AIDS Treatment Update, No. 44, August 1996
Edward King

The study recruited twelve anti-retroviral naive patients with high initial viral load (100,000 copies/ml) and an average CD4 count of 245. One participant dropped out because of diarrhoea, known to be a common side-effect of nelfinavir.

The remaining eleven had CD4 count increases averaging 95, their viral load fell to undetectably low levels (below 25 copies/ml) after 16 weeks of treatment, and infectious virus could not be grown in culture from their blood cells. The average reduction was 3.96 log - one of the best yet reported for an anti-viral combination. After twenty weeks several cases of candidiasis, neuropathy, folliculitis and oral hairy leucoplakia had cleared up (LB.B.6031).

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