MEDICAL UPDATE: D4T and 3TC

MEDICAL UPDATE: D4T and 3TC

Being Alive Newsletter, Being Alive/Los Angeles - August 1993
Mark Katz, MD and reported by Jim Stoecker

D4T and 3TC are two more reverse transcriptase inhibitor antivirals that are currently being tested. D4T studies have not yet yielded efficacy data, but the side effects profile has been published. As we have seen in other drugs, peripheral neuropathy is the major side effect. The incidence, however, is somewhat lower than what was seen in ddI and ddC studies. Once D4T efficacy data is published, we may see quick FDA approval of this antiviral.

3TC has been studied over the last few years. A Dutch study of about 100 people reported only transient increases in CD4 levels. A US study of over 200 people found a somewhat more sustained CD4 increase. So far, no major side effects have been noted. Now a large Phase II/III study of 3TC is being formed. This 32-week study will have two major groups: those with CD4 in the 200-500 range with no previous antiviral therapy and those in the 100-300 CD4 range with at least 24 weeks of AZT therapy (but no prior ddI or ddC). This study is being sponsored locally by a group called Combat. For information on the 3TC study, call Holly Boyd at 213.469.5888.
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