(ATN) Protease Inhibitor Trial Drops AZT-Only Arm

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(ATN) Protease Inhibitor Trial Drops AZT-Only Arm

AIDS TREATMENT NEWS #234, November 3, 1995
John S. James


Hoffmann-La Roche has changed its trial of the protease inhibitor saquinavir, due to new information from the ACTG 175 trial and the Delta trial showing that AZT alone was inferior to combination therapy (for background on ACTG 175, see AIDS TREATMENT NEWS #231, September 23, 1995; for background on Delta, see AIDS TREATMENT NEWS # 232, October 6, 1995).

Those in the saquinavir trial (named SV 1406) who were randomized to AZT will be offered a chance to switch to the triple combination of saquinavir plus AZT plus ddC. New volunteers entering the trial will be randomized to one of the three combination-therapy arms (saquinavir plus AZT, AZT plus ddC, or the triple combination).


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