Table of Contents: CATIE TreatmentUpdate - 2000


Canadian AIDS Treatment Information Exchange
Edited by: Sean Hosein

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TreatmentUpdate 108: June - Vol. 12, No. 4

 Does switching from protease inhibitors to nevirapine restore body shape?

 Peut-on restaurer sa forme corporelle en substituant la névirapine aux inhibiteurs de la protéase ?

HoseinSR
Protease inhibitors (PI) have made a huge impact on the AIDS pandemic in North America by prolonging the survival of people with HIV/AIDS (PHAs).

 GM-CSF raises CD4+ cell counts

 Le GM-CSF fait augmenter le nombre de cellules CD4+

HoseinSR
Although potent anti-HIV therapy can reduce viral load and increase CD4+ and CD8+ cell counts, complete restoration of immune function does not occur. To remedy this situation, doctors are conducting experiments with different products to try and enhance the function and activity of the immune systems's cells.

 Effect of HIV on the menstrual cycle

 Effets du VIH sur le cycle menstruel

HoseinSR
Reports in the early 1990s suggested that abnormal menstrual cycles may occur in women with HIV infection. Later studies found no connection between the two however. To find out if HIV does cause menstrual disturbances, researchers in the United States conducted a study involving more than 1,000 women.

 Large study looks for protease inhibitor side effects

 Une étude d'envergure évalue les effets secondaires des inhibiteurs de la protéase

HoseinSR
Researchers in Northern Italy recruited 1,207 HIV-positive subjects (27% female, 73% male) to investigate side effects that occurred while they used protease inhibitors.

 Protease inhibitors, high triglycerides, hormones and bone damage

 Inhibiteurs de la protéase, triglycérides élevés, hormones et dommages osseux

HoseinSR
Higher-than-normal levels of lipids, or fatty substances in the blood, such as triglycerides and cholesterol, have been reported in people who developed symptoms of AIDS in the early 1990s when protease inhibitors were not widely available. Since the introduction of HAART, some doctors have reported an increase in the number of their patients with high levels of triglycerides (TG) and other lipids.

 Help for protease inhibitor-associated diarrhea

 Soulagement de la diarrhée provoquée par les inhibiteurs de la protéase

HoseinSR
One of the side effects associated with protease inhibitors (PI) is diarrhea. During the first weeks of therapy the diarrhea (and other side effects) may be most common and severe. In as many as one third of users, PI-associated diarrhea can persist beyond the first month of therapy, which can reduce a PHA's enjoyment of life and may have a negative impact on his or her health. Indeed, one study has found that subjects taking nelfinavir and who did not experience diarrhea had "significantly greater increases in CD4+ cell counts than did [subjects with diarrhea]."

 HAART may affect thyroid hormone levels

 Perturbations des taux d'hormones thyroïdiennes sous l'effet de la multithérapie

HoseinSR
Doctors in Dijon, France, noticed that four of their patients taking HAART developed symptoms of low levels of thyroid hormones in the blood.

Table Of Contents

TreatmentUpdate 113: December - Vol. 12, No. 9
Protease inhibitors and pregnancy — reports from the U.S.; Effect of combination therapy on pregnancy — results from Europe; Two German studies find NAC supplements helpful; How nutrient deficiencies occur; Interferon and ribavirin for hepatitis B; Maintenance therapy for TB works

TreatmentUpdate 112: November - Vol. 12, No. 8
Lopinavir - Results after one year; The benefit of HAART in older people; Large study finds hepatitis C virus infection linked to reduced benefit from anti-HIV drugs; Safety and effectiveness of interferon and ribavirin in HIV+ people co-infected with hepatitis C virus; Vitamin A and abnormal cells on the cervix; FDA issues warning about d4T and ddI during pregnancy; Severe nevirapine rash found more likely in women than men

TreatmentUpdate 111: October - Vol. 12, No. 7
Bone marrow stimulant may boost immunity; MAC prevention takes a holiday; Treating parts of the lipodystrophy syndrome -- blood sugar problems; Metformin for blood sugar problems; Metformin - caution and concerns; Calcium supplements help metformin users absorb vitamin B12; Can antioxidants help reduce side effects from ribavirin?; High levels of testosterone develop in some women with body shape changes; A combination of testosterone and exercise for men

TreatmentUpdate 110: September - Vol. 12, No. 6
Different effects of nukes in men and women; Long-term use of hydroxyurea; Indinavir - 3 years and still going strong; Lymphoma in the age of HAART; Anti-viral therapy for lymphoma; Hydroxyurea as anti-viral therapy for brain lymphomas; Will cidofovir be useful against cervical lesions?; Bone Problems may occur with hepatitis treatment

TreatmentUpdate 109: August - Vol. 12, No. 5
Side Effects; Protease inhibitors and loss of fat; Some notes on energy; Nukes and fat cell damage; Helping to repair damaged nerves; Lactic acidosis; Growth hormone helps get rid of fat; Bone problems and anti-HIV therapy; Metformin for insulin and heart problems?; Niacin for cholesterol and weight problems?

TreatmentUpdate 108: June - Vol. 12, No. 4
Does switching from protease inhibitors to nevirapine restore body shape?; GM-CSF raises CD4+ cell counts; Effect of HIV on the menstrual cycle; Large study looks for protease inhibitor side effects; Protease inhibitors, high triglycerides, hormones and bone damage; Help for protease inhibitor-associated diarrhea; HAART may affect thyroid hormone levels; Indinavir and insulin

TreatmentUpdate 107: May - Vol. 12, No. 3
Testosterone and depression in men; Interferon and ribavirin for hepatitis C; CD8+ cell infusions; CD8+ cells - from suppressors to saviours; AMD-3100 - Chemokine blocker under study; Antibiotic holidays may be OK for some

TreatmentUpdate 106: March - Vol. 12, No. 2
Early versus delayed therapy - results from Switzerland; Questions about the early and aggressive use of therapy; Rescue Therapy; Infections after HAART- who is at risk?; The risk of cervical dysplasia;

TreatmentUpdate 105: February - Vol. 12, No. 1
Trizivir - three drugs in one pill; TXU-PAP - early results; Hitting hard, hitting early - one year later; Efavirenz versus indinavir: Who really wins?; Cream reduces reappearance of cervical lesions; Study finds that HAART is OK for some people co-infected with hepatitis B and C virus

TreatmentUpdate 104: January - Vol. 11, No. 10
Immunotoxins to the rescue; Cytokines can help fight HIV; HAART as an immune booster; A placebo-controlled study of Chinese herbs; Curcumin - some issues to consider; Curcumin and the immune system; Mistletoe extract for HIV/AIDS?;

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