AEGiS-CATIE: TESTING: Saquinavir levels reduced by rifabutin

TESTING: Saquinavir levels reduced by rifabutin

TreatmentUpdate 72, Vol. 8, No. 8; October 1996
Sean Hosein

Study details

Doctors in Ottawa enrolled 12 HIV-infected men to test the effect of rifabutin 300 mg/day on the amount of saquinavir that is absorbed and ends up in the blood. They found that rifabutin reduces levels of saquinavir in the blood by 40%. So doctors treating PHAs taking this combination are going to have to increase their dose of saquinavir, perhaps by 40%.

REFERENCES:

1. Sahai J, Stewart F, Swick L, et al . Rifabutin reduces saquinavir plasma levels in HIV-infected patients. Abstract A027.

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Always watch for outdated information. This article first appeard in 1996. This material is designed to support, not replace, the relationship that exists between you and your doctor.

Copyright © 1996 - TreatmentUpdate. Reproduced with permission. Reproduction of this article (other than one copy for personal reference) must be cleared through the Editor, The Canadian AIDS Treatment Information Exchange, 555 Richmond St. West, Suite 505, Box 1104, Toronto, ON, M5V 3B1 • Phone: 416-203-7122 • Toll Free: 1-800-263-1638 • Fax: 416-203-8284 http://www.catie.ca

This information is designed to support, not replace, the relationship that exists between you and your doctor.
©1996. AEGIS.