(ATN) New Double Vs. Triple Antiviral Combination Study, CD4 200-500, No Prior Treatment

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(ATN) New Double Vs. Triple Antiviral Combination Study, CD4 200-500, No Prior Treatment

AIDS TREATMENT NEWS Issue #236, December 1, 1995
John S. James


A clinical trial at 25 sites across the U.S. is now enrolling 225 volunteers to compare three different combination anti- HIV treatment regimens. Participants must have a CD4 count between 200 and 500, and not have previously used antiretrovirals. The trial will last one year.

Each volunteer will be randomly assigned to either: (1) AZT plus ddI, (2) AZT plus ddI plus 3TC, and (3) AZT plus ddI plus nevirapine (an experimental non-nucleoside reverse transcriptase inhibitor). The study will compare the effects of these different regimens on viral load, CD4 count, and perhaps other "markers" of disease progression.

This trial, known as protocol ICC-002, is sponsored by the Inter-Company Collaboration for AIDS Drug Development, a consortium of most of the large companies developing AIDS drug. For more information, or to find the location and contact information for a site near you, patients or physicians can call 800/925-AIDS, from 9 a.m. to 5 p.m. Eastern time.


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