TreatmentUpdate 70, Volume 8, No 6; September, 1996
Sean Hosein
* 2.4 g/day
* 3 g/day
* 3.2 g/day
Doctors reported results on 63 subjects who had been using indinavir for about 1 year. By the 6th month of the study, the amount of HIV in the blood of subjects had decreased to at least 1/100th of its pre-study level. Half the subjects had an increase of between "80 to 145 CD4+ cells." By the 12th month of the study, production of HIV remained as low as it had been 6 months earlier and subjects had 85 extra CD4+ cells than when they started. Technicians were not able to detect HIV in "54%" of subjects. Readers should note this does not mean that no virus was present, but simply that the equipment was not sensitive enough to detect it. Doses of indinavir greater than 2.4 g/day do not appear to provide any benefit beyond that seen with 2.4 g/day.
Toxicity
About 50% of subjects had higher than normal levels of bilirubin. This was detected in lab tests only, as subjects did not have any signs/symptoms associated with this. Kidney stones did develop in the following proportion of subjects:
* 2.4 g -- 10%
* 3.0 g -- 16%
* 3.2 g -- 12%
References:
1. Steigbel R, Berry P, Teppler H, et al. Extended follow-up of patientsin a study of indinavir at 800 mg every 8 hours (2.4 g/day) and 800 mg every 6 hours (3.2 g/day). Mo.B.412
960910
CATE7004
Copyright © 1996 - TreatmentUpdate. Reproduced with permission. Reproduction of this article (other than one copy for personal reference) must be cleared through the Editor, The Canadian AIDS Treatment Information Exchange, 555 Richmond St. West, Suite 505, Box 1104, Toronto, ON, M5V 3B1 • Phone: 416-203-7122 • Toll Free: 1-800-263-1638 • Fax: 416-203-8284 http://www.catie.ca
This information is designed to support, not replace, the relationship that exists between you and your doctor.