AIDS Vaccine Research

AIDS Vaccine Research

Marcel Dekker, 270 Madison Ave., New York, NY 10016. 342p., bibliog.., index. ISBN 0-8247-0645-5. $165.00.
edited by Flossie Wong-Staal, Robert C. Gallo. 2002.

Developing a vaccine for AIDS has been met with many obstacles. Researchers are still debating about what a vaccine must accomplish: should it completely prevent HIV infection or should it prevent disease but not infection. "Since sterilizing immunity seems out of reach, infection without disease would appear to be an acceptable alternative." But even here, one can never be sure that any infection will not ultimately lead to disease and will any effective vaccine lead to increased risky behavior, which will then increase the incidence of infection.

This book looks at some of the recent vaccine research with two of the chapters by leaders in the field, Tomas Hanke, Andrew McMichael, Guislaine Carcelain, Lucile Mollet, and Brigitte Autran. The 12 chapters cover: "AIDS Vaccines: Challenges and Opportunities," "Immunopathogenesis of HIV Infection," "The Genetic Diversity of HIV-1 and Its Implications for Vaccine Development," "The Role of Cytotoxic T Lymphocytes in Protection Against HIV Infection and AIDS," "Immune Reconstitution in HIV Infection," "Design of Engineered Vaccines for HIV," "DNA Vaccines for Immunodeficiency Viruses," "Replication-Deficient, Pseudotyped HIV-1 Vectors as HIV Vaccines," "Development of Mucosal DNA Vaccines Against HIV-1 Using Live Attenuated Salmonella typhi as a Vaccine-Delivery System," "Innate Immunity in HIV Infection," "The Role for Nonhuman Primate Models in the Development and Testing of AIDS Vaccines," and "International Perspectives on HIV Vaccine Development."

It is important that a vaccine be developed as quickly as possible. It represents our best hope of helping the developing countries. This is an excellent book that provides current research findings on an AIDS vaccine. It is highly recommended for all health science libraries.

Keywords: Vaccines
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