Table of Contents: CATIE TreatmentUpdate - 2000


Canadian AIDS Treatment Information Exchange
Edited by: Sean Hosein

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TreatmentUpdate 107: May - Vol. 12, No. 3

 Testosterone and depression in men

 Testostérone et dépression chez les hommes

HoseinSR
Researchers at Harvard University recently conducted a study to compare levels of testosterone among HIV-positive men who had HIV-related weight loss. The researchers also gave some subjects injections of testosterone to find out if supplements of this hormone had an impact on feelings of depression. The researchers found that men who had low levels of testosterone were more likely to be depressed than men who had normal levels of this hormone. Moreover, when the depressed men received regular injections of testosterone their mood significantly improved.

 Interferon and ribavirin for hepatitis C

 Interféron et ribavirine contre l'hépatite C

HoseinSR
Prolonged infection with hepatitis C virus (HCV) can lead to liver damage and, eventually, death. The combination of interferon-alpha and ribavirin has enabled as many as 40% of patients with HCV infection to recover. This rate of success was observed in people without HIV.

 CD8+ cell infusions

 Infusions de CD8+

HoseinSR
Several studies have found that infusing CD8+ cells into PHAs is generally safe. Results also show that the cells transferred during this process sometimes have anti-HIV activity. Unfortunately the transferred cells do not live long. In one study, about 90% of CD8+ cells died 48 hours after being infused. Researchers are conducting experiments to find out why this happens and to develop ways to extend the life of these CD8+ cells.

 CD8+ cells - from suppressors to saviours

 Cellules CD8+ - du statut de cellules suppressives à celui de cellules salvatrices

HoseinSR
Mistakenly cast as "suppressor" cells in the early 1980s, CD8+ cells were largely viewed as useless for the fight against HIV and other infections. Worse, the high levels of CD8+ cells that occurred as a result of HIV infection were seen as a bad thing. Researchers who have a more sophisticated understanding of immunology now know better.

 AMD-3100 - Chemokine blocker under study

 AMD-3100 - inhibiteur des chémokines à l'étude

HoseinSR
When invading bacteria, viruses and fungi need to be brought under control, the immune system directs T- and other cells to the location of the infection by producing a chemical trail. One group of chemicals used to produce this trail are called chemokines. These chemicals also appear to influence the movement of the immune system's cells around the body, whether an infection is present or not.

 Antibiotic holidays may be OK for some

 Congé thérapeutique des antibiotiques - solution acceptable dans certains cas

HoseinSR
Doctors first became aware of AIDS in the early 1980s when they began observing a range of life-threatening infections occurring in their patients. Doctors eventually found that giving their patients small, regular doses of antibiotics and other anti-microbial drugs helped to prevent many of the infections seen in AIDS. This practice is called prophylaxis.

Table Of Contents

TreatmentUpdate 113: December - Vol. 12, No. 9
Protease inhibitors and pregnancy — reports from the U.S.; Effect of combination therapy on pregnancy — results from Europe; Two German studies find NAC supplements helpful; How nutrient deficiencies occur; Interferon and ribavirin for hepatitis B; Maintenance therapy for TB works

TreatmentUpdate 112: November - Vol. 12, No. 8
Lopinavir - Results after one year; The benefit of HAART in older people; Large study finds hepatitis C virus infection linked to reduced benefit from anti-HIV drugs; Safety and effectiveness of interferon and ribavirin in HIV+ people co-infected with hepatitis C virus; Vitamin A and abnormal cells on the cervix; FDA issues warning about d4T and ddI during pregnancy; Severe nevirapine rash found more likely in women than men

TreatmentUpdate 111: October - Vol. 12, No. 7
Bone marrow stimulant may boost immunity; MAC prevention takes a holiday; Treating parts of the lipodystrophy syndrome -- blood sugar problems; Metformin for blood sugar problems; Metformin - caution and concerns; Calcium supplements help metformin users absorb vitamin B12; Can antioxidants help reduce side effects from ribavirin?; High levels of testosterone develop in some women with body shape changes; A combination of testosterone and exercise for men

TreatmentUpdate 110: September - Vol. 12, No. 6
Different effects of nukes in men and women; Long-term use of hydroxyurea; Indinavir - 3 years and still going strong; Lymphoma in the age of HAART; Anti-viral therapy for lymphoma; Hydroxyurea as anti-viral therapy for brain lymphomas; Will cidofovir be useful against cervical lesions?; Bone Problems may occur with hepatitis treatment

TreatmentUpdate 109: August - Vol. 12, No. 5
Side Effects; Protease inhibitors and loss of fat; Some notes on energy; Nukes and fat cell damage; Helping to repair damaged nerves; Lactic acidosis; Growth hormone helps get rid of fat; Bone problems and anti-HIV therapy; Metformin for insulin and heart problems?; Niacin for cholesterol and weight problems?

TreatmentUpdate 108: June - Vol. 12, No. 4
Does switching from protease inhibitors to nevirapine restore body shape?; GM-CSF raises CD4+ cell counts; Effect of HIV on the menstrual cycle; Large study looks for protease inhibitor side effects; Protease inhibitors, high triglycerides, hormones and bone damage; Help for protease inhibitor-associated diarrhea; HAART may affect thyroid hormone levels; Indinavir and insulin

TreatmentUpdate 107: May - Vol. 12, No. 3
Testosterone and depression in men; Interferon and ribavirin for hepatitis C; CD8+ cell infusions; CD8+ cells - from suppressors to saviours; AMD-3100 - Chemokine blocker under study; Antibiotic holidays may be OK for some

TreatmentUpdate 106: March - Vol. 12, No. 2
Early versus delayed therapy - results from Switzerland; Questions about the early and aggressive use of therapy; Rescue Therapy; Infections after HAART- who is at risk?; The risk of cervical dysplasia;

TreatmentUpdate 105: February - Vol. 12, No. 1
Trizivir - three drugs in one pill; TXU-PAP - early results; Hitting hard, hitting early - one year later; Efavirenz versus indinavir: Who really wins?; Cream reduces reappearance of cervical lesions; Study finds that HAART is OK for some people co-infected with hepatitis B and C virus

TreatmentUpdate 104: January - Vol. 11, No. 10
Immunotoxins to the rescue; Cytokines can help fight HIV; HAART as an immune booster; A placebo-controlled study of Chinese herbs; Curcumin - some issues to consider; Curcumin and the immune system; Mistletoe extract for HIV/AIDS?;

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