ANTI-HIV AGENTS: Saquinavir and indinavir -- some problems
TreatmentUpdate 71, Volume 8, No 7; October 1996 Sean Hosein
In an attempt to increase the anti-HIV activity of protease inhibitors researchers are testing several drug combinations in lab experiments. At low concentrations, indinavir used with saquinavir have increased anti-HIV activity than either drug used alone. At higher concentrations the anti-HIV effects of the drugs are reduced. When technicians tested the combination against HIV that was resistant to AZT, every concentration of the 2 drugs had reduced anti-HIV activity than when each was used alone.
REFERENCES:
1. Merril DR, Manion DJ, Chou T-C, et al . Protease inhibitor combination regimens against HIV-1 in vitro. Abstract I002.
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Always watch for outdated information. This article first appeard in 1996. This material is designed to support, not replace, the relationship that exists between you and your doctor.
This information is designed to support, not replace, the relationship that exists between you and your doctor.