AIDS Treatment News No. 147 - March 20, 1992
John S. James
* Those with T-helper counts less than 250 who have had a reaction to the drug; and
* Those with T-helper counts more than 400 who have never had a reaction to co-trimoxazole (whether or not they have ever used the drug).
For more information about this study, call Mark Dybul, M. D., at 415/923-1333.
Background
Co-trimoxazole is widely believed to be better than aerosol pentamidine for pneumocystis prophylaxis (prevention); it may also help to prevent toxoplasmosis. Co-trimoxazole is also much less expensive than aerosol pentamidine. But many people who are HIV positive cannot use this drug because of allergic reactions. In the past, Dr. Conant has had some success with a special protocol for desensitizing patients who had already developed sensitivity to co-trimoxazole; some of them have been able to resume its use. The new study attempts to build on this experience to see if it is possible to prevent the reaction in the first place; it is seeking quantitative data which can be used widely to improve the general standard of care.
920320
ATN14704
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