Table of Contents: CATIE TreatmentUpdate

Table of Contents: CATIE TreatmentUpdate - 2001

Canadian AIDS Treatment Information Exchange
Edited by: Sean Hosein

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TreatmentUpdate 117: May - Vol. 13, No. 1

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Bone damage - more than just nukes involved
L'affaiblissement des os – les autres coupables: HoseinSR; The Australian study that uncovered a link between high levels of lactic acid and bone damage in PHAs (see previous story) is perhaps not surprising. Last year, researchers in Spain found that people with hepatitis C virus infection (who were HIV negative) who used a combination of the anti-hepatitis-C nuke ribavirin with interferon-alpha had an increased risk of developing thinning bones compared to other people with hepatitis C who used interferon only.
Australian study links nukes, lactic acid to bone loss
Les nucléosides, l'acide lactique et l'affaiblissement des os: HoseinSR; Since high levels of lactic acid — a condition called lactic acidosis — have previously been linked to the use of nukes, these drugs may play a critical role in the loss of bone. Readers should be aware that there are likely other factors involved in the loss of bone in PHAs who were not in this study (for a list of risk factors for bone loss, see the next story).
High levels of lactic acid in some users of HAART
L'acide lactique et la multithérapie: HoseinSR; Symptoms of high levels of lactic acid are a rare complication of treatment with nukes. To find out more about this complication, researchers in Western Australia studied several hundred people with HIV who used HAART for about 1½ years.
Nukes may be linked to hearing loss
Une perte de l'acuité auditive serait liée à l'usage d'analogues nucléosidiques: HoseinSR; These complications occur because nukes can damage the energy-producing parts of a cell called mitochondria. When mitochondria are damaged, the cell experiences a power failure and gets injured. Prolonged power failures can cause the cell to die.
Of power plants and energy shortages
Centrales électriques et pannes d'énergie: HoseinSR; Inside nearly every person's cells are tiny kidney-bean-shaped bodies called mitochondria (Mt). Mitochondria act as tiny power plants. To do this, they "burn" sugar or fat with oxygen to produce energy.
German study finds whey protein supplement boosts antioxidants
Une étude allemande trouve que la protéine du lactosérum accroît les niveaux d'antioxydants: HoseinSR; The immune system needs a large amount of high-quality protein every day to perform repairs and make new T-cells, hormones and antioxidant enzymes. These enzymes help to protect cells from the damaging effects of highly active molecules called free-radicals. Research suggests that HIV infection increases the demand for antioxidants, a demand that the body is unable to meet on its own.
Spanish doctors try switching therapy from month to month
Des chercheurs espagnols tentent des changements de traitement mensuels: HoseinSR; Highly active antiretroviral therapy (HAART) often has high adherence requirements and unpleasant side effects. Not surprisingly, some people with HIV/AIDS (PHAs) who use HAART consider taking drug holidays. However, during drug holidays, levels of the immune system's vital CD4+ cells often fall significantly.

TreatmentUpdate 123: November/December - Vol. 13, No. 7: Can delavirdine substitute for ritonavir?; Hepatitis C treatment, HAART and side effects; Toxicity profile of HAART; Rosiglitazone for lipodstrophy?; Actos (pioglitazone); Focus on fat; Metformin — long-term results; Sugar blues and protease inhibitors; Glucose — from food to blood sugar; Lipodystrophy - introduction; Caution with nelfinavir and some lipid-lowering drugs; Trizivir approved in Canada;
TreatmentUpdate 122: October - Vol. 13, No. 6: Looking at soluble CD23 levels to predict lymphoma; Cidofovir for KS lesions; Can low-dose shark cartilage make Kaposi's sarcoma disappear?; Chemo and HAART extend survival with lymphoma; Encouraging news on lymphoma from France; AIDS and lymphoma; New formulation of ddI approved in Canada — Videx EC; Expanded access to tenofovir
TreatmentUpdate 121: September - Vol. 13, No. 5: SIDE EFFECTS - Andractim for HAART-associated breast enlargement; SIDE EFFECTS - Does efavirenz cause breast enlargement?; IMMUNE BOOSTERS - Interleukin-12 may be useful for hepatitis C; ANTI-HIV AGENTS - Study finds HIV subtly damages vision; ANTI-HIV AGENTS - Searching for the right dose of ritonavir-saquinavir; ANTI-HIV AGENTS - Different combinations of ritonavir-indinavir
TreatmentUpdate 120: August - Vol. 13, No. 4: Depression linked to immune system decline in women; Carnitine for high triglycerides; Lipid-lowering drugs and changes to diet can make a difference; Sexual dysfunction and HAART; Immune booster used to fight drug-resistant herpes; Effect of HAART on cervical growths; Switching to nevirapine — results after one year
TreatmentUpdate 119: July - Vol. 13, No. 3: Fosamax for HIV-related bone problems?; Indinavir and bones: Does thickness = strength?; Lipodystrophy — nukes vs. protease inhibitors; Spanish study looks at nevirapine's effect on the liver; Pesticides found in many ginseng supplements in the U.S.; Can ginseng help suppress HIV?; Large Italian study looks at when to start HAART;
TreatmentUpdate 118: June - Vol. 13, No. 2: Protease inhibitors and blood sugar problems; Indinavir - effect on sugar and insulin; Background on glucose — from food to blood sugar; Extra co-enzyme Q10 for statin-users?; Can vitamin E help people recover from hepatitis B?; Study examines link between low levels of zinc and survival; Zinc and the immune system;
TreatmentUpdate 117: May - Vol. 13, No. 1: Bone damage - more than just nukes involved; Australian study links nukes, lactic acid to bone loss;High levels of lactic acid in some users of HAART ;Nukes may be linked to hearing loss; Of power plants and energy shortages; German study finds whey protein supplement boosts antioxidants; Spanish doctors try switching therapy from month to month
TreatmentUpdate 115: February - Vol. 12, No. 11: St. John's wort found to lower nevirapine levels; Are deaths due to liver damage becoming more common?; St. John's wort extract found not helpful for hepatitis C; Canadian researchers study "immune healing"; Kaletra approved in Canada;
TreatmentUpdate 114: January - Vol. 12, No. 10: Some women may be at high risk for anal cancer; DHEA — Cautions and concerns; DHEA for depression?; Changes in DHEA levels in people taking anti-HIV therapy; DHEA — Background; Nukes linked to fat wasting; Triple nuke therapy — results after one year; Switching meds: from protease inhibitors to non-nukes
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TreatmentUpdate 117: May - Vol. 13, No. 1

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