Table of Contents: CATIE TreatmentUpdate

Table of Contents: CATIE TreatmentUpdate - 2000

Canadian AIDS Treatment Information Exchange
Edited by: Sean Hosein

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TreatmentUpdate 112: November - Vol. 12, No. 8

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Lopinavir - Results after one year
Lopinavir - les résultats après un an: HoseinSR; The product Kaletra, also known as ABT-378/r or lopinavir, is a combination of two protease inhibitors: lopinavir with a small amount of ritonavir (Norvir). The purpose of ritonavir is to boost levels of lopinavir to very high levels. Hopefully these high levels of lopinavir will make it difficult for HIV to develop drug resistance. Since the amount of ritonavir used with lopinavir is small, ritonavir does not have any significant anti-HIV activity in this formulation.
The benefit of HAART in older people
Les bienfaits des multithérapies chez les personnes âgées: HoseinSR; In the time before protease inhibitors became available, researchers found that, in general, older HIV+ people were more likely to develop AIDS and die faster than younger HIV+ people. In part this is probably related to the fact that as people age, the part of the immune system that fights certain viruses and tumours, called cellular immunity, grows weak.
Large study finds hepatitis C virus infection linked to reduced benefit from anti-HIV drugs
L'infection au virus de l'hépatite C réduirait les bienfaits des médicaments anti-VIH: HoseinSR; People with hemophilia as well as injection drug users (IDUs) who are infected with HIV are also likely to be co-infected with hepatitis C virus (HCV). As co-infections can speed up the decline of the immune system, it is important to prevent and treat them. To study the impact of HCV and HIV co-infection as well as that of anti-HIV drugs, researchers in Switzerland conducted a large 2-year study on more than 3,000 subjects who were taking potent anti-HIV therapy.
Safety and effectiveness of interferon and ribavirin in HIV+ people co-infected with hepatitis C virus
L'innocuité et l'efficacité de l'association interféron/ribavirine chez les personnes séropositives co-infectées par l'hépatite C: HoseinSR; Therapy for hepatitis C virus (HCV) infection is currently limited to a combination of the nucleoside analogue ribavirin and the immune booster interferon-alpha. In non-HIV-infected people who have HCV, up to 40% recover when treated with this combination. In people co-infected with both viruses, recovery rates are usually much lower.
Vitamin A and abnormal cells on the cervix
La vitamine A et les anomalies cellulaires du col utérin: HoseinSR; Certain strains of a virus called human papillomavirus (HPV) can infect cells of the cervix and trigger the growth of abnormal cells. In some cases these abnormal cells may turn into pre-cancerous cells, a few of which may eventually develop into cancer cells. Women with HIV infection, because of their weakened immunity, are at increased risk for the development of abnormal growths on their cervix as well as cervical cancer. Regular Pap smears and gynecologic exams to detect and monitor growths on the cervix are an important part of health maintenance for HIV+ women.
FDA issues warning about d4T and ddI during pregnancy
La FDA met en garde contre l'usage de d4T et de ddI pendant la grossesse: HoseinSR; Lactic acidosis, the name given to a condition where high levels of lactic acid build up in the blood, is a rare side effect that may be associated with the use of nucleoside analogues, or nukes, such as AZT, ddI, ddC, d4T and 3TC. These drugs may damage the energy-producing parts, or power plant, of a cell. When a cell can't produce enough power it begins to malfunction and can die.
Severe nevirapine rash found more likely in women than men
La névirapine provoquerait des éruptions plus graves chez les femmes: HoseinSR; The most common side effect linked to the use of nevirapine is rash. As many as 17% of people exposed to this drug develop a rash, and in about 0.5% the rash is so severe that it becomes life-threatening, a condition called Stevens-Johnson syndrome.

TreatmentUpdate 113: December - Vol. 12, No. 9: Protease inhibitors and pregnancy — reports from the U.S.; Effect of combination therapy on pregnancy — results from Europe; Two German studies find NAC supplements helpful; How nutrient deficiencies occur; Interferon and ribavirin for hepatitis B; Maintenance therapy for TB works
TreatmentUpdate 112: November - Vol. 12, No. 8: Lopinavir - Results after one year; The benefit of HAART in older people; Large study finds hepatitis C virus infection linked to reduced benefit from anti-HIV drugs; Safety and effectiveness of interferon and ribavirin in HIV+ people co-infected with hepatitis C virus; Vitamin A and abnormal cells on the cervix; FDA issues warning about d4T and ddI during pregnancy; Severe nevirapine rash found more likely in women than men
TreatmentUpdate 111: October - Vol. 12, No. 7: Bone marrow stimulant may boost immunity; MAC prevention takes a holiday; Treating parts of the lipodystrophy syndrome -- blood sugar problems; Metformin for blood sugar problems; Metformin - caution and concerns; Calcium supplements help metformin users absorb vitamin B12; Can antioxidants help reduce side effects from ribavirin?; High levels of testosterone develop in some women with body shape changes; A combination of testosterone and exercise for men
TreatmentUpdate 110: September - Vol. 12, No. 6: Different effects of nukes in men and women; Long-term use of hydroxyurea; Indinavir - 3 years and still going strong; Lymphoma in the age of HAART; Anti-viral therapy for lymphoma; Hydroxyurea as anti-viral therapy for brain lymphomas; Will cidofovir be useful against cervical lesions?; Bone Problems may occur with hepatitis treatment
TreatmentUpdate 109: August - Vol. 12, No. 5: Side Effects; Protease inhibitors and loss of fat; Some notes on energy; Nukes and fat cell damage; Helping to repair damaged nerves; Lactic acidosis; Growth hormone helps get rid of fat; Bone problems and anti-HIV therapy; Metformin for insulin and heart problems?; Niacin for cholesterol and weight problems?
TreatmentUpdate 108: June - Vol. 12, No. 4: Does switching from protease inhibitors to nevirapine restore body shape?; GM-CSF raises CD4+ cell counts; Effect of HIV on the menstrual cycle; Large study looks for protease inhibitor side effects; Protease inhibitors, high triglycerides, hormones and bone damage; Help for protease inhibitor-associated diarrhea; HAART may affect thyroid hormone levels; Indinavir and insulin
TreatmentUpdate 107: May - Vol. 12, No. 3: Testosterone and depression in men; Interferon and ribavirin for hepatitis C; CD8+ cell infusions; CD8+ cells - from suppressors to saviours; AMD-3100 - Chemokine blocker under study; Antibiotic holidays may be OK for some
TreatmentUpdate 106: March - Vol. 12, No. 2: Early versus delayed therapy - results from Switzerland; Questions about the early and aggressive use of therapy; Rescue Therapy; Infections after HAART- who is at risk?; The risk of cervical dysplasia;
TreatmentUpdate 105: February - Vol. 12, No. 1: Trizivir - three drugs in one pill; TXU-PAP - early results; Hitting hard, hitting early - one year later; Efavirenz versus indinavir: Who really wins?; Cream reduces reappearance of cervical lesions; Study finds that HAART is OK for some people co-infected with hepatitis B and C virus
TreatmentUpdate 104: January - Vol. 11, No. 10: Immunotoxins to the rescue; Cytokines can help fight HIV; HAART as an immune booster; A placebo-controlled study of Chinese herbs; Curcumin - some issues to consider; Curcumin and the immune system; Mistletoe extract for HIV/AIDS?;
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TreatmentUpdate 112: November - Vol. 12, No. 8

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