Table of Contents: CATIE TreatmentUpdate - 2000


Canadian AIDS Treatment Information Exchange
Edited by: Sean Hosein

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TreatmentUpdate 106: March - Vol. 12, No. 2

 Early versus delayed therapy - results from Switzerland

 Un traitement précoce comparativement à un traitement différé - résultats de Suisse

HoseinSR
Combination therapy with anti-HIV drugs, particularly protease inhibitors, has greatly reduced cases of HIV-related illness and death in North America, Western Europe, Australia and New Zealand

 Questions about the early and aggressive use of therapy

 Des questions sur le recours à un traitement énergique, appliqué tôt

HoseinSR
In certain countries the standard of care for people with HIV infection is usually early treatment with powerful combination therapy or HAART. This approach to treatment is founded on certain assumptions that are now being challenged by a number of leading doctors in Britain and the United States

 Rescue therapy

 Traitement de sauvetage

HoseinSR
Resistance to anti-HIV treatment regimens is probably inevitable, so doctors and their patients have to consider future options. Finding a reasonable treatment regimen for people with virus that is resistant to many anti-HIV drugs is not easy. Doctors often call such regimens "salvage" or rescue therapy. In one study, doctors tested the combination of efavirenz, nelfinavir and d4T and obtained promising results in just over 50% of the subjects

 Infections after HAART- who is at risk?

 Infections à la suite d'une multithérapie - quels sont les malades exposés?

HoseinSR
Resistance to anti-HIV treatment regimens is probably inevitable, so doctors and their patients have to consider future options. Finding a reasonable treatment regimen for people with virus that is resistant to many anti-HIV drugs is not easy. Doctors often call such regimens "salvage" or rescue therapy. In one study, doctors tested the combination of efavirenz, nelfinavir and d4T and obtained promising results in just over 50% of the subjects

 The risk of cervical dysplasia

 Le risque de dysplasie cervicale

HoseinSR
Studies performed in the early 1990s suggested that HIV-positive women were more likely to develop cervical dysplasia than HIV-negative women. A group of abnormal cells is called a lesion. Cervical dysplasia lesions can shrink or disappear, persist or progress to become cervical cancer. Cervical dysplasia has been linked to a common virus called HPV (human papilloma virus). There are over 70 strains of HPV, some cause warts, including genital warts, while others can cause cancer.

 Protecting the power plant

 Protection des mitochondries

HoseinSR
Ever wonder where your energy comes from? Inside nearly all the body's cells are tiny power plants called mitochondria (Mt). To provide cells with energy, Mt "burn" a mixture of fat and sugar. This process also requires the help of other substances such as B-complex vitamins.

 Vitamins C and E for nuke toxicity?

 Vitamines C et E contre la toxicité des analogues nucléosidiques?

HoseinSR
Some people who use AZT and other nukes develop muscle weakness. This occurs because AZT appears to damage the power plants or mitochondria (Mt) inside cells. AZT, however, is not the only drug that can damage Mt. In fact, other anti-HIV drugs, particularly other nukes, appear to have the same effect.

 St. John's wort - interaction with indinavir and other drugs

 Millepertuis (herbe de la Saint-Jean) - interaction avec l'indinavir et d'autres médicaments

HoseinSR
St. John's wort (Hypericum perforatum) is a plant that grows in parts of North America, Europe, Asia and North Africa. This herb contains many active compounds, including hypericin, pseudohypericin and hyperforin, some of which may help people better cope with anxiety and mild depression.

Table Of Contents

TreatmentUpdate 113: December - Vol. 12, No. 9
Protease inhibitors and pregnancy — reports from the U.S.; Effect of combination therapy on pregnancy — results from Europe; Two German studies find NAC supplements helpful; How nutrient deficiencies occur; Interferon and ribavirin for hepatitis B; Maintenance therapy for TB works

TreatmentUpdate 112: November - Vol. 12, No. 8
Lopinavir - Results after one year; The benefit of HAART in older people; Large study finds hepatitis C virus infection linked to reduced benefit from anti-HIV drugs; Safety and effectiveness of interferon and ribavirin in HIV+ people co-infected with hepatitis C virus; Vitamin A and abnormal cells on the cervix; FDA issues warning about d4T and ddI during pregnancy; Severe nevirapine rash found more likely in women than men

TreatmentUpdate 111: October - Vol. 12, No. 7
Bone marrow stimulant may boost immunity; MAC prevention takes a holiday; Treating parts of the lipodystrophy syndrome -- blood sugar problems; Metformin for blood sugar problems; Metformin - caution and concerns; Calcium supplements help metformin users absorb vitamin B12; Can antioxidants help reduce side effects from ribavirin?; High levels of testosterone develop in some women with body shape changes; A combination of testosterone and exercise for men

TreatmentUpdate 110: September - Vol. 12, No. 6
Different effects of nukes in men and women; Long-term use of hydroxyurea; Indinavir - 3 years and still going strong; Lymphoma in the age of HAART; Anti-viral therapy for lymphoma; Hydroxyurea as anti-viral therapy for brain lymphomas; Will cidofovir be useful against cervical lesions?; Bone Problems may occur with hepatitis treatment

TreatmentUpdate 109: August - Vol. 12, No. 5
Side Effects; Protease inhibitors and loss of fat; Some notes on energy; Nukes and fat cell damage; Helping to repair damaged nerves; Lactic acidosis; Growth hormone helps get rid of fat; Bone problems and anti-HIV therapy; Metformin for insulin and heart problems?; Niacin for cholesterol and weight problems?

TreatmentUpdate 108: June - Vol. 12, No. 4
Does switching from protease inhibitors to nevirapine restore body shape?; GM-CSF raises CD4+ cell counts; Effect of HIV on the menstrual cycle; Large study looks for protease inhibitor side effects; Protease inhibitors, high triglycerides, hormones and bone damage; Help for protease inhibitor-associated diarrhea; HAART may affect thyroid hormone levels; Indinavir and insulin

TreatmentUpdate 107: May - Vol. 12, No. 3
Testosterone and depression in men; Interferon and ribavirin for hepatitis C; CD8+ cell infusions; CD8+ cells - from suppressors to saviours; AMD-3100 - Chemokine blocker under study; Antibiotic holidays may be OK for some

TreatmentUpdate 106: March - Vol. 12, No. 2
Early versus delayed therapy - results from Switzerland; Questions about the early and aggressive use of therapy; Rescue Therapy; Infections after HAART- who is at risk?; The risk of cervical dysplasia;

TreatmentUpdate 105: February - Vol. 12, No. 1
Trizivir - three drugs in one pill; TXU-PAP - early results; Hitting hard, hitting early - one year later; Efavirenz versus indinavir: Who really wins?; Cream reduces reappearance of cervical lesions; Study finds that HAART is OK for some people co-infected with hepatitis B and C virus

TreatmentUpdate 104: January - Vol. 11, No. 10
Immunotoxins to the rescue; Cytokines can help fight HIV; HAART as an immune booster; A placebo-controlled study of Chinese herbs; Curcumin - some issues to consider; Curcumin and the immune system; Mistletoe extract for HIV/AIDS?;

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