NOTES FROM ICAAC: PCP Prophylaxis

NOTES FROM ICAAC: PCP Prophylaxis

Being Alive Newsletter; December 1992
Walt Senterfit

Four studies once again showed the superiority of Bactrim/Septra as prophylaxis against PCP, when compared to aerosolized pentamidine, both in people who have never had PCP (known as primary prophylaxis) and in those who have (secondary prophylaxis). Two studies from Europe showed Bactrim's superiority to dapsone as well, either dapsone alone or dapsone combined with pyramethamine. While dapsone significantly reduces the risk of PCP, and as such is a good alternative for those who have intolerable adverse reactions to Bactrim, the studies clearly showed that dapsone permitted more "PCP breakthrough" than Bactrim.

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