TreatmentUpdate 72, Vol. 8, No. 8; October 1996
Sean Hosein

Lamisil (terbinafine) is a new antifungal drug licensed for treating fungal infections of the nails. As more reports of fungal infections resistant to fluconazole or itraconazole appear, doctors are beginning to consider combination antifungal therapy . In lab experiments, terbinafine used with fluconazole had greater antifungal activity than either drug alone in 50% of tests using yeast resistant to fluconazole. Even greater antifungal activity was seen in 90% of tests using itraconazole and terbinafine. Now experiments on HIV-infected people are needed to find out if the combination is safe and effective.

REFERENCES:

1. Fothergill AW, Leitner I, Meingasser JG, et al . Combination antifungal susceptibility testing of terbinafine and the triazoles fluconaozle and itraconazole abstract E053.

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