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Mechanisms and Specificity of HIV Entry Into Host Cells

Plenum Press, 233 Spring St., New York, NY 10013. 242p., illus., bibliog., index. (Advances in Experimental Medicine and Biology, v. 300) ISBN 0-306-44008-3. $69.50.
Edited by Nejat Duzgunes. 1991.

This is the proceedings of a workshop on mechanisms and specificity of HIV entry into host cells, held June 19-20, 1989, in San Francisco, CA. Several of the chapters are the edited transcripts of the discussions following each presentation at the workshop. The individual papers cover such topics as viral and cellular factors influencing HIV tropism, molecular analysis of receptor binding and viral tropism, infected cells, virus infections, mediators of fusion between HIV-infected macrophages and lymphoid cells, mechanism of HIV-1 entry into CD4+ T cells, HIV-1 infection of a non-CD4-expressing variant of HUT-78 cells, endocytic pathway for human immunodeficiency virus infection, the role of CD4 in the penetration of cells, and CD4 envelop interactions of HIV-1 and related human retroviruses.

This is a highly technical account for the researcher who is working in this area of AIDS research. Each article is well-written and documented. All of the chapters are from camera-ready copy. There are lengthy bibliographies following most chapters and a fairly detailed index is included. It is recommended for all medical libraries where AIDS research is being conducted. (H. Robert Malinowsky)

Keywords: HIV, Host-Virus Relationships, Pathogenesis, Antigens, CD4, HIV Physiology, Viral Proteins, Virus Replication)

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Copyright © 1993 - The University of Illinois at Chicago. All materials in the journal are subject to copyright by the Board of Trustees of the University of Illinois and may be reprinted or redistributed for the noncommercial purpose of scientific or educational advancement granted by Sections 107 and 108 of the Copyright Revision Act of 1976. For other reprinting, redistribution, or translation, address requests to H. Robert Malinowsky, University of Illinois at Chicago Library, PO Box 8198, Chicago, IL 60680 or electronically to hrm@uic.edu.

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