AIDS Treatment Update, Issue 65, May 1998

- A comparison of AZT/3TC/abacavir (1592U89) versus AZT/3TC/indinavir for previously untreated people with CD4 counts above 100 and viral load above 10,000 (KCH, RF, RL).

- A trial of cidofovir for treating the brain infection PML (BRI, CW, EDI, RF).

- A trial for people whose viral load has been suppressed to below detection using a protease inhibitor plus two NRTIs. The study will see whether people who stop taking their NRTIs and add efavirenz (DMP-266) to their current protease inhibitor, or who stop their protease inhibitor and add efavirenz to their current NRTIs, sustain their `undetectable' viral load better than those who remain on their current triple therapy (KCH, CW).

- Two trials of the immune-booster interleukin-2, one in which it is taken in combination with anti-HIV therapy (CW), and one in which it is taken on its own (BRI, CW, MMC, RF, StM).

- A trial for people with viral load greater than 15,000 testing various doses of nelfinavir (twice or three times daily) in combination with d4T/3TC (BRI, CW, EDI, MMC, RF, StT).

- A trial of AZT/3TC/abacavir/amprenavir for newly infected people (BEL, BRI, CAR, CW, MAN, RF).

- Two trials of valganciclovir, which breaks down in the body to provide high levels of ganciclovir, to treat CMV retinitis and prevent recurrences (BRI, CW, MAN, StM).

CODE - CENTRE - WHO TO CONTACT

BEL - Royal Victoria Hospital, Belfast - Dr Raymond Maw, Tel: 01232 894777

BRI - Claude Nicol Centre, Brighton - Nicky Perry, Tel: 01273 664532

CAR - University Hospital of Wales, Cardiff - Dr A Freedman, Tel: 01222 742155

CW - Kobler Centre - Chris Higgs, Tel: 0181-746 8000

EDI - City Hospital, Edinnburgh - Sheila Morris, Tel: 0131-536 6548

KCH - Kings College Hospital - Rebecca McKay or Dee Graham, Tel: 0171-346 3479

MAN - North Manchester General Hospital - Dr Bibhat Mandal, Tel: 0161 720 2729

MMC - Mortimer Market Centre - Dr Ian Williams, Tel: 0171-530 5000

NOT - Nottingham City Hospital - Alison Cargill, Tel: 0115 962 7746

RFH - Royal Free Hospital - Deborah Wilson (bleep 955) or Sharon Chapman (bleep 660), Tel: 0171-794 0500

SH - Royal Hallamshire Hospital, Sheffield - Dr Bradbury, Tel: 0114 276 6928

RL - Royal London Hospital - Dr Celia Skinner, Tel: 0171-377 7308

StM - St Mary's Hospital - Ken Legg, Tel: 0171-725 6738

StT - St Thomas' Hospital - Nicky Hicky or Nikki Saint, Tel: 0181-528 9292 x1080

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