(ATN) Itraconazole Approved

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(ATN) Itraconazole Approved

AIDS Treatment News #161, October 16, 1992
John S. James


On September 11, the U. S. Food and Drug Administration approved itraconazole (brand name Sporanox), an antifungal. It is officially indicated for treatment of histoplasmosis and blastomycosis, but physicians can prescribe it for other conditions. Other AIDS-related uses have included aspergillosis (a rare but life-threatening fungal infection) and eosinophilic folliculitis (a skin condition which causes intense itching -- see article below). Before approval, the drug was obtained abroad or from buyers' clubs.

Itraconazole must not be combined with terfenadine (Seldane); other warnings are included in the package insert, which contains prescribing information for physicians.

Itraconazole will be expensive in the U. S., but somewhat less expensive than fluconazole.


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