The Human Immunodeficiency Virus: Biology, Immunology, and Therapy

The Human Immunodeficiency Virus: Biology, Immunology, and Therapy

Princeton University Press, 41 William St., Princeton, NJ 08540. 532p., illus., bibliog., index. ISBN 0-691-00454-4. $75.00.
edited by Emilio A. Emini. 2002,

This is a book that reviews what we know and what we do not know about the human immunodeficiency virus as we enter the third decade. Each chapter can be read independently, but taken together, "the chapters present a complete picture of the challenges that lie ahead." The 13 chapters cover: "The Structure and biology of HIV-1," "The Genetics of HIV-1," "Nucleoside Inhibitors of HIV Reverse Transcriptase and the Problem of Drug Resistance," "Non-Nucleoside Reverse Transcriptase Inhibitors of HIV-1," "HIV-1 Protease Inhibitors," "The Biology and Biochemistry of Integration as a Target for Chemotherapeutic Intervention," "Chemokine Receptors in HIV Infection and AIDS," "Novel HIV-1 Therapeutic Targets: Regulatory Functions," "Novel HIV-1 Therapeutic Targets: Accessory Functions," "The Interface between the Pathogenesis and Treatment of HIV Infection," "HIV Prevention: Implementing Proven Prevention Interventions to Control the Global Epidemic," "The Immunobiology of HIV-1 Infection," and "HIV Vaccines 2000: Prospects and Challenges."

The last three chapters are of particular interest in that they talk about the need to rely on prevention, either through social programs or through the development of a vaccine. It is the editor's sincere wish that in another decade's time "we will look back and be able to chronicle the defeat of the HIV-1 epidemic." This is a very important book, providing an excellent summary of where we are today and what needs to be done. It is extremely well documented with long bibliographic reference lists. Although the language is research oriented, the educated layperson will be able to read the book. Highly recommended for all academic and medical libraries.

Keywords: Biology; Immunology; Therapy
020918
BK021148

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