Chemokine Receptors and AIDS Books In Print
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Chemokine Receptors and AIDS

Marcel Dekker, 270 Madison Ave., New York, NY 10016. 260p., illus., bibliog., index. (Infectious Disease and Therapy). ISBN 0-8247-0636-6. $135.00.
edited by Thomas R. O'Brien. 2002.

"The past few years have seen dramatic advances in our understanding of how human immunodeficiency virus type 1 (HIV-1) enters cells. Chemokines (chemoatractant cytokines) and chemokine receptors form a complex system that is essential to inflammation." By studying the roles played by chemokines, chemokine receptors, and human genetic variability, scientists are discovering new therapeutic options for HIV-1 infected patients. The current "cocktail" therapies have provided dramatic improvements in patient survival but more research is needed to combat the resistance to the drugs that has developed in some patients. This book provides a comprehensive, yet comprehensible, review of recent seminal work in research associated with chemokine receptors.

The first four chapters provide background information on chemokines and chemokine receptor interactions and functions. The next three chapters discuss human genetics and AIDS and the last five chapters outline the therapeutic implications of this research. This is a highly technical book and intended for virologists, epidemiologist, and clinicians specializing in AIDS. It is highly recommended for all health science libraries.

Keywords: Chemokine Receptors; Genetics; Infectious Diseases; Therapies)

KWDchemokinereceptors;genetics;infectiousdiseases;therapies)
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