AEGiS-ATN: Vaccine Against Three Kinds of HIV Begins Human Tests

Important note: Information in this article was accurate in 2002. The state of the art may have changed since the publication date.

Vaccine Against Three Kinds of HIV Begins Human Tests

AIDS TREATMENT NEWS Issue #385, November 22, 2002
John S. James

The new Vaccine Research Center at the U.S. National Institute of Allergy and Infectious Diseases is starting the first human trial of its vaccine candidate, developed to target HIV clades (subtypes) A, B, and C. Together these subtypes are responsible for about 90% of the world's AIDS epidemic (clade B causes almost all of the infections in the U.S.). Also, it might be more difficult for HIV to develop mutations to escape control by a multiclade vaccine, since it targets the virus in different ways.

Fifty healthy HIV-negative volunteers between 18 and 40 are needed for the first trial, which will be conducted at the National Institutes of Health in Bethesda, Maryland. This placebo-controlled trial will check for safety and also for immune responses to HIV. Later trials will run in several U.S. sites, as well as in Haiti and South Africa.

For more information about the trial, including ways to volunteer, call 1-866-833-LIFE (5433), email vrcforlife@mail.nih.gov, or visit: http://www.niaid.nih.gov/vrc or http://www.clinicaltrials.gov
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