AEGiS-CATIE: IMMUNOMODULATORS: Cimetidine

IMMUNOMODULATORS: Cimetidine

TreatmentUpdate 73 - Volume 8, No 9; November 1996
Sean Hosein

The drug cimetidine (Tagamet ) is used to treat ulcers. In the late 1980s, German researchers reported that cimetidine raised the CD4+ cell counts of their subjects with HIV infection. This German study was not placebo-controlled. American researchers who have also been testing cimetidine have finally had their results published. The American study enrolled 182 subjects, some of whom received cimetidine (1200 mg/day) while others received fake cimetidine (placebo) for between 8 to 16 weeks. Cimetidine did not increase CD4+ cell counts nor reduce levels of HIV.

REFERENCES:

1. Cohen CJ, Hellinger JA, Day J, et al. Lack of effect of cimetidine on lymphocyte subsets in patients infected with Human Immunodeficiency Virus-type 1 infection. Clinical Infectious Diseases 1996;23:1045-1054.

961115
CATE7303

Always watch for outdated information. This article first appeard in 1996. This material is designed to support, not replace, the relationship that exists between you and your doctor.

Copyright © 1996 - TreatmentUpdate. Reproduced with permission. Reproduction of this article (other than one copy for personal reference) must be cleared through the Editor, The Canadian AIDS Treatment Information Exchange, 555 Richmond St. West, Suite 505, Box 1104, Toronto, ON, M5V 3B1 • Phone: 416-203-7122 • Toll Free: 1-800-263-1638 • Fax: 416-203-8284 http://www.catie.ca

This information is designed to support, not replace, the relationship that exists between you and your doctor.
©1996. AEGIS.