MEDICAL UPDATE: Fluconazole As Primary Treatment For Cryptococcal Meningitis

MEDICAL UPDATE: Fluconazole As Primary Treatment For Cryptococcal Meningitis

Being Alive; March 1992
presented by Mark Katz MD and reported by Jim Stoecker

Fluconazole was approved by the FDA a couple of years ago and has been used as maintenance therapy for cryptococcal meningitis. For the initial treatment of this opportunistic infection, physicians have used Amphotericin B, a toxic drug that many find difficult to take. Now researchers are asking whether oral fluconazole can be used as initial treatment. Can crypto be treated without the use of IV Amphotericin B? A report in a recent New England Journal of Medicine says that fluconazole may be a reasonable alternative for initial treatment in patients who are not critically ill.
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