MEDICAL UPDATE: Disappointing News On Convergent Combination Therapy


MEDICAL UPDATE: Disappointing News On Convergent Combination Therapy

Being Alive Newsletter; Beling Alive/Los Angeles - September 93
Mark Katz MD and reported by Jim Stoecker


Last year's front page news heralding the results of in vitro tests of combination AZT/ddI/Neviropine was premature and indicated the danger of publishing scientific results by press release. The resulting hoopla and demand for large scale trials obscured the facts that research was sloppily done and published without adequate verification of data, and that some laboratory data was misread and failed to detect significant viral mutation occurring in the test tube.

Although the news is disappointing, the trials of convergent combination therapy are going forward; certainly no one is being harmed by them. Perhaps we may yet find efficacy. Meanwhile, the emphasis may shift to divergent combination therapy approaches.


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