(BALA) MEDICAL UPDATE: Integrase Inhibitors

(BALA) MEDICAL UPDATE: Integrase Inhibitors

BEING ALIVE; April 1995
presented by Mark Katz MD and reported by Jim Stoecker

Integrase is an enzyme needed for incorporating HIV into a cell's DNA. This is yet another point in the virus's life cycle where we can intervene to stop proliferation. To develop an inhibitor, we need to understand the structure of the enzyme, and researchers now know the detailed three-dimensional structure of integrase. The next step in developing an integrase inhibitor is to search for compounds that have properties that will specifically inhibit this enzyme. Five such compounds have so far been identified. And so the development of integrase inhibitors is underway with, of course, a long way to go. But the hope is there for eventually having an antiviral that works at a point different from both reverse transcriptase and protease inhibitors.

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