TreatmentUpdate 126: March - Vol. 14, No. 3

English  Françaises

 SIDE EFFECTS : Protease inhibitors and lipid-lowering drugs -- interactions

 EFFECTS SECONDAIRES : Interactions entre les inhibiteurs de la protéase et les agents hypolipidémiants

HoseinSR
People with HIV/AIDS (PHAs) who use HAART can develop higher-than normal levels of lipids — cholesterol and triglycerides — in their blood. These changes can increase the risk of cardiovascular disease.

 Cause of serious illness among HAART-users not clear

 L'origine de maladies graves survenant sous l'effet d'une multithérapie reste à éclairer

HoseinSR
Highly active antiretroviral therapy (HAART) has dramatically decreased AIDS-related deaths in North America and Western Europe. Despite this benefit, some people with HIV/AIDS (PHAs) in these regions can still develop serious complications.

 Using abacavir to avoid lipid problems

 L'abacavir comme moyen d'éviter les problèmes de lipides

HoseinSR
A common side effect of some highly active antiretroviral therapy (HAART) regimens, particularly those containing protease inhibitors, is the development of higher-than-normal levels of lipids — cholesterol and triglycerides — in the blood.

 Switching to abacavir to reduce fat wasting

 L'abacavir à la rescousse dans les cas d'émaciation

HoseinSR
Although highly active antiretroviral therapy (HAART) has many benefits, its use is associated with side effects, including body shape changes. In such cases, fat that lies under the skin — called subcutaneous fat — disappears from the face, arms and legs. In some cases fat gets deposited in the breasts, abdomen and back of the neck (buffalo hump).

 9th Retrovirus Overview

 Survol de la IXe Conférence sur les rétrovirus

HoseinSR
The 9th annual Conference on Retroviruses and Opportunistic Infections was held in Seattle, Washington, February 24–28, 2002. While there were no major breakthroughs, there was some good news in the following areas...

 SIDE EFFECTS : Assessing nuke toxicity

 EFFECTS SECONDAIRES : L'évaluation de la toxicité des nucléosides

HoseinSR
Doctors at St. Paul's hospital in Vancouver, British Columbia, recruited three groups of people for their study...

 SIDE EFFECTS : Check-ups for the power plant?

 EFFECTS SECONDAIRES :Un examen de santé pour la centrale électrique?

HoseinSR
Nucleoside analogues — commonly called nukes — were among the earliest class of drugs developed for treating HIV/AIDS. These drugs work by interferring with a viral enzyme needed by HIV to help make new viruses. To a much lesser extent, nukes also interfere with at least one enzyme needed by cells, which is probably responsible for some of their side effects.

 SIDE EFFECTS : Damage to the power plant

 EFFECTS SECONDAIRES : L'endommagement de la centrale électrique

HoseinSR
The use of highly active antiretroviral therapy (HAART) has helped to reduce complications from AIDS in North America and Western Europe. Unfortunately, however, HAART-users can experience a range of side effects, including the following — which collectively is called the lipodystrophy syndrome...

Table Of Contents

TreatmentUpdate 132: December - Vol. 14, No. 9
INTRODUCTION: What's a conference about ?; SIDE EFFECTS: Who gets treatment and... side effects; SIDE EFFECTS: Protection from nuke side effects; SIDE EFFECTS: Breaking free from nukes; ADHERENCE: What helps adherence to therapy?; VACCINES: Rub-on vaccine study planned; CANCER: Cancer risk falls in some HAART users; INFECTIONS: Syphilis - the great masquerader; INFECTIONS: Is hepatitis C virus going to become a major STD

TreatmentUpdate 131: November - Vol. 14, No. 8
SIDE EFFECTS: The usual suspects; SIDE EFFECTS: A brief history of HIV drug therapy; SIDE EFFECTS: Strange side effects; SIDE EFFECTS: Focus on fat; SIDE EFFECTS: Lots of volunteers needed; SIDE EFFECTS: Lactic acid and nuke damage; SIDE EFFECTS: No nukes please; SIDE EFFECTS: Fat wasting - AZT vs. d4T; SIDE EFFECTS: Sugar blues; SIDE EFFECTS: Predicting body shape changes; SIDE EFFECTS: Niacin for high triglycerides; SIDE EFFECTS: Supplement fix for nelfinavir-related diarrhea

TreatmentUpdate 130: September/October - Vol. 14, No. 7
ANTI-HIV AGENTS - Drug holidays - an overview ; ANTI-HIV AGENTS - Here's a story about a drug holiday ; TOXICITY - Milk thistle and indinavir ; TESTING - Some factors affecting survival in HIV positive women ; ANTI-CANCER AGENTS - A new treatment for Kaposi's sarcoma

TreatmentUpdate 129: August - Vol. 14, No. 6
THE XIV INTERNATIONAL AIDS CONFERENCE - Overview of conferencel; ANTI-HIV AGENTS : American-Italian study produces unexpected results; ANTI-HIV AGENTS : Tenofovir looks good in initial therapy; ANTI-HIV AGENTS : Tenofovir and Videx (ddI) EC — some caution required; ANTI-HIV AGENTS : T-20 shows its potency; ANTI-HIV AGENTS : Efavirenz makes its mark in AIDS; TESTING : Study finds fatigue linked to quality of sleep; TESTING : High liver enzyme levels — a warning about survival?; NUTRITION : Nutrient deficits found in some HIV positive people; NUTRITION : Low zinc intake linked to reduced survival

TreatmentUpdate 128: July - Vol. 14, No. 5
SIDE EFFECTS: Sexual dysfunction in men: A report from France; SIDE EFFECTS: Sexual dysfunction in men: A report from Boston; SIDE EFFECTS: Male sexual dysfunction and HAART — the confusion continues; SIDE EFFECTS: Study finds problems with reporting side effects; ANTI-CANCER AGENTS: Recurring cervical growths; ANTI-HIV AGENTS: Starting therapy: study finds guidelines linked to level of immunity

TreatmentUpdate 127: May/June - Vol. 14, No. 4
ANTI-HIV AGENTS: Delavirdine in rescue regimens; ANTI-HIV AGENTS: Could cimetidine be used as a booster?; ANTI-HIV AGENTS: Teaching adherence to substance users; Fine-tuning saquinavir; ANTI-HIV AGENTS: Invirase vs. Fortovase: unexpected results?; ANTI-HIV AGENTS: Saquinavir once daily; ANTI-HIV AGENTS: Saquinavir with low-dose ritonavir twice daily; ANTI-HIV AGENTS: Highlights from the 3rd International Workshop on Clinical Pharmacology of HIV Therapy

TreatmentUpdate 126: March - Vol. 14, No. 3
SIDE EFFECTS : Protease inhibitors and lipid-lowering drugs -- interactions; Cause of serious illness among HAART-users not clear; Using abacavir to avoid lipid problems; Switching to abacavir to reduce fat wasting; 9th Retrovirus Overview; SIDE EFFECTS : Assessing nuke toxicity; SIDE EFFECTS : Check-ups for the power plant?; SIDE EFFECTS : Damage to the power plant

TreatmentUpdate 125: February - Vol. 14, No. 2
SIDE EFFECTS: Comparing liver toxicity between efavirenz and nevirapine; SIDE EFFECTS: Nevirapine levels may predict toxicity; SIDE EFFECTS: Health Canada advises against kava; SIDE EFFECTS: Birth defect in baby born to efavirenz-user; SIDE EFFECTS: Viagra and grapefruit juice - not a good mix; INFECTION FIGHTERS: Cidofovir and surgery for genital warts; ANTI-HIV AGENTS: Swiss study switching to efavirenz

TreatmentUpdate 124: January - Vol. 14, No. 1
SIDE EFFECTS: Testosterone troubles; SIDE EFFECTS: Growth hormone: Does less equal more?; SIDE EFFECTS: Thyroid troubles in Montreal; SIDE EFFECTS: Thyroid troubles in France; HIGHLIGHTS FROM ICAAC: Directly observed therapy (DOT); HIGHLIGHTS FROM ICAAC: Amprenavir and low-dose ritonavir; HIGHLIGHTS FROM ICAAC: Saquinavir vs. Sustiva once daily; HIGHLIGHTS FROM ICAAC: Tenofovir; HIGHLIGHTS FROM ICAAC: Atazanavir boosts saquinavir; HIGHLIGHTS FROM ICAAC: Atazanavir vs. nelfinavir; HIGHLIGHTS FROM ICAAC: Atazanavir overview; ANTI-HIV AGENTS: Starting HAART and its effect on survival; ANTI-HIV AGENTS: Response to HAART depends on T-cell count; ANTI-HIV AGENTS: Delaying therapy - the pendulum swings back

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