News in brief: ADHOC trial begins

News in brief: ADHOC trial begins

AIDS Treatment Update, Issue 55, July 1997
Keith Alcorn

Recruitment to the ADHOC trial will begin shortly at the Royal Free Hospital, King's College Hospital, St George's Hospital and St Thomas' Hospital in London, and at the General Infirmary at Leeds, Royal Hallamshire Hospital (Sheffield), Newcastle General Hospital and North Manchester Hospital. At least 20 more centres will eventually join in.

ADHOC is a large European/Australian trial testing adefovir dipivoxil (also known as bis-POM PMEA) which is active against HIV but also against CMV, other herpes viruses and hepatitis B virus. ADHOC will enrol people with a CD4 count below 100 who have never had CMV disease and will assess, primarily, whether adefovir prolongs survival and/or prevents the development of CMV disease in individuals already on antiretroviral therapy. The trial is co-ordinated in the UK by the Medical Research Council HIV Clinical Trials Centre.

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Always watch for outdated information. This article first appeared in 1997. This material is designed to support, not replace, the relationship that exists between you and your doctor.

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